Amino acid dipepetide frequency for Pararhodobacter oceanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.633AlaAla: 17.633 ± 0.197	1.123AlaCys: 1.123 ± 0.03	6.696AlaAsp: 6.696 ± 0.087	8.899AlaGlu: 8.899 ± 0.114	4.267AlaPhe: 4.267 ± 0.06	10.985AlaGly: 10.985 ± 0.127	2.59AlaHis: 2.59 ± 0.047	5.886AlaIle: 5.886 ± 0.074	3.327AlaLys: 3.327 ± 0.068	15.297AlaLeu: 15.297 ± 0.183	3.983AlaMet: 3.983 ± 0.059	2.606AlaAsn: 2.606 ± 0.048	6.583AlaPro: 6.583 ± 0.105	5.807AlaGln: 5.807 ± 0.076	9.52AlaArg: 9.52 ± 0.113	6.079AlaSer: 6.079 ± 0.086	5.999AlaThr: 5.999 ± 0.073	8.489AlaVal: 8.489 ± 0.095	1.497AlaTrp: 1.497 ± 0.041	2.551AlaTyr: 2.551 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.173CysAla: 1.173 ± 0.034	0.106CysCys: 0.106 ± 0.01	0.621CysAsp: 0.621 ± 0.023	0.497CysGlu: 0.497 ± 0.021	0.352CysPhe: 0.352 ± 0.018	0.912CysGly: 0.912 ± 0.029	0.241CysHis: 0.241 ± 0.014	0.394CysIle: 0.394 ± 0.019	0.192CysLys: 0.192 ± 0.012	0.848CysLeu: 0.848 ± 0.031	0.152CysMet: 0.152 ± 0.013	0.242CysAsn: 0.242 ± 0.014	0.514CysPro: 0.514 ± 0.022	0.229CysGln: 0.229 ± 0.014	0.558CysArg: 0.558 ± 0.022	0.419CysSer: 0.419 ± 0.016	0.45CysThr: 0.45 ± 0.022	0.599CysVal: 0.599 ± 0.024	0.108CysTrp: 0.108 ± 0.01	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.288AspAla: 7.288 ± 0.1	0.528AspCys: 0.528 ± 0.022	3.085AspAsp: 3.085 ± 0.065	3.23AspGlu: 3.23 ± 0.061	2.25AspPhe: 2.25 ± 0.052	5.018AspGly: 5.018 ± 0.08	1.371AspHis: 1.371 ± 0.038	2.938AspIle: 2.938 ± 0.063	1.319AspLys: 1.319 ± 0.037	6.484AspLeu: 6.484 ± 0.087	1.575AspMet: 1.575 ± 0.037	1.244AspAsn: 1.244 ± 0.039	3.731AspPro: 3.731 ± 0.049	1.756AspGln: 1.756 ± 0.039	3.713AspArg: 3.713 ± 0.065	2.342AspSer: 2.342 ± 0.045	2.799AspThr: 2.799 ± 0.056	3.615AspVal: 3.615 ± 0.059	1.217AspTrp: 1.217 ± 0.033	1.443AspTyr: 1.443 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.67GluAla: 8.67 ± 0.111	0.392GluCys: 0.392 ± 0.018	3.304GluAsp: 3.304 ± 0.062	3.03GluGlu: 3.03 ± 0.059	1.92GluPhe: 1.92 ± 0.043	5.016GluGly: 5.016 ± 0.069	1.221GluHis: 1.221 ± 0.032	3.676GluIle: 3.676 ± 0.065	1.597GluLys: 1.597 ± 0.047	5.249GluLeu: 5.249 ± 0.097	1.842GluMet: 1.842 ± 0.039	1.597GluAsn: 1.597 ± 0.041	2.541GluPro: 2.541 ± 0.053	1.862GluGln: 1.862 ± 0.044	4.447GluArg: 4.447 ± 0.067	2.335GluSer: 2.335 ± 0.047	3.546GluThr: 3.546 ± 0.051	4.509GluVal: 4.509 ± 0.064	0.68GluTrp: 0.68 ± 0.024	1.051GluTyr: 1.051 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.588PheAla: 4.588 ± 0.073	0.378PheCys: 0.378 ± 0.016	2.763PheAsp: 2.763 ± 0.054	2.22PheGlu: 2.22 ± 0.05	1.351PhePhe: 1.351 ± 0.038	3.6PheGly: 3.6 ± 0.066	0.791PheHis: 0.791 ± 0.027	1.761PheIle: 1.761 ± 0.044	0.811PheLys: 0.811 ± 0.027	3.397PheLeu: 3.397 ± 0.068	0.866PheMet: 0.866 ± 0.03	1.094PheAsn: 1.094 ± 0.035	1.553PhePro: 1.553 ± 0.036	0.985PheGln: 0.985 ± 0.031	2.096PheArg: 2.096 ± 0.04	2.049PheSer: 2.049 ± 0.039	2.248PheThr: 2.248 ± 0.058	2.542PheVal: 2.542 ± 0.044	0.543PheTrp: 0.543 ± 0.025	0.907PheTyr: 0.907 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	10.727GlyAla: 10.727 ± 0.116	0.852GlyCys: 0.852 ± 0.033	4.536GlyAsp: 4.536 ± 0.075	4.765GlyGlu: 4.765 ± 0.07	3.867GlyPhe: 3.867 ± 0.057	7.507GlyGly: 7.507 ± 0.114	1.943GlyHis: 1.943 ± 0.044	4.473GlyIle: 4.473 ± 0.064	2.779GlyLys: 2.779 ± 0.063	9.088GlyLeu: 9.088 ± 0.097	2.731GlyMet: 2.731 ± 0.044	2.066GlyAsn: 2.066 ± 0.044	3.469GlyPro: 3.469 ± 0.055	3.157GlyGln: 3.157 ± 0.049	5.676GlyArg: 5.676 ± 0.08	4.306GlySer: 4.306 ± 0.068	4.306GlyThr: 4.306 ± 0.066	6.568GlyVal: 6.568 ± 0.077	1.488GlyTrp: 1.488 ± 0.038	2.353GlyTyr: 2.353 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.553HisAla: 2.553 ± 0.054	0.244HisCys: 0.244 ± 0.015	1.344HisAsp: 1.344 ± 0.046	1.092HisGlu: 1.092 ± 0.031	0.874HisPhe: 0.874 ± 0.025	2.017HisGly: 2.017 ± 0.04	0.589HisHis: 0.589 ± 0.027	1.069HisIle: 1.069 ± 0.032	0.521HisLys: 0.521 ± 0.023	2.28HisLeu: 2.28 ± 0.047	0.575HisMet: 0.575 ± 0.023	0.525HisAsn: 0.525 ± 0.021	1.463HisPro: 1.463 ± 0.035	0.665HisGln: 0.665 ± 0.023	1.459HisArg: 1.459 ± 0.037	1.048HisSer: 1.048 ± 0.027	0.824HisThr: 0.824 ± 0.026	1.421HisVal: 1.421 ± 0.034	0.345HisTrp: 0.345 ± 0.018	0.554HisTyr: 0.554 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.33IleAla: 7.33 ± 0.092	0.626IleCys: 0.626 ± 0.021	3.553IleAsp: 3.553 ± 0.064	3.558IleGlu: 3.558 ± 0.051	1.664IlePhe: 1.664 ± 0.04	4.954IleGly: 4.954 ± 0.069	1.022IleHis: 1.022 ± 0.03	2.362IleIle: 2.362 ± 0.057	1.285IleLys: 1.285 ± 0.032	4.764IleLeu: 4.764 ± 0.079	1.157IleMet: 1.157 ± 0.034	1.487IleAsn: 1.487 ± 0.042	2.324IlePro: 2.324 ± 0.043	1.137IleGln: 1.137 ± 0.035	3.1IleArg: 3.1 ± 0.058	3.1IleSer: 3.1 ± 0.058	3.244IleThr: 3.244 ± 0.049	3.512IleVal: 3.512 ± 0.074	0.753IleTrp: 0.753 ± 0.026	1.143IleTyr: 1.143 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.39LysAla: 3.39 ± 0.058	0.146LysCys: 0.146 ± 0.014	1.403LysAsp: 1.403 ± 0.039	1.127LysGlu: 1.127 ± 0.037	0.795LysPhe: 0.795 ± 0.029	2.288LysGly: 2.288 ± 0.058	0.554LysHis: 0.554 ± 0.024	1.504LysIle: 1.504 ± 0.038	0.834LysLys: 0.834 ± 0.034	2.61LysLeu: 2.61 ± 0.051	0.728LysMet: 0.728 ± 0.028	0.604LysAsn: 0.604 ± 0.024	1.592LysPro: 1.592 ± 0.039	0.724LysGln: 0.724 ± 0.025	1.986LysArg: 1.986 ± 0.041	1.609LysSer: 1.609 ± 0.041	1.709LysThr: 1.709 ± 0.042	1.828LysVal: 1.828 ± 0.046	0.264LysTrp: 0.264 ± 0.014	0.52LysTyr: 0.52 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.925LeuAla: 13.925 ± 0.147	0.941LeuCys: 0.941 ± 0.028	5.669LeuAsp: 5.669 ± 0.085	5.459LeuGlu: 5.459 ± 0.072	3.468LeuPhe: 3.468 ± 0.059	8.676LeuGly: 8.676 ± 0.098	2.111LeuHis: 2.111 ± 0.041	5.476LeuIle: 5.476 ± 0.079	2.667LeuLys: 2.667 ± 0.051	9.353LeuLeu: 9.353 ± 0.116	2.75LeuMet: 2.75 ± 0.048	2.717LeuAsn: 2.717 ± 0.044	5.938LeuPro: 5.938 ± 0.075	3.125LeuGln: 3.125 ± 0.057	7.714LeuArg: 7.714 ± 0.086	6.451LeuSer: 6.451 ± 0.087	6.289LeuThr: 6.289 ± 0.093	7.02LeuVal: 7.02 ± 0.089	1.354LeuTrp: 1.354 ± 0.041	1.961LeuTyr: 1.961 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.549MetAla: 3.549 ± 0.06	0.19MetCys: 0.19 ± 0.013	1.349MetAsp: 1.349 ± 0.034	1.294MetGlu: 1.294 ± 0.039	0.878MetPhe: 0.878 ± 0.027	2.351MetGly: 2.351 ± 0.044	0.537MetHis: 0.537 ± 0.022	1.662MetIle: 1.662 ± 0.038	0.847MetLys: 0.847 ± 0.029	2.798MetLeu: 2.798 ± 0.05	0.825MetMet: 0.825 ± 0.024	0.799MetAsn: 0.799 ± 0.025	1.695MetPro: 1.695 ± 0.041	1.028MetGln: 1.028 ± 0.031	2.115MetArg: 2.115 ± 0.038	1.796MetSer: 1.796 ± 0.042	1.961MetThr: 1.961 ± 0.041	2.01MetVal: 2.01 ± 0.042	0.263MetTrp: 0.263 ± 0.015	0.318MetTyr: 0.318 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.34AsnAla: 3.34 ± 0.055	0.256AsnCys: 0.256 ± 0.015	1.353AsnAsp: 1.353 ± 0.038	1.107AsnGlu: 1.107 ± 0.029	0.907AsnPhe: 0.907 ± 0.028	2.245AsnGly: 2.245 ± 0.048	0.539AsnHis: 0.539 ± 0.021	1.319AsnIle: 1.319 ± 0.035	0.56AsnLys: 0.56 ± 0.027	2.497AsnLeu: 2.497 ± 0.048	0.672AsnMet: 0.672 ± 0.023	0.692AsnAsn: 0.692 ± 0.029	1.869AsnPro: 1.869 ± 0.04	0.708AsnGln: 0.708 ± 0.026	1.769AsnArg: 1.769 ± 0.04	1.151AsnSer: 1.151 ± 0.032	1.369AsnThr: 1.369 ± 0.039	1.677AsnVal: 1.677 ± 0.047	0.442AsnTrp: 0.442 ± 0.021	0.634AsnTyr: 0.634 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.351ProAla: 6.351 ± 0.091	0.372ProCys: 0.372 ± 0.018	3.633ProAsp: 3.633 ± 0.061	4.576ProGlu: 4.576 ± 0.063	1.934ProPhe: 1.934 ± 0.038	3.984ProGly: 3.984 ± 0.063	1.134ProHis: 1.134 ± 0.033	2.243ProIle: 2.243 ± 0.046	1.459ProLys: 1.459 ± 0.037	5.025ProLeu: 5.025 ± 0.071	1.41ProMet: 1.41 ± 0.035	1.281ProAsn: 1.281 ± 0.034	2.461ProPro: 2.461 ± 0.054	2.038ProGln: 2.038 ± 0.045	3.125ProArg: 3.125 ± 0.059	2.634ProSer: 2.634 ± 0.044	2.371ProThr: 2.371 ± 0.053	4.339ProVal: 4.339 ± 0.074	0.689ProTrp: 0.689 ± 0.024	1.177ProTyr: 1.177 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.683GlnAla: 4.683 ± 0.078	0.221GlnCys: 0.221 ± 0.013	1.622GlnAsp: 1.622 ± 0.038	1.608GlnGlu: 1.608 ± 0.036	1.094GlnPhe: 1.094 ± 0.032	2.905GlnGly: 2.905 ± 0.052	0.665GlnHis: 0.665 ± 0.026	2.178GlnIle: 2.178 ± 0.044	0.855GlnLys: 0.855 ± 0.028	2.962GlnLeu: 2.962 ± 0.052	1.194GlnMet: 1.194 ± 0.029	0.926GlnAsn: 0.926 ± 0.028	1.752GlnPro: 1.752 ± 0.044	1.163GlnGln: 1.163 ± 0.044	2.585GlnArg: 2.585 ± 0.052	2.002GlnSer: 2.002 ± 0.042	1.863GlnThr: 1.863 ± 0.045	2.618GlnVal: 2.618 ± 0.045	0.385GlnTrp: 0.385 ± 0.018	0.539GlnTyr: 0.539 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.871ArgAla: 8.871 ± 0.093	0.522ArgCys: 0.522 ± 0.025	4.262ArgAsp: 4.262 ± 0.071	3.98ArgGlu: 3.98 ± 0.069	2.742ArgPhe: 2.742 ± 0.051	5.086ArgGly: 5.086 ± 0.065	1.6ArgHis: 1.6 ± 0.037	3.954ArgIle: 3.954 ± 0.059	2.047ArgLys: 2.047 ± 0.048	7.631ArgLeu: 7.631 ± 0.092	2.078ArgMet: 2.078 ± 0.037	1.801ArgAsn: 1.801 ± 0.039	3.263ArgPro: 3.263 ± 0.061	2.326ArgGln: 2.326 ± 0.047	5.245ArgArg: 5.245 ± 0.081	3.331ArgSer: 3.331 ± 0.055	2.644ArgThr: 2.644 ± 0.045	4.798ArgVal: 4.798 ± 0.08	0.959ArgTrp: 0.959 ± 0.031	1.592ArgTyr: 1.592 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.423SerAla: 6.423 ± 0.076	0.437SerCys: 0.437 ± 0.02	3.137SerAsp: 3.137 ± 0.061	2.886SerGlu: 2.886 ± 0.051	2.179SerPhe: 2.179 ± 0.049	5.751SerGly: 5.751 ± 0.078	1.137SerHis: 1.137 ± 0.029	2.516SerIle: 2.516 ± 0.048	1.3SerLys: 1.3 ± 0.041	5.112SerLeu: 5.112 ± 0.075	1.36SerMet: 1.36 ± 0.034	1.324SerAsn: 1.324 ± 0.04	2.417SerPro: 2.417 ± 0.046	1.619SerGln: 1.619 ± 0.038	3.307SerArg: 3.307 ± 0.063	2.491SerSer: 2.491 ± 0.049	2.613SerThr: 2.613 ± 0.048	3.859SerVal: 3.859 ± 0.062	0.681SerTrp: 0.681 ± 0.026	1.247SerTyr: 1.247 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.369ThrAla: 6.369 ± 0.096	0.502ThrCys: 0.502 ± 0.019	2.735ThrAsp: 2.735 ± 0.061	3.046ThrGlu: 3.046 ± 0.061	1.617ThrPhe: 1.617 ± 0.041	5.224ThrGly: 5.224 ± 0.071	1.163ThrHis: 1.163 ± 0.033	2.562ThrIle: 2.562 ± 0.051	1.212ThrLys: 1.212 ± 0.038	6.237ThrLeu: 6.237 ± 0.084	1.27ThrMet: 1.27 ± 0.031	1.203ThrAsn: 1.203 ± 0.031	3.815ThrPro: 3.815 ± 0.064	1.777ThrGln: 1.777 ± 0.04	3.675ThrArg: 3.675 ± 0.059	2.667ThrSer: 2.667 ± 0.055	2.762ThrThr: 2.762 ± 0.057	3.778ThrVal: 3.778 ± 0.074	0.675ThrTrp: 0.675 ± 0.024	1.194ThrTyr: 1.194 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.86ValAla: 8.86 ± 0.083	0.596ValCys: 0.596 ± 0.025	3.717ValAsp: 3.717 ± 0.066	4.285ValGlu: 4.285 ± 0.059	2.961ValPhe: 2.961 ± 0.056	5.093ValGly: 5.093 ± 0.064	1.323ValHis: 1.323 ± 0.038	4.465ValIle: 4.465 ± 0.068	1.784ValLys: 1.784 ± 0.042	7.481ValLeu: 7.481 ± 0.107	2.204ValMet: 2.204 ± 0.039	1.911ValAsn: 1.911 ± 0.042	3.461ValPro: 3.461 ± 0.049	2.276ValGln: 2.276 ± 0.043	3.996ValArg: 3.996 ± 0.059	4.091ValSer: 4.091 ± 0.061	4.664ValThr: 4.664 ± 0.078	5.541ValVal: 5.541 ± 0.076	0.91ValTrp: 0.91 ± 0.028	1.399ValTyr: 1.399 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.479TrpAla: 1.479 ± 0.039	0.124TrpCys: 0.124 ± 0.01	0.694TrpAsp: 0.694 ± 0.031	0.659TrpGlu: 0.659 ± 0.023	0.562TrpPhe: 0.562 ± 0.021	1.001TrpGly: 1.001 ± 0.035	0.356TrpHis: 0.356 ± 0.018	0.698TrpIle: 0.698 ± 0.024	0.35TrpLys: 0.35 ± 0.015	1.701TrpLeu: 1.701 ± 0.045	0.391TrpMet: 0.391 ± 0.017	0.409TrpAsn: 0.409 ± 0.019	0.728TrpPro: 0.728 ± 0.025	0.701TrpGln: 0.701 ± 0.027	1.211TrpArg: 1.211 ± 0.035	0.772TrpSer: 0.772 ± 0.028	0.692TrpThr: 0.692 ± 0.025	0.847TrpVal: 0.847 ± 0.03	0.233TrpTrp: 0.233 ± 0.017	0.255TrpTyr: 0.255 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.613TyrAla: 2.613 ± 0.047	0.25TyrCys: 0.25 ± 0.013	1.465TyrAsp: 1.465 ± 0.04	1.167TyrGlu: 1.167 ± 0.032	0.861TyrPhe: 0.861 ± 0.029	2.044TyrGly: 2.044 ± 0.039	0.575TyrHis: 0.575 ± 0.021	0.941TyrIle: 0.941 ± 0.027	0.47TyrLys: 0.47 ± 0.02	2.255TyrLeu: 2.255 ± 0.043	0.499TyrMet: 0.499 ± 0.019	0.58TyrAsn: 0.58 ± 0.02	1.067TyrPro: 1.067 ± 0.03	0.738TyrGln: 0.738 ± 0.023	1.437TyrArg: 1.437 ± 0.034	1.123TyrSer: 1.123 ± 0.034	1.13TyrThr: 1.13 ± 0.035	1.448TyrVal: 1.448 ± 0.039	0.376TyrTrp: 0.376 ± 0.017	0.574TyrTyr: 0.574 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3661 proteins (1181261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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