Amino acid dipepetide frequency for Dorea sp. CAG:105

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.712AlaAla: 6.712 ± 0.138
1.161AlaCys: 1.161 ± 0.046
4.611AlaAsp: 4.611 ± 0.088
5.323AlaGlu: 5.323 ± 0.114
3.097AlaPhe: 3.097 ± 0.096
6.389AlaGly: 6.389 ± 0.111
1.238AlaHis: 1.238 ± 0.043
5.171AlaIle: 5.171 ± 0.095
5.843AlaLys: 5.843 ± 0.109
6.484AlaLeu: 6.484 ± 0.103
2.386AlaMet: 2.386 ± 0.064
2.719AlaAsn: 2.719 ± 0.073
1.924AlaPro: 1.924 ± 0.051
2.209AlaGln: 2.209 ± 0.065
2.892AlaArg: 2.892 ± 0.085
3.878AlaSer: 3.878 ± 0.092
3.495AlaThr: 3.495 ± 0.095
6.167AlaVal: 6.167 ± 0.096
0.571AlaTrp: 0.571 ± 0.028
2.989AlaTyr: 2.989 ± 0.068
0.003AlaXaa: 0.003 ± 0.002
Cys
1.061CysAla: 1.061 ± 0.037
0.279CysCys: 0.279 ± 0.023
0.774CysAsp: 0.774 ± 0.037
0.952CysGlu: 0.952 ± 0.038
0.574CysPhe: 0.574 ± 0.032
1.559CysGly: 1.559 ± 0.05
0.299CysHis: 0.299 ± 0.02
1.045CysIle: 1.045 ± 0.041
0.981CysLys: 0.981 ± 0.045
1.076CysLeu: 1.076 ± 0.035
0.482CysMet: 0.482 ± 0.026
0.542CysAsn: 0.542 ± 0.029
0.648CysPro: 0.648 ± 0.037
0.362CysGln: 0.362 ± 0.023
0.604CysArg: 0.604 ± 0.029
0.755CysSer: 0.755 ± 0.039
0.816CysThr: 0.816 ± 0.037
1.092CysVal: 1.092 ± 0.042
0.114CysTrp: 0.114 ± 0.015
0.59CysTyr: 0.59 ± 0.032
0.0CysXaa: 0.0 ± 0.0
Asp
4.351AspAla: 4.351 ± 0.088
0.762AspCys: 0.762 ± 0.033
2.938AspAsp: 2.938 ± 0.095
4.638AspGlu: 4.638 ± 0.092
2.419AspPhe: 2.419 ± 0.066
4.284AspGly: 4.284 ± 0.087
0.964AspHis: 0.964 ± 0.052
4.479AspIle: 4.479 ± 0.09
3.949AspLys: 3.949 ± 0.091
4.538AspLeu: 4.538 ± 0.083
1.851AspMet: 1.851 ± 0.047
2.059AspAsn: 2.059 ± 0.05
1.675AspPro: 1.675 ± 0.047
1.469AspGln: 1.469 ± 0.048
2.286AspArg: 2.286 ± 0.061
2.889AspSer: 2.889 ± 0.069
3.117AspThr: 3.117 ± 0.071
4.235AspVal: 4.235 ± 0.08
0.505AspTrp: 0.505 ± 0.028
2.7AspTyr: 2.7 ± 0.068
0.001AspXaa: 0.001 ± 0.001
Glu
5.574GluAla: 5.574 ± 0.118
0.872GluCys: 0.872 ± 0.034
4.485GluAsp: 4.485 ± 0.088
8.071GluGlu: 8.071 ± 0.163
2.374GluPhe: 2.374 ± 0.058
4.381GluGly: 4.381 ± 0.087
1.594GluHis: 1.594 ± 0.062
5.71GluIle: 5.71 ± 0.114
7.588GluLys: 7.588 ± 0.13
6.789GluLeu: 6.789 ± 0.119
2.587GluMet: 2.587 ± 0.073
3.984GluAsn: 3.984 ± 0.082
1.936GluPro: 1.936 ± 0.058
2.974GluGln: 2.974 ± 0.076
3.38GluArg: 3.38 ± 0.071
3.123GluSer: 3.123 ± 0.072
3.897GluThr: 3.897 ± 0.072
5.182GluVal: 5.182 ± 0.108
0.583GluTrp: 0.583 ± 0.028
3.138GluTyr: 3.138 ± 0.072
0.0GluXaa: 0.0 ± 0.0
Phe
2.999PheAla: 2.999 ± 0.066
0.65PheCys: 0.65 ± 0.031
2.332PheAsp: 2.332 ± 0.065
2.583PheGlu: 2.583 ± 0.064
1.657PhePhe: 1.657 ± 0.057
3.019PheGly: 3.019 ± 0.078
0.847PheHis: 0.847 ± 0.038
2.603PheIle: 2.603 ± 0.071
2.177PheLys: 2.177 ± 0.063
3.611PheLeu: 3.611 ± 0.088
1.127PheMet: 1.127 ± 0.041
1.223PheAsn: 1.223 ± 0.044
1.352PhePro: 1.352 ± 0.044
1.121PheGln: 1.121 ± 0.038
1.6PheArg: 1.6 ± 0.05
2.443PheSer: 2.443 ± 0.078
2.202PheThr: 2.202 ± 0.062
2.751PheVal: 2.751 ± 0.078
0.339PheTrp: 0.339 ± 0.024
1.575PheTyr: 1.575 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.214GlyAla: 5.214 ± 0.119
1.242GlyCys: 1.242 ± 0.053
3.434GlyAsp: 3.434 ± 0.069
4.898GlyGlu: 4.898 ± 0.09
2.907GlyPhe: 2.907 ± 0.068
4.828GlyGly: 4.828 ± 0.106
1.381GlyHis: 1.381 ± 0.048
6.274GlyIle: 6.274 ± 0.108
6.462GlyLys: 6.462 ± 0.098
5.679GlyLeu: 5.679 ± 0.103
2.64GlyMet: 2.64 ± 0.064
3.065GlyAsn: 3.065 ± 0.064
1.353GlyPro: 1.353 ± 0.047
2.085GlyGln: 2.085 ± 0.06
3.046GlyArg: 3.046 ± 0.072
3.736GlySer: 3.736 ± 0.083
4.58GlyThr: 4.58 ± 0.084
5.158GlyVal: 5.158 ± 0.095
0.641GlyTrp: 0.641 ± 0.034
3.292GlyTyr: 3.292 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.301HisAla: 1.301 ± 0.044
0.331HisCys: 0.331 ± 0.02
0.959HisAsp: 0.959 ± 0.048
1.13HisGlu: 1.13 ± 0.053
0.777HisPhe: 0.777 ± 0.029
1.405HisGly: 1.405 ± 0.042
0.454HisHis: 0.454 ± 0.054
1.418HisIle: 1.418 ± 0.053
1.089HisLys: 1.089 ± 0.048
1.663HisLeu: 1.663 ± 0.051
0.647HisMet: 0.647 ± 0.027
0.718HisAsn: 0.718 ± 0.028
0.934HisPro: 0.934 ± 0.037
0.505HisGln: 0.505 ± 0.028
0.758HisArg: 0.758 ± 0.038
0.971HisSer: 0.971 ± 0.037
1.072HisThr: 1.072 ± 0.039
1.279HisVal: 1.279 ± 0.041
0.145HisTrp: 0.145 ± 0.013
0.771HisTyr: 0.771 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.729IleAla: 5.729 ± 0.106
1.437IleCys: 1.437 ± 0.049
4.037IleAsp: 4.037 ± 0.081
4.91IleGlu: 4.91 ± 0.102
2.946IlePhe: 2.946 ± 0.079
5.456IleGly: 5.456 ± 0.098
1.442IleHis: 1.442 ± 0.052
4.993IleIle: 4.993 ± 0.096
4.292IleLys: 4.292 ± 0.083
6.859IleLeu: 6.859 ± 0.126
1.987IleMet: 1.987 ± 0.057
2.574IleAsn: 2.574 ± 0.073
3.142IlePro: 3.142 ± 0.076
2.342IleGln: 2.342 ± 0.055
3.689IleArg: 3.689 ± 0.079
4.507IleSer: 4.507 ± 0.088
4.161IleThr: 4.161 ± 0.086
5.262IleVal: 5.262 ± 0.093
0.597IleTrp: 0.597 ± 0.033
2.886IleTyr: 2.886 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
5.871LysAla: 5.871 ± 0.116
0.769LysCys: 0.769 ± 0.037
4.465LysAsp: 4.465 ± 0.08
8.094LysGlu: 8.094 ± 0.127
1.965LysPhe: 1.965 ± 0.055
4.752LysGly: 4.752 ± 0.088
1.077LysHis: 1.077 ± 0.04
5.687LysIle: 5.687 ± 0.094
8.22LysLys: 8.22 ± 0.158
5.976LysLeu: 5.976 ± 0.085
2.697LysMet: 2.697 ± 0.06
4.06LysAsn: 4.06 ± 0.08
2.114LysPro: 2.114 ± 0.063
2.476LysGln: 2.476 ± 0.062
3.322LysArg: 3.322 ± 0.077
3.657LysSer: 3.657 ± 0.087
4.325LysThr: 4.325 ± 0.095
5.233LysVal: 5.233 ± 0.105
0.686LysTrp: 0.686 ± 0.035
3.3LysTyr: 3.3 ± 0.071
0.001LysXaa: 0.001 ± 0.001
Leu
6.725LeuAla: 6.725 ± 0.1
1.333LeuCys: 1.333 ± 0.053
4.983LeuAsp: 4.983 ± 0.107
6.385LeuGlu: 6.385 ± 0.117
3.462LeuPhe: 3.462 ± 0.083
5.898LeuGly: 5.898 ± 0.1
1.607LeuHis: 1.607 ± 0.051
5.604LeuIle: 5.604 ± 0.105
6.901LeuLys: 6.901 ± 0.113
8.005LeuLeu: 8.005 ± 0.153
2.469LeuMet: 2.469 ± 0.058
3.384LeuAsn: 3.384 ± 0.068
3.405LeuPro: 3.405 ± 0.078
2.672LeuGln: 2.672 ± 0.079
3.489LeuArg: 3.489 ± 0.067
5.46LeuSer: 5.46 ± 0.118
5.113LeuThr: 5.113 ± 0.089
5.46LeuVal: 5.46 ± 0.093
0.667LeuTrp: 0.667 ± 0.035
3.282LeuTyr: 3.282 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
2.371MetAla: 2.371 ± 0.061
0.394MetCys: 0.394 ± 0.022
1.936MetAsp: 1.936 ± 0.057
2.593MetGlu: 2.593 ± 0.061
0.991MetPhe: 0.991 ± 0.039
2.095MetGly: 2.095 ± 0.059
0.603MetHis: 0.603 ± 0.026
2.254MetIle: 2.254 ± 0.057
2.878MetLys: 2.878 ± 0.06
2.835MetLeu: 2.835 ± 0.068
1.085MetMet: 1.085 ± 0.044
1.631MetAsn: 1.631 ± 0.047
1.105MetPro: 1.105 ± 0.041
1.18MetGln: 1.18 ± 0.049
1.329MetArg: 1.329 ± 0.05
1.797MetSer: 1.797 ± 0.047
1.86MetThr: 1.86 ± 0.056
1.92MetVal: 1.92 ± 0.049
0.232MetTrp: 0.232 ± 0.019
0.949MetTyr: 0.949 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.069AsnAla: 3.069 ± 0.065
0.629AsnCys: 0.629 ± 0.032
2.098AsnAsp: 2.098 ± 0.065
2.651AsnGlu: 2.651 ± 0.066
1.424AsnPhe: 1.424 ± 0.045
3.275AsnGly: 3.275 ± 0.07
0.851AsnHis: 0.851 ± 0.035
3.2AsnIle: 3.2 ± 0.073
2.863AsnLys: 2.863 ± 0.077
3.533AsnLeu: 3.533 ± 0.066
1.394AsnMet: 1.394 ± 0.048
1.701AsnAsn: 1.701 ± 0.055
1.875AsnPro: 1.875 ± 0.052
1.33AsnGln: 1.33 ± 0.044
1.927AsnArg: 1.927 ± 0.06
2.081AsnSer: 2.081 ± 0.064
2.222AsnThr: 2.222 ± 0.064
2.908AsnVal: 2.908 ± 0.063
0.368AsnTrp: 0.368 ± 0.023
1.856AsnTyr: 1.856 ± 0.061
0.0AsnXaa: 0.0 ± 0.0
Pro
2.339ProAla: 2.339 ± 0.073
0.486ProCys: 0.486 ± 0.029
2.245ProAsp: 2.245 ± 0.055
3.469ProGlu: 3.469 ± 0.076
1.348ProPhe: 1.348 ± 0.048
2.402ProGly: 2.402 ± 0.066
0.59ProHis: 0.59 ± 0.034
2.021ProIle: 2.021 ± 0.063
2.143ProLys: 2.143 ± 0.058
2.529ProLeu: 2.529 ± 0.069
0.857ProMet: 0.857 ± 0.032
1.137ProAsn: 1.137 ± 0.045
0.578ProPro: 0.578 ± 0.03
0.835ProGln: 0.835 ± 0.033
0.879ProArg: 0.879 ± 0.037
1.713ProSer: 1.713 ± 0.049
1.517ProThr: 1.517 ± 0.059
3.024ProVal: 3.024 ± 0.059
0.267ProTrp: 0.267 ± 0.021
1.435ProTyr: 1.435 ± 0.054
0.0ProXaa: 0.0 ± 0.0
Gln
2.359GlnAla: 2.359 ± 0.058
0.35GlnCys: 0.35 ± 0.023
1.459GlnAsp: 1.459 ± 0.046
2.6GlnGlu: 2.6 ± 0.07
1.126GlnPhe: 1.126 ± 0.038
1.781GlnGly: 1.781 ± 0.047
0.472GlnHis: 0.472 ± 0.025
2.672GlnIle: 2.672 ± 0.061
2.975GlnLys: 2.975 ± 0.079
2.552GlnLeu: 2.552 ± 0.062
1.323GlnMet: 1.323 ± 0.048
1.44GlnAsn: 1.44 ± 0.038
0.772GlnPro: 0.772 ± 0.033
0.975GlnGln: 0.975 ± 0.041
1.181GlnArg: 1.181 ± 0.042
1.556GlnSer: 1.556 ± 0.047
1.699GlnThr: 1.699 ± 0.05
2.194GlnVal: 2.194 ± 0.065
0.261GlnTrp: 0.261 ± 0.022
1.276GlnTyr: 1.276 ± 0.043
0.001GlnXaa: 0.001 ± 0.002
Arg
2.675ArgAla: 2.675 ± 0.062
0.495ArgCys: 0.495 ± 0.028
1.958ArgAsp: 1.958 ± 0.056
3.662ArgGlu: 3.662 ± 0.092
1.727ArgPhe: 1.727 ± 0.045
2.498ArgGly: 2.498 ± 0.067
0.783ArgHis: 0.783 ± 0.037
3.428ArgIle: 3.428 ± 0.074
3.757ArgLys: 3.757 ± 0.088
3.596ArgLeu: 3.596 ± 0.076
1.574ArgMet: 1.574 ± 0.051
1.834ArgAsn: 1.834 ± 0.052
1.202ArgPro: 1.202 ± 0.042
1.606ArgGln: 1.606 ± 0.053
2.187ArgArg: 2.187 ± 0.068
2.118ArgSer: 2.118 ± 0.06
2.305ArgThr: 2.305 ± 0.063
2.666ArgVal: 2.666 ± 0.067
0.298ArgTrp: 0.298 ± 0.021
1.764ArgTyr: 1.764 ± 0.056
0.0ArgXaa: 0.0 ± 0.0
Ser
3.942SerAla: 3.942 ± 0.079
0.746SerCys: 0.746 ± 0.032
3.095SerAsp: 3.095 ± 0.076
3.611SerGlu: 3.611 ± 0.077
2.291SerPhe: 2.291 ± 0.062
4.846SerGly: 4.846 ± 0.095
0.93SerHis: 0.93 ± 0.035
3.669SerIle: 3.669 ± 0.086
3.824SerLys: 3.824 ± 0.081
4.504SerLeu: 4.504 ± 0.091
1.793SerMet: 1.793 ± 0.053
2.034SerAsn: 2.034 ± 0.06
1.568SerPro: 1.568 ± 0.048
1.653SerGln: 1.653 ± 0.05
2.412SerArg: 2.412 ± 0.056
3.136SerSer: 3.136 ± 0.078
2.656SerThr: 2.656 ± 0.082
4.354SerVal: 4.354 ± 0.097
0.52SerTrp: 0.52 ± 0.031
2.378SerTyr: 2.378 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.352ThrAla: 4.352 ± 0.082
0.749ThrCys: 0.749 ± 0.029
3.412ThrAsp: 3.412 ± 0.081
3.967ThrGlu: 3.967 ± 0.07
2.178ThrPhe: 2.178 ± 0.054
4.916ThrGly: 4.916 ± 0.097
0.896ThrHis: 0.896 ± 0.033
4.04ThrIle: 4.04 ± 0.084
3.73ThrLys: 3.73 ± 0.078
4.831ThrLeu: 4.831 ± 0.081
1.488ThrMet: 1.488 ± 0.047
2.099ThrAsn: 2.099 ± 0.058
2.117ThrPro: 2.117 ± 0.059
1.391ThrGln: 1.391 ± 0.045
1.942ThrArg: 1.942 ± 0.056
3.027ThrSer: 3.027 ± 0.072
3.032ThrThr: 3.032 ± 0.076
4.443ThrVal: 4.443 ± 0.092
0.453ThrTrp: 0.453 ± 0.029
2.351ThrTyr: 2.351 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.262ValAla: 5.262 ± 0.089
1.196ValCys: 1.196 ± 0.044
3.793ValAsp: 3.793 ± 0.073
4.86ValGlu: 4.86 ± 0.094
2.904ValPhe: 2.904 ± 0.072
4.519ValGly: 4.519 ± 0.078
1.25ValHis: 1.25 ± 0.038
5.476ValIle: 5.476 ± 0.101
5.554ValLys: 5.554 ± 0.107
6.808ValLeu: 6.808 ± 0.11
2.14ValMet: 2.14 ± 0.066
2.8ValAsn: 2.8 ± 0.068
2.561ValPro: 2.561 ± 0.053
2.111ValGln: 2.111 ± 0.062
2.897ValArg: 2.897 ± 0.07
4.435ValSer: 4.435 ± 0.079
4.59ValThr: 4.59 ± 0.095
5.082ValVal: 5.082 ± 0.102
0.559ValTrp: 0.559 ± 0.031
2.758ValTyr: 2.758 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.48TrpAla: 0.48 ± 0.028
0.137TrpCys: 0.137 ± 0.013
0.47TrpAsp: 0.47 ± 0.024
0.591TrpGlu: 0.591 ± 0.031
0.372TrpPhe: 0.372 ± 0.027
0.565TrpGly: 0.565 ± 0.033
0.162TrpHis: 0.162 ± 0.016
0.651TrpIle: 0.651 ± 0.032
0.815TrpLys: 0.815 ± 0.041
0.727TrpLeu: 0.727 ± 0.033
0.366TrpMet: 0.366 ± 0.023
0.442TrpAsn: 0.442 ± 0.028
0.188TrpPro: 0.188 ± 0.018
0.305TrpGln: 0.305 ± 0.022
0.291TrpArg: 0.291 ± 0.022
0.432TrpSer: 0.432 ± 0.026
0.385TrpThr: 0.385 ± 0.027
0.42TrpVal: 0.42 ± 0.024
0.093TrpTrp: 0.093 ± 0.011
0.333TrpTyr: 0.333 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.875TyrAla: 2.875 ± 0.069
0.587TyrCys: 0.587 ± 0.031
2.627TyrAsp: 2.627 ± 0.063
3.234TyrGlu: 3.234 ± 0.078
1.67TyrPhe: 1.67 ± 0.053
3.047TyrGly: 3.047 ± 0.07
0.885TyrHis: 0.885 ± 0.038
2.854TyrIle: 2.854 ± 0.065
2.704TyrLys: 2.704 ± 0.073
3.71TyrLeu: 3.71 ± 0.079
1.145TyrMet: 1.145 ± 0.042
1.809TyrAsn: 1.809 ± 0.058
1.364TyrPro: 1.364 ± 0.041
1.425TyrGln: 1.425 ± 0.043
2.021TyrArg: 2.021 ± 0.053
2.241TyrSer: 2.241 ± 0.063
2.37TyrThr: 2.37 ± 0.057
2.726TyrVal: 2.726 ± 0.069
0.33TyrTrp: 0.33 ± 0.022
1.989TyrTyr: 1.989 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.002
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.002
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.004XaaSer: 0.004 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.007XaaXaa: 0.007 ± 0.005
Statistics based on 2158 proteins (684930 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski