Amino acid dipepetide frequency for Butyrivibrio sp. INlla21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.65AlaAla: 6.65 ± 0.133	1.032AlaCys: 1.032 ± 0.03	4.826AlaAsp: 4.826 ± 0.078	5.169AlaGlu: 5.169 ± 0.095	3.165AlaPhe: 3.165 ± 0.053	5.477AlaGly: 5.477 ± 0.083	1.016AlaHis: 1.016 ± 0.034	5.486AlaIle: 5.486 ± 0.087	5.244AlaLys: 5.244 ± 0.096	6.575AlaLeu: 6.575 ± 0.092	2.298AlaMet: 2.298 ± 0.05	2.826AlaAsn: 2.826 ± 0.055	2.052AlaPro: 2.052 ± 0.06	2.073AlaGln: 2.073 ± 0.05	2.631AlaArg: 2.631 ± 0.053	4.557AlaSer: 4.557 ± 0.07	3.749AlaThr: 3.749 ± 0.07	5.579AlaVal: 5.579 ± 0.08	0.574AlaTrp: 0.574 ± 0.027	2.76AlaTyr: 2.76 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.035	0.256CysCys: 0.256 ± 0.019	0.951CysAsp: 0.951 ± 0.03	0.908CysGlu: 0.908 ± 0.027	0.64CysPhe: 0.64 ± 0.027	1.286CysGly: 1.286 ± 0.041	0.256CysHis: 0.256 ± 0.016	1.072CysIle: 1.072 ± 0.032	0.893CysLys: 0.893 ± 0.03	1.015CysLeu: 1.015 ± 0.03	0.418CysMet: 0.418 ± 0.02	0.592CysAsn: 0.592 ± 0.026	0.52CysPro: 0.52 ± 0.022	0.236CysGln: 0.236 ± 0.016	0.495CysArg: 0.495 ± 0.025	0.819CysSer: 0.819 ± 0.028	0.614CysThr: 0.614 ± 0.027	0.933CysVal: 0.933 ± 0.033	0.11CysTrp: 0.11 ± 0.011	0.559CysTyr: 0.559 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.732AspAla: 4.732 ± 0.068	0.739AspCys: 0.739 ± 0.031	4.264AspAsp: 4.264 ± 0.089	5.776AspGlu: 5.776 ± 0.092	2.954AspPhe: 2.954 ± 0.052	4.677AspGly: 4.677 ± 0.088	0.928AspHis: 0.928 ± 0.033	5.691AspIle: 5.691 ± 0.078	5.223AspLys: 5.223 ± 0.08	4.66AspLeu: 4.66 ± 0.072	2.029AspMet: 2.029 ± 0.044	3.265AspAsn: 3.265 ± 0.061	1.978AspPro: 1.978 ± 0.049	1.246AspGln: 1.246 ± 0.036	2.571AspArg: 2.571 ± 0.067	3.748AspSer: 3.748 ± 0.074	3.224AspThr: 3.224 ± 0.059	4.393AspVal: 4.393 ± 0.062	0.568AspTrp: 0.568 ± 0.025	3.332AspTyr: 3.332 ± 0.069	0.0AspXaa: 0.0 ± 0.0
Glu	5.509GluAla: 5.509 ± 0.094	0.797GluCys: 0.797 ± 0.028	4.835GluAsp: 4.835 ± 0.084	6.456GluGlu: 6.456 ± 0.12	2.871GluPhe: 2.871 ± 0.061	4.374GluGly: 4.374 ± 0.075	1.261GluHis: 1.261 ± 0.039	5.626GluIle: 5.626 ± 0.08	6.6GluLys: 6.6 ± 0.094	6.781GluLeu: 6.781 ± 0.078	2.16GluMet: 2.16 ± 0.048	4.142GluAsn: 4.142 ± 0.066	1.788GluPro: 1.788 ± 0.051	2.165GluGln: 2.165 ± 0.057	2.931GluArg: 2.931 ± 0.06	3.645GluSer: 3.645 ± 0.074	3.425GluThr: 3.425 ± 0.053	4.527GluVal: 4.527 ± 0.074	0.658GluTrp: 0.658 ± 0.027	3.426GluTyr: 3.426 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	3.051PheAla: 3.051 ± 0.067	0.683PheCys: 0.683 ± 0.027	3.246PheAsp: 3.246 ± 0.064	2.784PheGlu: 2.784 ± 0.048	2.171PhePhe: 2.171 ± 0.056	3.157PheGly: 3.157 ± 0.06	0.675PheHis: 0.675 ± 0.026	3.491PheIle: 3.491 ± 0.073	2.677PheLys: 2.677 ± 0.057	3.691PheLeu: 3.691 ± 0.086	1.32PheMet: 1.32 ± 0.039	1.91PheAsn: 1.91 ± 0.044	1.307PhePro: 1.307 ± 0.033	0.83PheGln: 0.83 ± 0.031	1.513PheArg: 1.513 ± 0.037	2.884PheSer: 2.884 ± 0.064	2.378PheThr: 2.378 ± 0.045	2.997PheVal: 2.997 ± 0.063	0.449PheTrp: 0.449 ± 0.024	1.909PheTyr: 1.909 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	5.013GlyAla: 5.013 ± 0.082	1.147GlyCys: 1.147 ± 0.039	4.164GlyAsp: 4.164 ± 0.072	4.696GlyGlu: 4.696 ± 0.074	3.241GlyPhe: 3.241 ± 0.054	4.533GlyGly: 4.533 ± 0.093	1.162GlyHis: 1.162 ± 0.034	6.114GlyIle: 6.114 ± 0.086	5.718GlyLys: 5.718 ± 0.08	5.46GlyLeu: 5.46 ± 0.079	2.252GlyMet: 2.252 ± 0.05	3.382GlyAsn: 3.382 ± 0.071	1.294GlyPro: 1.294 ± 0.039	1.722GlyGln: 1.722 ± 0.043	2.637GlyArg: 2.637 ± 0.061	4.141GlySer: 4.141 ± 0.072	3.896GlyThr: 3.896 ± 0.07	4.692GlyVal: 4.692 ± 0.063	0.585GlyTrp: 0.585 ± 0.024	3.383GlyTyr: 3.383 ± 0.067	0.0GlyXaa: 0.0 ± 0.0
His	1.035HisAla: 1.035 ± 0.035	0.247HisCys: 0.247 ± 0.016	0.984HisAsp: 0.984 ± 0.032	1.057HisGlu: 1.057 ± 0.038	0.739HisPhe: 0.739 ± 0.029	1.17HisGly: 1.17 ± 0.036	0.383HisHis: 0.383 ± 0.04	1.263HisIle: 1.263 ± 0.04	1.016HisLys: 1.016 ± 0.036	1.253HisLeu: 1.253 ± 0.038	0.483HisMet: 0.483 ± 0.021	0.789HisAsn: 0.789 ± 0.031	0.756HisPro: 0.756 ± 0.029	0.379HisGln: 0.379 ± 0.02	0.641HisArg: 0.641 ± 0.024	0.91HisSer: 0.91 ± 0.031	0.76HisThr: 0.76 ± 0.029	1.042HisVal: 1.042 ± 0.031	0.127HisTrp: 0.127 ± 0.011	0.734HisTyr: 0.734 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.052IleAla: 6.052 ± 0.086	1.255IleCys: 1.255 ± 0.042	5.159IleAsp: 5.159 ± 0.073	5.192IleGlu: 5.192 ± 0.08	3.081IlePhe: 3.081 ± 0.068	5.278IleGly: 5.278 ± 0.079	1.191IleHis: 1.191 ± 0.036	5.944IleIle: 5.944 ± 0.103	5.597IleLys: 5.597 ± 0.079	6.51IleLeu: 6.51 ± 0.09	2.213IleMet: 2.213 ± 0.044	3.649IleAsn: 3.649 ± 0.066	3.077IlePro: 3.077 ± 0.059	1.763IleGln: 1.763 ± 0.042	3.197IleArg: 3.197 ± 0.057	5.354IleSer: 5.354 ± 0.079	4.511IleThr: 4.511 ± 0.073	5.414IleVal: 5.414 ± 0.077	0.615IleTrp: 0.615 ± 0.027	3.127IleTyr: 3.127 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	5.585LysAla: 5.585 ± 0.085	0.806LysCys: 0.806 ± 0.031	5.163LysAsp: 5.163 ± 0.08	7.382LysGlu: 7.382 ± 0.092	2.298LysPhe: 2.298 ± 0.043	4.416LysGly: 4.416 ± 0.072	1.147LysHis: 1.147 ± 0.035	5.363LysIle: 5.363 ± 0.074	7.08LysLys: 7.08 ± 0.112	5.972LysLeu: 5.972 ± 0.072	2.246LysMet: 2.246 ± 0.045	4.013LysAsn: 4.013 ± 0.065	2.003LysPro: 2.003 ± 0.05	1.951LysGln: 1.951 ± 0.047	3.184LysArg: 3.184 ± 0.061	3.814LysSer: 3.814 ± 0.059	3.938LysThr: 3.938 ± 0.071	4.714LysVal: 4.714 ± 0.069	0.649LysTrp: 0.649 ± 0.025	3.333LysTyr: 3.333 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.951LeuAla: 5.951 ± 0.094	1.232LeuCys: 1.232 ± 0.036	5.23LeuAsp: 5.23 ± 0.079	5.441LeuGlu: 5.441 ± 0.082	3.889LeuPhe: 3.889 ± 0.082	5.666LeuGly: 5.666 ± 0.097	1.295LeuHis: 1.295 ± 0.035	6.312LeuIle: 6.312 ± 0.091	6.259LeuLys: 6.259 ± 0.086	7.313LeuLeu: 7.313 ± 0.123	2.51LeuMet: 2.51 ± 0.051	3.832LeuAsn: 3.832 ± 0.067	2.963LeuPro: 2.963 ± 0.057	2.101LeuGln: 2.101 ± 0.049	3.153LeuArg: 3.153 ± 0.062	6.395LeuSer: 6.395 ± 0.082	4.489LeuThr: 4.489 ± 0.077	5.31LeuVal: 5.31 ± 0.08	0.655LeuTrp: 0.655 ± 0.029	3.384LeuTyr: 3.384 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.375MetAla: 2.375 ± 0.048	0.381MetCys: 0.381 ± 0.02	1.931MetAsp: 1.931 ± 0.037	1.96MetGlu: 1.96 ± 0.046	1.04MetPhe: 1.04 ± 0.035	2.049MetGly: 2.049 ± 0.052	0.484MetHis: 0.484 ± 0.022	2.308MetIle: 2.308 ± 0.05	2.328MetLys: 2.328 ± 0.044	2.634MetLeu: 2.634 ± 0.058	0.894MetMet: 0.894 ± 0.035	1.678MetAsn: 1.678 ± 0.043	1.074MetPro: 1.074 ± 0.038	0.979MetGln: 0.979 ± 0.033	1.149MetArg: 1.149 ± 0.039	1.957MetSer: 1.957 ± 0.047	1.686MetThr: 1.686 ± 0.043	1.797MetVal: 1.797 ± 0.048	0.206MetTrp: 0.206 ± 0.013	0.989MetTyr: 0.989 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.447AsnAla: 3.447 ± 0.057	0.598AsnCys: 0.598 ± 0.027	2.805AsnAsp: 2.805 ± 0.057	3.354AsnGlu: 3.354 ± 0.062	1.792AsnPhe: 1.792 ± 0.044	3.671AsnGly: 3.671 ± 0.071	0.758AsnHis: 0.758 ± 0.028	4.002AsnIle: 4.002 ± 0.075	3.456AsnLys: 3.456 ± 0.058	3.756AsnLeu: 3.756 ± 0.064	1.482AsnMet: 1.482 ± 0.042	2.575AsnAsn: 2.575 ± 0.058	1.98AsnPro: 1.98 ± 0.05	1.088AsnGln: 1.088 ± 0.032	1.909AsnArg: 1.909 ± 0.052	2.788AsnSer: 2.788 ± 0.063	2.567AsnThr: 2.567 ± 0.048	3.428AsnVal: 3.428 ± 0.057	0.418AsnTrp: 0.418 ± 0.021	2.189AsnTyr: 2.189 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.193ProAla: 2.193 ± 0.057	0.38ProCys: 0.38 ± 0.02	2.376ProAsp: 2.376 ± 0.056	2.923ProGlu: 2.923 ± 0.07	1.487ProPhe: 1.487 ± 0.039	2.148ProGly: 2.148 ± 0.049	0.501ProHis: 0.501 ± 0.025	2.282ProIle: 2.282 ± 0.045	1.958ProLys: 1.958 ± 0.048	2.364ProLeu: 2.364 ± 0.051	0.874ProMet: 0.874 ± 0.031	1.329ProAsn: 1.329 ± 0.04	0.619ProPro: 0.619 ± 0.025	0.866ProGln: 0.866 ± 0.03	0.926ProArg: 0.926 ± 0.03	1.809ProSer: 1.809 ± 0.041	1.587ProThr: 1.587 ± 0.042	2.604ProVal: 2.604 ± 0.051	0.286ProTrp: 0.286 ± 0.017	1.446ProTyr: 1.446 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	1.888GlnAla: 1.888 ± 0.05	0.264GlnCys: 0.264 ± 0.018	1.392GlnAsp: 1.392 ± 0.042	1.781GlnGlu: 1.781 ± 0.05	0.988GlnPhe: 0.988 ± 0.032	1.546GlnGly: 1.546 ± 0.041	0.361GlnHis: 0.361 ± 0.019	2.113GlnIle: 2.113 ± 0.045	2.127GlnLys: 2.127 ± 0.055	2.202GlnLeu: 2.202 ± 0.051	0.931GlnMet: 0.931 ± 0.033	1.279GlnAsn: 1.279 ± 0.035	0.707GlnPro: 0.707 ± 0.031	0.855GlnGln: 0.855 ± 0.034	1.075GlnArg: 1.075 ± 0.033	1.431GlnSer: 1.431 ± 0.044	1.34GlnThr: 1.34 ± 0.036	1.569GlnVal: 1.569 ± 0.042	0.239GlnTrp: 0.239 ± 0.017	1.177GlnTyr: 1.177 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.591ArgAla: 2.591 ± 0.06	0.503ArgCys: 0.503 ± 0.022	2.432ArgAsp: 2.432 ± 0.059	2.966ArgGlu: 2.966 ± 0.064	1.795ArgPhe: 1.795 ± 0.041	2.313ArgGly: 2.313 ± 0.047	0.685ArgHis: 0.685 ± 0.023	3.225ArgIle: 3.225 ± 0.053	3.046ArgLys: 3.046 ± 0.059	3.267ArgLeu: 3.267 ± 0.055	1.248ArgMet: 1.248 ± 0.033	1.947ArgAsn: 1.947 ± 0.05	1.145ArgPro: 1.145 ± 0.036	1.111ArgGln: 1.111 ± 0.034	1.85ArgArg: 1.85 ± 0.052	2.042ArgSer: 2.042 ± 0.046	1.954ArgThr: 1.954 ± 0.046	2.516ArgVal: 2.516 ± 0.051	0.33ArgTrp: 0.33 ± 0.018	1.905ArgTyr: 1.905 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.431SerAla: 4.431 ± 0.076	0.794SerCys: 0.794 ± 0.03	4.32SerAsp: 4.32 ± 0.067	4.496SerGlu: 4.496 ± 0.077	3.234SerPhe: 3.234 ± 0.071	5.088SerGly: 5.088 ± 0.078	0.987SerHis: 0.987 ± 0.035	4.415SerIle: 4.415 ± 0.073	4.249SerLys: 4.249 ± 0.077	5.001SerLeu: 5.001 ± 0.08	1.733SerMet: 1.733 ± 0.047	2.661SerAsn: 2.661 ± 0.059	1.706SerPro: 1.706 ± 0.041	1.563SerGln: 1.563 ± 0.042	2.368SerArg: 2.368 ± 0.05	4.006SerSer: 4.006 ± 0.082	2.996SerThr: 2.996 ± 0.064	4.376SerVal: 4.376 ± 0.07	0.49SerTrp: 0.49 ± 0.026	2.719SerTyr: 2.719 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	4.133ThrAla: 4.133 ± 0.072	0.62ThrCys: 0.62 ± 0.024	3.672ThrAsp: 3.672 ± 0.065	3.546ThrGlu: 3.546 ± 0.063	2.287ThrPhe: 2.287 ± 0.049	4.462ThrGly: 4.462 ± 0.068	0.782ThrHis: 0.782 ± 0.028	3.968ThrIle: 3.968 ± 0.063	3.209ThrLys: 3.209 ± 0.062	4.43ThrLeu: 4.43 ± 0.07	1.369ThrMet: 1.369 ± 0.035	2.143ThrAsn: 2.143 ± 0.052	1.99ThrPro: 1.99 ± 0.048	1.39ThrGln: 1.39 ± 0.041	1.841ThrArg: 1.841 ± 0.047	3.126ThrSer: 3.126 ± 0.058	2.917ThrThr: 2.917 ± 0.055	4.141ThrVal: 4.141 ± 0.064	0.478ThrTrp: 0.478 ± 0.023	2.21ThrTyr: 2.21 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.805ValAla: 4.805 ± 0.07	1.09ValCys: 1.09 ± 0.031	4.351ValAsp: 4.351 ± 0.065	4.282ValGlu: 4.282 ± 0.074	3.085ValPhe: 3.085 ± 0.056	4.289ValGly: 4.289 ± 0.069	0.992ValHis: 0.992 ± 0.03	5.664ValIle: 5.664 ± 0.08	4.765ValLys: 4.765 ± 0.074	6.138ValLeu: 6.138 ± 0.098	1.985ValMet: 1.985 ± 0.043	3.176ValAsn: 3.176 ± 0.058	2.378ValPro: 2.378 ± 0.044	1.578ValGln: 1.578 ± 0.035	2.584ValArg: 2.584 ± 0.062	4.901ValSer: 4.901 ± 0.077	3.945ValThr: 3.945 ± 0.066	4.957ValVal: 4.957 ± 0.075	0.536ValTrp: 0.536 ± 0.025	2.795ValTyr: 2.795 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.507TrpAla: 0.507 ± 0.026	0.128TrpCys: 0.128 ± 0.011	0.562TrpAsp: 0.562 ± 0.027	0.561TrpGlu: 0.561 ± 0.026	0.394TrpPhe: 0.394 ± 0.019	0.602TrpGly: 0.602 ± 0.026	0.165TrpHis: 0.165 ± 0.014	0.643TrpIle: 0.643 ± 0.025	0.615TrpLys: 0.615 ± 0.025	0.765TrpLeu: 0.765 ± 0.03	0.282TrpMet: 0.282 ± 0.015	0.547TrpAsn: 0.547 ± 0.025	0.193TrpPro: 0.193 ± 0.015	0.292TrpGln: 0.292 ± 0.019	0.345TrpArg: 0.345 ± 0.02	0.453TrpSer: 0.453 ± 0.019	0.418TrpThr: 0.418 ± 0.021	0.463TrpVal: 0.463 ± 0.022	0.106TrpTrp: 0.106 ± 0.01	0.394TrpTyr: 0.394 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.816TyrAla: 2.816 ± 0.056	0.592TyrCys: 0.592 ± 0.027	3.336TyrAsp: 3.336 ± 0.078	3.246TyrGlu: 3.246 ± 0.061	1.969TyrPhe: 1.969 ± 0.049	3.029TyrGly: 3.029 ± 0.057	0.743TyrHis: 0.743 ± 0.024	3.197TyrIle: 3.197 ± 0.057	2.999TyrLys: 2.999 ± 0.069	3.59TyrLeu: 3.59 ± 0.062	1.172TyrMet: 1.172 ± 0.034	2.33TyrAsn: 2.33 ± 0.055	1.429TyrPro: 1.429 ± 0.038	1.078TyrGln: 1.078 ± 0.033	1.87TyrArg: 1.87 ± 0.045	2.854TyrSer: 2.854 ± 0.052	2.323TyrThr: 2.323 ± 0.049	2.842TyrVal: 2.842 ± 0.053	0.358TyrTrp: 0.358 ± 0.022	2.101TyrTyr: 2.101 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3162 proteins (1012116 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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