Amino acid dipepetide frequency for Burkholderia sp. ST111

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.494AlaAla: 16.494 ± 0.155
1.244AlaCys: 1.244 ± 0.027
6.328AlaAsp: 6.328 ± 0.059
6.098AlaGlu: 6.098 ± 0.066
4.373AlaPhe: 4.373 ± 0.059
9.828AlaGly: 9.828 ± 0.088
2.782AlaHis: 2.782 ± 0.043
5.863AlaIle: 5.863 ± 0.06
3.832AlaLys: 3.832 ± 0.062
13.601AlaLeu: 13.601 ± 0.105
3.223AlaMet: 3.223 ± 0.047
3.387AlaAsn: 3.387 ± 0.053
5.462AlaPro: 5.462 ± 0.065
5.139AlaGln: 5.139 ± 0.072
8.139AlaArg: 8.139 ± 0.087
7.328AlaSer: 7.328 ± 0.074
6.459AlaThr: 6.459 ± 0.074
8.824AlaVal: 8.824 ± 0.083
1.652AlaTrp: 1.652 ± 0.036
2.706AlaTyr: 2.706 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
1.173CysAla: 1.173 ± 0.028
0.136CysCys: 0.136 ± 0.009
0.521CysAsp: 0.521 ± 0.018
0.495CysGlu: 0.495 ± 0.018
0.339CysPhe: 0.339 ± 0.015
1.003CysGly: 1.003 ± 0.027
0.243CysHis: 0.243 ± 0.012
0.433CysIle: 0.433 ± 0.016
0.242CysLys: 0.242 ± 0.012
0.836CysLeu: 0.836 ± 0.023
0.215CysMet: 0.215 ± 0.011
0.254CysAsn: 0.254 ± 0.013
0.443CysPro: 0.443 ± 0.016
0.234CysGln: 0.234 ± 0.012
0.611CysArg: 0.611 ± 0.022
0.557CysSer: 0.557 ± 0.021
0.505CysThr: 0.505 ± 0.017
0.831CysVal: 0.831 ± 0.024
0.118CysTrp: 0.118 ± 0.009
0.238CysTyr: 0.238 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.184AspAla: 7.184 ± 0.079
0.507AspCys: 0.507 ± 0.018
2.997AspAsp: 2.997 ± 0.049
3.341AspGlu: 3.341 ± 0.048
1.984AspPhe: 1.984 ± 0.033
4.353AspGly: 4.353 ± 0.05
1.2AspHis: 1.2 ± 0.032
2.625AspIle: 2.625 ± 0.041
1.647AspLys: 1.647 ± 0.035
5.088AspLeu: 5.088 ± 0.054
1.192AspMet: 1.192 ± 0.026
1.407AspAsn: 1.407 ± 0.027
2.811AspPro: 2.811 ± 0.039
1.61AspGln: 1.61 ± 0.035
3.196AspArg: 3.196 ± 0.045
2.644AspSer: 2.644 ± 0.041
2.843AspThr: 2.843 ± 0.037
4.301AspVal: 4.301 ± 0.058
0.905AspTrp: 0.905 ± 0.024
1.52AspTyr: 1.52 ± 0.031
0.0AspXaa: 0.0 ± 0.0
Glu
6.389GluAla: 6.389 ± 0.069
0.419GluCys: 0.419 ± 0.017
2.147GluAsp: 2.147 ± 0.041
2.508GluGlu: 2.508 ± 0.044
1.833GluPhe: 1.833 ± 0.033
3.371GluGly: 3.371 ± 0.049
1.474GluHis: 1.474 ± 0.034
2.871GluIle: 2.871 ± 0.048
1.814GluLys: 1.814 ± 0.04
5.53GluLeu: 5.53 ± 0.065
1.242GluMet: 1.242 ± 0.029
1.423GluAsn: 1.423 ± 0.03
2.51GluPro: 2.51 ± 0.042
2.46GluGln: 2.46 ± 0.041
4.687GluArg: 4.687 ± 0.06
2.751GluSer: 2.751 ± 0.04
2.917GluThr: 2.917 ± 0.046
3.669GluVal: 3.669 ± 0.058
0.738GluTrp: 0.738 ± 0.021
1.182GluTyr: 1.182 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
4.597PheAla: 4.597 ± 0.055
0.424PheCys: 0.424 ± 0.015
2.731PheAsp: 2.731 ± 0.046
2.064PheGlu: 2.064 ± 0.035
1.503PhePhe: 1.503 ± 0.036
3.806PheGly: 3.806 ± 0.048
0.775PheHis: 0.775 ± 0.025
1.726PheIle: 1.726 ± 0.036
1.135PheLys: 1.135 ± 0.028
3.086PheLeu: 3.086 ± 0.047
0.86PheMet: 0.86 ± 0.025
1.243PheAsn: 1.243 ± 0.031
1.653PhePro: 1.653 ± 0.035
1.024PheGln: 1.024 ± 0.023
1.995PheArg: 1.995 ± 0.033
2.382PheSer: 2.382 ± 0.044
2.015PheThr: 2.015 ± 0.032
3.313PheVal: 3.313 ± 0.047
0.527PheTrp: 0.527 ± 0.019
1.041PheTyr: 1.041 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.894GlyAla: 8.894 ± 0.086
0.876GlyCys: 0.876 ± 0.025
3.803GlyAsp: 3.803 ± 0.054
4.19GlyGlu: 4.19 ± 0.053
3.482GlyPhe: 3.482 ± 0.049
6.584GlyGly: 6.584 ± 0.082
1.957GlyHis: 1.957 ± 0.037
4.389GlyIle: 4.389 ± 0.058
3.247GlyLys: 3.247 ± 0.049
8.025GlyLeu: 8.025 ± 0.074
2.237GlyMet: 2.237 ± 0.036
2.386GlyAsn: 2.386 ± 0.038
2.843GlyPro: 2.843 ± 0.044
2.742GlyGln: 2.742 ± 0.041
4.858GlyArg: 4.858 ± 0.054
4.727GlySer: 4.727 ± 0.059
4.63GlyThr: 4.63 ± 0.061
6.667GlyVal: 6.667 ± 0.073
1.354GlyTrp: 1.354 ± 0.032
2.471GlyTyr: 2.471 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
3.028HisAla: 3.028 ± 0.049
0.264HisCys: 0.264 ± 0.014
1.331HisAsp: 1.331 ± 0.032
1.27HisGlu: 1.27 ± 0.028
1.001HisPhe: 1.001 ± 0.028
2.199HisGly: 2.199 ± 0.041
0.647HisHis: 0.647 ± 0.02
0.988HisIle: 0.988 ± 0.027
0.576HisLys: 0.576 ± 0.018
2.248HisLeu: 2.248 ± 0.041
0.534HisMet: 0.534 ± 0.019
0.534HisAsn: 0.534 ± 0.02
1.452HisPro: 1.452 ± 0.031
0.703HisGln: 0.703 ± 0.018
1.565HisArg: 1.565 ± 0.033
1.128HisSer: 1.128 ± 0.025
1.13HisThr: 1.13 ± 0.025
1.789HisVal: 1.789 ± 0.035
0.389HisTrp: 0.389 ± 0.017
0.664HisTyr: 0.664 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
7.143IleAla: 7.143 ± 0.078
0.467IleCys: 0.467 ± 0.017
3.491IleAsp: 3.491 ± 0.047
3.393IleGlu: 3.393 ± 0.047
1.571IlePhe: 1.571 ± 0.036
4.908IleGly: 4.908 ± 0.063
0.941IleHis: 0.941 ± 0.027
1.755IleIle: 1.755 ± 0.035
1.525IleLys: 1.525 ± 0.035
3.577IleLeu: 3.577 ± 0.051
0.836IleMet: 0.836 ± 0.024
1.539IleAsn: 1.539 ± 0.033
2.177IlePro: 2.177 ± 0.041
1.351IleGln: 1.351 ± 0.028
2.931IleArg: 2.931 ± 0.042
2.74IleSer: 2.74 ± 0.042
2.545IleThr: 2.545 ± 0.042
4.49IleVal: 4.49 ± 0.056
0.532IleTrp: 0.532 ± 0.018
1.083IleTyr: 1.083 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.706LysAla: 3.706 ± 0.054
0.166LysCys: 0.166 ± 0.009
1.545LysAsp: 1.545 ± 0.033
1.467LysGlu: 1.467 ± 0.035
0.978LysPhe: 0.978 ± 0.026
2.23LysGly: 2.23 ± 0.04
0.752LysHis: 0.752 ± 0.022
1.7LysIle: 1.7 ± 0.035
1.344LysLys: 1.344 ± 0.034
3.528LysLeu: 3.528 ± 0.049
0.851LysMet: 0.851 ± 0.023
0.946LysAsn: 0.946 ± 0.025
1.998LysPro: 1.998 ± 0.04
1.398LysGln: 1.398 ± 0.034
2.49LysArg: 2.49 ± 0.036
1.863LysSer: 1.863 ± 0.035
1.985LysThr: 1.985 ± 0.035
2.462LysVal: 2.462 ± 0.044
0.415LysTrp: 0.415 ± 0.017
0.767LysTyr: 0.767 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.271LeuAla: 13.271 ± 0.111
1.021LeuCys: 1.021 ± 0.026
5.815LeuAsp: 5.815 ± 0.061
5.108LeuGlu: 5.108 ± 0.065
3.728LeuPhe: 3.728 ± 0.047
7.949LeuGly: 7.949 ± 0.071
2.259LeuHis: 2.259 ± 0.041
5.006LeuIle: 5.006 ± 0.065
3.543LeuLys: 3.543 ± 0.049
10.122LeuLeu: 10.122 ± 0.09
2.309LeuMet: 2.309 ± 0.041
2.878LeuAsn: 2.878 ± 0.04
5.64LeuPro: 5.64 ± 0.066
3.423LeuGln: 3.423 ± 0.049
6.919LeuArg: 6.919 ± 0.065
6.543LeuSer: 6.543 ± 0.059
5.83LeuThr: 5.83 ± 0.062
7.456LeuVal: 7.456 ± 0.076
1.143LeuTrp: 1.143 ± 0.028
2.27LeuTyr: 2.27 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.511MetAla: 2.511 ± 0.042
0.165MetCys: 0.165 ± 0.01
1.008MetAsp: 1.008 ± 0.024
0.936MetGlu: 0.936 ± 0.024
0.82MetPhe: 0.82 ± 0.023
1.54MetGly: 1.54 ± 0.034
0.541MetHis: 0.541 ± 0.019
1.191MetIle: 1.191 ± 0.033
1.103MetLys: 1.103 ± 0.023
2.692MetLeu: 2.692 ± 0.045
0.577MetMet: 0.577 ± 0.02
0.99MetAsn: 0.99 ± 0.026
1.416MetPro: 1.416 ± 0.03
1.037MetGln: 1.037 ± 0.029
1.8MetArg: 1.8 ± 0.037
1.825MetSer: 1.825 ± 0.034
1.681MetThr: 1.681 ± 0.034
1.563MetVal: 1.563 ± 0.033
0.242MetTrp: 0.242 ± 0.012
0.434MetTyr: 0.434 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.665AsnAla: 3.665 ± 0.046
0.255AsnCys: 0.255 ± 0.014
1.536AsnAsp: 1.536 ± 0.028
1.385AsnGlu: 1.385 ± 0.029
1.06AsnPhe: 1.06 ± 0.025
2.711AsnGly: 2.711 ± 0.045
0.559AsnHis: 0.559 ± 0.018
1.313AsnIle: 1.313 ± 0.03
0.756AsnLys: 0.756 ± 0.023
2.829AsnLeu: 2.829 ± 0.04
0.597AsnMet: 0.597 ± 0.017
0.905AsnAsn: 0.905 ± 0.025
1.864AsnPro: 1.864 ± 0.031
0.96AsnGln: 0.96 ± 0.024
1.824AsnArg: 1.824 ± 0.032
1.489AsnSer: 1.489 ± 0.034
1.558AsnThr: 1.558 ± 0.035
2.369AsnVal: 2.369 ± 0.035
0.466AsnTrp: 0.466 ± 0.019
0.799AsnTyr: 0.799 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
6.132ProAla: 6.132 ± 0.07
0.368ProCys: 0.368 ± 0.014
3.126ProAsp: 3.126 ± 0.041
2.986ProGlu: 2.986 ± 0.048
1.956ProPhe: 1.956 ± 0.034
3.942ProGly: 3.942 ± 0.066
1.261ProHis: 1.261 ± 0.029
2.093ProIle: 2.093 ± 0.039
1.476ProLys: 1.476 ± 0.028
5.131ProLeu: 5.131 ± 0.065
1.113ProMet: 1.113 ± 0.025
1.495ProAsn: 1.495 ± 0.033
2.272ProPro: 2.272 ± 0.042
1.913ProGln: 1.913 ± 0.035
2.718ProArg: 2.718 ± 0.037
2.897ProSer: 2.897 ± 0.046
2.616ProThr: 2.616 ± 0.039
4.191ProVal: 4.191 ± 0.056
0.636ProTrp: 0.636 ± 0.02
1.244ProTyr: 1.244 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.376GlnAla: 4.376 ± 0.058
0.29GlnCys: 0.29 ± 0.014
1.376GlnAsp: 1.376 ± 0.03
1.367GlnGlu: 1.367 ± 0.032
1.35GlnPhe: 1.35 ± 0.029
2.488GlnGly: 2.488 ± 0.033
1.007GlnHis: 1.007 ± 0.022
2.079GlnIle: 2.079 ± 0.033
1.195GlnLys: 1.195 ± 0.029
3.814GlnLeu: 3.814 ± 0.052
1.038GlnMet: 1.038 ± 0.026
1.034GlnAsn: 1.034 ± 0.026
2.01GlnPro: 2.01 ± 0.035
1.963GlnGln: 1.963 ± 0.042
2.901GlnArg: 2.901 ± 0.046
2.149GlnSer: 2.149 ± 0.032
2.102GlnThr: 2.102 ± 0.038
2.547GlnVal: 2.547 ± 0.041
0.591GlnTrp: 0.591 ± 0.02
0.957GlnTyr: 0.957 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
7.654ArgAla: 7.654 ± 0.077
0.621ArgCys: 0.621 ± 0.02
3.739ArgAsp: 3.739 ± 0.051
4.111ArgGlu: 4.111 ± 0.057
2.862ArgPhe: 2.862 ± 0.042
4.407ArgGly: 4.407 ± 0.053
1.803ArgHis: 1.803 ± 0.032
3.66ArgIle: 3.66 ± 0.049
2.124ArgLys: 2.124 ± 0.034
7.021ArgLeu: 7.021 ± 0.073
1.784ArgMet: 1.784 ± 0.032
1.913ArgAsn: 1.913 ± 0.034
2.838ArgPro: 2.838 ± 0.044
2.446ArgGln: 2.446 ± 0.043
4.991ArgArg: 4.991 ± 0.061
3.684ArgSer: 3.684 ± 0.057
3.378ArgThr: 3.378 ± 0.045
5.073ArgVal: 5.073 ± 0.062
0.984ArgTrp: 0.984 ± 0.027
1.991ArgTyr: 1.991 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
7.089SerAla: 7.089 ± 0.076
0.47SerCys: 0.47 ± 0.018
2.895SerAsp: 2.895 ± 0.045
2.761SerGlu: 2.761 ± 0.042
2.323SerPhe: 2.323 ± 0.039
5.448SerGly: 5.448 ± 0.059
1.346SerHis: 1.346 ± 0.034
3.021SerIle: 3.021 ± 0.046
1.853SerLys: 1.853 ± 0.033
5.895SerLeu: 5.895 ± 0.059
1.48SerMet: 1.48 ± 0.03
1.763SerAsn: 1.763 ± 0.041
2.889SerPro: 2.889 ± 0.043
1.949SerGln: 1.949 ± 0.034
3.711SerArg: 3.711 ± 0.05
3.668SerSer: 3.668 ± 0.062
3.439SerThr: 3.439 ± 0.049
4.544SerVal: 4.544 ± 0.052
0.733SerTrp: 0.733 ± 0.021
1.457SerTyr: 1.457 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
6.132ThrAla: 6.132 ± 0.071
0.467ThrCys: 0.467 ± 0.018
2.745ThrAsp: 2.745 ± 0.039
2.485ThrGlu: 2.485 ± 0.041
2.061ThrPhe: 2.061 ± 0.038
4.78ThrGly: 4.78 ± 0.051
1.351ThrHis: 1.351 ± 0.029
2.683ThrIle: 2.683 ± 0.043
1.425ThrLys: 1.425 ± 0.032
6.583ThrLeu: 6.583 ± 0.066
1.187ThrMet: 1.187 ± 0.027
1.425ThrAsn: 1.425 ± 0.034
3.529ThrPro: 3.529 ± 0.051
2.104ThrGln: 2.104 ± 0.038
3.597ThrArg: 3.597 ± 0.044
3.247ThrSer: 3.247 ± 0.048
3.05ThrThr: 3.05 ± 0.059
4.458ThrVal: 4.458 ± 0.052
0.761ThrTrp: 0.761 ± 0.021
1.34ThrTyr: 1.34 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.3ValAla: 9.3 ± 0.08
0.853ValCys: 0.853 ± 0.023
4.235ValAsp: 4.235 ± 0.05
4.233ValGlu: 4.233 ± 0.051
3.017ValPhe: 3.017 ± 0.041
5.688ValGly: 5.688 ± 0.07
1.591ValHis: 1.591 ± 0.029
3.936ValIle: 3.936 ± 0.057
2.62ValLys: 2.62 ± 0.045
8.062ValLeu: 8.062 ± 0.085
1.944ValMet: 1.944 ± 0.037
2.228ValAsn: 2.228 ± 0.038
3.837ValPro: 3.837 ± 0.046
2.562ValGln: 2.562 ± 0.038
5.107ValArg: 5.107 ± 0.059
4.905ValSer: 4.905 ± 0.055
4.673ValThr: 4.673 ± 0.057
6.429ValVal: 6.429 ± 0.074
0.957ValTrp: 0.957 ± 0.027
1.728ValTyr: 1.728 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.159TrpAla: 1.159 ± 0.027
0.142TrpCys: 0.142 ± 0.009
0.584TrpAsp: 0.584 ± 0.018
0.506TrpGlu: 0.506 ± 0.015
0.591TrpPhe: 0.591 ± 0.019
0.889TrpGly: 0.889 ± 0.022
0.419TrpHis: 0.419 ± 0.016
0.731TrpIle: 0.731 ± 0.022
0.454TrpLys: 0.454 ± 0.017
1.951TrpLeu: 1.951 ± 0.037
0.373TrpMet: 0.373 ± 0.014
0.478TrpAsn: 0.478 ± 0.018
0.615TrpPro: 0.615 ± 0.022
0.676TrpGln: 0.676 ± 0.021
1.152TrpArg: 1.152 ± 0.029
0.823TrpSer: 0.823 ± 0.023
0.731TrpThr: 0.731 ± 0.023
0.949TrpVal: 0.949 ± 0.026
0.232TrpTrp: 0.232 ± 0.012
0.328TrpTyr: 0.328 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.864TyrAla: 2.864 ± 0.04
0.274TyrCys: 0.274 ± 0.014
1.402TyrAsp: 1.402 ± 0.031
1.23TyrGlu: 1.23 ± 0.034
1.068TyrPhe: 1.068 ± 0.027
2.24TyrGly: 2.24 ± 0.034
0.532TyrHis: 0.532 ± 0.019
0.933TyrIle: 0.933 ± 0.025
0.677TyrLys: 0.677 ± 0.023
2.613TyrLeu: 2.613 ± 0.04
0.479TyrMet: 0.479 ± 0.017
0.671TyrAsn: 0.671 ± 0.021
1.307TyrPro: 1.307 ± 0.025
0.94TyrGln: 0.94 ± 0.023
1.895TyrArg: 1.895 ± 0.038
1.385TyrSer: 1.385 ± 0.029
1.325TyrThr: 1.325 ± 0.032
1.98TyrVal: 1.98 ± 0.04
0.404TyrTrp: 0.404 ± 0.015
0.705TyrTyr: 0.705 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5742 proteins (1645715 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski