Amino acid dipepetide frequency for Pseudooceanicola sp. GBMRC 2024

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.199AlaAla: 18.199 ± 0.16	1.239AlaCys: 1.239 ± 0.031	6.565AlaAsp: 6.565 ± 0.078	8.46AlaGlu: 8.46 ± 0.099	4.365AlaPhe: 4.365 ± 0.058	11.604AlaGly: 11.604 ± 0.116	2.414AlaHis: 2.414 ± 0.037	5.593AlaIle: 5.593 ± 0.057	3.221AlaLys: 3.221 ± 0.058	16.184AlaLeu: 16.184 ± 0.134	3.945AlaMet: 3.945 ± 0.054	2.412AlaAsn: 2.412 ± 0.044	6.899AlaPro: 6.899 ± 0.091	4.754AlaGln: 4.754 ± 0.067	10.444AlaArg: 10.444 ± 0.111	5.598AlaSer: 5.598 ± 0.075	6.121AlaThr: 6.121 ± 0.078	8.343AlaVal: 8.343 ± 0.082	1.503AlaTrp: 1.503 ± 0.031	2.508AlaTyr: 2.508 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.183CysAla: 1.183 ± 0.03	0.117CysCys: 0.117 ± 0.008	0.646CysAsp: 0.646 ± 0.022	0.382CysGlu: 0.382 ± 0.017	0.332CysPhe: 0.332 ± 0.015	0.964CysGly: 0.964 ± 0.024	0.292CysHis: 0.292 ± 0.014	0.403CysIle: 0.403 ± 0.015	0.184CysLys: 0.184 ± 0.01	0.944CysLeu: 0.944 ± 0.023	0.175CysMet: 0.175 ± 0.011	0.206CysAsn: 0.206 ± 0.011	0.515CysPro: 0.515 ± 0.021	0.234CysGln: 0.234 ± 0.013	0.598CysArg: 0.598 ± 0.02	0.441CysSer: 0.441 ± 0.019	0.502CysThr: 0.502 ± 0.018	0.61CysVal: 0.61 ± 0.018	0.132CysTrp: 0.132 ± 0.009	0.216CysTyr: 0.216 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.58AspAla: 6.58 ± 0.088	0.529AspCys: 0.529 ± 0.023	2.701AspAsp: 2.701 ± 0.058	2.789AspGlu: 2.789 ± 0.046	2.298AspPhe: 2.298 ± 0.04	4.933AspGly: 4.933 ± 0.08	1.399AspHis: 1.399 ± 0.033	2.688AspIle: 2.688 ± 0.044	1.384AspLys: 1.384 ± 0.037	6.465AspLeu: 6.465 ± 0.073	1.608AspMet: 1.608 ± 0.026	1.05AspAsn: 1.05 ± 0.034	4.179AspPro: 4.179 ± 0.058	1.843AspGln: 1.843 ± 0.037	4.134AspArg: 4.134 ± 0.054	2.322AspSer: 2.322 ± 0.052	2.818AspThr: 2.818 ± 0.06	3.665AspVal: 3.665 ± 0.063	1.199AspTrp: 1.199 ± 0.029	1.518AspTyr: 1.518 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	9.102GluAla: 9.102 ± 0.085	0.329GluCys: 0.329 ± 0.016	3.188GluAsp: 3.188 ± 0.046	3.62GluGlu: 3.62 ± 0.064	1.492GluPhe: 1.492 ± 0.028	5.208GluGly: 5.208 ± 0.061	1.019GluHis: 1.019 ± 0.029	3.392GluIle: 3.392 ± 0.058	1.912GluLys: 1.912 ± 0.045	4.877GluLeu: 4.877 ± 0.063	1.738GluMet: 1.738 ± 0.032	1.376GluAsn: 1.376 ± 0.029	2.266GluPro: 2.266 ± 0.046	1.802GluGln: 1.802 ± 0.037	4.068GluArg: 4.068 ± 0.064	1.952GluSer: 1.952 ± 0.036	3.695GluThr: 3.695 ± 0.058	4.263GluVal: 4.263 ± 0.057	0.577GluTrp: 0.577 ± 0.021	0.873GluTyr: 0.873 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.35PheAla: 4.35 ± 0.053	0.428PheCys: 0.428 ± 0.014	2.662PheAsp: 2.662 ± 0.051	2.036PheGlu: 2.036 ± 0.039	1.331PhePhe: 1.331 ± 0.03	3.596PheGly: 3.596 ± 0.05	0.75PheHis: 0.75 ± 0.022	1.418PheIle: 1.418 ± 0.035	0.749PheLys: 0.749 ± 0.023	3.572PheLeu: 3.572 ± 0.059	0.808PheMet: 0.808 ± 0.026	0.934PheAsn: 0.934 ± 0.023	1.682PhePro: 1.682 ± 0.035	1.002PheGln: 1.002 ± 0.023	2.377PheArg: 2.377 ± 0.04	2.051PheSer: 2.051 ± 0.032	2.052PheThr: 2.052 ± 0.036	2.425PheVal: 2.425 ± 0.043	0.581PheTrp: 0.581 ± 0.022	0.859PheTyr: 0.859 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.785GlyAla: 10.785 ± 0.112	0.907GlyCys: 0.907 ± 0.024	4.394GlyAsp: 4.394 ± 0.111	4.329GlyGlu: 4.329 ± 0.048	3.574GlyPhe: 3.574 ± 0.055	7.471GlyGly: 7.471 ± 0.115	1.983GlyHis: 1.983 ± 0.044	4.573GlyIle: 4.573 ± 0.054	2.872GlyLys: 2.872 ± 0.052	10.433GlyLeu: 10.433 ± 0.092	2.672GlyMet: 2.672 ± 0.045	2.012GlyAsn: 2.012 ± 0.051	4.269GlyPro: 4.269 ± 0.061	3.396GlyGln: 3.396 ± 0.049	6.341GlyArg: 6.341 ± 0.08	4.238GlySer: 4.238 ± 0.08	5.066GlyThr: 5.066 ± 0.071	6.075GlyVal: 6.075 ± 0.065	1.546GlyTrp: 1.546 ± 0.032	2.359GlyTyr: 2.359 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.451HisAla: 2.451 ± 0.042	0.225HisCys: 0.225 ± 0.012	1.309HisAsp: 1.309 ± 0.031	1.046HisGlu: 1.046 ± 0.028	0.886HisPhe: 0.886 ± 0.028	1.979HisGly: 1.979 ± 0.035	0.565HisHis: 0.565 ± 0.022	0.827HisIle: 0.827 ± 0.023	0.408HisLys: 0.408 ± 0.017	2.181HisLeu: 2.181 ± 0.035	0.54HisMet: 0.54 ± 0.02	0.438HisAsn: 0.438 ± 0.017	1.53HisPro: 1.53 ± 0.035	0.549HisGln: 0.549 ± 0.02	1.386HisArg: 1.386 ± 0.028	0.878HisSer: 0.878 ± 0.025	0.725HisThr: 0.725 ± 0.021	1.588HisVal: 1.588 ± 0.032	0.342HisTrp: 0.342 ± 0.014	0.53HisTyr: 0.53 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.914IleAla: 6.914 ± 0.073	0.598IleCys: 0.598 ± 0.018	3.059IleAsp: 3.059 ± 0.057	3.046IleGlu: 3.046 ± 0.046	1.732IlePhe: 1.732 ± 0.042	4.631IleGly: 4.631 ± 0.066	0.896IleHis: 0.896 ± 0.024	1.859IleIle: 1.859 ± 0.044	1.033IleLys: 1.033 ± 0.029	4.836IleLeu: 4.836 ± 0.07	0.99IleMet: 0.99 ± 0.026	1.119IleAsn: 1.119 ± 0.035	2.361IlePro: 2.361 ± 0.038	1.127IleGln: 1.127 ± 0.028	3.417IleArg: 3.417 ± 0.049	2.784IleSer: 2.784 ± 0.045	2.904IleThr: 2.904 ± 0.053	3.361IleVal: 3.361 ± 0.055	0.628IleTrp: 0.628 ± 0.019	1.079IleTyr: 1.079 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	3.61LysAla: 3.61 ± 0.066	0.151LysCys: 0.151 ± 0.011	1.561LysAsp: 1.561 ± 0.037	1.334LysGlu: 1.334 ± 0.033	0.769LysPhe: 0.769 ± 0.024	2.526LysGly: 2.526 ± 0.049	0.447LysHis: 0.447 ± 0.016	1.535LysIle: 1.535 ± 0.036	1.03LysLys: 1.03 ± 0.033	2.723LysLeu: 2.723 ± 0.047	0.793LysMet: 0.793 ± 0.023	0.656LysAsn: 0.656 ± 0.02	1.577LysPro: 1.577 ± 0.038	0.8LysGln: 0.8 ± 0.024	1.835LysArg: 1.835 ± 0.037	1.492LysSer: 1.492 ± 0.031	1.727LysThr: 1.727 ± 0.037	2.25LysVal: 2.25 ± 0.043	0.309LysTrp: 0.309 ± 0.015	0.555LysTyr: 0.555 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.5LeuAla: 14.5 ± 0.128	1.112LeuCys: 1.112 ± 0.027	6.004LeuAsp: 6.004 ± 0.06	6.025LeuGlu: 6.025 ± 0.072	3.539LeuPhe: 3.539 ± 0.052	9.254LeuGly: 9.254 ± 0.08	2.14LeuHis: 2.14 ± 0.039	5.04LeuIle: 5.04 ± 0.076	3.427LeuLys: 3.427 ± 0.048	10.581LeuLeu: 10.581 ± 0.136	2.739LeuMet: 2.739 ± 0.047	2.427LeuAsn: 2.427 ± 0.048	6.639LeuPro: 6.639 ± 0.077	2.881LeuGln: 2.881 ± 0.047	7.894LeuArg: 7.894 ± 0.1	7.497LeuSer: 7.497 ± 0.066	5.803LeuThr: 5.803 ± 0.064	7.357LeuVal: 7.357 ± 0.083	1.36LeuTrp: 1.36 ± 0.032	2.01LeuTyr: 2.01 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.595MetAla: 3.595 ± 0.054	0.183MetCys: 0.183 ± 0.011	1.282MetAsp: 1.282 ± 0.034	1.326MetGlu: 1.326 ± 0.029	0.757MetPhe: 0.757 ± 0.025	2.247MetGly: 2.247 ± 0.042	0.431MetHis: 0.431 ± 0.016	1.499MetIle: 1.499 ± 0.03	1.05MetLys: 1.05 ± 0.024	2.69MetLeu: 2.69 ± 0.048	0.778MetMet: 0.778 ± 0.026	0.811MetAsn: 0.811 ± 0.022	1.576MetPro: 1.576 ± 0.03	1.018MetGln: 1.018 ± 0.028	1.869MetArg: 1.869 ± 0.039	1.788MetSer: 1.788 ± 0.034	2.205MetThr: 2.205 ± 0.038	1.841MetVal: 1.841 ± 0.037	0.209MetTrp: 0.209 ± 0.012	0.333MetTyr: 0.333 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.95AsnAla: 2.95 ± 0.056	0.238AsnCys: 0.238 ± 0.012	1.189AsnAsp: 1.189 ± 0.042	0.982AsnGlu: 0.982 ± 0.025	0.842AsnPhe: 0.842 ± 0.022	2.092AsnGly: 2.092 ± 0.042	0.451AsnHis: 0.451 ± 0.017	1.22AsnIle: 1.22 ± 0.031	0.49AsnLys: 0.49 ± 0.021	2.385AsnLeu: 2.385 ± 0.041	0.616AsnMet: 0.616 ± 0.022	0.521AsnAsn: 0.521 ± 0.02	1.656AsnPro: 1.656 ± 0.035	0.612AsnGln: 0.612 ± 0.02	1.578AsnArg: 1.578 ± 0.031	1.035AsnSer: 1.035 ± 0.031	1.159AsnThr: 1.159 ± 0.032	1.617AsnVal: 1.617 ± 0.036	0.35AsnTrp: 0.35 ± 0.015	0.567AsnTyr: 0.567 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.065ProAla: 7.065 ± 0.082	0.399ProCys: 0.399 ± 0.018	3.782ProAsp: 3.782 ± 0.058	4.899ProGlu: 4.899 ± 0.068	2.0ProPhe: 2.0 ± 0.036	5.626ProGly: 5.626 ± 0.062	1.036ProHis: 1.036 ± 0.025	1.908ProIle: 1.908 ± 0.037	1.534ProLys: 1.534 ± 0.036	5.381ProLeu: 5.381 ± 0.055	1.432ProMet: 1.432 ± 0.031	1.094ProAsn: 1.094 ± 0.025	2.685ProPro: 2.685 ± 0.06	1.91ProGln: 1.91 ± 0.04	3.33ProArg: 3.33 ± 0.06	2.503ProSer: 2.503 ± 0.044	2.289ProThr: 2.289 ± 0.04	4.537ProVal: 4.537 ± 0.055	0.76ProTrp: 0.76 ± 0.022	1.184ProTyr: 1.184 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.321GlnAla: 4.321 ± 0.06	0.189GlnCys: 0.189 ± 0.011	1.778GlnAsp: 1.778 ± 0.034	1.664GlnGlu: 1.664 ± 0.034	0.985GlnPhe: 0.985 ± 0.025	2.751GlnGly: 2.751 ± 0.043	0.558GlnHis: 0.558 ± 0.02	2.019GlnIle: 2.019 ± 0.039	1.026GlnLys: 1.026 ± 0.029	3.072GlnLeu: 3.072 ± 0.046	1.1GlnMet: 1.1 ± 0.029	0.771GlnAsn: 0.771 ± 0.024	1.731GlnPro: 1.731 ± 0.035	1.145GlnGln: 1.145 ± 0.032	2.159GlnArg: 2.159 ± 0.04	1.668GlnSer: 1.668 ± 0.035	1.661GlnThr: 1.661 ± 0.029	2.548GlnVal: 2.548 ± 0.048	0.382GlnTrp: 0.382 ± 0.016	0.559GlnTyr: 0.559 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.505ArgAla: 9.505 ± 0.107	0.495ArgCys: 0.495 ± 0.021	4.352ArgAsp: 4.352 ± 0.066	3.6ArgGlu: 3.6 ± 0.053	2.613ArgPhe: 2.613 ± 0.043	5.102ArgGly: 5.102 ± 0.066	1.697ArgHis: 1.697 ± 0.032	4.103ArgIle: 4.103 ± 0.054	1.971ArgLys: 1.971 ± 0.045	8.134ArgLeu: 8.134 ± 0.103	2.102ArgMet: 2.102 ± 0.038	1.712ArgAsn: 1.712 ± 0.036	3.786ArgPro: 3.786 ± 0.058	2.454ArgGln: 2.454 ± 0.051	5.728ArgArg: 5.728 ± 0.085	3.385ArgSer: 3.385 ± 0.053	3.122ArgThr: 3.122 ± 0.043	4.585ArgVal: 4.585 ± 0.061	0.916ArgTrp: 0.916 ± 0.026	1.55ArgTyr: 1.55 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.216SerAla: 6.216 ± 0.067	0.441SerCys: 0.441 ± 0.018	3.031SerAsp: 3.031 ± 0.058	2.738SerGlu: 2.738 ± 0.044	2.197SerPhe: 2.197 ± 0.038	5.679SerGly: 5.679 ± 0.068	1.057SerHis: 1.057 ± 0.025	2.201SerIle: 2.201 ± 0.045	1.262SerLys: 1.262 ± 0.032	5.194SerLeu: 5.194 ± 0.06	1.265SerMet: 1.265 ± 0.027	1.158SerAsn: 1.158 ± 0.031	2.63SerPro: 2.63 ± 0.047	1.532SerGln: 1.532 ± 0.03	3.264SerArg: 3.264 ± 0.05	2.558SerSer: 2.558 ± 0.051	2.465SerThr: 2.465 ± 0.043	3.873SerVal: 3.873 ± 0.068	0.752SerTrp: 0.752 ± 0.023	1.365SerTyr: 1.365 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.343ThrAla: 6.343 ± 0.09	0.497ThrCys: 0.497 ± 0.017	2.822ThrAsp: 2.822 ± 0.052	2.843ThrGlu: 2.843 ± 0.044	1.981ThrPhe: 1.981 ± 0.039	5.548ThrGly: 5.548 ± 0.081	1.055ThrHis: 1.055 ± 0.027	2.393ThrIle: 2.393 ± 0.044	1.169ThrLys: 1.169 ± 0.029	6.546ThrLeu: 6.546 ± 0.071	1.224ThrMet: 1.224 ± 0.033	1.111ThrAsn: 1.111 ± 0.033	3.752ThrPro: 3.752 ± 0.052	1.487ThrGln: 1.487 ± 0.031	3.8ThrArg: 3.8 ± 0.05	2.618ThrSer: 2.618 ± 0.048	2.731ThrThr: 2.731 ± 0.069	3.866ThrVal: 3.866 ± 0.061	0.668ThrTrp: 0.668 ± 0.023	1.128ThrTyr: 1.128 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.829ValAla: 8.829 ± 0.086	0.648ValCys: 0.648 ± 0.02	3.509ValAsp: 3.509 ± 0.046	3.861ValGlu: 3.861 ± 0.06	2.639ValPhe: 2.639 ± 0.041	4.982ValGly: 4.982 ± 0.068	1.328ValHis: 1.328 ± 0.029	4.122ValIle: 4.122 ± 0.063	1.993ValLys: 1.993 ± 0.048	8.107ValLeu: 8.107 ± 0.086	2.063ValMet: 2.063 ± 0.04	1.8ValAsn: 1.8 ± 0.033	3.811ValPro: 3.811 ± 0.051	2.185ValGln: 2.185 ± 0.038	4.092ValArg: 4.092 ± 0.052	4.194ValSer: 4.194 ± 0.056	4.738ValThr: 4.738 ± 0.075	5.227ValVal: 5.227 ± 0.071	0.865ValTrp: 0.865 ± 0.026	1.301ValTyr: 1.301 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.294TrpAla: 1.294 ± 0.028	0.125TrpCys: 0.125 ± 0.009	0.712TrpAsp: 0.712 ± 0.024	0.627TrpGlu: 0.627 ± 0.021	0.508TrpPhe: 0.508 ± 0.018	1.016TrpGly: 1.016 ± 0.03	0.356TrpHis: 0.356 ± 0.016	0.691TrpIle: 0.691 ± 0.021	0.477TrpLys: 0.477 ± 0.018	1.62TrpLeu: 1.62 ± 0.036	0.422TrpMet: 0.422 ± 0.016	0.414TrpAsn: 0.414 ± 0.016	0.754TrpPro: 0.754 ± 0.022	0.679TrpGln: 0.679 ± 0.023	1.044TrpArg: 1.044 ± 0.028	0.814TrpSer: 0.814 ± 0.024	0.747TrpThr: 0.747 ± 0.024	0.819TrpVal: 0.819 ± 0.026	0.199TrpTrp: 0.199 ± 0.011	0.285TrpTyr: 0.285 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.582TyrAla: 2.582 ± 0.039	0.226TyrCys: 0.226 ± 0.012	1.556TyrAsp: 1.556 ± 0.031	1.141TyrGlu: 1.141 ± 0.032	0.825TyrPhe: 0.825 ± 0.023	2.084TyrGly: 2.084 ± 0.042	0.504TyrHis: 0.504 ± 0.019	0.889TyrIle: 0.889 ± 0.024	0.49TyrLys: 0.49 ± 0.018	2.304TyrLeu: 2.304 ± 0.039	0.478TyrMet: 0.478 ± 0.016	0.529TyrAsn: 0.529 ± 0.02	1.055TyrPro: 1.055 ± 0.023	0.678TyrGln: 0.678 ± 0.019	1.551TyrArg: 1.551 ± 0.033	1.062TyrSer: 1.062 ± 0.025	1.053TyrThr: 1.053 ± 0.03	1.444TyrVal: 1.444 ± 0.034	0.327TyrTrp: 0.327 ± 0.013	0.551TyrTyr: 0.551 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5050 proteins (1626961 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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