Amino acid dipepetide frequency for Staphylococcus virus 187

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.373AlaAla: 1.373 ± 0.253
0.458AlaCys: 0.458 ± 0.181
2.975AlaAsp: 2.975 ± 0.441
4.577AlaGlu: 4.577 ± 0.691
3.204AlaPhe: 3.204 ± 0.533
2.441AlaGly: 2.441 ± 0.629
0.915AlaHis: 0.915 ± 0.312
5.874AlaIle: 5.874 ± 0.972
5.874AlaLys: 5.874 ± 0.738
5.34AlaLeu: 5.34 ± 0.668
1.297AlaMet: 1.297 ± 0.328
2.975AlaAsn: 2.975 ± 0.5
1.297AlaPro: 1.297 ± 0.288
2.67AlaGln: 2.67 ± 0.352
2.212AlaArg: 2.212 ± 0.414
3.051AlaSer: 3.051 ± 0.527
4.653AlaThr: 4.653 ± 0.541
3.585AlaVal: 3.585 ± 0.444
0.763AlaTrp: 0.763 ± 0.25
1.983AlaTyr: 1.983 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.076CysAla: 0.076 ± 0.078
0.0CysCys: 0.0 ± 0.0
0.687CysAsp: 0.687 ± 0.299
0.534CysGlu: 0.534 ± 0.235
0.229CysPhe: 0.229 ± 0.13
0.153CysGly: 0.153 ± 0.106
0.381CysHis: 0.381 ± 0.181
0.381CysIle: 0.381 ± 0.153
0.381CysLys: 0.381 ± 0.155
0.763CysLeu: 0.763 ± 0.235
0.229CysMet: 0.229 ± 0.123
0.687CysAsn: 0.687 ± 0.307
0.0CysPro: 0.0 ± 0.0
0.229CysGln: 0.229 ± 0.136
0.534CysArg: 0.534 ± 0.215
0.458CysSer: 0.458 ± 0.166
0.305CysThr: 0.305 ± 0.139
0.153CysVal: 0.153 ± 0.108
0.076CysTrp: 0.076 ± 0.087
0.687CysTyr: 0.687 ± 0.413
0.0CysXaa: 0.0 ± 0.0
Asp
2.975AspAla: 2.975 ± 0.632
0.61AspCys: 0.61 ± 0.282
4.119AspAsp: 4.119 ± 0.765
4.577AspGlu: 4.577 ± 0.753
2.746AspPhe: 2.746 ± 0.465
3.433AspGly: 3.433 ± 0.528
0.839AspHis: 0.839 ± 0.28
4.653AspIle: 4.653 ± 0.69
6.103AspLys: 6.103 ± 0.912
4.424AspLeu: 4.424 ± 0.68
1.602AspMet: 1.602 ± 0.347
3.967AspAsn: 3.967 ± 0.664
0.915AspPro: 0.915 ± 0.202
0.992AspGln: 0.992 ± 0.295
1.831AspArg: 1.831 ± 0.323
3.89AspSer: 3.89 ± 0.661
2.746AspThr: 2.746 ± 0.353
3.967AspVal: 3.967 ± 0.429
0.763AspTrp: 0.763 ± 0.228
3.128AspTyr: 3.128 ± 0.444
0.0AspXaa: 0.0 ± 0.0
Glu
4.424GluAla: 4.424 ± 0.654
0.687GluCys: 0.687 ± 0.244
3.89GluAsp: 3.89 ± 0.61
5.035GluGlu: 5.035 ± 0.67
3.509GluPhe: 3.509 ± 0.516
2.441GluGly: 2.441 ± 0.371
0.839GluHis: 0.839 ± 0.209
5.34GluIle: 5.34 ± 0.644
6.332GluLys: 6.332 ± 0.755
7.094GluLeu: 7.094 ± 0.833
2.67GluMet: 2.67 ± 0.455
5.874GluAsn: 5.874 ± 0.814
1.831GluPro: 1.831 ± 0.371
3.356GluGln: 3.356 ± 0.53
3.509GluArg: 3.509 ± 0.528
3.967GluSer: 3.967 ± 0.568
3.28GluThr: 3.28 ± 0.457
5.798GluVal: 5.798 ± 0.72
0.992GluTrp: 0.992 ± 0.272
4.043GluTyr: 4.043 ± 0.583
0.0GluXaa: 0.0 ± 0.0
Phe
2.365PheAla: 2.365 ± 0.544
0.305PheCys: 0.305 ± 0.132
3.128PheAsp: 3.128 ± 0.518
3.89PheGlu: 3.89 ± 0.614
1.602PhePhe: 1.602 ± 0.301
2.975PheGly: 2.975 ± 0.61
1.068PheHis: 1.068 ± 0.407
3.051PheIle: 3.051 ± 0.432
4.501PheLys: 4.501 ± 0.454
2.746PheLeu: 2.746 ± 0.599
1.221PheMet: 1.221 ± 0.303
2.899PheAsn: 2.899 ± 0.509
0.687PhePro: 0.687 ± 0.232
0.992PheGln: 0.992 ± 0.314
1.373PheArg: 1.373 ± 0.247
2.746PheSer: 2.746 ± 0.52
2.441PheThr: 2.441 ± 0.403
3.204PheVal: 3.204 ± 0.5
0.153PheTrp: 0.153 ± 0.104
1.678PheTyr: 1.678 ± 0.333
0.0PheXaa: 0.0 ± 0.0
Gly
2.975GlyAla: 2.975 ± 0.604
0.534GlyCys: 0.534 ± 0.173
2.594GlyAsp: 2.594 ± 0.422
4.348GlyGlu: 4.348 ± 0.642
2.365GlyPhe: 2.365 ± 0.391
1.449GlyGly: 1.449 ± 0.323
1.373GlyHis: 1.373 ± 0.321
3.89GlyIle: 3.89 ± 0.494
4.653GlyLys: 4.653 ± 0.546
4.73GlyLeu: 4.73 ± 0.834
1.755GlyMet: 1.755 ± 0.365
2.517GlyAsn: 2.517 ± 0.34
0.305GlyPro: 0.305 ± 0.139
1.297GlyGln: 1.297 ± 0.351
2.136GlyArg: 2.136 ± 0.361
2.67GlySer: 2.67 ± 0.392
3.356GlyThr: 3.356 ± 0.525
4.424GlyVal: 4.424 ± 0.732
0.458GlyTrp: 0.458 ± 0.221
2.67GlyTyr: 2.67 ± 0.463
0.0GlyXaa: 0.0 ± 0.0
His
0.763HisAla: 0.763 ± 0.266
0.229HisCys: 0.229 ± 0.118
0.687HisAsp: 0.687 ± 0.242
1.373HisGlu: 1.373 ± 0.355
1.221HisPhe: 1.221 ± 0.335
1.373HisGly: 1.373 ± 0.357
0.381HisHis: 0.381 ± 0.169
1.907HisIle: 1.907 ± 0.452
1.221HisLys: 1.221 ± 0.413
1.907HisLeu: 1.907 ± 0.403
0.153HisMet: 0.153 ± 0.1
1.221HisAsn: 1.221 ± 0.313
0.61HisPro: 0.61 ± 0.188
1.221HisGln: 1.221 ± 0.282
0.458HisArg: 0.458 ± 0.24
1.068HisSer: 1.068 ± 0.266
1.526HisThr: 1.526 ± 0.373
0.915HisVal: 0.915 ± 0.278
0.153HisTrp: 0.153 ± 0.091
0.915HisTyr: 0.915 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
4.577IleAla: 4.577 ± 0.651
0.305IleCys: 0.305 ± 0.137
5.95IleAsp: 5.95 ± 0.634
5.111IleGlu: 5.111 ± 0.746
3.28IlePhe: 3.28 ± 0.445
4.272IleGly: 4.272 ± 0.635
1.373IleHis: 1.373 ± 0.346
4.653IleIle: 4.653 ± 0.555
7.476IleLys: 7.476 ± 0.518
5.569IleLeu: 5.569 ± 0.611
2.289IleMet: 2.289 ± 0.411
5.798IleAsn: 5.798 ± 0.458
2.06IlePro: 2.06 ± 0.389
2.899IleGln: 2.899 ± 0.443
2.899IleArg: 2.899 ± 0.461
4.501IleSer: 4.501 ± 0.617
5.416IleThr: 5.416 ± 0.718
5.95IleVal: 5.95 ± 0.555
0.763IleTrp: 0.763 ± 0.314
2.67IleTyr: 2.67 ± 0.473
0.0IleXaa: 0.0 ± 0.0
Lys
6.255LysAla: 6.255 ± 0.597
0.458LysCys: 0.458 ± 0.185
5.34LysAsp: 5.34 ± 0.637
6.942LysGlu: 6.942 ± 0.955
3.509LysPhe: 3.509 ± 0.492
4.577LysGly: 4.577 ± 0.594
1.831LysHis: 1.831 ± 0.392
7.247LysIle: 7.247 ± 0.693
9.307LysLys: 9.307 ± 1.018
9.154LysLeu: 9.154 ± 0.813
2.517LysMet: 2.517 ± 0.367
4.043LysAsn: 4.043 ± 0.518
3.128LysPro: 3.128 ± 0.875
5.187LysGln: 5.187 ± 0.62
3.585LysArg: 3.585 ± 0.454
5.264LysSer: 5.264 ± 0.554
5.416LysThr: 5.416 ± 0.645
6.484LysVal: 6.484 ± 0.637
0.534LysTrp: 0.534 ± 0.184
5.34LysTyr: 5.34 ± 0.664
0.0LysXaa: 0.0 ± 0.0
Leu
4.958LeuAla: 4.958 ± 0.501
0.534LeuCys: 0.534 ± 0.223
5.187LeuAsp: 5.187 ± 0.662
6.713LeuGlu: 6.713 ± 0.71
3.509LeuPhe: 3.509 ± 0.457
3.814LeuGly: 3.814 ± 0.572
1.602LeuHis: 1.602 ± 0.326
5.798LeuIle: 5.798 ± 0.537
8.467LeuLys: 8.467 ± 0.825
8.01LeuLeu: 8.01 ± 0.635
1.983LeuMet: 1.983 ± 0.361
6.026LeuAsn: 6.026 ± 0.664
2.594LeuPro: 2.594 ± 0.372
2.441LeuGln: 2.441 ± 0.427
3.738LeuArg: 3.738 ± 0.699
5.798LeuSer: 5.798 ± 0.747
5.187LeuThr: 5.187 ± 0.646
4.424LeuVal: 4.424 ± 0.625
0.839LeuTrp: 0.839 ± 0.374
2.517LeuTyr: 2.517 ± 0.45
0.0LeuXaa: 0.0 ± 0.0
Met
1.678MetAla: 1.678 ± 0.369
0.153MetCys: 0.153 ± 0.112
0.992MetAsp: 0.992 ± 0.241
1.831MetGlu: 1.831 ± 0.48
0.839MetPhe: 0.839 ± 0.211
0.687MetGly: 0.687 ± 0.21
0.61MetHis: 0.61 ± 0.186
1.755MetIle: 1.755 ± 0.397
1.983MetLys: 1.983 ± 0.398
2.06MetLeu: 2.06 ± 0.355
0.687MetMet: 0.687 ± 0.239
2.365MetAsn: 2.365 ± 0.357
0.839MetPro: 0.839 ± 0.249
0.915MetGln: 0.915 ± 0.256
0.915MetArg: 0.915 ± 0.278
2.212MetSer: 2.212 ± 0.391
2.289MetThr: 2.289 ± 0.415
1.297MetVal: 1.297 ± 0.328
0.229MetTrp: 0.229 ± 0.126
0.992MetTyr: 0.992 ± 0.329
0.0MetXaa: 0.0 ± 0.0
Asn
4.73AsnAla: 4.73 ± 0.689
0.458AsnCys: 0.458 ± 0.206
4.043AsnAsp: 4.043 ± 0.728
4.73AsnGlu: 4.73 ± 0.559
1.983AsnPhe: 1.983 ± 0.341
5.721AsnGly: 5.721 ± 0.694
0.992AsnHis: 0.992 ± 0.219
4.043AsnIle: 4.043 ± 0.537
6.56AsnLys: 6.56 ± 0.746
6.103AsnLeu: 6.103 ± 0.741
1.907AsnMet: 1.907 ± 0.358
5.492AsnAsn: 5.492 ± 1.07
1.983AsnPro: 1.983 ± 0.408
1.526AsnGln: 1.526 ± 0.362
2.212AsnArg: 2.212 ± 0.411
3.738AsnSer: 3.738 ± 0.489
3.967AsnThr: 3.967 ± 0.505
4.577AsnVal: 4.577 ± 0.621
1.068AsnTrp: 1.068 ± 0.289
2.975AsnTyr: 2.975 ± 0.466
0.0AsnXaa: 0.0 ± 0.0
Pro
1.526ProAla: 1.526 ± 0.41
0.076ProCys: 0.076 ± 0.082
0.839ProAsp: 0.839 ± 0.271
1.678ProGlu: 1.678 ± 0.41
0.839ProPhe: 0.839 ± 0.257
1.221ProGly: 1.221 ± 0.313
0.458ProHis: 0.458 ± 0.174
2.365ProIle: 2.365 ± 0.54
3.128ProLys: 3.128 ± 0.604
1.221ProLeu: 1.221 ± 0.332
0.687ProMet: 0.687 ± 0.211
1.678ProAsn: 1.678 ± 0.311
0.61ProPro: 0.61 ± 0.241
1.068ProGln: 1.068 ± 0.307
0.915ProArg: 0.915 ± 0.203
1.831ProSer: 1.831 ± 0.389
1.449ProThr: 1.449 ± 0.373
1.755ProVal: 1.755 ± 0.351
0.076ProTrp: 0.076 ± 0.07
0.763ProTyr: 0.763 ± 0.29
0.0ProXaa: 0.0 ± 0.0
Gln
2.594GlnAla: 2.594 ± 0.441
0.381GlnCys: 0.381 ± 0.191
1.983GlnAsp: 1.983 ± 0.383
2.212GlnGlu: 2.212 ± 0.432
1.831GlnPhe: 1.831 ± 0.38
1.907GlnGly: 1.907 ± 0.298
0.61GlnHis: 0.61 ± 0.201
2.289GlnIle: 2.289 ± 0.35
4.043GlnLys: 4.043 ± 0.486
2.975GlnLeu: 2.975 ± 0.534
0.381GlnMet: 0.381 ± 0.142
2.975GlnAsn: 2.975 ± 0.404
0.534GlnPro: 0.534 ± 0.165
1.373GlnGln: 1.373 ± 0.406
1.831GlnArg: 1.831 ± 0.463
1.602GlnSer: 1.602 ± 0.302
2.136GlnThr: 2.136 ± 0.381
2.212GlnVal: 2.212 ± 0.351
0.229GlnTrp: 0.229 ± 0.121
1.831GlnTyr: 1.831 ± 0.429
0.0GlnXaa: 0.0 ± 0.0
Arg
1.678ArgAla: 1.678 ± 0.48
0.076ArgCys: 0.076 ± 0.082
2.746ArgAsp: 2.746 ± 0.469
3.356ArgGlu: 3.356 ± 0.518
1.678ArgPhe: 1.678 ± 0.318
1.755ArgGly: 1.755 ± 0.335
1.144ArgHis: 1.144 ± 0.302
2.975ArgIle: 2.975 ± 0.564
3.433ArgLys: 3.433 ± 0.584
4.272ArgLeu: 4.272 ± 0.502
1.144ArgMet: 1.144 ± 0.26
2.517ArgAsn: 2.517 ± 0.385
0.61ArgPro: 0.61 ± 0.252
1.755ArgGln: 1.755 ± 0.322
1.602ArgArg: 1.602 ± 0.396
1.526ArgSer: 1.526 ± 0.321
1.449ArgThr: 1.449 ± 0.36
1.907ArgVal: 1.907 ± 0.359
0.61ArgTrp: 0.61 ± 0.214
2.06ArgTyr: 2.06 ± 0.424
0.0ArgXaa: 0.0 ± 0.0
Ser
3.814SerAla: 3.814 ± 0.652
0.381SerCys: 0.381 ± 0.139
2.975SerAsp: 2.975 ± 0.416
4.73SerGlu: 4.73 ± 0.542
3.128SerPhe: 3.128 ± 0.583
3.051SerGly: 3.051 ± 0.49
0.992SerHis: 0.992 ± 0.269
6.179SerIle: 6.179 ± 0.702
5.34SerLys: 5.34 ± 0.582
3.967SerLeu: 3.967 ± 0.632
1.449SerMet: 1.449 ± 0.337
4.272SerAsn: 4.272 ± 0.522
1.068SerPro: 1.068 ± 0.234
1.602SerGln: 1.602 ± 0.347
2.517SerArg: 2.517 ± 0.406
3.051SerSer: 3.051 ± 0.647
3.662SerThr: 3.662 ± 0.512
3.356SerVal: 3.356 ± 0.63
0.305SerTrp: 0.305 ± 0.191
2.441SerTyr: 2.441 ± 0.438
0.0SerXaa: 0.0 ± 0.0
Thr
3.356ThrAla: 3.356 ± 0.531
0.153ThrCys: 0.153 ± 0.098
3.738ThrAsp: 3.738 ± 0.553
4.043ThrGlu: 4.043 ± 0.516
2.289ThrPhe: 2.289 ± 0.465
3.662ThrGly: 3.662 ± 0.58
1.678ThrHis: 1.678 ± 0.312
5.569ThrIle: 5.569 ± 0.816
5.111ThrLys: 5.111 ± 0.666
5.187ThrLeu: 5.187 ± 0.543
0.763ThrMet: 0.763 ± 0.228
4.119ThrAsn: 4.119 ± 0.644
1.907ThrPro: 1.907 ± 0.353
1.678ThrGln: 1.678 ± 0.382
1.755ThrArg: 1.755 ± 0.344
3.738ThrSer: 3.738 ± 0.592
3.814ThrThr: 3.814 ± 0.623
5.035ThrVal: 5.035 ± 0.88
0.534ThrTrp: 0.534 ± 0.21
2.289ThrTyr: 2.289 ± 0.469
0.0ThrXaa: 0.0 ± 0.0
Val
3.967ValAla: 3.967 ± 0.554
0.839ValCys: 0.839 ± 0.282
3.433ValAsp: 3.433 ± 0.567
5.416ValGlu: 5.416 ± 0.679
2.822ValPhe: 2.822 ± 0.511
3.204ValGly: 3.204 ± 0.502
1.068ValHis: 1.068 ± 0.252
5.798ValIle: 5.798 ± 0.784
6.255ValLys: 6.255 ± 0.611
4.653ValLeu: 4.653 ± 0.578
1.449ValMet: 1.449 ± 0.338
4.653ValAsn: 4.653 ± 0.572
2.365ValPro: 2.365 ± 0.4
2.289ValGln: 2.289 ± 0.363
1.602ValArg: 1.602 ± 0.3
4.196ValSer: 4.196 ± 0.716
4.653ValThr: 4.653 ± 0.592
4.424ValVal: 4.424 ± 0.639
0.534ValTrp: 0.534 ± 0.214
2.746ValTyr: 2.746 ± 0.5
0.0ValXaa: 0.0 ± 0.0
Trp
0.839TrpAla: 0.839 ± 0.313
0.076TrpCys: 0.076 ± 0.078
0.687TrpAsp: 0.687 ± 0.224
0.381TrpGlu: 0.381 ± 0.154
0.153TrpPhe: 0.153 ± 0.112
0.229TrpGly: 0.229 ± 0.116
0.153TrpHis: 0.153 ± 0.11
0.915TrpIle: 0.915 ± 0.278
0.534TrpLys: 0.534 ± 0.196
0.763TrpLeu: 0.763 ± 0.179
0.305TrpMet: 0.305 ± 0.15
1.297TrpAsn: 1.297 ± 0.527
0.076TrpPro: 0.076 ± 0.07
0.534TrpGln: 0.534 ± 0.25
0.305TrpArg: 0.305 ± 0.142
0.687TrpSer: 0.687 ± 0.219
0.458TrpThr: 0.458 ± 0.211
0.763TrpVal: 0.763 ± 0.245
0.076TrpTrp: 0.076 ± 0.073
0.534TrpTyr: 0.534 ± 0.287
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.594TyrAla: 2.594 ± 0.418
0.229TyrCys: 0.229 ± 0.172
2.289TyrAsp: 2.289 ± 0.427
3.433TyrGlu: 3.433 ± 0.489
2.289TyrPhe: 2.289 ± 0.518
2.136TyrGly: 2.136 ± 0.411
0.992TyrHis: 0.992 ± 0.303
3.128TyrIle: 3.128 ± 0.494
5.416TyrLys: 5.416 ± 0.74
3.204TyrLeu: 3.204 ± 0.471
0.763TyrMet: 0.763 ± 0.246
3.433TyrAsn: 3.433 ± 0.467
0.763TyrPro: 0.763 ± 0.217
1.907TyrGln: 1.907 ± 0.389
2.365TyrArg: 2.365 ± 0.487
2.365TyrSer: 2.365 ± 0.423
2.212TyrThr: 2.212 ± 0.445
2.136TyrVal: 2.136 ± 0.327
0.61TyrTrp: 0.61 ± 0.198
1.831TyrTyr: 1.831 ± 0.371
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 77 proteins (13110 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski