Amino acid dipepetide frequency for Marinobacter vinifirmus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.645AlaAla: 11.645 ± 0.48
0.845AlaCys: 0.845 ± 0.093
5.925AlaAsp: 5.925 ± 0.284
6.526AlaGlu: 6.526 ± 0.345
4.389AlaPhe: 4.389 ± 0.255
8.241AlaGly: 8.241 ± 0.367
2.06AlaHis: 2.06 ± 0.166
6.296AlaIle: 6.296 ± 0.363
3.801AlaLys: 3.801 ± 0.258
10.979AlaLeu: 10.979 ± 0.388
3.046AlaMet: 3.046 ± 0.213
3.289AlaAsn: 3.289 ± 0.227
4.005AlaPro: 4.005 ± 0.245
3.378AlaGln: 3.378 ± 0.191
6.321AlaArg: 6.321 ± 0.317
5.49AlaSer: 5.49 ± 0.296
5.029AlaThr: 5.029 ± 0.243
7.806AlaVal: 7.806 ± 0.319
1.216AlaTrp: 1.216 ± 0.128
2.7AlaTyr: 2.7 ± 0.195
0.0AlaXaa: 0.0 ± 0.0
Cys
0.883CysAla: 0.883 ± 0.133
0.102CysCys: 0.102 ± 0.039
0.614CysAsp: 0.614 ± 0.078
0.537CysGlu: 0.537 ± 0.085
0.333CysPhe: 0.333 ± 0.062
0.909CysGly: 0.909 ± 0.122
0.269CysHis: 0.269 ± 0.054
0.346CysIle: 0.346 ± 0.074
0.307CysLys: 0.307 ± 0.057
0.973CysLeu: 0.973 ± 0.127
0.205CysMet: 0.205 ± 0.048
0.358CysAsn: 0.358 ± 0.072
0.422CysPro: 0.422 ± 0.076
0.371CysGln: 0.371 ± 0.073
0.486CysArg: 0.486 ± 0.081
0.525CysSer: 0.525 ± 0.086
0.435CysThr: 0.435 ± 0.069
0.691CysVal: 0.691 ± 0.089
0.077CysTrp: 0.077 ± 0.029
0.243CysTyr: 0.243 ± 0.05
0.0CysXaa: 0.0 ± 0.0
Asp
5.579AspAla: 5.579 ± 0.281
0.473AspCys: 0.473 ± 0.078
3.621AspAsp: 3.621 ± 0.249
3.762AspGlu: 3.762 ± 0.24
2.278AspPhe: 2.278 ± 0.174
5.029AspGly: 5.029 ± 0.283
1.51AspHis: 1.51 ± 0.119
3.647AspIle: 3.647 ± 0.241
2.086AspLys: 2.086 ± 0.171
6.68AspLeu: 6.68 ± 0.313
1.612AspMet: 1.612 ± 0.144
1.676AspAsn: 1.676 ± 0.14
3.327AspPro: 3.327 ± 0.194
2.099AspGln: 2.099 ± 0.168
3.826AspArg: 3.826 ± 0.251
2.559AspSer: 2.559 ± 0.18
2.521AspThr: 2.521 ± 0.173
4.248AspVal: 4.248 ± 0.217
0.819AspTrp: 0.819 ± 0.108
1.728AspTyr: 1.728 ± 0.131
0.0AspXaa: 0.0 ± 0.0
Glu
6.027GluAla: 6.027 ± 0.335
0.461GluCys: 0.461 ± 0.068
3.033GluAsp: 3.033 ± 0.218
3.647GluGlu: 3.647 ± 0.243
2.086GluPhe: 2.086 ± 0.156
4.069GluGly: 4.069 ± 0.203
1.203GluHis: 1.203 ± 0.136
4.108GluIle: 4.108 ± 0.217
2.969GluLys: 2.969 ± 0.186
6.398GluLeu: 6.398 ± 0.33
1.907GluMet: 1.907 ± 0.16
2.124GluAsn: 2.124 ± 0.159
2.188GluPro: 2.188 ± 0.17
2.7GluGln: 2.7 ± 0.208
4.517GluArg: 4.517 ± 0.332
2.866GluSer: 2.866 ± 0.214
3.852GluThr: 3.852 ± 0.226
4.133GluVal: 4.133 ± 0.26
0.755GluTrp: 0.755 ± 0.096
1.19GluTyr: 1.19 ± 0.132
0.0GluXaa: 0.0 ± 0.0
Phe
4.914PheAla: 4.914 ± 0.273
0.397PheCys: 0.397 ± 0.071
3.046PheAsp: 3.046 ± 0.23
2.457PheGlu: 2.457 ± 0.176
1.625PhePhe: 1.625 ± 0.17
3.749PheGly: 3.749 ± 0.234
0.87PheHis: 0.87 ± 0.097
2.521PheIle: 2.521 ± 0.214
1.011PheLys: 1.011 ± 0.115
3.545PheLeu: 3.545 ± 0.228
1.126PheMet: 1.126 ± 0.126
1.446PheAsn: 1.446 ± 0.145
1.625PhePro: 1.625 ± 0.157
0.845PheGln: 0.845 ± 0.104
2.329PheArg: 2.329 ± 0.163
2.687PheSer: 2.687 ± 0.151
1.983PheThr: 1.983 ± 0.159
3.596PheVal: 3.596 ± 0.271
0.55PheTrp: 0.55 ± 0.076
1.049PheTyr: 1.049 ± 0.137
0.0PheXaa: 0.0 ± 0.0
Gly
7.358GlyAla: 7.358 ± 0.354
0.806GlyCys: 0.806 ± 0.106
4.543GlyAsp: 4.543 ± 0.258
4.85GlyGlu: 4.85 ± 0.269
3.826GlyPhe: 3.826 ± 0.242
6.449GlyGly: 6.449 ± 0.342
1.6GlyHis: 1.6 ± 0.141
5.464GlyIle: 5.464 ± 0.324
3.775GlyLys: 3.775 ± 0.205
8.266GlyLeu: 8.266 ± 0.38
2.316GlyMet: 2.316 ± 0.199
2.457GlyAsn: 2.457 ± 0.158
3.135GlyPro: 3.135 ± 0.192
3.237GlyGln: 3.237 ± 0.249
4.568GlyArg: 4.568 ± 0.213
4.594GlySer: 4.594 ± 0.283
3.941GlyThr: 3.941 ± 0.23
6.411GlyVal: 6.411 ± 0.334
1.241GlyTrp: 1.241 ± 0.153
2.342GlyTyr: 2.342 ± 0.156
0.0GlyXaa: 0.0 ± 0.0
His
1.83HisAla: 1.83 ± 0.151
0.269HisCys: 0.269 ± 0.056
1.216HisAsp: 1.216 ± 0.119
1.356HisGlu: 1.356 ± 0.139
0.857HisPhe: 0.857 ± 0.094
1.523HisGly: 1.523 ± 0.125
0.563HisHis: 0.563 ± 0.088
1.164HisIle: 1.164 ± 0.121
0.665HisLys: 0.665 ± 0.081
2.022HisLeu: 2.022 ± 0.156
0.601HisMet: 0.601 ± 0.09
0.768HisAsn: 0.768 ± 0.108
1.433HisPro: 1.433 ± 0.145
0.704HisGln: 0.704 ± 0.087
1.292HisArg: 1.292 ± 0.157
1.075HisSer: 1.075 ± 0.113
1.062HisThr: 1.062 ± 0.126
1.472HisVal: 1.472 ± 0.139
0.282HisTrp: 0.282 ± 0.06
0.55HisTyr: 0.55 ± 0.071
0.0HisXaa: 0.0 ± 0.0
Ile
7.358IleAla: 7.358 ± 0.39
0.806IleCys: 0.806 ± 0.099
4.018IleAsp: 4.018 ± 0.283
4.018IleGlu: 4.018 ± 0.224
2.201IlePhe: 2.201 ± 0.205
5.797IleGly: 5.797 ± 0.312
1.1IleHis: 1.1 ± 0.118
2.79IleIle: 2.79 ± 0.217
1.868IleLys: 1.868 ± 0.18
5.49IleLeu: 5.49 ± 0.304
1.446IleMet: 1.446 ± 0.163
2.073IleAsn: 2.073 ± 0.136
2.79IlePro: 2.79 ± 0.224
1.472IleGln: 1.472 ± 0.145
3.378IleArg: 3.378 ± 0.231
3.852IleSer: 3.852 ± 0.236
3.57IleThr: 3.57 ± 0.18
4.236IleVal: 4.236 ± 0.237
0.819IleTrp: 0.819 ± 0.111
1.548IleTyr: 1.548 ± 0.146
0.0IleXaa: 0.0 ± 0.0
Lys
3.557LysAla: 3.557 ± 0.212
0.23LysCys: 0.23 ± 0.045
2.316LysAsp: 2.316 ± 0.224
1.996LysGlu: 1.996 ± 0.208
1.267LysPhe: 1.267 ± 0.126
2.802LysGly: 2.802 ± 0.231
0.614LysHis: 0.614 ± 0.091
2.009LysIle: 2.009 ± 0.148
1.971LysLys: 1.971 ± 0.208
3.762LysLeu: 3.762 ± 0.221
0.973LysMet: 0.973 ± 0.126
1.408LysAsn: 1.408 ± 0.144
2.175LysPro: 2.175 ± 0.164
1.203LysGln: 1.203 ± 0.151
2.623LysArg: 2.623 ± 0.212
2.342LysSer: 2.342 ± 0.16
2.342LysThr: 2.342 ± 0.194
2.598LysVal: 2.598 ± 0.195
0.563LysTrp: 0.563 ± 0.096
0.755LysTyr: 0.755 ± 0.088
0.0LysXaa: 0.0 ± 0.0
Leu
11.325LeuAla: 11.325 ± 0.426
0.985LeuCys: 0.985 ± 0.11
5.835LeuAsp: 5.835 ± 0.304
5.797LeuGlu: 5.797 ± 0.31
4.53LeuPhe: 4.53 ± 0.323
7.947LeuGly: 7.947 ± 0.353
1.843LeuHis: 1.843 ± 0.154
6.475LeuIle: 6.475 ± 0.314
3.621LeuLys: 3.621 ± 0.206
9.098LeuLeu: 9.098 ± 0.409
2.918LeuMet: 2.918 ± 0.197
3.186LeuAsn: 3.186 ± 0.199
5.221LeuPro: 5.221 ± 0.308
3.046LeuGln: 3.046 ± 0.222
6.603LeuArg: 6.603 ± 0.348
6.91LeuSer: 6.91 ± 0.305
5.643LeuThr: 5.643 ± 0.282
6.833LeuVal: 6.833 ± 0.317
0.973LeuTrp: 0.973 ± 0.118
2.329LeuTyr: 2.329 ± 0.184
0.0LeuXaa: 0.0 ± 0.0
Met
3.02MetAla: 3.02 ± 0.188
0.192MetCys: 0.192 ± 0.054
1.228MetAsp: 1.228 ± 0.115
1.356MetGlu: 1.356 ± 0.132
1.152MetPhe: 1.152 ± 0.133
1.791MetGly: 1.791 ± 0.184
0.448MetHis: 0.448 ± 0.072
1.894MetIle: 1.894 ± 0.166
1.062MetLys: 1.062 ± 0.134
2.93MetLeu: 2.93 ± 0.191
0.819MetMet: 0.819 ± 0.104
0.947MetAsn: 0.947 ± 0.106
1.459MetPro: 1.459 ± 0.161
0.96MetGln: 0.96 ± 0.108
1.804MetArg: 1.804 ± 0.129
1.817MetSer: 1.817 ± 0.142
1.919MetThr: 1.919 ± 0.143
2.099MetVal: 2.099 ± 0.144
0.141MetTrp: 0.141 ± 0.049
0.448MetTyr: 0.448 ± 0.075
0.0MetXaa: 0.0 ± 0.0
Asn
3.468AsnAla: 3.468 ± 0.203
0.409AsnCys: 0.409 ± 0.073
2.073AsnAsp: 2.073 ± 0.155
1.472AsnGlu: 1.472 ± 0.153
1.203AsnPhe: 1.203 ± 0.131
3.186AsnGly: 3.186 ± 0.205
0.678AsnHis: 0.678 ± 0.098
1.958AsnIle: 1.958 ± 0.165
1.049AsnLys: 1.049 ± 0.127
3.621AsnLeu: 3.621 ± 0.207
0.806AsnMet: 0.806 ± 0.095
0.947AsnAsn: 0.947 ± 0.141
2.035AsnPro: 2.035 ± 0.187
1.126AsnGln: 1.126 ± 0.134
2.022AsnArg: 2.022 ± 0.142
1.395AsnSer: 1.395 ± 0.114
1.42AsnThr: 1.42 ± 0.117
2.534AsnVal: 2.534 ± 0.179
0.627AsnTrp: 0.627 ± 0.099
0.883AsnTyr: 0.883 ± 0.116
0.0AsnXaa: 0.0 ± 0.0
Pro
4.338ProAla: 4.338 ± 0.257
0.256ProCys: 0.256 ± 0.052
3.698ProAsp: 3.698 ± 0.224
3.928ProGlu: 3.928 ± 0.205
2.099ProPhe: 2.099 ± 0.158
4.069ProGly: 4.069 ± 0.231
1.062ProHis: 1.062 ± 0.118
2.7ProIle: 2.7 ± 0.191
1.83ProLys: 1.83 ± 0.133
4.108ProLeu: 4.108 ± 0.239
1.344ProMet: 1.344 ± 0.117
1.497ProAsn: 1.497 ± 0.146
1.868ProPro: 1.868 ± 0.186
1.638ProGln: 1.638 ± 0.15
2.278ProArg: 2.278 ± 0.182
2.495ProSer: 2.495 ± 0.202
2.06ProThr: 2.06 ± 0.188
4.082ProVal: 4.082 ± 0.218
0.653ProTrp: 0.653 ± 0.097
1.139ProTyr: 1.139 ± 0.118
0.0ProXaa: 0.0 ± 0.0
Gln
3.429GlnAla: 3.429 ± 0.236
0.269GlnCys: 0.269 ± 0.064
1.638GlnAsp: 1.638 ± 0.145
1.919GlnGlu: 1.919 ± 0.186
1.408GlnPhe: 1.408 ± 0.127
2.559GlnGly: 2.559 ± 0.219
0.742GlnHis: 0.742 ± 0.105
1.894GlnIle: 1.894 ± 0.145
1.164GlnLys: 1.164 ± 0.137
3.429GlnLeu: 3.429 ± 0.229
0.973GlnMet: 0.973 ± 0.108
1.1GlnAsn: 1.1 ± 0.122
1.42GlnPro: 1.42 ± 0.123
1.74GlnGln: 1.74 ± 0.245
2.291GlnArg: 2.291 ± 0.185
2.073GlnSer: 2.073 ± 0.176
1.894GlnThr: 1.894 ± 0.159
2.764GlnVal: 2.764 ± 0.201
0.397GlnTrp: 0.397 ± 0.079
0.934GlnTyr: 0.934 ± 0.134
0.0GlnXaa: 0.0 ± 0.0
Arg
6.193ArgAla: 6.193 ± 0.36
0.448ArgCys: 0.448 ± 0.064
3.89ArgAsp: 3.89 ± 0.228
4.056ArgGlu: 4.056 ± 0.297
2.598ArgPhe: 2.598 ± 0.183
3.89ArgGly: 3.89 ± 0.238
1.587ArgHis: 1.587 ± 0.15
3.954ArgIle: 3.954 ± 0.209
2.777ArgLys: 2.777 ± 0.216
6.872ArgLeu: 6.872 ± 0.371
1.664ArgMet: 1.664 ± 0.143
2.495ArgAsn: 2.495 ± 0.186
2.7ArgPro: 2.7 ± 0.184
2.163ArgGln: 2.163 ± 0.167
3.967ArgArg: 3.967 ± 0.25
3.071ArgSer: 3.071 ± 0.155
2.636ArgThr: 2.636 ± 0.203
4.312ArgVal: 4.312 ± 0.236
0.87ArgTrp: 0.87 ± 0.11
2.06ArgTyr: 2.06 ± 0.167
0.0ArgXaa: 0.0 ± 0.0
Ser
5.541SerAla: 5.541 ± 0.245
0.346SerCys: 0.346 ± 0.061
3.148SerAsp: 3.148 ± 0.248
3.186SerGlu: 3.186 ± 0.206
2.572SerPhe: 2.572 ± 0.176
5.477SerGly: 5.477 ± 0.278
1.254SerHis: 1.254 ± 0.129
3.122SerIle: 3.122 ± 0.218
2.047SerLys: 2.047 ± 0.177
5.72SerLeu: 5.72 ± 0.243
1.472SerMet: 1.472 ± 0.13
2.047SerAsn: 2.047 ± 0.149
2.828SerPro: 2.828 ± 0.193
1.919SerGln: 1.919 ± 0.143
3.365SerArg: 3.365 ± 0.179
3.084SerSer: 3.084 ± 0.219
2.943SerThr: 2.943 ± 0.193
4.095SerVal: 4.095 ± 0.177
1.024SerTrp: 1.024 ± 0.109
1.561SerTyr: 1.561 ± 0.144
0.0SerXaa: 0.0 ± 0.0
Thr
5.541ThrAla: 5.541 ± 0.303
0.473ThrCys: 0.473 ± 0.083
2.982ThrAsp: 2.982 ± 0.185
2.879ThrGlu: 2.879 ± 0.202
1.958ThrPhe: 1.958 ± 0.192
4.991ThrGly: 4.991 ± 0.256
1.088ThrHis: 1.088 ± 0.121
3.225ThrIle: 3.225 ± 0.217
1.548ThrLys: 1.548 ± 0.152
5.656ThrLeu: 5.656 ± 0.237
1.267ThrMet: 1.267 ± 0.14
1.523ThrAsn: 1.523 ± 0.141
3.097ThrPro: 3.097 ± 0.186
1.779ThrGln: 1.779 ± 0.141
2.969ThrArg: 2.969 ± 0.175
2.854ThrSer: 2.854 ± 0.204
2.802ThrThr: 2.802 ± 0.211
4.248ThrVal: 4.248 ± 0.215
0.704ThrTrp: 0.704 ± 0.107
1.075ThrTyr: 1.075 ± 0.113
0.0ThrXaa: 0.0 ± 0.0
Val
7.448ValAla: 7.448 ± 0.361
0.896ValCys: 0.896 ± 0.107
4.184ValAsp: 4.184 ± 0.211
4.556ValGlu: 4.556 ± 0.272
3.161ValPhe: 3.161 ± 0.227
5.515ValGly: 5.515 ± 0.289
1.331ValHis: 1.331 ± 0.123
5.106ValIle: 5.106 ± 0.285
2.687ValLys: 2.687 ± 0.213
7.217ValLeu: 7.217 ± 0.327
1.958ValMet: 1.958 ± 0.157
2.291ValAsn: 2.291 ± 0.17
3.788ValPro: 3.788 ± 0.222
1.868ValGln: 1.868 ± 0.159
4.645ValArg: 4.645 ± 0.247
4.735ValSer: 4.735 ± 0.305
4.632ValThr: 4.632 ± 0.26
5.72ValVal: 5.72 ± 0.295
0.909ValTrp: 0.909 ± 0.111
1.843ValTyr: 1.843 ± 0.145
0.0ValXaa: 0.0 ± 0.0
Trp
1.177TrpAla: 1.177 ± 0.118
0.128TrpCys: 0.128 ± 0.038
0.614TrpAsp: 0.614 ± 0.077
0.614TrpGlu: 0.614 ± 0.089
0.742TrpPhe: 0.742 ± 0.102
0.768TrpGly: 0.768 ± 0.098
0.294TrpHis: 0.294 ± 0.061
0.691TrpIle: 0.691 ± 0.101
0.563TrpLys: 0.563 ± 0.094
1.74TrpLeu: 1.74 ± 0.162
0.499TrpMet: 0.499 ± 0.092
0.294TrpAsn: 0.294 ± 0.057
0.486TrpPro: 0.486 ± 0.095
0.781TrpGln: 0.781 ± 0.103
1.1TrpArg: 1.1 ± 0.133
0.704TrpSer: 0.704 ± 0.094
0.601TrpThr: 0.601 ± 0.09
0.845TrpVal: 0.845 ± 0.101
0.282TrpTrp: 0.282 ± 0.063
0.269TrpTyr: 0.269 ± 0.052
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.355TyrAla: 2.355 ± 0.185
0.294TyrCys: 0.294 ± 0.056
1.459TyrAsp: 1.459 ± 0.142
1.318TyrGlu: 1.318 ± 0.135
1.088TyrPhe: 1.088 ± 0.138
2.419TyrGly: 2.419 ± 0.169
0.589TyrHis: 0.589 ± 0.07
1.267TyrIle: 1.267 ± 0.126
0.704TyrLys: 0.704 ± 0.099
2.61TyrLeu: 2.61 ± 0.214
0.525TyrMet: 0.525 ± 0.083
0.985TyrAsn: 0.985 ± 0.098
1.139TyrPro: 1.139 ± 0.124
1.011TyrGln: 1.011 ± 0.123
1.83TyrArg: 1.83 ± 0.166
1.625TyrSer: 1.625 ± 0.151
1.369TyrThr: 1.369 ± 0.153
1.766TyrVal: 1.766 ± 0.147
0.294TyrTrp: 0.294 ± 0.058
0.589TyrTyr: 0.589 ± 0.102
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 263 proteins (78148 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski