Amino acid dipepetide frequency for Pneumococcus phage Dp-1 (Bacteriophage Dp-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.259AlaAla: 5.259 ± 0.864
0.396AlaCys: 0.396 ± 0.158
3.959AlaAsp: 3.959 ± 0.516
5.994AlaGlu: 5.994 ± 0.743
2.658AlaPhe: 2.658 ± 0.474
5.485AlaGly: 5.485 ± 1.071
0.792AlaHis: 0.792 ± 0.261
4.468AlaIle: 4.468 ± 0.55
5.09AlaLys: 5.09 ± 0.524
6.39AlaLeu: 6.39 ± 1.064
1.923AlaMet: 1.923 ± 0.337
3.337AlaAsn: 3.337 ± 0.335
1.923AlaPro: 1.923 ± 0.32
3.167AlaGln: 3.167 ± 0.528
3.054AlaArg: 3.054 ± 0.448
5.259AlaSer: 5.259 ± 0.746
3.959AlaThr: 3.959 ± 0.449
4.694AlaVal: 4.694 ± 0.596
0.735AlaTrp: 0.735 ± 0.197
2.884AlaTyr: 2.884 ± 0.444
0.0AlaXaa: 0.0 ± 0.0
Cys
0.339CysAla: 0.339 ± 0.149
0.057CysCys: 0.057 ± 0.054
0.509CysAsp: 0.509 ± 0.187
0.792CysGlu: 0.792 ± 0.215
0.396CysPhe: 0.396 ± 0.168
0.509CysGly: 0.509 ± 0.176
0.283CysHis: 0.283 ± 0.133
1.131CysIle: 1.131 ± 0.308
0.509CysLys: 0.509 ± 0.173
1.074CysLeu: 1.074 ± 0.286
0.226CysMet: 0.226 ± 0.132
0.452CysAsn: 0.452 ± 0.16
0.679CysPro: 0.679 ± 0.172
0.339CysGln: 0.339 ± 0.154
0.339CysArg: 0.339 ± 0.146
0.396CysSer: 0.396 ± 0.142
0.452CysThr: 0.452 ± 0.181
0.339CysVal: 0.339 ± 0.148
0.17CysTrp: 0.17 ± 0.091
0.283CysTyr: 0.283 ± 0.107
0.0CysXaa: 0.0 ± 0.0
Asp
4.581AspAla: 4.581 ± 0.586
0.452AspCys: 0.452 ± 0.173
2.941AspAsp: 2.941 ± 0.393
5.712AspGlu: 5.712 ± 0.702
2.658AspPhe: 2.658 ± 0.377
5.485AspGly: 5.485 ± 0.843
1.074AspHis: 1.074 ± 0.301
3.902AspIle: 3.902 ± 0.439
3.167AspLys: 3.167 ± 0.405
4.524AspLeu: 4.524 ± 0.518
1.753AspMet: 1.753 ± 0.325
3.223AspAsn: 3.223 ± 0.472
1.753AspPro: 1.753 ± 0.31
1.866AspGln: 1.866 ± 0.35
2.375AspArg: 2.375 ± 0.341
3.789AspSer: 3.789 ± 0.522
2.771AspThr: 2.771 ± 0.36
4.241AspVal: 4.241 ± 0.366
0.452AspTrp: 0.452 ± 0.147
2.658AspTyr: 2.658 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
5.994GluAla: 5.994 ± 0.638
0.735GluCys: 0.735 ± 0.207
4.863GluAsp: 4.863 ± 0.553
6.786GluGlu: 6.786 ± 0.965
3.45GluPhe: 3.45 ± 0.448
3.732GluGly: 3.732 ± 0.446
1.301GluHis: 1.301 ± 0.329
5.372GluIle: 5.372 ± 0.675
6.277GluLys: 6.277 ± 0.777
6.843GluLeu: 6.843 ± 0.628
1.64GluMet: 1.64 ± 0.325
3.846GluAsn: 3.846 ± 0.467
2.545GluPro: 2.545 ± 0.42
4.354GluGln: 4.354 ± 0.51
3.393GluArg: 3.393 ± 0.534
4.072GluSer: 4.072 ± 0.439
4.581GluThr: 4.581 ± 0.449
4.298GluVal: 4.298 ± 0.559
1.357GluTrp: 1.357 ± 0.252
3.223GluTyr: 3.223 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
1.753PheAla: 1.753 ± 0.321
0.396PheCys: 0.396 ± 0.181
3.11PheAsp: 3.11 ± 0.447
3.902PheGlu: 3.902 ± 0.427
1.131PhePhe: 1.131 ± 0.213
2.432PheGly: 2.432 ± 0.479
1.018PheHis: 1.018 ± 0.187
2.658PheIle: 2.658 ± 0.437
3.619PheLys: 3.619 ± 0.516
3.11PheLeu: 3.11 ± 0.427
0.905PheMet: 0.905 ± 0.202
2.658PheAsn: 2.658 ± 0.376
0.792PhePro: 0.792 ± 0.204
1.527PheGln: 1.527 ± 0.269
2.149PheArg: 2.149 ± 0.384
2.884PheSer: 2.884 ± 0.434
2.658PheThr: 2.658 ± 0.397
2.262PheVal: 2.262 ± 0.344
0.848PheTrp: 0.848 ± 0.218
1.753PheTyr: 1.753 ± 0.271
0.0PheXaa: 0.0 ± 0.0
Gly
4.581GlyAla: 4.581 ± 0.519
0.283GlyCys: 0.283 ± 0.128
2.319GlyAsp: 2.319 ± 0.363
4.92GlyGlu: 4.92 ± 0.422
2.658GlyPhe: 2.658 ± 0.363
3.732GlyGly: 3.732 ± 0.482
0.905GlyHis: 0.905 ± 0.228
5.09GlyIle: 5.09 ± 0.706
6.221GlyLys: 6.221 ± 0.62
5.09GlyLeu: 5.09 ± 0.67
1.866GlyMet: 1.866 ± 0.338
3.563GlyAsn: 3.563 ± 0.45
1.414GlyPro: 1.414 ± 0.363
2.262GlyGln: 2.262 ± 0.443
3.11GlyArg: 3.11 ± 0.632
4.015GlySer: 4.015 ± 0.563
4.354GlyThr: 4.354 ± 0.459
4.468GlyVal: 4.468 ± 0.453
0.735GlyTrp: 0.735 ± 0.233
2.601GlyTyr: 2.601 ± 0.479
0.0GlyXaa: 0.0 ± 0.0
His
1.131HisAla: 1.131 ± 0.271
0.396HisCys: 0.396 ± 0.153
1.131HisAsp: 1.131 ± 0.215
0.622HisGlu: 0.622 ± 0.177
1.018HisPhe: 1.018 ± 0.259
1.244HisGly: 1.244 ± 0.315
0.452HisHis: 0.452 ± 0.156
1.018HisIle: 1.018 ± 0.247
0.848HisLys: 0.848 ± 0.246
1.131HisLeu: 1.131 ± 0.302
0.396HisMet: 0.396 ± 0.135
0.339HisAsn: 0.339 ± 0.196
0.792HisPro: 0.792 ± 0.219
0.452HisGln: 0.452 ± 0.145
0.509HisArg: 0.509 ± 0.162
1.074HisSer: 1.074 ± 0.283
1.074HisThr: 1.074 ± 0.259
0.622HisVal: 0.622 ± 0.178
0.0HisTrp: 0.0 ± 0.0
0.792HisTyr: 0.792 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
5.542IleAla: 5.542 ± 0.766
0.396IleCys: 0.396 ± 0.12
5.655IleAsp: 5.655 ± 0.623
6.334IleGlu: 6.334 ± 0.646
2.545IlePhe: 2.545 ± 0.335
3.676IleGly: 3.676 ± 0.579
0.961IleHis: 0.961 ± 0.223
4.015IleIle: 4.015 ± 0.486
4.128IleLys: 4.128 ± 0.629
5.372IleLeu: 5.372 ± 0.51
1.753IleMet: 1.753 ± 0.38
2.488IleAsn: 2.488 ± 0.353
2.771IlePro: 2.771 ± 0.383
3.846IleGln: 3.846 ± 0.494
3.167IleArg: 3.167 ± 0.419
5.203IleSer: 5.203 ± 0.542
3.223IleThr: 3.223 ± 0.371
4.637IleVal: 4.637 ± 0.573
0.679IleTrp: 0.679 ± 0.248
2.092IleTyr: 2.092 ± 0.298
0.0IleXaa: 0.0 ± 0.0
Lys
4.977LysAla: 4.977 ± 0.626
0.679LysCys: 0.679 ± 0.217
3.732LysAsp: 3.732 ± 0.485
5.316LysGlu: 5.316 ± 0.548
2.545LysPhe: 2.545 ± 0.338
4.524LysGly: 4.524 ± 0.485
1.301LysHis: 1.301 ± 0.233
5.033LysIle: 5.033 ± 0.544
5.033LysLys: 5.033 ± 0.834
6.108LysLeu: 6.108 ± 0.573
2.997LysMet: 2.997 ± 0.473
3.28LysAsn: 3.28 ± 0.534
2.714LysPro: 2.714 ± 0.411
3.11LysGln: 3.11 ± 0.541
3.45LysArg: 3.45 ± 0.676
4.241LysSer: 4.241 ± 0.39
4.128LysThr: 4.128 ± 0.449
5.429LysVal: 5.429 ± 0.613
1.301LysTrp: 1.301 ± 0.303
2.771LysTyr: 2.771 ± 0.379
0.0LysXaa: 0.0 ± 0.0
Leu
6.108LeuAla: 6.108 ± 0.547
0.735LeuCys: 0.735 ± 0.174
5.599LeuAsp: 5.599 ± 0.635
7.239LeuGlu: 7.239 ± 0.702
3.45LeuPhe: 3.45 ± 0.432
5.09LeuGly: 5.09 ± 0.646
1.018LeuHis: 1.018 ± 0.207
5.372LeuIle: 5.372 ± 0.68
5.655LeuLys: 5.655 ± 0.647
6.277LeuLeu: 6.277 ± 0.927
2.714LeuMet: 2.714 ± 0.374
4.298LeuAsn: 4.298 ± 0.533
4.128LeuPro: 4.128 ± 0.539
3.45LeuGln: 3.45 ± 0.389
2.941LeuArg: 2.941 ± 0.351
4.637LeuSer: 4.637 ± 0.574
5.09LeuThr: 5.09 ± 0.602
6.277LeuVal: 6.277 ± 0.713
0.848LeuTrp: 0.848 ± 0.322
3.223LeuTyr: 3.223 ± 0.526
0.0LeuXaa: 0.0 ± 0.0
Met
2.262MetAla: 2.262 ± 0.491
0.339MetCys: 0.339 ± 0.134
1.47MetAsp: 1.47 ± 0.28
1.583MetGlu: 1.583 ± 0.287
1.018MetPhe: 1.018 ± 0.219
1.64MetGly: 1.64 ± 0.399
0.057MetHis: 0.057 ± 0.056
1.583MetIle: 1.583 ± 0.354
2.828MetLys: 2.828 ± 0.409
1.979MetLeu: 1.979 ± 0.297
0.283MetMet: 0.283 ± 0.115
1.64MetAsn: 1.64 ± 0.339
0.848MetPro: 0.848 ± 0.187
1.074MetGln: 1.074 ± 0.231
0.735MetArg: 0.735 ± 0.228
2.149MetSer: 2.149 ± 0.268
2.319MetThr: 2.319 ± 0.373
1.81MetVal: 1.81 ± 0.44
0.339MetTrp: 0.339 ± 0.134
0.848MetTyr: 0.848 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
3.789AsnAla: 3.789 ± 0.467
0.735AsnCys: 0.735 ± 0.248
2.884AsnAsp: 2.884 ± 0.337
3.337AsnGlu: 3.337 ± 0.467
2.658AsnPhe: 2.658 ± 0.386
4.185AsnGly: 4.185 ± 0.477
0.905AsnHis: 0.905 ± 0.22
3.223AsnIle: 3.223 ± 0.396
2.545AsnLys: 2.545 ± 0.432
5.09AsnLeu: 5.09 ± 0.48
1.244AsnMet: 1.244 ± 0.368
2.092AsnAsn: 2.092 ± 0.4
2.262AsnPro: 2.262 ± 0.335
2.149AsnGln: 2.149 ± 0.298
1.753AsnArg: 1.753 ± 0.406
3.45AsnSer: 3.45 ± 0.54
1.244AsnThr: 1.244 ± 0.205
3.11AsnVal: 3.11 ± 0.422
0.848AsnTrp: 0.848 ± 0.237
1.753AsnTyr: 1.753 ± 0.349
0.0AsnXaa: 0.0 ± 0.0
Pro
2.828ProAla: 2.828 ± 0.453
0.17ProCys: 0.17 ± 0.097
2.771ProAsp: 2.771 ± 0.372
3.054ProGlu: 3.054 ± 0.435
1.357ProPhe: 1.357 ± 0.286
1.753ProGly: 1.753 ± 0.537
0.113ProHis: 0.113 ± 0.07
1.866ProIle: 1.866 ± 0.3
3.167ProLys: 3.167 ± 0.641
2.036ProLeu: 2.036 ± 0.357
0.848ProMet: 0.848 ± 0.192
1.527ProAsn: 1.527 ± 0.253
0.509ProPro: 0.509 ± 0.16
1.583ProGln: 1.583 ± 0.325
1.357ProArg: 1.357 ± 0.327
2.601ProSer: 2.601 ± 0.357
2.036ProThr: 2.036 ± 0.271
1.527ProVal: 1.527 ± 0.315
0.17ProTrp: 0.17 ± 0.095
1.244ProTyr: 1.244 ± 0.256
0.0ProXaa: 0.0 ± 0.0
Gln
3.11GlnAla: 3.11 ± 0.671
0.226GlnCys: 0.226 ± 0.144
2.036GlnAsp: 2.036 ± 0.413
3.223GlnGlu: 3.223 ± 0.471
2.714GlnPhe: 2.714 ± 0.466
2.714GlnGly: 2.714 ± 0.388
0.396GlnHis: 0.396 ± 0.126
3.11GlnIle: 3.11 ± 0.541
2.601GlnLys: 2.601 ± 0.296
4.298GlnLeu: 4.298 ± 0.446
1.357GlnMet: 1.357 ± 0.299
1.753GlnAsn: 1.753 ± 0.27
1.357GlnPro: 1.357 ± 0.284
1.414GlnGln: 1.414 ± 0.345
1.414GlnArg: 1.414 ± 0.295
1.81GlnSer: 1.81 ± 0.371
1.979GlnThr: 1.979 ± 0.318
3.28GlnVal: 3.28 ± 0.492
0.339GlnTrp: 0.339 ± 0.144
1.979GlnTyr: 1.979 ± 0.453
0.0GlnXaa: 0.0 ± 0.0
Arg
2.997ArgAla: 2.997 ± 0.399
0.509ArgCys: 0.509 ± 0.191
2.149ArgAsp: 2.149 ± 0.312
2.828ArgGlu: 2.828 ± 0.432
2.036ArgPhe: 2.036 ± 0.341
2.262ArgGly: 2.262 ± 0.441
0.679ArgHis: 0.679 ± 0.207
4.072ArgIle: 4.072 ± 0.465
3.846ArgLys: 3.846 ± 0.593
4.185ArgLeu: 4.185 ± 0.456
0.961ArgMet: 0.961 ± 0.21
3.563ArgAsn: 3.563 ± 0.49
1.357ArgPro: 1.357 ± 0.288
1.697ArgGln: 1.697 ± 0.38
2.262ArgArg: 2.262 ± 0.542
2.149ArgSer: 2.149 ± 0.37
2.601ArgThr: 2.601 ± 0.37
2.319ArgVal: 2.319 ± 0.311
0.566ArgTrp: 0.566 ± 0.18
2.488ArgTyr: 2.488 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
5.033SerAla: 5.033 ± 0.576
0.735SerCys: 0.735 ± 0.191
2.206SerAsp: 2.206 ± 0.326
2.206SerGlu: 2.206 ± 0.323
2.149SerPhe: 2.149 ± 0.38
4.072SerGly: 4.072 ± 0.425
0.961SerHis: 0.961 ± 0.249
4.694SerIle: 4.694 ± 0.455
5.485SerLys: 5.485 ± 0.515
5.994SerLeu: 5.994 ± 0.589
1.64SerMet: 1.64 ± 0.305
3.789SerAsn: 3.789 ± 0.51
2.206SerPro: 2.206 ± 0.364
2.375SerGln: 2.375 ± 0.3
3.902SerArg: 3.902 ± 0.484
5.429SerSer: 5.429 ± 0.483
4.015SerThr: 4.015 ± 0.491
3.846SerVal: 3.846 ± 0.491
1.131SerTrp: 1.131 ± 0.291
3.054SerTyr: 3.054 ± 0.418
0.0SerXaa: 0.0 ± 0.0
Thr
3.393ThrAla: 3.393 ± 0.609
0.848ThrCys: 0.848 ± 0.265
3.619ThrAsp: 3.619 ± 0.485
4.468ThrGlu: 4.468 ± 0.604
3.054ThrPhe: 3.054 ± 0.435
4.468ThrGly: 4.468 ± 0.512
0.452ThrHis: 0.452 ± 0.14
4.354ThrIle: 4.354 ± 0.437
3.337ThrLys: 3.337 ± 0.443
4.637ThrLeu: 4.637 ± 0.533
1.47ThrMet: 1.47 ± 0.278
2.432ThrAsn: 2.432 ± 0.324
1.697ThrPro: 1.697 ± 0.289
1.866ThrGln: 1.866 ± 0.354
3.223ThrArg: 3.223 ± 0.439
3.054ThrSer: 3.054 ± 0.49
3.337ThrThr: 3.337 ± 0.43
4.694ThrVal: 4.694 ± 0.478
0.848ThrTrp: 0.848 ± 0.192
2.036ThrTyr: 2.036 ± 0.399
0.0ThrXaa: 0.0 ± 0.0
Val
4.128ValAla: 4.128 ± 0.442
0.566ValCys: 0.566 ± 0.161
4.75ValAsp: 4.75 ± 0.598
5.938ValGlu: 5.938 ± 0.631
1.583ValPhe: 1.583 ± 0.275
3.732ValGly: 3.732 ± 0.423
1.244ValHis: 1.244 ± 0.317
3.789ValIle: 3.789 ± 0.532
4.694ValLys: 4.694 ± 0.484
5.542ValLeu: 5.542 ± 0.622
1.188ValMet: 1.188 ± 0.286
2.714ValAsn: 2.714 ± 0.44
1.979ValPro: 1.979 ± 0.432
3.054ValGln: 3.054 ± 0.475
3.45ValArg: 3.45 ± 0.47
5.429ValSer: 5.429 ± 0.698
4.637ValThr: 4.637 ± 0.448
4.298ValVal: 4.298 ± 0.546
0.905ValTrp: 0.905 ± 0.29
1.527ValTyr: 1.527 ± 0.268
0.0ValXaa: 0.0 ± 0.0
Trp
0.848TrpAla: 0.848 ± 0.168
0.057TrpCys: 0.057 ± 0.048
0.792TrpAsp: 0.792 ± 0.191
0.905TrpGlu: 0.905 ± 0.231
0.735TrpPhe: 0.735 ± 0.242
0.396TrpGly: 0.396 ± 0.16
0.283TrpHis: 0.283 ± 0.105
0.622TrpIle: 0.622 ± 0.185
1.244TrpLys: 1.244 ± 0.252
1.357TrpLeu: 1.357 ± 0.259
0.226TrpMet: 0.226 ± 0.129
0.622TrpAsn: 0.622 ± 0.187
0.0TrpPro: 0.0 ± 0.0
0.396TrpGln: 0.396 ± 0.161
0.792TrpArg: 0.792 ± 0.261
0.509TrpSer: 0.509 ± 0.189
1.018TrpThr: 1.018 ± 0.335
0.792TrpVal: 0.792 ± 0.208
0.17TrpTrp: 0.17 ± 0.107
1.074TrpTyr: 1.074 ± 0.368
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.771TyrAla: 2.771 ± 0.44
0.566TyrCys: 0.566 ± 0.261
2.884TyrAsp: 2.884 ± 0.379
3.506TyrGlu: 3.506 ± 0.361
1.753TyrPhe: 1.753 ± 0.325
3.054TyrGly: 3.054 ± 0.535
0.848TyrHis: 0.848 ± 0.232
3.167TyrIle: 3.167 ± 0.395
2.375TyrLys: 2.375 ± 0.418
3.11TyrLeu: 3.11 ± 0.376
1.357TyrMet: 1.357 ± 0.264
1.64TyrAsn: 1.64 ± 0.298
0.792TyrPro: 0.792 ± 0.208
1.131TyrGln: 1.131 ± 0.276
2.149TyrArg: 2.149 ± 0.402
2.771TyrSer: 2.771 ± 0.439
1.81TyrThr: 1.81 ± 0.308
2.206TyrVal: 2.206 ± 0.311
0.396TyrTrp: 0.396 ± 0.169
1.47TyrTyr: 1.47 ± 0.472
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (17684 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski