Amino acid dipepetide frequency for Nique virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.558AlaAla: 3.558 ± 1.273
0.254AlaCys: 0.254 ± 0.149
1.271AlaAsp: 1.271 ± 0.427
3.304AlaGlu: 3.304 ± 0.644
3.05AlaPhe: 3.05 ± 2.21
2.033AlaGly: 2.033 ± 1.05
1.271AlaHis: 1.271 ± 0.331
5.591AlaIle: 5.591 ± 0.661
2.287AlaLys: 2.287 ± 1.231
4.066AlaLeu: 4.066 ± 0.445
0.762AlaMet: 0.762 ± 0.555
0.762AlaAsn: 0.762 ± 0.171
1.525AlaPro: 1.525 ± 0.262
1.017AlaGln: 1.017 ± 0.596
1.779AlaArg: 1.779 ± 0.844
4.574AlaSer: 4.574 ± 0.464
2.541AlaThr: 2.541 ± 1.114
1.525AlaVal: 1.525 ± 0.369
0.254AlaTrp: 0.254 ± 0.403
1.271AlaTyr: 1.271 ± 0.63
0.0AlaXaa: 0.0 ± 0.0
Cys
1.017CysAla: 1.017 ± 0.325
0.508CysCys: 0.508 ± 0.415
1.779CysAsp: 1.779 ± 0.461
2.795CysGlu: 2.795 ± 0.785
1.779CysPhe: 1.779 ± 0.545
1.017CysGly: 1.017 ± 0.724
0.762CysHis: 0.762 ± 0.639
0.508CysIle: 0.508 ± 0.298
2.541CysLys: 2.541 ± 0.517
3.304CysLeu: 3.304 ± 1.528
0.508CysMet: 0.508 ± 0.279
1.017CysAsn: 1.017 ± 0.296
0.508CysPro: 0.508 ± 0.123
1.525CysGln: 1.525 ± 0.456
1.271CysArg: 1.271 ± 0.902
3.05CysSer: 3.05 ± 0.375
1.779CysThr: 1.779 ± 0.624
1.271CysVal: 1.271 ± 0.733
0.0CysTrp: 0.0 ± 0.0
0.762CysTyr: 0.762 ± 0.314
0.0CysXaa: 0.0 ± 0.0
Asp
3.05AspAla: 3.05 ± 1.317
1.271AspCys: 1.271 ± 0.259
6.353AspAsp: 6.353 ± 1.27
2.795AspGlu: 2.795 ± 0.55
3.05AspPhe: 3.05 ± 1.537
4.32AspGly: 4.32 ± 0.666
2.033AspHis: 2.033 ± 0.593
1.779AspIle: 1.779 ± 0.728
3.304AspLys: 3.304 ± 0.726
8.132AspLeu: 8.132 ± 1.26
1.525AspMet: 1.525 ± 0.893
2.287AspAsn: 2.287 ± 0.664
1.779AspPro: 1.779 ± 0.28
2.287AspGln: 2.287 ± 0.409
2.287AspArg: 2.287 ± 0.349
5.591AspSer: 5.591 ± 1.1
2.033AspThr: 2.033 ± 0.693
3.05AspVal: 3.05 ± 1.537
0.762AspTrp: 0.762 ± 0.171
2.795AspTyr: 2.795 ± 0.571
0.0AspXaa: 0.0 ± 0.0
Glu
2.795GluAla: 2.795 ± 0.272
1.271GluCys: 1.271 ± 0.733
5.337GluAsp: 5.337 ± 1.061
4.574GluGlu: 4.574 ± 0.171
3.558GluPhe: 3.558 ± 0.675
4.066GluGly: 4.066 ± 0.886
0.762GluHis: 0.762 ± 0.314
5.083GluIle: 5.083 ± 0.498
3.558GluLys: 3.558 ± 0.899
5.591GluLeu: 5.591 ± 1.099
1.017GluMet: 1.017 ± 0.246
2.795GluAsn: 2.795 ± 0.589
1.525GluPro: 1.525 ± 0.416
1.779GluGln: 1.779 ± 0.589
2.541GluArg: 2.541 ± 0.591
5.591GluSer: 5.591 ± 0.597
2.033GluThr: 2.033 ± 0.593
5.337GluVal: 5.337 ± 1.636
0.254GluTrp: 0.254 ± 0.149
2.287GluTyr: 2.287 ± 0.65
0.0GluXaa: 0.0 ± 0.0
Phe
2.541PheAla: 2.541 ± 0.719
1.271PheCys: 1.271 ± 0.427
3.558PheAsp: 3.558 ± 0.89
1.525PheGlu: 1.525 ± 0.504
3.05PhePhe: 3.05 ± 0.832
1.271PheGly: 1.271 ± 0.745
0.762PheHis: 0.762 ± 0.438
1.525PheIle: 1.525 ± 0.262
4.32PheLys: 4.32 ± 0.802
5.591PheLeu: 5.591 ± 0.955
1.271PheMet: 1.271 ± 0.329
3.558PheAsn: 3.558 ± 1.052
1.779PhePro: 1.779 ± 0.845
0.762PheGln: 0.762 ± 0.438
2.287PheArg: 2.287 ± 0.787
4.32PheSer: 4.32 ± 0.909
2.541PheThr: 2.541 ± 0.577
3.304PheVal: 3.304 ± 0.677
0.508PheTrp: 0.508 ± 0.123
0.762PheTyr: 0.762 ± 0.171
0.0PheXaa: 0.0 ± 0.0
Gly
2.795GlyAla: 2.795 ± 0.747
2.287GlyCys: 2.287 ± 1.016
3.558GlyAsp: 3.558 ± 0.596
2.795GlyGlu: 2.795 ± 0.453
3.304GlyPhe: 3.304 ± 0.413
3.812GlyGly: 3.812 ± 0.036
0.762GlyHis: 0.762 ± 0.41
2.541GlyIle: 2.541 ± 0.352
5.337GlyLys: 5.337 ± 0.248
5.591GlyLeu: 5.591 ± 1.915
1.525GlyMet: 1.525 ± 0.327
3.304GlyAsn: 3.304 ± 1.309
3.05GlyPro: 3.05 ± 0.623
1.779GlyGln: 1.779 ± 0.742
2.287GlyArg: 2.287 ± 0.28
5.083GlySer: 5.083 ± 1.449
3.558GlyThr: 3.558 ± 1.671
4.574GlyVal: 4.574 ± 0.965
0.762GlyTrp: 0.762 ± 0.639
2.033GlyTyr: 2.033 ± 0.278
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
1.017HisCys: 1.017 ± 0.246
0.254HisAsp: 0.254 ± 0.149
1.017HisGlu: 1.017 ± 0.598
1.017HisPhe: 1.017 ± 0.296
1.271HisGly: 1.271 ± 0.437
0.254HisHis: 0.254 ± 0.149
3.05HisIle: 3.05 ± 0.557
1.525HisLys: 1.525 ± 0.629
2.033HisLeu: 2.033 ± 0.493
0.762HisMet: 0.762 ± 0.344
0.508HisAsn: 0.508 ± 0.298
1.271HisPro: 1.271 ± 0.329
1.525HisGln: 1.525 ± 0.262
1.271HisArg: 1.271 ± 0.259
2.033HisSer: 2.033 ± 1.197
1.017HisThr: 1.017 ± 0.523
1.271HisVal: 1.271 ± 0.437
0.254HisTrp: 0.254 ± 0.444
1.271HisTyr: 1.271 ± 0.437
0.0HisXaa: 0.0 ± 0.0
Ile
2.541IleAla: 2.541 ± 0.76
1.779IleCys: 1.779 ± 0.367
5.083IleAsp: 5.083 ± 0.619
4.828IleGlu: 4.828 ± 1.147
1.779IlePhe: 1.779 ± 0.523
3.812IleGly: 3.812 ± 1.028
1.525IleHis: 1.525 ± 0.416
3.558IleIle: 3.558 ± 1.176
4.828IleLys: 4.828 ± 1.488
5.845IleLeu: 5.845 ± 0.737
1.271IleMet: 1.271 ± 0.331
3.812IleAsn: 3.812 ± 0.611
2.795IlePro: 2.795 ± 1.018
2.033IleGln: 2.033 ± 0.593
2.541IleArg: 2.541 ± 0.517
7.878IleSer: 7.878 ± 1.014
6.099IleThr: 6.099 ± 0.691
1.779IleVal: 1.779 ± 0.525
0.254IleTrp: 0.254 ± 0.149
2.541IleTyr: 2.541 ± 0.629
0.0IleXaa: 0.0 ± 0.0
Lys
3.812LysAla: 3.812 ± 0.843
2.541LysCys: 2.541 ± 0.561
2.541LysAsp: 2.541 ± 0.629
3.558LysGlu: 3.558 ± 0.137
2.287LysPhe: 2.287 ± 0.732
4.066LysGly: 4.066 ± 1.817
1.017LysHis: 1.017 ± 0.296
5.591LysIle: 5.591 ± 0.74
6.607LysLys: 6.607 ± 0.771
6.607LysLeu: 6.607 ± 1.171
3.05LysMet: 3.05 ± 0.813
3.304LysAsn: 3.304 ± 1.085
2.541LysPro: 2.541 ± 0.455
2.795LysGln: 2.795 ± 0.747
3.05LysArg: 3.05 ± 0.685
6.353LysSer: 6.353 ± 1.505
4.32LysThr: 4.32 ± 1.398
3.05LysVal: 3.05 ± 0.975
1.779LysTrp: 1.779 ± 0.742
2.033LysTyr: 2.033 ± 0.363
0.0LysXaa: 0.0 ± 0.0
Leu
3.812LeuAla: 3.812 ± 1.369
2.287LeuCys: 2.287 ± 0.479
5.337LeuAsp: 5.337 ± 0.593
4.574LeuGlu: 4.574 ± 0.935
4.32LeuPhe: 4.32 ± 1.689
8.386LeuGly: 8.386 ± 0.664
1.779LeuHis: 1.779 ± 0.367
6.353LeuIle: 6.353 ± 1.268
6.353LeuLys: 6.353 ± 0.581
7.116LeuLeu: 7.116 ± 1.818
3.558LeuMet: 3.558 ± 0.758
2.541LeuAsn: 2.541 ± 0.561
3.05LeuPro: 3.05 ± 1.419
2.541LeuGln: 2.541 ± 0.927
7.116LeuArg: 7.116 ± 0.718
12.452LeuSer: 12.452 ± 0.987
4.828LeuThr: 4.828 ± 1.103
6.099LeuVal: 6.099 ± 0.995
1.017LeuTrp: 1.017 ± 0.296
2.287LeuTyr: 2.287 ± 0.62
0.0LeuXaa: 0.0 ± 0.0
Met
0.254MetAla: 0.254 ± 0.213
0.762MetCys: 0.762 ± 0.171
2.287MetAsp: 2.287 ± 0.395
2.287MetGlu: 2.287 ± 0.656
1.017MetPhe: 1.017 ± 0.596
1.525MetGly: 1.525 ± 0.581
1.525MetHis: 1.525 ± 0.456
1.779MetIle: 1.779 ± 0.347
4.066MetLys: 4.066 ± 0.849
2.541MetLeu: 2.541 ± 0.874
3.05MetMet: 3.05 ± 1.046
1.271MetAsn: 1.271 ± 0.329
0.0MetPro: 0.0 ± 0.0
0.762MetGln: 0.762 ± 0.447
1.017MetArg: 1.017 ± 1.319
2.795MetSer: 2.795 ± 0.96
3.05MetThr: 3.05 ± 0.432
1.271MetVal: 1.271 ± 0.329
0.0MetTrp: 0.0 ± 0.0
0.508MetTyr: 0.508 ± 0.123
0.0MetXaa: 0.0 ± 0.0
Asn
1.271AsnAla: 1.271 ± 0.533
0.762AsnCys: 0.762 ± 0.314
1.271AsnAsp: 1.271 ± 0.427
2.795AsnGlu: 2.795 ± 0.601
2.287AsnPhe: 2.287 ± 0.461
1.779AsnGly: 1.779 ± 0.836
0.762AsnHis: 0.762 ± 0.171
3.304AsnIle: 3.304 ± 0.846
3.05AsnLys: 3.05 ± 0.432
5.845AsnLeu: 5.845 ± 1.65
1.271AsnMet: 1.271 ± 0.342
2.541AsnAsn: 2.541 ± 0.313
3.304AsnPro: 3.304 ± 0.562
1.525AsnGln: 1.525 ± 0.945
2.795AsnArg: 2.795 ± 0.55
3.812AsnSer: 3.812 ± 1.616
2.033AsnThr: 2.033 ± 0.593
0.762AsnVal: 0.762 ± 0.314
0.254AsnTrp: 0.254 ± 0.213
1.525AsnTyr: 1.525 ± 1.01
0.0AsnXaa: 0.0 ± 0.0
Pro
0.762ProAla: 0.762 ± 0.41
0.508ProCys: 0.508 ± 0.415
1.779ProAsp: 1.779 ± 0.461
3.812ProGlu: 3.812 ± 1.051
2.541ProPhe: 2.541 ± 0.616
2.541ProGly: 2.541 ± 0.352
1.017ProHis: 1.017 ± 0.325
1.779ProIle: 1.779 ± 0.728
1.525ProLys: 1.525 ± 0.369
3.05ProLeu: 3.05 ± 0.524
1.525ProMet: 1.525 ± 0.263
1.271ProAsn: 1.271 ± 0.331
0.508ProPro: 0.508 ± 0.298
2.287ProGln: 2.287 ± 1.016
1.525ProArg: 1.525 ± 0.688
3.812ProSer: 3.812 ± 1.215
1.525ProThr: 1.525 ± 0.691
1.017ProVal: 1.017 ± 0.598
1.017ProTrp: 1.017 ± 0.596
1.525ProTyr: 1.525 ± 0.262
0.0ProXaa: 0.0 ± 0.0
Gln
2.033GlnAla: 2.033 ± 0.902
1.017GlnCys: 1.017 ± 0.523
1.525GlnAsp: 1.525 ± 0.369
3.05GlnGlu: 3.05 ± 0.685
1.017GlnPhe: 1.017 ± 0.302
3.304GlnGly: 3.304 ± 0.671
1.017GlnHis: 1.017 ± 0.296
2.541GlnIle: 2.541 ± 1.207
1.779GlnLys: 1.779 ± 1.042
2.795GlnLeu: 2.795 ± 0.578
1.271GlnMet: 1.271 ± 0.323
1.017GlnAsn: 1.017 ± 0.325
0.762GlnPro: 0.762 ± 0.41
1.525GlnGln: 1.525 ± 0.719
1.017GlnArg: 1.017 ± 0.302
2.287GlnSer: 2.287 ± 0.241
2.033GlnThr: 2.033 ± 0.513
2.033GlnVal: 2.033 ± 0.347
0.0GlnTrp: 0.0 ± 0.0
1.017GlnTyr: 1.017 ± 0.506
0.0GlnXaa: 0.0 ± 0.0
Arg
2.033ArgAla: 2.033 ± 0.278
1.779ArgCys: 1.779 ± 0.953
3.05ArgAsp: 3.05 ± 1.008
4.32ArgGlu: 4.32 ± 0.867
1.525ArgPhe: 1.525 ± 0.629
2.795ArgGly: 2.795 ± 0.98
0.762ArgHis: 0.762 ± 0.41
2.795ArgIle: 2.795 ± 0.787
2.287ArgLys: 2.287 ± 0.479
3.304ArgLeu: 3.304 ± 0.427
1.525ArgMet: 1.525 ± 0.416
2.287ArgAsn: 2.287 ± 0.395
1.525ArgPro: 1.525 ± 0.456
1.271ArgGln: 1.271 ± 0.603
1.779ArgArg: 1.779 ± 0.347
4.574ArgSer: 4.574 ± 1.744
1.779ArgThr: 1.779 ± 0.688
4.574ArgVal: 4.574 ± 0.288
0.508ArgTrp: 0.508 ± 0.298
2.033ArgTyr: 2.033 ± 1.197
0.0ArgXaa: 0.0 ± 0.0
Ser
4.066SerAla: 4.066 ± 0.693
4.828SerCys: 4.828 ± 1.452
6.099SerAsp: 6.099 ± 2.361
5.337SerGlu: 5.337 ± 0.72
5.337SerPhe: 5.337 ± 1.381
6.353SerGly: 6.353 ± 1.488
2.033SerHis: 2.033 ± 0.493
5.591SerIle: 5.591 ± 0.887
7.116SerLys: 7.116 ± 1.63
11.436SerLeu: 11.436 ± 1.65
2.287SerMet: 2.287 ± 0.514
3.05SerAsn: 3.05 ± 0.644
3.304SerPro: 3.304 ± 0.78
2.033SerGln: 2.033 ± 0.646
4.32SerArg: 4.32 ± 1.208
9.149SerSer: 9.149 ± 0.979
5.337SerThr: 5.337 ± 0.998
5.591SerVal: 5.591 ± 0.828
2.541SerTrp: 2.541 ± 0.749
2.033SerTyr: 2.033 ± 0.777
0.0SerXaa: 0.0 ± 0.0
Thr
2.287ThrAla: 2.287 ± 0.981
1.525ThrCys: 1.525 ± 0.456
3.304ThrAsp: 3.304 ± 0.848
2.795ThrGlu: 2.795 ± 0.494
2.287ThrPhe: 2.287 ± 1.499
3.558ThrGly: 3.558 ± 0.137
1.017ThrHis: 1.017 ± 0.246
5.591ThrIle: 5.591 ± 0.955
3.812ThrLys: 3.812 ± 1.144
5.337ThrLeu: 5.337 ± 0.346
1.779ThrMet: 1.779 ± 0.624
2.033ThrAsn: 2.033 ± 0.421
1.779ThrPro: 1.779 ± 0.461
1.271ThrGln: 1.271 ± 0.745
2.287ThrArg: 2.287 ± 0.799
4.574ThrSer: 4.574 ± 0.171
3.812ThrThr: 3.812 ± 1.927
2.795ThrVal: 2.795 ± 0.589
1.017ThrTrp: 1.017 ± 0.724
1.271ThrTyr: 1.271 ± 0.585
0.0ThrXaa: 0.0 ± 0.0
Val
2.033ValAla: 2.033 ± 0.421
1.271ValCys: 1.271 ± 0.585
3.304ValAsp: 3.304 ± 0.478
2.795ValGlu: 2.795 ± 0.965
2.033ValPhe: 2.033 ± 0.593
2.033ValGly: 2.033 ± 0.493
1.525ValHis: 1.525 ± 0.369
4.574ValIle: 4.574 ± 0.464
4.066ValLys: 4.066 ± 0.189
4.32ValLeu: 4.32 ± 0.538
1.779ValMet: 1.779 ± 0.682
2.541ValAsn: 2.541 ± 0.294
2.033ValPro: 2.033 ± 0.493
3.05ValGln: 3.05 ± 1.115
3.304ValArg: 3.304 ± 0.846
5.845ValSer: 5.845 ± 0.841
1.779ValThr: 1.779 ± 0.347
4.066ValVal: 4.066 ± 0.532
1.017ValTrp: 1.017 ± 0.296
3.304ValTyr: 3.304 ± 0.346
0.0ValXaa: 0.0 ± 0.0
Trp
0.508TrpAla: 0.508 ± 0.298
0.254TrpCys: 0.254 ± 0.149
0.762TrpAsp: 0.762 ± 0.372
0.762TrpGlu: 0.762 ± 0.569
0.254TrpPhe: 0.254 ± 0.149
0.762TrpGly: 0.762 ± 0.372
0.0TrpHis: 0.0 ± 0.0
1.271TrpIle: 1.271 ± 0.427
0.254TrpLys: 0.254 ± 0.149
1.271TrpLeu: 1.271 ± 0.427
0.762TrpMet: 0.762 ± 0.41
1.017TrpAsn: 1.017 ± 0.441
0.508TrpPro: 0.508 ± 0.415
0.254TrpGln: 0.254 ± 0.149
0.762TrpArg: 0.762 ± 0.447
1.779TrpSer: 1.779 ± 0.269
0.762TrpThr: 0.762 ± 0.171
0.508TrpVal: 0.508 ± 0.436
0.254TrpTrp: 0.254 ± 0.149
0.254TrpTyr: 0.254 ± 0.149
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.525TyrAla: 1.525 ± 0.452
0.762TyrCys: 0.762 ± 0.314
2.033TyrAsp: 2.033 ± 0.777
2.033TyrGlu: 2.033 ± 0.816
1.017TyrPhe: 1.017 ± 0.596
2.033TyrGly: 2.033 ± 0.493
2.033TyrHis: 2.033 ± 1.15
1.779TyrIle: 1.779 ± 0.461
2.287TyrLys: 2.287 ± 1.152
2.033TyrLeu: 2.033 ± 0.646
1.017TyrMet: 1.017 ± 0.296
2.033TyrAsn: 2.033 ± 0.717
1.779TyrPro: 1.779 ± 0.635
1.017TyrGln: 1.017 ± 0.302
1.271TyrArg: 1.271 ± 0.585
2.287TyrSer: 2.287 ± 0.461
1.271TyrThr: 1.271 ± 0.323
2.795TyrVal: 2.795 ± 1.002
0.508TyrTrp: 0.508 ± 0.123
1.525TyrTyr: 1.525 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski