Amino acid dipepetide frequency for Mycobacterium sp. 852013-51886_SCH5428379

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.849AlaAla: 20.849 ± 0.183	0.929AlaCys: 0.929 ± 0.03	9.079AlaAsp: 9.079 ± 0.091	8.075AlaGlu: 8.075 ± 0.082	3.546AlaPhe: 3.546 ± 0.057	12.436AlaGly: 12.436 ± 0.158	2.564AlaHis: 2.564 ± 0.046	5.056AlaIle: 5.056 ± 0.07	2.715AlaLys: 2.715 ± 0.057	13.509AlaLeu: 13.509 ± 0.107	2.935AlaMet: 2.935 ± 0.05	2.378AlaAsn: 2.378 ± 0.041	6.637AlaPro: 6.637 ± 0.094	3.94AlaGln: 3.94 ± 0.064	8.755AlaArg: 8.755 ± 0.089	5.608AlaSer: 5.608 ± 0.063	7.254AlaThr: 7.254 ± 0.071	12.621AlaVal: 12.621 ± 0.104	1.595AlaTrp: 1.595 ± 0.034	2.323AlaTyr: 2.323 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	1.077CysAla: 1.077 ± 0.029	0.074CysCys: 0.074 ± 0.008	0.523CysAsp: 0.523 ± 0.02	0.366CysGlu: 0.366 ± 0.017	0.211CysPhe: 0.211 ± 0.013	0.87CysGly: 0.87 ± 0.027	0.168CysHis: 0.168 ± 0.01	0.252CysIle: 0.252 ± 0.014	0.113CysLys: 0.113 ± 0.009	0.624CysLeu: 0.624 ± 0.02	0.121CysMet: 0.121 ± 0.01	0.155CysAsn: 0.155 ± 0.011	0.459CysPro: 0.459 ± 0.021	0.187CysGln: 0.187 ± 0.013	0.606CysArg: 0.606 ± 0.02	0.436CysSer: 0.436 ± 0.018	0.47CysThr: 0.47 ± 0.022	0.657CysVal: 0.657 ± 0.022	0.113CysTrp: 0.113 ± 0.009	0.179CysTyr: 0.179 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.357AspAla: 8.357 ± 0.084	0.439AspCys: 0.439 ± 0.015	4.715AspAsp: 4.715 ± 0.071	4.193AspGlu: 4.193 ± 0.062	1.831AspPhe: 1.831 ± 0.036	6.476AspGly: 6.476 ± 0.102	1.453AspHis: 1.453 ± 0.035	2.647AspIle: 2.647 ± 0.044	1.159AspLys: 1.159 ± 0.033	6.226AspLeu: 6.226 ± 0.066	1.08AspMet: 1.08 ± 0.03	1.183AspAsn: 1.183 ± 0.029	4.559AspPro: 4.559 ± 0.059	1.673AspGln: 1.673 ± 0.034	5.058AspArg: 5.058 ± 0.061	2.741AspSer: 2.741 ± 0.046	3.415AspThr: 3.415 ± 0.048	5.677AspVal: 5.677 ± 0.067	1.021AspTrp: 1.021 ± 0.029	1.39AspTyr: 1.39 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	6.253GluAla: 6.253 ± 0.071	0.334GluCys: 0.334 ± 0.015	2.738GluAsp: 2.738 ± 0.042	2.567GluGlu: 2.567 ± 0.049	1.84GluPhe: 1.84 ± 0.04	3.378GluGly: 3.378 ± 0.055	1.457GluHis: 1.457 ± 0.036	2.583GluIle: 2.583 ± 0.046	1.344GluLys: 1.344 ± 0.036	6.448GluLeu: 6.448 ± 0.072	1.082GluMet: 1.082 ± 0.024	1.097GluAsn: 1.097 ± 0.026	3.093GluPro: 3.093 ± 0.059	2.235GluGln: 2.235 ± 0.039	4.583GluArg: 4.583 ± 0.055	2.561GluSer: 2.561 ± 0.042	2.813GluThr: 2.813 ± 0.037	4.566GluVal: 4.566 ± 0.061	0.775GluTrp: 0.775 ± 0.026	1.1GluTyr: 1.1 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.117PheAla: 4.117 ± 0.063	0.311PheCys: 0.311 ± 0.016	2.555PheAsp: 2.555 ± 0.04	1.554PheGlu: 1.554 ± 0.032	1.004PhePhe: 1.004 ± 0.031	3.501PheGly: 3.501 ± 0.056	0.616PheHis: 0.616 ± 0.02	1.1PheIle: 1.1 ± 0.03	0.494PheLys: 0.494 ± 0.02	2.619PheLeu: 2.619 ± 0.046	0.501PheMet: 0.501 ± 0.017	0.697PheAsn: 0.697 ± 0.021	1.37PhePro: 1.37 ± 0.027	0.677PheGln: 0.677 ± 0.019	1.687PheArg: 1.687 ± 0.034	1.645PheSer: 1.645 ± 0.035	2.09PheThr: 2.09 ± 0.033	2.61PheVal: 2.61 ± 0.044	0.434PheTrp: 0.434 ± 0.018	0.673PheTyr: 0.673 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.886GlyAla: 10.886 ± 0.135	0.753GlyCys: 0.753 ± 0.027	5.47GlyAsp: 5.47 ± 0.085	4.497GlyGlu: 4.497 ± 0.062	3.127GlyPhe: 3.127 ± 0.048	8.663GlyGly: 8.663 ± 0.367	2.07GlyHis: 2.07 ± 0.041	4.053GlyIle: 4.053 ± 0.057	2.064GlyLys: 2.064 ± 0.042	8.655GlyLeu: 8.655 ± 0.081	2.158GlyMet: 2.158 ± 0.036	1.964GlyAsn: 1.964 ± 0.07	4.637GlyPro: 4.637 ± 0.063	2.672GlyGln: 2.672 ± 0.057	6.703GlyArg: 6.703 ± 0.079	5.1GlySer: 5.1 ± 0.065	5.352GlyThr: 5.352 ± 0.106	8.095GlyVal: 8.095 ± 0.075	1.624GlyTrp: 1.624 ± 0.035	2.336GlyTyr: 2.336 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.388HisAla: 2.388 ± 0.045	0.203HisCys: 0.203 ± 0.012	1.343HisAsp: 1.343 ± 0.03	1.012HisGlu: 1.012 ± 0.023	0.703HisPhe: 0.703 ± 0.021	2.106HisGly: 2.106 ± 0.042	0.667HisHis: 0.667 ± 0.024	0.793HisIle: 0.793 ± 0.022	0.305HisLys: 0.305 ± 0.015	2.144HisLeu: 2.144 ± 0.041	0.347HisMet: 0.347 ± 0.016	0.412HisAsn: 0.412 ± 0.016	1.65HisPro: 1.65 ± 0.034	0.579HisGln: 0.579 ± 0.019	1.937HisArg: 1.937 ± 0.039	0.995HisSer: 0.995 ± 0.024	1.205HisThr: 1.205 ± 0.032	1.696HisVal: 1.696 ± 0.036	0.356HisTrp: 0.356 ± 0.015	0.549HisTyr: 0.549 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.38IleAla: 6.38 ± 0.081	0.407IleCys: 0.407 ± 0.018	3.334IleAsp: 3.334 ± 0.055	2.503IleGlu: 2.503 ± 0.042	1.003IlePhe: 1.003 ± 0.027	4.571IleGly: 4.571 ± 0.062	0.726IleHis: 0.726 ± 0.025	1.415IleIle: 1.415 ± 0.041	0.773IleLys: 0.773 ± 0.028	3.044IleLeu: 3.044 ± 0.052	0.59IleMet: 0.59 ± 0.022	1.006IleAsn: 1.006 ± 0.028	2.309IlePro: 2.309 ± 0.041	0.866IleGln: 0.866 ± 0.022	2.572IleArg: 2.572 ± 0.043	2.128IleSer: 2.128 ± 0.036	2.76IleThr: 2.76 ± 0.039	3.745IleVal: 3.745 ± 0.054	0.449IleTrp: 0.449 ± 0.019	0.77IleTyr: 0.77 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.409LysAla: 2.409 ± 0.049	0.101LysCys: 0.101 ± 0.008	1.007LysAsp: 1.007 ± 0.026	0.884LysGlu: 0.884 ± 0.027	0.534LysPhe: 0.534 ± 0.02	1.448LysGly: 1.448 ± 0.033	0.44LysHis: 0.44 ± 0.02	0.914LysIle: 0.914 ± 0.027	0.62LysLys: 0.62 ± 0.027	1.965LysLeu: 1.965 ± 0.046	0.447LysMet: 0.447 ± 0.016	0.498LysAsn: 0.498 ± 0.019	1.309LysPro: 1.309 ± 0.034	0.648LysGln: 0.648 ± 0.019	1.526LysArg: 1.526 ± 0.037	1.097LysSer: 1.097 ± 0.029	1.275LysThr: 1.275 ± 0.035	1.808LysVal: 1.808 ± 0.042	0.278LysTrp: 0.278 ± 0.013	0.411LysTyr: 0.411 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.941LeuAla: 13.941 ± 0.119	0.786LeuCys: 0.786 ± 0.024	6.755LeuAsp: 6.755 ± 0.086	4.535LeuGlu: 4.535 ± 0.061	2.811LeuPhe: 2.811 ± 0.046	8.692LeuGly: 8.692 ± 0.096	2.035LeuHis: 2.035 ± 0.046	4.155LeuIle: 4.155 ± 0.061	1.642LeuLys: 1.642 ± 0.034	9.784LeuLeu: 9.784 ± 0.112	1.75LeuMet: 1.75 ± 0.033	2.012LeuAsn: 2.012 ± 0.04	5.774LeuPro: 5.774 ± 0.069	2.507LeuGln: 2.507 ± 0.04	7.74LeuArg: 7.74 ± 0.079	5.513LeuSer: 5.513 ± 0.061	6.607LeuThr: 6.607 ± 0.07	8.393LeuVal: 8.393 ± 0.108	1.233LeuTrp: 1.233 ± 0.032	1.673LeuTyr: 1.673 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	2.731MetAla: 2.731 ± 0.04	0.174MetCys: 0.174 ± 0.011	0.839MetAsp: 0.839 ± 0.024	0.701MetGlu: 0.701 ± 0.022	0.636MetPhe: 0.636 ± 0.02	1.517MetGly: 1.517 ± 0.032	0.394MetHis: 0.394 ± 0.02	0.869MetIle: 0.869 ± 0.026	0.427MetLys: 0.427 ± 0.018	2.017MetLeu: 2.017 ± 0.04	0.425MetMet: 0.425 ± 0.016	0.484MetAsn: 0.484 ± 0.016	1.205MetPro: 1.205 ± 0.029	0.531MetGln: 0.531 ± 0.019	1.593MetArg: 1.593 ± 0.036	1.624MetSer: 1.624 ± 0.031	1.936MetThr: 1.936 ± 0.038	1.642MetVal: 1.642 ± 0.037	0.274MetTrp: 0.274 ± 0.014	0.337MetTyr: 0.337 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.554AsnAla: 2.554 ± 0.037	0.175AsnCys: 0.175 ± 0.01	1.185AsnAsp: 1.185 ± 0.029	0.925AsnGlu: 0.925 ± 0.024	0.613AsnPhe: 0.613 ± 0.02	2.088AsnGly: 2.088 ± 0.078	0.417AsnHis: 0.417 ± 0.017	0.906AsnIle: 0.906 ± 0.027	0.405AsnLys: 0.405 ± 0.018	1.939AsnLeu: 1.939 ± 0.038	0.416AsnMet: 0.416 ± 0.017	0.525AsnAsn: 0.525 ± 0.019	1.659AsnPro: 1.659 ± 0.037	0.603AsnGln: 0.603 ± 0.023	1.54AsnArg: 1.54 ± 0.032	1.045AsnSer: 1.045 ± 0.028	1.219AsnThr: 1.219 ± 0.032	1.711AsnVal: 1.711 ± 0.032	0.367AsnTrp: 0.367 ± 0.016	0.534AsnTyr: 0.534 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.598ProAla: 7.598 ± 0.141	0.289ProCys: 0.289 ± 0.013	4.574ProAsp: 4.574 ± 0.063	3.761ProGlu: 3.761 ± 0.06	1.712ProPhe: 1.712 ± 0.029	5.755ProGly: 5.755 ± 0.07	1.176ProHis: 1.176 ± 0.032	2.028ProIle: 2.028 ± 0.037	1.161ProLys: 1.161 ± 0.029	4.996ProLeu: 4.996 ± 0.073	1.23ProMet: 1.23 ± 0.032	1.188ProAsn: 1.188 ± 0.03	3.814ProPro: 3.814 ± 0.107	1.827ProGln: 1.827 ± 0.042	3.493ProArg: 3.493 ± 0.046	2.938ProSer: 2.938 ± 0.045	3.457ProThr: 3.457 ± 0.056	5.353ProVal: 5.353 ± 0.066	0.814ProTrp: 0.814 ± 0.022	1.175ProTyr: 1.175 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.428GlnAla: 3.428 ± 0.058	0.215GlnCys: 0.215 ± 0.013	1.247GlnAsp: 1.247 ± 0.032	1.139GlnGlu: 1.139 ± 0.029	0.92GlnPhe: 0.92 ± 0.025	1.982GlnGly: 1.982 ± 0.047	0.659GlnHis: 0.659 ± 0.019	1.464GlnIle: 1.464 ± 0.033	0.591GlnLys: 0.591 ± 0.022	3.24GlnLeu: 3.24 ± 0.046	0.726GlnMet: 0.726 ± 0.025	0.594GlnAsn: 0.594 ± 0.02	1.791GlnPro: 1.791 ± 0.04	1.254GlnGln: 1.254 ± 0.037	2.675GlnArg: 2.675 ± 0.041	1.424GlnSer: 1.424 ± 0.032	1.627GlnThr: 1.627 ± 0.033	2.359GlnVal: 2.359 ± 0.047	0.567GlnTrp: 0.567 ± 0.025	0.623GlnTyr: 0.623 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.559ArgAla: 8.559 ± 0.095	0.572ArgCys: 0.572 ± 0.021	4.541ArgAsp: 4.541 ± 0.053	3.917ArgGlu: 3.917 ± 0.05	2.5ArgPhe: 2.5 ± 0.046	5.361ArgGly: 5.361 ± 0.064	1.806ArgHis: 1.806 ± 0.037	3.562ArgIle: 3.562 ± 0.058	1.457ArgLys: 1.457 ± 0.034	7.629ArgLeu: 7.629 ± 0.079	1.858ArgMet: 1.858 ± 0.036	1.618ArgAsn: 1.618 ± 0.035	4.199ArgPro: 4.199 ± 0.049	2.175ArgGln: 2.175 ± 0.036	6.954ArgArg: 6.954 ± 0.074	4.046ArgSer: 4.046 ± 0.049	4.432ArgThr: 4.432 ± 0.062	5.684ArgVal: 5.684 ± 0.074	1.393ArgTrp: 1.393 ± 0.031	1.883ArgTyr: 1.883 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.877SerAla: 6.877 ± 0.064	0.386SerCys: 0.386 ± 0.017	3.178SerAsp: 3.178 ± 0.048	2.508SerGlu: 2.508 ± 0.042	1.549SerPhe: 1.549 ± 0.029	5.596SerGly: 5.596 ± 0.065	0.974SerHis: 0.974 ± 0.027	2.037SerIle: 2.037 ± 0.039	1.01SerLys: 1.01 ± 0.029	4.547SerLeu: 4.547 ± 0.061	1.247SerMet: 1.247 ± 0.032	0.996SerAsn: 0.996 ± 0.027	2.985SerPro: 2.985 ± 0.048	1.322SerGln: 1.322 ± 0.032	3.666SerArg: 3.666 ± 0.048	2.962SerSer: 2.962 ± 0.057	3.313SerThr: 3.313 ± 0.048	4.418SerVal: 4.418 ± 0.055	0.867SerTrp: 0.867 ± 0.022	1.156SerTyr: 1.156 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	8.374ThrAla: 8.374 ± 0.089	0.4ThrCys: 0.4 ± 0.017	3.854ThrAsp: 3.854 ± 0.057	3.223ThrGlu: 3.223 ± 0.046	1.827ThrPhe: 1.827 ± 0.041	6.176ThrGly: 6.176 ± 0.091	1.135ThrHis: 1.135 ± 0.028	2.341ThrIle: 2.341 ± 0.047	1.107ThrLys: 1.107 ± 0.028	5.658ThrLeu: 5.658 ± 0.06	1.213ThrMet: 1.213 ± 0.032	1.145ThrAsn: 1.145 ± 0.032	3.993ThrPro: 3.993 ± 0.057	1.433ThrGln: 1.433 ± 0.032	3.778ThrArg: 3.778 ± 0.046	3.095ThrSer: 3.095 ± 0.051	3.874ThrThr: 3.874 ± 0.064	6.336ThrVal: 6.336 ± 0.065	0.886ThrTrp: 0.886 ± 0.028	1.301ThrTyr: 1.301 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.04ValAla: 12.04 ± 0.103	0.733ValCys: 0.733 ± 0.025	6.131ValAsp: 6.131 ± 0.079	4.77ValGlu: 4.77 ± 0.051	2.634ValPhe: 2.634 ± 0.047	7.221ValGly: 7.221 ± 0.074	1.874ValHis: 1.874 ± 0.039	3.899ValIle: 3.899 ± 0.058	1.602ValLys: 1.602 ± 0.036	9.267ValLeu: 9.267 ± 0.104	1.614ValMet: 1.614 ± 0.039	2.017ValAsn: 2.017 ± 0.043	4.832ValPro: 4.832 ± 0.065	2.146ValGln: 2.146 ± 0.038	6.146ValArg: 6.146 ± 0.069	4.651ValSer: 4.651 ± 0.054	5.896ValThr: 5.896 ± 0.074	8.775ValVal: 8.775 ± 0.098	1.077ValTrp: 1.077 ± 0.027	1.613ValTyr: 1.613 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.513TrpAla: 1.513 ± 0.035	0.15TrpCys: 0.15 ± 0.012	0.794TrpAsp: 0.794 ± 0.024	0.652TrpGlu: 0.652 ± 0.023	0.514TrpPhe: 0.514 ± 0.02	1.032TrpGly: 1.032 ± 0.03	0.344TrpHis: 0.344 ± 0.014	0.636TrpIle: 0.636 ± 0.022	0.289TrpLys: 0.289 ± 0.016	1.744TrpLeu: 1.744 ± 0.041	0.332TrpMet: 0.332 ± 0.016	0.387TrpAsn: 0.387 ± 0.017	0.848TrpPro: 0.848 ± 0.025	0.635TrpGln: 0.635 ± 0.021	1.272TrpArg: 1.272 ± 0.032	0.917TrpSer: 0.917 ± 0.026	0.938TrpThr: 0.938 ± 0.028	1.12TrpVal: 1.12 ± 0.028	0.349TrpTrp: 0.349 ± 0.013	0.351TrpTyr: 0.351 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.471TyrAla: 2.471 ± 0.041	0.229TyrCys: 0.229 ± 0.012	1.431TyrAsp: 1.431 ± 0.032	1.062TyrGlu: 1.062 ± 0.029	0.74TyrPhe: 0.74 ± 0.022	2.01TyrGly: 2.01 ± 0.04	0.414TyrHis: 0.414 ± 0.02	0.643TyrIle: 0.643 ± 0.023	0.344TyrLys: 0.344 ± 0.016	2.284TyrLeu: 2.284 ± 0.043	0.286TyrMet: 0.286 ± 0.015	0.468TyrAsn: 0.468 ± 0.016	1.216TyrPro: 1.216 ± 0.032	0.615TyrGln: 0.615 ± 0.018	1.862TyrArg: 1.862 ± 0.039	1.069TyrSer: 1.069 ± 0.028	1.217TyrThr: 1.217 ± 0.028	1.671TyrVal: 1.671 ± 0.037	0.345TyrTrp: 0.345 ± 0.016	0.484TyrTyr: 0.484 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4393 proteins (1448496 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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