Amino acid dipepetide frequency for Alfalfa dwarf virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.335AlaAla: 5.335 ± 2.096
0.508AlaCys: 0.508 ± 0.276
5.081AlaAsp: 5.081 ± 1.006
4.319AlaGlu: 4.319 ± 1.566
1.27AlaPhe: 1.27 ± 1.42
4.065AlaGly: 4.065 ± 1.279
1.27AlaHis: 1.27 ± 1.139
4.065AlaIle: 4.065 ± 1.768
2.541AlaLys: 2.541 ± 0.502
5.843AlaLeu: 5.843 ± 1.432
1.778AlaMet: 1.778 ± 0.475
3.303AlaAsn: 3.303 ± 0.811
2.287AlaPro: 2.287 ± 0.778
1.016AlaGln: 1.016 ± 0.69
2.541AlaArg: 2.541 ± 0.817
4.319AlaSer: 4.319 ± 0.934
3.557AlaThr: 3.557 ± 0.824
4.065AlaVal: 4.065 ± 1.281
0.762AlaTrp: 0.762 ± 0.316
1.27AlaTyr: 1.27 ± 0.405
0.0AlaXaa: 0.0 ± 0.0
Cys
0.762CysAla: 0.762 ± 0.29
0.508CysCys: 0.508 ± 0.295
2.033CysAsp: 2.033 ± 0.572
1.27CysGlu: 1.27 ± 0.866
0.254CysPhe: 0.254 ± 0.148
1.27CysGly: 1.27 ± 0.996
0.0CysHis: 0.0 ± 0.0
1.016CysIle: 1.016 ± 0.368
1.016CysLys: 1.016 ± 0.499
0.762CysLeu: 0.762 ± 0.29
0.508CysMet: 0.508 ± 0.295
0.254CysAsn: 0.254 ± 0.403
1.016CysPro: 1.016 ± 0.925
0.254CysGln: 0.254 ± 0.32
2.287CysArg: 2.287 ± 0.703
1.016CysSer: 1.016 ± 0.368
1.524CysThr: 1.524 ± 0.704
1.016CysVal: 1.016 ± 0.278
0.508CysTrp: 0.508 ± 0.295
1.524CysTyr: 1.524 ± 0.586
0.0CysXaa: 0.0 ± 0.0
Asp
4.065AspAla: 4.065 ± 1.584
2.795AspCys: 2.795 ± 1.275
5.335AspAsp: 5.335 ± 0.768
4.065AspGlu: 4.065 ± 2.036
2.795AspPhe: 2.795 ± 1.323
2.795AspGly: 2.795 ± 0.831
1.27AspHis: 1.27 ± 0.48
5.335AspIle: 5.335 ± 2.038
4.573AspLys: 4.573 ± 1.22
6.098AspLeu: 6.098 ± 1.374
1.778AspMet: 1.778 ± 1.3
2.795AspAsn: 2.795 ± 0.752
3.557AspPro: 3.557 ± 0.684
1.27AspGln: 1.27 ± 0.65
2.033AspArg: 2.033 ± 0.882
5.335AspSer: 5.335 ± 0.701
2.795AspThr: 2.795 ± 0.65
5.589AspVal: 5.589 ± 1.466
0.508AspTrp: 0.508 ± 0.295
1.778AspTyr: 1.778 ± 0.704
0.0AspXaa: 0.0 ± 0.0
Glu
2.795GluAla: 2.795 ± 0.741
1.016GluCys: 1.016 ± 0.409
5.081GluAsp: 5.081 ± 1.481
3.049GluGlu: 3.049 ± 1.936
1.524GluPhe: 1.524 ± 0.828
5.589GluGly: 5.589 ± 0.602
1.016GluHis: 1.016 ± 0.696
4.319GluIle: 4.319 ± 1.253
3.303GluLys: 3.303 ± 1.181
5.335GluLeu: 5.335 ± 0.87
2.033GluMet: 2.033 ± 0.273
2.541GluAsn: 2.541 ± 0.989
2.033GluPro: 2.033 ± 0.933
1.016GluGln: 1.016 ± 0.425
2.795GluArg: 2.795 ± 0.934
3.557GluSer: 3.557 ± 1.195
3.811GluThr: 3.811 ± 0.872
5.081GluVal: 5.081 ± 1.135
1.27GluTrp: 1.27 ± 0.628
1.524GluTyr: 1.524 ± 0.48
0.0GluXaa: 0.0 ± 0.0
Phe
1.27PheAla: 1.27 ± 0.313
1.016PheCys: 1.016 ± 0.516
2.795PheAsp: 2.795 ± 0.826
1.524PheGlu: 1.524 ± 0.853
1.016PhePhe: 1.016 ± 0.429
0.762PheGly: 0.762 ± 0.443
1.27PheHis: 1.27 ± 0.628
1.27PheIle: 1.27 ± 0.767
2.541PheLys: 2.541 ± 1.069
1.524PheLeu: 1.524 ± 0.566
1.27PheMet: 1.27 ± 0.405
0.762PheAsn: 0.762 ± 0.29
1.778PhePro: 1.778 ± 0.858
1.27PheGln: 1.27 ± 0.46
2.287PheArg: 2.287 ± 0.395
2.033PheSer: 2.033 ± 1.005
1.524PheThr: 1.524 ± 0.608
1.524PheVal: 1.524 ± 0.659
0.508PheTrp: 0.508 ± 0.381
0.762PheTyr: 0.762 ± 0.316
0.0PheXaa: 0.0 ± 0.0
Gly
3.557GlyAla: 3.557 ± 0.865
1.27GlyCys: 1.27 ± 0.988
5.081GlyAsp: 5.081 ± 0.703
3.811GlyGlu: 3.811 ± 1.04
0.762GlyPhe: 0.762 ± 0.359
3.811GlyGly: 3.811 ± 1.08
1.778GlyHis: 1.778 ± 0.743
3.557GlyIle: 3.557 ± 1.19
3.557GlyLys: 3.557 ± 1.527
6.86GlyLeu: 6.86 ± 0.658
3.303GlyMet: 3.303 ± 1.503
1.524GlyAsn: 1.524 ± 0.461
1.524GlyPro: 1.524 ± 0.93
1.27GlyGln: 1.27 ± 0.738
3.049GlyArg: 3.049 ± 0.67
4.573GlySer: 4.573 ± 1.662
2.541GlyThr: 2.541 ± 1.2
4.319GlyVal: 4.319 ± 0.98
1.27GlyTrp: 1.27 ± 0.48
2.541GlyTyr: 2.541 ± 1.154
0.0GlyXaa: 0.0 ± 0.0
His
0.508HisAla: 0.508 ± 0.321
0.254HisCys: 0.254 ± 0.335
0.762HisAsp: 0.762 ± 0.443
0.762HisGlu: 0.762 ± 0.29
1.016HisPhe: 1.016 ± 0.368
1.27HisGly: 1.27 ± 0.313
0.0HisHis: 0.0 ± 0.0
1.778HisIle: 1.778 ± 0.743
1.524HisLys: 1.524 ± 0.58
2.795HisLeu: 2.795 ± 0.854
0.762HisMet: 0.762 ± 0.317
0.762HisAsn: 0.762 ± 0.595
1.524HisPro: 1.524 ± 0.345
1.27HisGln: 1.27 ± 0.65
1.27HisArg: 1.27 ± 0.574
1.524HisSer: 1.524 ± 0.586
0.508HisThr: 0.508 ± 0.414
1.016HisVal: 1.016 ± 0.455
0.254HisTrp: 0.254 ± 0.148
0.762HisTyr: 0.762 ± 0.595
0.0HisXaa: 0.0 ± 0.0
Ile
3.049IleAla: 3.049 ± 0.321
0.762IleCys: 0.762 ± 0.29
3.557IleAsp: 3.557 ± 0.723
4.319IleGlu: 4.319 ± 0.843
1.778IlePhe: 1.778 ± 0.595
3.557IleGly: 3.557 ± 0.789
1.27IleHis: 1.27 ± 0.313
4.573IleIle: 4.573 ± 1.521
5.843IleLys: 5.843 ± 1.172
4.827IleLeu: 4.827 ± 1.018
2.541IleMet: 2.541 ± 1.166
3.811IleAsn: 3.811 ± 1.052
3.049IlePro: 3.049 ± 0.889
1.778IleGln: 1.778 ± 0.438
4.065IleArg: 4.065 ± 1.182
5.335IleSer: 5.335 ± 1.231
3.811IleThr: 3.811 ± 1.134
4.319IleVal: 4.319 ± 1.403
1.27IleTrp: 1.27 ± 0.525
1.778IleTyr: 1.778 ± 0.356
0.0IleXaa: 0.0 ± 0.0
Lys
4.573LysAla: 4.573 ± 1.642
1.27LysCys: 1.27 ± 0.866
5.081LysAsp: 5.081 ± 1.256
3.557LysGlu: 3.557 ± 1.498
1.524LysPhe: 1.524 ± 0.715
4.065LysGly: 4.065 ± 0.724
1.27LysHis: 1.27 ± 0.476
3.303LysIle: 3.303 ± 0.555
3.811LysLys: 3.811 ± 0.712
6.352LysLeu: 6.352 ± 1.317
2.033LysMet: 2.033 ± 0.908
1.778LysAsn: 1.778 ± 0.811
4.065LysPro: 4.065 ± 1.316
2.795LysGln: 2.795 ± 0.902
4.065LysArg: 4.065 ± 1.088
5.081LysSer: 5.081 ± 0.515
5.335LysThr: 5.335 ± 1.174
5.843LysVal: 5.843 ± 1.293
1.27LysTrp: 1.27 ± 0.752
1.778LysTyr: 1.778 ± 0.52
0.0LysXaa: 0.0 ± 0.0
Leu
5.081LeuAla: 5.081 ± 1.371
3.303LeuCys: 3.303 ± 0.911
4.573LeuAsp: 4.573 ± 0.635
5.335LeuGlu: 5.335 ± 0.837
3.049LeuPhe: 3.049 ± 1.035
4.573LeuGly: 4.573 ± 0.962
2.795LeuHis: 2.795 ± 1.067
4.827LeuIle: 4.827 ± 1.018
6.098LeuLys: 6.098 ± 0.601
8.13LeuLeu: 8.13 ± 1.241
2.287LeuMet: 2.287 ± 0.488
4.065LeuAsn: 4.065 ± 0.938
4.319LeuPro: 4.319 ± 1.44
2.541LeuGln: 2.541 ± 0.503
6.352LeuArg: 6.352 ± 1.158
8.892LeuSer: 8.892 ± 1.603
5.335LeuThr: 5.335 ± 0.637
3.557LeuVal: 3.557 ± 0.595
1.016LeuTrp: 1.016 ± 0.368
4.827LeuTyr: 4.827 ± 1.013
0.0LeuXaa: 0.0 ± 0.0
Met
1.778MetAla: 1.778 ± 1.734
0.762MetCys: 0.762 ± 0.444
2.033MetAsp: 2.033 ± 0.815
1.524MetGlu: 1.524 ± 0.633
1.778MetPhe: 1.778 ± 0.743
3.049MetGly: 3.049 ± 0.589
0.508MetHis: 0.508 ± 0.408
2.287MetIle: 2.287 ± 0.836
3.557MetLys: 3.557 ± 0.877
2.287MetLeu: 2.287 ± 0.596
1.778MetMet: 1.778 ± 0.469
1.27MetAsn: 1.27 ± 0.738
0.762MetPro: 0.762 ± 0.414
0.254MetGln: 0.254 ± 0.148
3.303MetArg: 3.303 ± 0.948
3.303MetSer: 3.303 ± 1.573
3.557MetThr: 3.557 ± 1.059
1.27MetVal: 1.27 ± 0.988
0.254MetTrp: 0.254 ± 0.148
0.762MetTyr: 0.762 ± 0.455
0.0MetXaa: 0.0 ± 0.0
Asn
2.795AsnAla: 2.795 ± 0.487
0.762AsnCys: 0.762 ± 1.004
2.033AsnAsp: 2.033 ± 0.924
1.524AsnGlu: 1.524 ± 0.905
1.27AsnPhe: 1.27 ± 0.625
1.778AsnGly: 1.778 ± 0.356
0.762AsnHis: 0.762 ± 0.701
2.795AsnIle: 2.795 ± 0.899
3.557AsnLys: 3.557 ± 1.428
2.795AsnLeu: 2.795 ± 0.579
0.508AsnMet: 0.508 ± 0.295
1.778AsnAsn: 1.778 ± 0.841
3.049AsnPro: 3.049 ± 0.71
1.524AsnGln: 1.524 ± 0.962
1.778AsnArg: 1.778 ± 0.842
2.287AsnSer: 2.287 ± 0.721
3.049AsnThr: 3.049 ± 0.837
0.762AsnVal: 0.762 ± 0.444
1.016AsnTrp: 1.016 ± 0.591
1.778AsnTyr: 1.778 ± 0.342
0.0AsnXaa: 0.0 ± 0.0
Pro
2.287ProAla: 2.287 ± 0.746
0.0ProCys: 0.0 ± 0.0
3.049ProAsp: 3.049 ± 0.882
4.573ProGlu: 4.573 ± 0.424
0.762ProPhe: 0.762 ± 0.414
2.033ProGly: 2.033 ± 1.408
1.27ProHis: 1.27 ± 0.48
3.557ProIle: 3.557 ± 0.961
2.033ProLys: 2.033 ± 0.656
4.573ProLeu: 4.573 ± 1.026
1.016ProMet: 1.016 ± 0.384
1.27ProAsn: 1.27 ± 0.646
2.287ProPro: 2.287 ± 0.805
0.508ProGln: 0.508 ± 0.306
2.795ProArg: 2.795 ± 0.659
4.065ProSer: 4.065 ± 1.005
4.319ProThr: 4.319 ± 1.235
2.541ProVal: 2.541 ± 1.439
0.254ProTrp: 0.254 ± 0.148
1.778ProTyr: 1.778 ± 0.646
0.0ProXaa: 0.0 ± 0.0
Gln
1.524GlnAla: 1.524 ± 0.918
1.27GlnCys: 1.27 ± 0.313
2.795GlnAsp: 2.795 ± 1.406
2.541GlnGlu: 2.541 ± 0.78
0.508GlnPhe: 0.508 ± 0.295
0.508GlnGly: 0.508 ± 0.408
0.508GlnHis: 0.508 ± 0.321
1.27GlnIle: 1.27 ± 0.42
1.524GlnLys: 1.524 ± 0.666
2.795GlnLeu: 2.795 ± 0.764
1.016GlnMet: 1.016 ± 0.407
0.254GlnAsn: 0.254 ± 0.148
1.778GlnPro: 1.778 ± 1.523
0.762GlnGln: 0.762 ± 0.455
2.033GlnArg: 2.033 ± 1.107
2.287GlnSer: 2.287 ± 0.483
2.033GlnThr: 2.033 ± 1.067
1.778GlnVal: 1.778 ± 0.659
0.0GlnTrp: 0.0 ± 0.0
0.508GlnTyr: 0.508 ± 0.276
0.0GlnXaa: 0.0 ± 0.0
Arg
4.065ArgAla: 4.065 ± 1.054
0.254ArgCys: 0.254 ± 0.148
1.778ArgAsp: 1.778 ± 0.399
3.811ArgGlu: 3.811 ± 0.919
2.795ArgPhe: 2.795 ± 1.167
3.811ArgGly: 3.811 ± 0.814
0.762ArgHis: 0.762 ± 0.29
3.557ArgIle: 3.557 ± 1.774
2.541ArgLys: 2.541 ± 1.385
6.098ArgLeu: 6.098 ± 1.12
3.557ArgMet: 3.557 ± 1.194
2.033ArgAsn: 2.033 ± 0.614
2.033ArgPro: 2.033 ± 0.692
1.778ArgGln: 1.778 ± 0.558
2.795ArgArg: 2.795 ± 0.838
5.335ArgSer: 5.335 ± 0.997
3.303ArgThr: 3.303 ± 0.886
3.557ArgVal: 3.557 ± 1.038
1.778ArgTrp: 1.778 ± 0.727
2.541ArgTyr: 2.541 ± 0.581
0.0ArgXaa: 0.0 ± 0.0
Ser
6.86SerAla: 6.86 ± 1.72
0.508SerCys: 0.508 ± 0.64
5.335SerAsp: 5.335 ± 1.572
4.827SerGlu: 4.827 ± 1.026
2.287SerPhe: 2.287 ± 0.55
3.811SerGly: 3.811 ± 1.147
2.033SerHis: 2.033 ± 0.752
6.606SerIle: 6.606 ± 0.863
6.86SerLys: 6.86 ± 1.421
5.335SerLeu: 5.335 ± 1.646
2.541SerMet: 2.541 ± 1.142
2.795SerAsn: 2.795 ± 0.632
3.049SerPro: 3.049 ± 0.994
2.033SerGln: 2.033 ± 0.767
5.081SerArg: 5.081 ± 1.437
7.368SerSer: 7.368 ± 1.846
4.319SerThr: 4.319 ± 0.66
4.065SerVal: 4.065 ± 0.934
0.508SerTrp: 0.508 ± 0.295
2.033SerTyr: 2.033 ± 0.452
0.0SerXaa: 0.0 ± 0.0
Thr
3.811ThrAla: 3.811 ± 0.967
1.016ThrCys: 1.016 ± 0.368
4.573ThrAsp: 4.573 ± 1.128
3.049ThrGlu: 3.049 ± 1.104
0.762ThrPhe: 0.762 ± 0.29
6.098ThrGly: 6.098 ± 1.122
0.254ThrHis: 0.254 ± 0.32
3.303ThrIle: 3.303 ± 0.627
4.319ThrLys: 4.319 ± 1.482
6.606ThrLeu: 6.606 ± 1.439
1.778ThrMet: 1.778 ± 1.066
1.524ThrAsn: 1.524 ± 0.651
2.033ThrPro: 2.033 ± 0.691
3.811ThrGln: 3.811 ± 1.164
2.795ThrArg: 2.795 ± 0.908
4.573ThrSer: 4.573 ± 0.815
4.827ThrThr: 4.827 ± 2.15
4.319ThrVal: 4.319 ± 1.296
1.524ThrTrp: 1.524 ± 0.632
3.303ThrTyr: 3.303 ± 1.191
0.0ThrXaa: 0.0 ± 0.0
Val
2.795ValAla: 2.795 ± 1.2
0.762ValCys: 0.762 ± 0.558
2.795ValAsp: 2.795 ± 0.547
3.303ValGlu: 3.303 ± 1.192
1.778ValPhe: 1.778 ± 0.951
3.557ValGly: 3.557 ± 1.504
0.508ValHis: 0.508 ± 0.295
4.827ValIle: 4.827 ± 0.742
6.86ValLys: 6.86 ± 1.411
4.319ValLeu: 4.319 ± 0.628
2.795ValMet: 2.795 ± 0.795
2.541ValAsn: 2.541 ± 0.479
3.303ValPro: 3.303 ± 0.274
1.778ValGln: 1.778 ± 0.468
4.065ValArg: 4.065 ± 0.807
5.081ValSer: 5.081 ± 1.521
4.065ValThr: 4.065 ± 1.093
5.335ValVal: 5.335 ± 0.918
1.524ValTrp: 1.524 ± 0.403
2.541ValTyr: 2.541 ± 0.553
0.0ValXaa: 0.0 ± 0.0
Trp
0.254TrpAla: 0.254 ± 0.148
0.0TrpCys: 0.0 ± 0.0
0.762TrpAsp: 0.762 ± 0.595
0.508TrpGlu: 0.508 ± 0.381
0.762TrpPhe: 0.762 ± 0.465
1.524TrpGly: 1.524 ± 0.608
0.0TrpHis: 0.0 ± 0.0
0.508TrpIle: 0.508 ± 0.523
0.762TrpLys: 0.762 ± 0.359
1.778TrpLeu: 1.778 ± 1.034
0.254TrpMet: 0.254 ± 0.148
1.27TrpAsn: 1.27 ± 0.371
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.524TrpArg: 1.524 ± 0.704
1.016TrpSer: 1.016 ± 0.552
2.033TrpThr: 2.033 ± 0.527
2.033TrpVal: 2.033 ± 0.91
0.254TrpTrp: 0.254 ± 0.148
0.508TrpTyr: 0.508 ± 0.321
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.033TyrAla: 2.033 ± 1.027
0.762TyrCys: 0.762 ± 0.29
2.033TyrAsp: 2.033 ± 0.575
1.016TyrGlu: 1.016 ± 0.505
1.016TyrPhe: 1.016 ± 0.612
2.033TyrGly: 2.033 ± 0.543
1.778TyrHis: 1.778 ± 0.646
2.541TyrIle: 2.541 ± 1.258
2.033TyrLys: 2.033 ± 0.436
5.843TyrLeu: 5.843 ± 1.712
2.287TyrMet: 2.287 ± 0.728
1.27TyrAsn: 1.27 ± 0.65
1.524TyrPro: 1.524 ± 0.595
0.762TyrGln: 0.762 ± 0.316
1.27TyrArg: 1.27 ± 1.146
1.27TyrSer: 1.27 ± 0.752
2.287TyrThr: 2.287 ± 0.568
2.541TyrVal: 2.541 ± 1.264
0.0TyrTrp: 0.0 ± 0.0
1.016TyrTyr: 1.016 ± 0.368
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (3937 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski