Amino acid dipepetide frequency for Clostridium sp. CAG:533

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.636AlaAla: 2.636 ± 0.105
0.54AlaCys: 0.54 ± 0.045
2.588AlaAsp: 2.588 ± 0.107
3.001AlaGlu: 3.001 ± 0.117
2.165AlaPhe: 2.165 ± 0.096
3.063AlaGly: 3.063 ± 0.114
0.69AlaHis: 0.69 ± 0.061
4.414AlaIle: 4.414 ± 0.145
4.501AlaLys: 4.501 ± 0.122
5.144AlaLeu: 5.144 ± 0.155
1.062AlaMet: 1.062 ± 0.061
2.84AlaAsn: 2.84 ± 0.113
1.165AlaPro: 1.165 ± 0.078
0.913AlaGln: 0.913 ± 0.06
1.92AlaArg: 1.92 ± 0.096
4.02AlaSer: 4.02 ± 0.146
2.585AlaThr: 2.585 ± 0.105
3.264AlaVal: 3.264 ± 0.14
0.277AlaTrp: 0.277 ± 0.031
2.326AlaTyr: 2.326 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.701CysAla: 0.701 ± 0.05
0.142CysCys: 0.142 ± 0.026
0.781CysAsp: 0.781 ± 0.059
0.785CysGlu: 0.785 ± 0.059
0.413CysPhe: 0.413 ± 0.039
1.062CysGly: 1.062 ± 0.065
0.168CysHis: 0.168 ± 0.028
0.854CysIle: 0.854 ± 0.052
0.862CysLys: 0.862 ± 0.056
0.989CysLeu: 0.989 ± 0.058
0.226CysMet: 0.226 ± 0.024
0.716CysAsn: 0.716 ± 0.064
0.456CysPro: 0.456 ± 0.052
0.161CysGln: 0.161 ± 0.025
0.237CysArg: 0.237 ± 0.026
0.727CysSer: 0.727 ± 0.055
0.69CysThr: 0.69 ± 0.056
0.595CysVal: 0.595 ± 0.04
0.073CysTrp: 0.073 ± 0.014
0.507CysTyr: 0.507 ± 0.041
0.0CysXaa: 0.0 ± 0.0
Asp
3.377AspAla: 3.377 ± 0.116
0.529AspCys: 0.529 ± 0.047
3.863AspAsp: 3.863 ± 0.133
5.319AspGlu: 5.319 ± 0.18
2.727AspPhe: 2.727 ± 0.111
3.746AspGly: 3.746 ± 0.127
0.548AspHis: 0.548 ± 0.046
5.896AspIle: 5.896 ± 0.154
6.122AspLys: 6.122 ± 0.149
5.374AspLeu: 5.374 ± 0.141
1.336AspMet: 1.336 ± 0.067
4.421AspAsn: 4.421 ± 0.113
1.219AspPro: 1.219 ± 0.073
0.588AspGln: 0.588 ± 0.044
1.595AspArg: 1.595 ± 0.085
3.125AspSer: 3.125 ± 0.119
3.008AspThr: 3.008 ± 0.131
3.676AspVal: 3.676 ± 0.134
0.212AspTrp: 0.212 ± 0.029
3.804AspTyr: 3.804 ± 0.13
0.0AspXaa: 0.0 ± 0.0
Glu
3.702GluAla: 3.702 ± 0.131
0.737GluCys: 0.737 ± 0.05
4.056GluAsp: 4.056 ± 0.119
7.229GluGlu: 7.229 ± 0.227
2.855GluPhe: 2.855 ± 0.109
3.311GluGly: 3.311 ± 0.115
0.884GluHis: 0.884 ± 0.063
6.579GluIle: 6.579 ± 0.18
6.977GluLys: 6.977 ± 0.198
7.101GluLeu: 7.101 ± 0.168
1.825GluMet: 1.825 ± 0.077
5.122GluAsn: 5.122 ± 0.128
1.511GluPro: 1.511 ± 0.085
1.398GluGln: 1.398 ± 0.07
2.322GluArg: 2.322 ± 0.108
3.603GluSer: 3.603 ± 0.111
3.695GluThr: 3.695 ± 0.132
4.965GluVal: 4.965 ± 0.146
0.321GluTrp: 0.321 ± 0.039
3.614GluTyr: 3.614 ± 0.124
0.0GluXaa: 0.0 ± 0.0
Phe
2.096PheAla: 2.096 ± 0.093
0.482PheCys: 0.482 ± 0.042
2.895PheAsp: 2.895 ± 0.111
2.475PheGlu: 2.475 ± 0.096
1.621PhePhe: 1.621 ± 0.099
2.596PheGly: 2.596 ± 0.124
0.453PheHis: 0.453 ± 0.042
4.355PheIle: 4.355 ± 0.141
4.125PheLys: 4.125 ± 0.125
3.815PheLeu: 3.815 ± 0.125
1.048PheMet: 1.048 ± 0.068
3.107PheAsn: 3.107 ± 0.106
1.055PhePro: 1.055 ± 0.064
0.672PheGln: 0.672 ± 0.053
1.208PheArg: 1.208 ± 0.067
2.84PheSer: 2.84 ± 0.099
2.596PheThr: 2.596 ± 0.103
2.373PheVal: 2.373 ± 0.101
0.186PheTrp: 0.186 ± 0.027
2.034PheTyr: 2.034 ± 0.096
0.0PheXaa: 0.0 ± 0.0
Gly
3.494GlyAla: 3.494 ± 0.132
0.661GlyCys: 0.661 ± 0.055
3.275GlyAsp: 3.275 ± 0.126
3.428GlyGlu: 3.428 ± 0.12
2.515GlyPhe: 2.515 ± 0.098
3.238GlyGly: 3.238 ± 0.142
0.953GlyHis: 0.953 ± 0.061
5.213GlyIle: 5.213 ± 0.166
5.677GlyLys: 5.677 ± 0.138
5.151GlyLeu: 5.151 ± 0.143
1.435GlyMet: 1.435 ± 0.083
2.983GlyAsn: 2.983 ± 0.108
0.982GlyPro: 0.982 ± 0.065
0.902GlyGln: 0.902 ± 0.064
1.654GlyArg: 1.654 ± 0.09
3.6GlySer: 3.6 ± 0.143
3.863GlyThr: 3.863 ± 0.152
4.085GlyVal: 4.085 ± 0.117
0.347GlyTrp: 0.347 ± 0.037
3.253GlyTyr: 3.253 ± 0.115
0.0GlyXaa: 0.0 ± 0.0
His
0.745HisAla: 0.745 ± 0.058
0.12HisCys: 0.12 ± 0.02
0.668HisAsp: 0.668 ± 0.054
0.836HisGlu: 0.836 ± 0.062
0.573HisPhe: 0.573 ± 0.044
0.767HisGly: 0.767 ± 0.062
0.27HisHis: 0.27 ± 0.028
1.157HisIle: 1.157 ± 0.066
0.982HisLys: 0.982 ± 0.064
1.219HisLeu: 1.219 ± 0.077
0.285HisMet: 0.285 ± 0.032
0.851HisAsn: 0.851 ± 0.06
0.551HisPro: 0.551 ± 0.05
0.303HisGln: 0.303 ± 0.035
0.405HisArg: 0.405 ± 0.042
0.646HisSer: 0.646 ± 0.056
0.686HisThr: 0.686 ± 0.051
0.832HisVal: 0.832 ± 0.058
0.037HisTrp: 0.037 ± 0.011
0.591HisTyr: 0.591 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
4.428IleAla: 4.428 ± 0.116
1.208IleCys: 1.208 ± 0.068
5.987IleAsp: 5.987 ± 0.186
5.754IleGlu: 5.754 ± 0.175
4.122IlePhe: 4.122 ± 0.142
4.998IleGly: 4.998 ± 0.157
0.975IleHis: 0.975 ± 0.061
10.587IleIle: 10.587 ± 0.241
9.733IleLys: 9.733 ± 0.188
8.707IleLeu: 8.707 ± 0.206
2.165IleMet: 2.165 ± 0.094
7.415IleAsn: 7.415 ± 0.161
2.866IlePro: 2.866 ± 0.116
1.201IleGln: 1.201 ± 0.072
2.596IleArg: 2.596 ± 0.096
6.747IleSer: 6.747 ± 0.17
6.09IleThr: 6.09 ± 0.176
5.604IleVal: 5.604 ± 0.162
0.467IleTrp: 0.467 ± 0.037
4.374IleTyr: 4.374 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
4.023LysAla: 4.023 ± 0.123
1.121LysCys: 1.121 ± 0.071
6.531LysAsp: 6.531 ± 0.154
9.653LysGlu: 9.653 ± 0.223
3.114LysPhe: 3.114 ± 0.109
4.673LysGly: 4.673 ± 0.134
1.132LysHis: 1.132 ± 0.067
9.12LysIle: 9.12 ± 0.177
9.792LysLys: 9.792 ± 0.184
8.185LysLeu: 8.185 ± 0.192
2.881LysMet: 2.881 ± 0.098
7.079LysAsn: 7.079 ± 0.197
2.03LysPro: 2.03 ± 0.078
2.004LysGln: 2.004 ± 0.097
3.326LysArg: 3.326 ± 0.106
5.159LysSer: 5.159 ± 0.143
5.498LysThr: 5.498 ± 0.154
6.112LysVal: 6.112 ± 0.15
0.533LysTrp: 0.533 ± 0.047
5.882LysTyr: 5.882 ± 0.163
0.0LysXaa: 0.0 ± 0.0
Leu
4.534LeuAla: 4.534 ± 0.144
1.019LeuCys: 1.019 ± 0.066
5.721LeuAsp: 5.721 ± 0.164
6.564LeuGlu: 6.564 ± 0.171
3.968LeuPhe: 3.968 ± 0.134
5.133LeuGly: 5.133 ± 0.14
1.124LeuHis: 1.124 ± 0.062
8.715LeuIle: 8.715 ± 0.216
9.211LeuLys: 9.211 ± 0.215
8.539LeuLeu: 8.539 ± 0.228
2.194LeuMet: 2.194 ± 0.096
6.714LeuAsn: 6.714 ± 0.153
2.523LeuPro: 2.523 ± 0.1
1.468LeuGln: 1.468 ± 0.08
2.632LeuArg: 2.632 ± 0.11
6.805LeuSer: 6.805 ± 0.174
5.56LeuThr: 5.56 ± 0.139
6.049LeuVal: 6.049 ± 0.174
0.522LeuTrp: 0.522 ± 0.051
3.753LeuTyr: 3.753 ± 0.129
0.0LeuXaa: 0.0 ± 0.0
Met
1.245MetAla: 1.245 ± 0.073
0.329MetCys: 0.329 ± 0.031
1.555MetAsp: 1.555 ± 0.082
1.53MetGlu: 1.53 ± 0.074
1.135MetPhe: 1.135 ± 0.066
1.347MetGly: 1.347 ± 0.075
0.354MetHis: 0.354 ± 0.037
2.074MetIle: 2.074 ± 0.093
2.647MetLys: 2.647 ± 0.084
2.315MetLeu: 2.315 ± 0.105
0.57MetMet: 0.57 ± 0.049
1.526MetAsn: 1.526 ± 0.083
0.891MetPro: 0.891 ± 0.059
0.628MetGln: 0.628 ± 0.053
0.694MetArg: 0.694 ± 0.046
1.468MetSer: 1.468 ± 0.078
1.084MetThr: 1.084 ± 0.059
1.358MetVal: 1.358 ± 0.069
0.124MetTrp: 0.124 ± 0.022
0.938MetTyr: 0.938 ± 0.058
0.0MetXaa: 0.0 ± 0.0
Asn
3.322AsnAla: 3.322 ± 0.123
0.672AsnCys: 0.672 ± 0.051
4.104AsnAsp: 4.104 ± 0.148
4.841AsnGlu: 4.841 ± 0.131
2.756AsnPhe: 2.756 ± 0.103
4.366AsnGly: 4.366 ± 0.159
0.916AsnHis: 0.916 ± 0.06
7.429AsnIle: 7.429 ± 0.179
7.481AsnLys: 7.481 ± 0.183
6.276AsnLeu: 6.276 ± 0.163
1.745AsnMet: 1.745 ± 0.081
5.878AsnAsn: 5.878 ± 0.191
1.971AsnPro: 1.971 ± 0.09
1.329AsnGln: 1.329 ± 0.07
1.814AsnArg: 1.814 ± 0.093
3.811AsnSer: 3.811 ± 0.14
3.786AsnThr: 3.786 ± 0.132
3.877AsnVal: 3.877 ± 0.123
0.307AsnTrp: 0.307 ± 0.036
4.071AsnTyr: 4.071 ± 0.134
0.0AsnXaa: 0.0 ± 0.0
Pro
1.168ProAla: 1.168 ± 0.062
0.31ProCys: 0.31 ± 0.033
1.486ProAsp: 1.486 ± 0.088
2.136ProGlu: 2.136 ± 0.098
1.325ProPhe: 1.325 ± 0.075
1.347ProGly: 1.347 ± 0.071
0.387ProHis: 0.387 ± 0.041
2.307ProIle: 2.307 ± 0.086
2.402ProLys: 2.402 ± 0.107
2.223ProLeu: 2.223 ± 0.099
0.464ProMet: 0.464 ± 0.04
1.8ProAsn: 1.8 ± 0.09
0.321ProPro: 0.321 ± 0.031
0.413ProGln: 0.413 ± 0.042
0.686ProArg: 0.686 ± 0.055
1.847ProSer: 1.847 ± 0.067
1.424ProThr: 1.424 ± 0.071
1.814ProVal: 1.814 ± 0.084
0.164ProTrp: 0.164 ± 0.024
1.406ProTyr: 1.406 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
1.008GlnAla: 1.008 ± 0.065
0.135GlnCys: 0.135 ± 0.021
0.884GlnAsp: 0.884 ± 0.059
1.176GlnGlu: 1.176 ± 0.076
0.548GlnPhe: 0.548 ± 0.045
0.935GlnGly: 0.935 ± 0.059
0.161GlnHis: 0.161 ± 0.024
1.993GlnIle: 1.993 ± 0.096
1.968GlnLys: 1.968 ± 0.091
1.139GlnLeu: 1.139 ± 0.059
0.54GlnMet: 0.54 ± 0.041
1.574GlnAsn: 1.574 ± 0.09
0.307GlnPro: 0.307 ± 0.032
0.314GlnGln: 0.314 ± 0.036
0.767GlnArg: 0.767 ± 0.048
1.026GlnSer: 1.026 ± 0.065
1.128GlnThr: 1.128 ± 0.068
0.975GlnVal: 0.975 ± 0.061
0.091GlnTrp: 0.091 ± 0.019
0.661GlnTyr: 0.661 ± 0.053
0.0GlnXaa: 0.0 ± 0.0
Arg
1.362ArgAla: 1.362 ± 0.074
0.434ArgCys: 0.434 ± 0.043
1.745ArgAsp: 1.745 ± 0.082
2.205ArgGlu: 2.205 ± 0.097
1.205ArgPhe: 1.205 ± 0.084
1.679ArgGly: 1.679 ± 0.082
0.372ArgHis: 0.372 ± 0.036
2.724ArgIle: 2.724 ± 0.113
3.038ArgLys: 3.038 ± 0.114
2.899ArgLeu: 2.899 ± 0.111
0.953ArgMet: 0.953 ± 0.054
1.961ArgAsn: 1.961 ± 0.095
0.796ArgPro: 0.796 ± 0.048
0.672ArgGln: 0.672 ± 0.051
1.263ArgArg: 1.263 ± 0.078
1.672ArgSer: 1.672 ± 0.073
1.727ArgThr: 1.727 ± 0.076
1.993ArgVal: 1.993 ± 0.101
0.164ArgTrp: 0.164 ± 0.025
1.497ArgTyr: 1.497 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.341SerAla: 3.341 ± 0.134
0.639SerCys: 0.639 ± 0.045
3.947SerAsp: 3.947 ± 0.137
4.282SerGlu: 4.282 ± 0.127
3.052SerPhe: 3.052 ± 0.12
4.031SerGly: 4.031 ± 0.137
0.778SerHis: 0.778 ± 0.056
5.688SerIle: 5.688 ± 0.154
6.363SerLys: 6.363 ± 0.144
6.363SerLeu: 6.363 ± 0.143
1.365SerMet: 1.365 ± 0.07
4.414SerAsn: 4.414 ± 0.142
1.519SerPro: 1.519 ± 0.077
1.135SerGln: 1.135 ± 0.066
1.804SerArg: 1.804 ± 0.086
4.841SerSer: 4.841 ± 0.163
3.392SerThr: 3.392 ± 0.13
4.206SerVal: 4.206 ± 0.14
0.434SerTrp: 0.434 ± 0.041
3.454SerTyr: 3.454 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
2.494ThrAla: 2.494 ± 0.092
0.621ThrCys: 0.621 ± 0.06
3.508ThrAsp: 3.508 ± 0.112
3.541ThrGlu: 3.541 ± 0.134
2.771ThrPhe: 2.771 ± 0.111
3.914ThrGly: 3.914 ± 0.127
0.719ThrHis: 0.719 ± 0.043
5.524ThrIle: 5.524 ± 0.148
5.159ThrLys: 5.159 ± 0.166
5.374ThrLeu: 5.374 ± 0.15
1.011ThrMet: 1.011 ± 0.057
3.899ThrAsn: 3.899 ± 0.141
1.877ThrPro: 1.877 ± 0.094
1.008ThrGln: 1.008 ± 0.063
1.533ThrArg: 1.533 ± 0.065
4.381ThrSer: 4.381 ± 0.178
3.793ThrThr: 3.793 ± 0.203
3.129ThrVal: 3.129 ± 0.136
0.259ThrTrp: 0.259 ± 0.028
3.03ThrTyr: 3.03 ± 0.116
0.0ThrXaa: 0.0 ± 0.0
Val
2.709ValAla: 2.709 ± 0.113
0.796ValCys: 0.796 ± 0.049
3.348ValAsp: 3.348 ± 0.123
3.205ValGlu: 3.205 ± 0.119
2.483ValPhe: 2.483 ± 0.095
3.388ValGly: 3.388 ± 0.121
0.759ValHis: 0.759 ± 0.063
6.48ValIle: 6.48 ± 0.173
6.031ValLys: 6.031 ± 0.163
6.166ValLeu: 6.166 ± 0.185
1.515ValMet: 1.515 ± 0.091
4.158ValAsn: 4.158 ± 0.116
1.95ValPro: 1.95 ± 0.079
0.858ValGln: 0.858 ± 0.047
2.136ValArg: 2.136 ± 0.089
5.111ValSer: 5.111 ± 0.141
3.841ValThr: 3.841 ± 0.129
4.334ValVal: 4.334 ± 0.153
0.347ValTrp: 0.347 ± 0.041
2.862ValTyr: 2.862 ± 0.105
0.0ValXaa: 0.0 ± 0.0
Trp
0.234TrpAla: 0.234 ± 0.03
0.113TrpCys: 0.113 ± 0.022
0.336TrpAsp: 0.336 ± 0.04
0.321TrpGlu: 0.321 ± 0.036
0.332TrpPhe: 0.332 ± 0.034
0.329TrpGly: 0.329 ± 0.036
0.102TrpHis: 0.102 ± 0.02
0.493TrpIle: 0.493 ± 0.046
0.314TrpLys: 0.314 ± 0.033
0.5TrpLeu: 0.5 ± 0.047
0.128TrpMet: 0.128 ± 0.022
0.307TrpAsn: 0.307 ± 0.034
0.124TrpPro: 0.124 ± 0.02
0.128TrpGln: 0.128 ± 0.023
0.168TrpArg: 0.168 ± 0.026
0.387TrpSer: 0.387 ± 0.037
0.245TrpThr: 0.245 ± 0.032
0.237TrpVal: 0.237 ± 0.031
0.102TrpTrp: 0.102 ± 0.021
0.329TrpTyr: 0.329 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.497TyrAla: 2.497 ± 0.089
0.537TyrCys: 0.537 ± 0.045
3.213TyrAsp: 3.213 ± 0.117
3.527TyrGlu: 3.527 ± 0.113
2.351TyrPhe: 2.351 ± 0.11
2.786TyrGly: 2.786 ± 0.106
0.781TyrHis: 0.781 ± 0.054
4.421TyrIle: 4.421 ± 0.141
4.461TyrLys: 4.461 ± 0.157
5.268TyrLeu: 5.268 ± 0.128
1.059TyrMet: 1.059 ± 0.065
3.99TyrAsn: 3.99 ± 0.134
1.318TyrPro: 1.318 ± 0.07
1.234TyrGln: 1.234 ± 0.074
1.599TyrArg: 1.599 ± 0.076
3.231TyrSer: 3.231 ± 0.116
2.855TyrThr: 2.855 ± 0.128
2.997TyrVal: 2.997 ± 0.119
0.259TyrTrp: 0.259 ± 0.031
3.191TyrTyr: 3.191 ± 0.13
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 969 proteins (273910 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski