Amino acid dipepetide frequency for Coraliomargarita sp. CAG:312

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.952AlaAla: 9.952 ± 0.161	1.357AlaCys: 1.357 ± 0.046	5.159AlaAsp: 5.159 ± 0.091	6.094AlaGlu: 6.094 ± 0.114	4.124AlaPhe: 4.124 ± 0.085	6.305AlaGly: 6.305 ± 0.12	1.365AlaHis: 1.365 ± 0.055	5.822AlaIle: 5.822 ± 0.105	6.367AlaLys: 6.367 ± 0.111	8.45AlaLeu: 8.45 ± 0.141	2.546AlaMet: 2.546 ± 0.062	3.419AlaAsn: 3.419 ± 0.072	3.11AlaPro: 3.11 ± 0.074	2.874AlaGln: 2.874 ± 0.073	4.681AlaArg: 4.681 ± 0.103	5.992AlaSer: 5.992 ± 0.094	3.556AlaThr: 3.556 ± 0.091	6.173AlaVal: 6.173 ± 0.111	0.936AlaTrp: 0.936 ± 0.037	2.709AlaTyr: 2.709 ± 0.076	0.019AlaXaa: 0.019 ± 0.005
Cys	1.918CysAla: 1.918 ± 0.062	0.198CysCys: 0.198 ± 0.02	0.982CysAsp: 0.982 ± 0.04	0.831CysGlu: 0.831 ± 0.043	0.669CysPhe: 0.669 ± 0.03	1.726CysGly: 1.726 ± 0.061	0.275CysHis: 0.275 ± 0.025	0.862CysIle: 0.862 ± 0.042	0.936CysLys: 0.936 ± 0.038	1.081CysLeu: 1.081 ± 0.045	0.341CysMet: 0.341 ± 0.024	0.475CysAsn: 0.475 ± 0.026	0.714CysPro: 0.714 ± 0.034	0.337CysGln: 0.337 ± 0.02	0.787CysArg: 0.787 ± 0.038	1.058CysSer: 1.058 ± 0.04	0.582CysThr: 0.582 ± 0.027	1.163CysVal: 1.163 ± 0.042	0.128CysTrp: 0.128 ± 0.013	0.397CysTyr: 0.397 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	5.177AspAla: 5.177 ± 0.079	0.986AspCys: 0.986 ± 0.038	2.749AspAsp: 2.749 ± 0.07	3.431AspGlu: 3.431 ± 0.08	3.562AspPhe: 3.562 ± 0.077	4.886AspGly: 4.886 ± 0.091	0.571AspHis: 0.571 ± 0.033	4.39AspIle: 4.39 ± 0.084	3.674AspLys: 3.674 ± 0.079	4.203AspLeu: 4.203 ± 0.083	1.554AspMet: 1.554 ± 0.045	2.152AspAsn: 2.152 ± 0.061	2.105AspPro: 2.105 ± 0.062	0.732AspGln: 0.732 ± 0.031	2.083AspArg: 2.083 ± 0.062	4.516AspSer: 4.516 ± 0.082	2.29AspThr: 2.29 ± 0.066	3.553AspVal: 3.553 ± 0.073	0.89AspTrp: 0.89 ± 0.042	2.129AspTyr: 2.129 ± 0.058	0.001AspXaa: 0.001 ± 0.001
Glu	4.502GluAla: 4.502 ± 0.082	0.834GluCys: 0.834 ± 0.038	3.199GluAsp: 3.199 ± 0.077	3.069GluGlu: 3.069 ± 0.078	3.128GluPhe: 3.128 ± 0.073	3.652GluGly: 3.652 ± 0.08	0.88GluHis: 0.88 ± 0.04	5.723GluIle: 5.723 ± 0.101	5.423GluLys: 5.423 ± 0.106	5.229GluLeu: 5.229 ± 0.083	1.544GluMet: 1.544 ± 0.053	4.039GluAsn: 4.039 ± 0.075	1.934GluPro: 1.934 ± 0.049	1.572GluGln: 1.572 ± 0.054	3.419GluArg: 3.419 ± 0.077	4.269GluSer: 4.269 ± 0.091	2.967GluThr: 2.967 ± 0.059	3.404GluVal: 3.404 ± 0.079	0.735GluTrp: 0.735 ± 0.037	2.223GluTyr: 2.223 ± 0.068	0.004GluXaa: 0.004 ± 0.003
Phe	4.772PheAla: 4.772 ± 0.095	0.973PheCys: 0.973 ± 0.043	3.274PheAsp: 3.274 ± 0.077	3.372PheGlu: 3.372 ± 0.069	2.76PhePhe: 2.76 ± 0.082	3.992PheGly: 3.992 ± 0.087	0.648PheHis: 0.648 ± 0.031	3.088PheIle: 3.088 ± 0.075	3.23PheLys: 3.23 ± 0.069	4.176PheLeu: 4.176 ± 0.089	1.209PheMet: 1.209 ± 0.046	2.106PheAsn: 2.106 ± 0.06	1.819PhePro: 1.819 ± 0.056	1.027PheGln: 1.027 ± 0.041	1.98PheArg: 1.98 ± 0.062	4.154PheSer: 4.154 ± 0.089	2.089PheThr: 2.089 ± 0.06	2.963PheVal: 2.963 ± 0.085	0.551PheTrp: 0.551 ± 0.028	1.695PheTyr: 1.695 ± 0.053	0.004PheXaa: 0.004 ± 0.002
Gly	6.762GlyAla: 6.762 ± 0.113	1.209GlyCys: 1.209 ± 0.047	4.142GlyAsp: 4.142 ± 0.075	4.811GlyGlu: 4.811 ± 0.11	3.583GlyPhe: 3.583 ± 0.083	6.159GlyGly: 6.159 ± 0.106	1.088GlyHis: 1.088 ± 0.038	5.125GlyIle: 5.125 ± 0.089	6.098GlyLys: 6.098 ± 0.1	5.54GlyLeu: 5.54 ± 0.097	2.046GlyMet: 2.046 ± 0.059	3.47GlyAsn: 3.47 ± 0.082	1.36GlyPro: 1.36 ± 0.046	1.671GlyGln: 1.671 ± 0.053	3.379GlyArg: 3.379 ± 0.076	4.581GlySer: 4.581 ± 0.104	3.466GlyThr: 3.466 ± 0.081	5.243GlyVal: 5.243 ± 0.107	0.962GlyTrp: 0.962 ± 0.036	2.523GlyTyr: 2.523 ± 0.062	0.009GlyXaa: 0.009 ± 0.004
His	1.29HisAla: 1.29 ± 0.044	0.323HisCys: 0.323 ± 0.021	0.63HisAsp: 0.63 ± 0.035	0.62HisGlu: 0.62 ± 0.028	0.838HisPhe: 0.838 ± 0.038	1.106HisGly: 1.106 ± 0.045	0.273HisHis: 0.273 ± 0.022	1.119HisIle: 1.119 ± 0.044	0.757HisLys: 0.757 ± 0.035	1.261HisLeu: 1.261 ± 0.039	0.418HisMet: 0.418 ± 0.024	0.626HisAsn: 0.626 ± 0.034	0.949HisPro: 0.949 ± 0.036	0.322HisGln: 0.322 ± 0.021	0.62HisArg: 0.62 ± 0.032	1.154HisSer: 1.154 ± 0.048	0.729HisThr: 0.729 ± 0.034	0.726HisVal: 0.726 ± 0.037	0.216HisTrp: 0.216 ± 0.017	0.509HisTyr: 0.509 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.38IleAla: 6.38 ± 0.107	1.199IleCys: 1.199 ± 0.044	3.931IleAsp: 3.931 ± 0.079	4.312IleGlu: 4.312 ± 0.083	3.704IlePhe: 3.704 ± 0.086	4.867IleGly: 4.867 ± 0.119	0.843IleHis: 0.843 ± 0.032	4.25IleIle: 4.25 ± 0.099	4.346IleLys: 4.346 ± 0.09	6.472IleLeu: 6.472 ± 0.102	1.581IleMet: 1.581 ± 0.054	2.787IleAsn: 2.787 ± 0.069	3.234IlePro: 3.234 ± 0.071	1.377IleGln: 1.377 ± 0.045	2.941IleArg: 2.941 ± 0.074	5.987IleSer: 5.987 ± 0.115	3.143IleThr: 3.143 ± 0.078	4.491IleVal: 4.491 ± 0.084	0.683IleTrp: 0.683 ± 0.032	2.191IleTyr: 2.191 ± 0.054	0.003IleXaa: 0.003 ± 0.003
Lys	5.121LysAla: 5.121 ± 0.1	0.824LysCys: 0.824 ± 0.041	3.718LysAsp: 3.718 ± 0.079	3.769LysGlu: 3.769 ± 0.084	3.408LysPhe: 3.408 ± 0.079	3.935LysGly: 3.935 ± 0.083	0.911LysHis: 0.911 ± 0.036	6.284LysIle: 6.284 ± 0.119	5.728LysLys: 5.728 ± 0.127	6.091LysLeu: 6.091 ± 0.1	2.199LysMet: 2.199 ± 0.056	4.403LysAsn: 4.403 ± 0.087	2.656LysPro: 2.656 ± 0.071	1.678LysGln: 1.678 ± 0.049	3.267LysArg: 3.267 ± 0.075	5.288LysSer: 5.288 ± 0.101	3.747LysThr: 3.747 ± 0.081	3.893LysVal: 3.893 ± 0.077	0.797LysTrp: 0.797 ± 0.04	2.778LysTyr: 2.778 ± 0.077	0.0LysXaa: 0.0 ± 0.0
Leu	8.202LeuAla: 8.202 ± 0.12	1.507LeuCys: 1.507 ± 0.048	5.028LeuAsp: 5.028 ± 0.082	5.617LeuGlu: 5.617 ± 0.093	3.857LeuPhe: 3.857 ± 0.089	6.182LeuGly: 6.182 ± 0.127	1.318LeuHis: 1.318 ± 0.044	4.647LeuIle: 4.647 ± 0.088	6.662LeuLys: 6.662 ± 0.124	6.861LeuLeu: 6.861 ± 0.121	2.065LeuMet: 2.065 ± 0.057	3.708LeuAsn: 3.708 ± 0.08	4.176LeuPro: 4.176 ± 0.089	2.157LeuGln: 2.157 ± 0.059	4.837LeuArg: 4.837 ± 0.1	6.996LeuSer: 6.996 ± 0.123	3.68LeuThr: 3.68 ± 0.079	4.904LeuVal: 4.904 ± 0.096	0.902LeuTrp: 0.902 ± 0.037	2.496LeuTyr: 2.496 ± 0.057	0.009LeuXaa: 0.009 ± 0.004
Met	2.388MetAla: 2.388 ± 0.06	0.345MetCys: 0.345 ± 0.024	1.376MetAsp: 1.376 ± 0.044	1.55MetGlu: 1.55 ± 0.051	1.163MetPhe: 1.163 ± 0.048	1.963MetGly: 1.963 ± 0.065	0.455MetHis: 0.455 ± 0.025	1.246MetIle: 1.246 ± 0.043	2.095MetLys: 2.095 ± 0.056	2.586MetLeu: 2.586 ± 0.064	0.626MetMet: 0.626 ± 0.031	1.119MetAsn: 1.119 ± 0.041	1.332MetPro: 1.332 ± 0.044	0.884MetGln: 0.884 ± 0.039	1.792MetArg: 1.792 ± 0.056	1.894MetSer: 1.894 ± 0.052	1.144MetThr: 1.144 ± 0.043	1.389MetVal: 1.389 ± 0.05	0.208MetTrp: 0.208 ± 0.017	0.681MetTyr: 0.681 ± 0.031	0.001MetXaa: 0.001 ± 0.002
Asn	4.114AsnAla: 4.114 ± 0.087	0.762AsnCys: 0.762 ± 0.039	1.789AsnAsp: 1.789 ± 0.049	1.982AsnGlu: 1.982 ± 0.053	2.56AsnPhe: 2.56 ± 0.07	3.555AsnGly: 3.555 ± 0.077	0.462AsnHis: 0.462 ± 0.026	3.581AsnIle: 3.581 ± 0.081	2.458AsnLys: 2.458 ± 0.07	4.387AsnLeu: 4.387 ± 0.085	1.253AsnMet: 1.253 ± 0.043	1.798AsnAsn: 1.798 ± 0.059	2.876AsnPro: 2.876 ± 0.069	0.915AsnGln: 0.915 ± 0.045	1.915AsnArg: 1.915 ± 0.051	3.627AsnSer: 3.627 ± 0.093	2.146AsnThr: 2.146 ± 0.067	2.957AsnVal: 2.957 ± 0.072	0.655AsnTrp: 0.655 ± 0.03	1.547AsnTyr: 1.547 ± 0.064	0.004AsnXaa: 0.004 ± 0.002
Pro	3.481ProAla: 3.481 ± 0.08	0.493ProCys: 0.493 ± 0.028	2.926ProAsp: 2.926 ± 0.072	3.599ProGlu: 3.599 ± 0.072	1.847ProPhe: 1.847 ± 0.056	2.179ProGly: 2.179 ± 0.056	0.748ProHis: 0.748 ± 0.037	2.529ProIle: 2.529 ± 0.059	2.827ProLys: 2.827 ± 0.065	3.208ProLeu: 3.208 ± 0.063	0.986ProMet: 0.986 ± 0.041	1.912ProAsn: 1.912 ± 0.055	1.625ProPro: 1.625 ± 0.058	1.538ProGln: 1.538 ± 0.051	1.887ProArg: 1.887 ± 0.058	3.116ProSer: 3.116 ± 0.071	1.847ProThr: 1.847 ± 0.05	2.7ProVal: 2.7 ± 0.066	0.419ProTrp: 0.419 ± 0.025	1.352ProTyr: 1.352 ± 0.049	0.013ProXaa: 0.013 ± 0.005
Gln	2.146GlnAla: 2.146 ± 0.062	0.323GlnCys: 0.323 ± 0.023	1.221GlnAsp: 1.221 ± 0.045	1.355GlnGlu: 1.355 ± 0.054	0.998GlnPhe: 0.998 ± 0.039	1.478GlnGly: 1.478 ± 0.048	0.338GlnHis: 0.338 ± 0.022	2.238GlnIle: 2.238 ± 0.057	2.137GlnLys: 2.137 ± 0.048	1.934GlnLeu: 1.934 ± 0.06	0.899GlnMet: 0.899 ± 0.035	1.526GlnAsn: 1.526 ± 0.05	1.036GlnPro: 1.036 ± 0.042	0.83GlnGln: 0.83 ± 0.046	1.243GlnArg: 1.243 ± 0.043	1.709GlnSer: 1.709 ± 0.051	1.482GlnThr: 1.482 ± 0.045	1.376GlnVal: 1.376 ± 0.048	0.338GlnTrp: 0.338 ± 0.03	0.871GlnTyr: 0.871 ± 0.038	0.001GlnXaa: 0.001 ± 0.001
Arg	4.275ArgAla: 4.275 ± 0.091	0.568ArgCys: 0.568 ± 0.036	2.642ArgAsp: 2.642 ± 0.063	3.37ArgGlu: 3.37 ± 0.079	2.223ArgPhe: 2.223 ± 0.063	3.494ArgGly: 3.494 ± 0.073	0.868ArgHis: 0.868 ± 0.035	3.683ArgIle: 3.683 ± 0.079	3.618ArgLys: 3.618 ± 0.076	4.281ArgLeu: 4.281 ± 0.088	1.518ArgMet: 1.518 ± 0.048	2.437ArgAsn: 2.437 ± 0.066	1.798ArgPro: 1.798 ± 0.052	1.441ArgGln: 1.441 ± 0.045	3.023ArgArg: 3.023 ± 0.075	2.772ArgSer: 2.772 ± 0.064	2.229ArgThr: 2.229 ± 0.062	2.859ArgVal: 2.859 ± 0.071	0.502ArgTrp: 0.502 ± 0.03	1.531ArgTyr: 1.531 ± 0.046	0.006ArgXaa: 0.006 ± 0.003
Ser	7.452SerAla: 7.452 ± 0.129	0.991SerCys: 0.991 ± 0.042	4.482SerAsp: 4.482 ± 0.078	5.022SerGlu: 5.022 ± 0.089	3.361SerPhe: 3.361 ± 0.079	6.226SerGly: 6.226 ± 0.108	1.109SerHis: 1.109 ± 0.037	4.746SerIle: 4.746 ± 0.084	4.919SerLys: 4.919 ± 0.106	6.04SerLeu: 6.04 ± 0.105	1.734SerMet: 1.734 ± 0.057	2.995SerAsn: 2.995 ± 0.083	3.462SerPro: 3.462 ± 0.066	2.152SerGln: 2.152 ± 0.05	3.547SerArg: 3.547 ± 0.079	5.249SerSer: 5.249 ± 0.113	3.1SerThr: 3.1 ± 0.068	4.607SerVal: 4.607 ± 0.084	0.794SerTrp: 0.794 ± 0.038	2.226SerTyr: 2.226 ± 0.054	0.001SerXaa: 0.001 ± 0.001
Thr	3.9ThrAla: 3.9 ± 0.074	0.554ThrCys: 0.554 ± 0.029	2.3ThrAsp: 2.3 ± 0.051	2.111ThrGlu: 2.111 ± 0.053	2.263ThrPhe: 2.263 ± 0.068	3.55ThrGly: 3.55 ± 0.078	0.707ThrHis: 0.707 ± 0.031	3.036ThrIle: 3.036 ± 0.071	2.256ThrLys: 2.256 ± 0.059	4.483ThrLeu: 4.483 ± 0.087	1.033ThrMet: 1.033 ± 0.042	1.729ThrAsn: 1.729 ± 0.057	2.588ThrPro: 2.588 ± 0.06	1.244ThrGln: 1.244 ± 0.047	1.975ThrArg: 1.975 ± 0.055	3.261ThrSer: 3.261 ± 0.089	1.95ThrThr: 1.95 ± 0.068	3.24ThrVal: 3.24 ± 0.079	0.558ThrTrp: 0.558 ± 0.029	1.466ThrTyr: 1.466 ± 0.06	0.001ThrXaa: 0.001 ± 0.001
Val	5.426ValAla: 5.426 ± 0.104	1.27ValCys: 1.27 ± 0.042	3.432ValAsp: 3.432 ± 0.064	4.368ValGlu: 4.368 ± 0.08	3.534ValPhe: 3.534 ± 0.088	4.409ValGly: 4.409 ± 0.092	0.889ValHis: 0.889 ± 0.037	3.528ValIle: 3.528 ± 0.07	4.154ValLys: 4.154 ± 0.081	5.629ValLeu: 5.629 ± 0.11	1.464ValMet: 1.464 ± 0.05	2.492ValAsn: 2.492 ± 0.077	2.579ValPro: 2.579 ± 0.059	1.453ValGln: 1.453 ± 0.043	3.265ValArg: 3.265 ± 0.077	5.325ValSer: 5.325 ± 0.103	2.074ValThr: 2.074 ± 0.065	4.446ValVal: 4.446 ± 0.096	0.785ValTrp: 0.785 ± 0.037	2.083ValTyr: 2.083 ± 0.051	0.003ValXaa: 0.003 ± 0.002
Trp	0.75TrpAla: 0.75 ± 0.032	0.159TrpCys: 0.159 ± 0.015	0.728TrpAsp: 0.728 ± 0.038	0.632TrpGlu: 0.632 ± 0.031	0.45TrpPhe: 0.45 ± 0.023	0.954TrpGly: 0.954 ± 0.039	0.267TrpHis: 0.267 ± 0.022	0.818TrpIle: 0.818 ± 0.03	0.734TrpLys: 0.734 ± 0.038	1.113TrpLeu: 1.113 ± 0.042	0.397TrpMet: 0.397 ± 0.024	0.704TrpAsn: 0.704 ± 0.035	0.31TrpPro: 0.31 ± 0.021	0.456TrpGln: 0.456 ± 0.039	0.76TrpArg: 0.76 ± 0.033	0.799TrpSer: 0.799 ± 0.03	0.567TrpThr: 0.567 ± 0.029	0.593TrpVal: 0.593 ± 0.031	0.193TrpTrp: 0.193 ± 0.017	0.391TrpTyr: 0.391 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.986TyrAla: 2.986 ± 0.068	0.583TyrCys: 0.583 ± 0.03	1.925TyrAsp: 1.925 ± 0.062	1.836TyrGlu: 1.836 ± 0.051	1.845TyrPhe: 1.845 ± 0.053	2.595TyrGly: 2.595 ± 0.067	0.469TyrHis: 0.469 ± 0.024	2.0TyrIle: 2.0 ± 0.056	2.071TyrLys: 2.071 ± 0.058	2.783TyrLeu: 2.783 ± 0.063	0.819TyrMet: 0.819 ± 0.033	1.445TyrAsn: 1.445 ± 0.051	1.565TyrPro: 1.565 ± 0.055	0.816TyrGln: 0.816 ± 0.035	1.732TyrArg: 1.732 ± 0.061	2.465TyrSer: 2.465 ± 0.066	1.419TyrThr: 1.419 ± 0.047	1.922TyrVal: 1.922 ± 0.053	0.518TyrTrp: 0.518 ± 0.03	1.315TyrTyr: 1.315 ± 0.053	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.015XaaAla: 0.015 ± 0.004	0.001XaaCys: 0.001 ± 0.002	0.001XaaAsp: 0.001 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.003XaaPhe: 0.003 ± 0.002	0.015XaaGly: 0.015 ± 0.005	0.003XaaHis: 0.003 ± 0.002	0.004XaaIle: 0.004 ± 0.003	0.006XaaLys: 0.006 ± 0.003	0.006XaaLeu: 0.006 ± 0.003	0.001XaaMet: 0.001 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.003XaaGln: 0.003 ± 0.002	0.007XaaArg: 0.007 ± 0.003	0.004XaaSer: 0.004 ± 0.003	0.001XaaThr: 0.001 ± 0.001	0.004XaaVal: 0.004 ± 0.003	0.003XaaTrp: 0.003 ± 0.002	0.0XaaTyr: 0.0 ± 0.0	0.096XaaXaa: 0.096 ± 0.016

Statistics based on 2060 proteins (677430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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