Amino acid dipepetide frequency for Freshwater phage uvFW-CGR-AMD-COM-C403

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.076AlaAla: 14.076 ± 3.051
0.254AlaCys: 0.254 ± 0.156
6.784AlaAsp: 6.784 ± 0.642
6.105AlaGlu: 6.105 ± 0.679
3.561AlaPhe: 3.561 ± 0.453
10.26AlaGly: 10.26 ± 1.928
0.763AlaHis: 0.763 ± 0.32
4.833AlaIle: 4.833 ± 0.585
9.243AlaLys: 9.243 ± 2.141
9.073AlaLeu: 9.073 ± 1.026
2.713AlaMet: 2.713 ± 0.432
4.155AlaAsn: 4.155 ± 0.703
3.053AlaPro: 3.053 ± 0.751
3.985AlaGln: 3.985 ± 0.6
5.342AlaArg: 5.342 ± 0.726
9.243AlaSer: 9.243 ± 2.287
9.497AlaThr: 9.497 ± 2.159
6.784AlaVal: 6.784 ± 0.767
1.781AlaTrp: 1.781 ± 0.338
3.561AlaTyr: 3.561 ± 0.512
0.0AlaXaa: 0.0 ± 0.0
Cys
0.509CysAla: 0.509 ± 0.234
0.085CysCys: 0.085 ± 0.088
0.085CysAsp: 0.085 ± 0.089
0.509CysGlu: 0.509 ± 0.197
0.0CysPhe: 0.0 ± 0.0
0.424CysGly: 0.424 ± 0.205
0.17CysHis: 0.17 ± 0.123
0.424CysIle: 0.424 ± 0.227
0.424CysLys: 0.424 ± 0.199
0.254CysLeu: 0.254 ± 0.178
0.0CysMet: 0.0 ± 0.0
0.339CysAsn: 0.339 ± 0.22
0.509CysPro: 0.509 ± 0.216
0.0CysGln: 0.0 ± 0.0
0.339CysArg: 0.339 ± 0.219
0.339CysSer: 0.339 ± 0.174
0.254CysThr: 0.254 ± 0.143
0.424CysVal: 0.424 ± 0.223
0.085CysTrp: 0.085 ± 0.085
0.424CysTyr: 0.424 ± 0.219
0.0CysXaa: 0.0 ± 0.0
Asp
5.427AspAla: 5.427 ± 0.648
0.254AspCys: 0.254 ± 0.129
3.477AspAsp: 3.477 ± 0.607
3.731AspGlu: 3.731 ± 0.44
2.035AspPhe: 2.035 ± 0.444
4.833AspGly: 4.833 ± 0.647
0.848AspHis: 0.848 ± 0.237
2.459AspIle: 2.459 ± 0.51
3.561AspLys: 3.561 ± 0.627
5.257AspLeu: 5.257 ± 0.885
1.018AspMet: 1.018 ± 0.276
2.713AspAsn: 2.713 ± 0.525
3.561AspPro: 3.561 ± 0.607
1.526AspGln: 1.526 ± 0.292
2.459AspArg: 2.459 ± 0.486
4.325AspSer: 4.325 ± 0.553
3.392AspThr: 3.392 ± 0.643
5.088AspVal: 5.088 ± 0.658
0.848AspTrp: 0.848 ± 0.29
2.205AspTyr: 2.205 ± 0.431
0.0AspXaa: 0.0 ± 0.0
Glu
5.681GluAla: 5.681 ± 0.667
0.254GluCys: 0.254 ± 0.174
3.731GluAsp: 3.731 ± 0.561
4.325GluGlu: 4.325 ± 0.674
2.629GluPhe: 2.629 ± 0.563
2.374GluGly: 2.374 ± 0.519
0.339GluHis: 0.339 ± 0.116
3.731GluIle: 3.731 ± 0.563
3.816GluLys: 3.816 ± 0.753
4.664GluLeu: 4.664 ± 0.854
1.102GluMet: 1.102 ± 0.278
2.883GluAsn: 2.883 ± 0.573
1.866GluPro: 1.866 ± 0.406
2.289GluGln: 2.289 ± 0.542
3.137GluArg: 3.137 ± 0.608
3.731GluSer: 3.731 ± 0.559
2.629GluThr: 2.629 ± 0.63
4.07GluVal: 4.07 ± 0.737
1.866GluTrp: 1.866 ± 0.459
3.477GluTyr: 3.477 ± 0.599
0.0GluXaa: 0.0 ± 0.0
Phe
3.731PheAla: 3.731 ± 0.624
0.254PheCys: 0.254 ± 0.136
2.374PheAsp: 2.374 ± 0.43
1.018PheGlu: 1.018 ± 0.257
0.594PhePhe: 0.594 ± 0.296
2.629PheGly: 2.629 ± 0.484
0.339PheHis: 0.339 ± 0.171
1.272PheIle: 1.272 ± 0.274
1.442PheLys: 1.442 ± 0.304
1.781PheLeu: 1.781 ± 0.568
0.678PheMet: 0.678 ± 0.251
1.526PheAsn: 1.526 ± 0.38
1.781PhePro: 1.781 ± 0.486
1.018PheGln: 1.018 ± 0.34
2.12PheArg: 2.12 ± 0.409
1.95PheSer: 1.95 ± 0.509
2.374PheThr: 2.374 ± 0.578
1.611PheVal: 1.611 ± 0.384
0.424PheTrp: 0.424 ± 0.183
0.594PheTyr: 0.594 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
7.886GlyAla: 7.886 ± 1.436
0.509GlyCys: 0.509 ± 0.283
4.155GlyAsp: 4.155 ± 0.513
4.325GlyGlu: 4.325 ± 0.736
2.035GlyPhe: 2.035 ± 0.442
12.38GlyGly: 12.38 ± 5.178
0.678GlyHis: 0.678 ± 0.225
4.664GlyIle: 4.664 ± 0.602
5.766GlyLys: 5.766 ± 0.865
5.512GlyLeu: 5.512 ± 0.658
1.781GlyMet: 1.781 ± 0.334
3.222GlyAsn: 3.222 ± 0.744
1.781GlyPro: 1.781 ± 0.413
2.798GlyGln: 2.798 ± 0.584
2.459GlyArg: 2.459 ± 0.482
6.699GlySer: 6.699 ± 1.521
6.105GlyThr: 6.105 ± 1.014
5.681GlyVal: 5.681 ± 0.712
1.187GlyTrp: 1.187 ± 0.318
3.053GlyTyr: 3.053 ± 0.654
0.0GlyXaa: 0.0 ± 0.0
His
0.933HisAla: 0.933 ± 0.303
0.17HisCys: 0.17 ± 0.125
0.763HisAsp: 0.763 ± 0.32
0.763HisGlu: 0.763 ± 0.235
0.254HisPhe: 0.254 ± 0.157
0.509HisGly: 0.509 ± 0.237
0.17HisHis: 0.17 ± 0.135
0.509HisIle: 0.509 ± 0.196
0.424HisLys: 0.424 ± 0.187
0.678HisLeu: 0.678 ± 0.258
0.17HisMet: 0.17 ± 0.12
0.509HisAsn: 0.509 ± 0.237
0.509HisPro: 0.509 ± 0.228
0.339HisGln: 0.339 ± 0.193
0.254HisArg: 0.254 ± 0.133
0.254HisSer: 0.254 ± 0.132
0.339HisThr: 0.339 ± 0.159
0.933HisVal: 0.933 ± 0.305
0.509HisTrp: 0.509 ± 0.222
0.678HisTyr: 0.678 ± 0.262
0.0HisXaa: 0.0 ± 0.0
Ile
6.529IleAla: 6.529 ± 0.66
0.678IleCys: 0.678 ± 0.305
3.901IleAsp: 3.901 ± 0.553
4.07IleGlu: 4.07 ± 0.558
1.102IlePhe: 1.102 ± 0.259
3.222IleGly: 3.222 ± 0.603
0.339IleHis: 0.339 ± 0.182
2.374IleIle: 2.374 ± 0.419
2.798IleLys: 2.798 ± 0.461
3.053IleLeu: 3.053 ± 0.482
1.187IleMet: 1.187 ± 0.289
2.289IleAsn: 2.289 ± 0.393
2.035IlePro: 2.035 ± 0.474
1.95IleGln: 1.95 ± 0.409
2.798IleArg: 2.798 ± 0.519
3.137IleSer: 3.137 ± 0.402
3.561IleThr: 3.561 ± 0.724
3.222IleVal: 3.222 ± 0.741
0.594IleTrp: 0.594 ± 0.249
1.357IleTyr: 1.357 ± 0.325
0.0IleXaa: 0.0 ± 0.0
Lys
8.734LysAla: 8.734 ± 1.714
0.424LysCys: 0.424 ± 0.249
2.713LysAsp: 2.713 ± 0.474
3.985LysGlu: 3.985 ± 0.596
1.272LysPhe: 1.272 ± 0.344
3.816LysGly: 3.816 ± 0.629
0.509LysHis: 0.509 ± 0.225
2.883LysIle: 2.883 ± 0.556
6.19LysLys: 6.19 ± 1.41
4.155LysLeu: 4.155 ± 0.545
2.289LysMet: 2.289 ± 0.427
3.137LysAsn: 3.137 ± 0.569
3.137LysPro: 3.137 ± 0.938
3.392LysGln: 3.392 ± 0.578
3.053LysArg: 3.053 ± 0.548
3.646LysSer: 3.646 ± 0.767
3.222LysThr: 3.222 ± 0.696
4.664LysVal: 4.664 ± 0.665
0.763LysTrp: 0.763 ± 0.301
2.459LysTyr: 2.459 ± 0.582
0.0LysXaa: 0.0 ± 0.0
Leu
7.462LeuAla: 7.462 ± 1.048
0.678LeuCys: 0.678 ± 0.283
4.494LeuAsp: 4.494 ± 0.695
4.409LeuGlu: 4.409 ± 0.579
1.272LeuPhe: 1.272 ± 0.265
5.088LeuGly: 5.088 ± 0.506
0.763LeuHis: 0.763 ± 0.327
3.731LeuIle: 3.731 ± 0.453
3.901LeuLys: 3.901 ± 0.553
4.918LeuLeu: 4.918 ± 0.66
1.781LeuMet: 1.781 ± 0.469
3.816LeuAsn: 3.816 ± 0.729
2.968LeuPro: 2.968 ± 0.47
2.798LeuGln: 2.798 ± 0.686
3.137LeuArg: 3.137 ± 0.524
5.427LeuSer: 5.427 ± 0.59
5.427LeuThr: 5.427 ± 0.749
4.664LeuVal: 4.664 ± 0.577
0.933LeuTrp: 0.933 ± 0.323
2.713LeuTyr: 2.713 ± 0.435
0.0LeuXaa: 0.0 ± 0.0
Met
3.053MetAla: 3.053 ± 0.467
0.17MetCys: 0.17 ± 0.097
0.933MetAsp: 0.933 ± 0.266
0.933MetGlu: 0.933 ± 0.279
0.848MetPhe: 0.848 ± 0.206
2.289MetGly: 2.289 ± 0.362
0.0MetHis: 0.0 ± 0.0
0.848MetIle: 0.848 ± 0.236
1.526MetLys: 1.526 ± 0.409
1.357MetLeu: 1.357 ± 0.288
0.424MetMet: 0.424 ± 0.212
1.696MetAsn: 1.696 ± 0.412
1.357MetPro: 1.357 ± 0.298
0.594MetGln: 0.594 ± 0.296
1.357MetArg: 1.357 ± 0.342
2.035MetSer: 2.035 ± 0.462
1.95MetThr: 1.95 ± 0.4
1.272MetVal: 1.272 ± 0.336
0.254MetTrp: 0.254 ± 0.158
0.594MetTyr: 0.594 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
3.561AsnAla: 3.561 ± 0.434
0.17AsnCys: 0.17 ± 0.126
2.713AsnAsp: 2.713 ± 0.526
2.798AsnGlu: 2.798 ± 0.52
1.357AsnPhe: 1.357 ± 0.316
4.494AsnGly: 4.494 ± 0.705
0.678AsnHis: 0.678 ± 0.222
2.289AsnIle: 2.289 ± 0.321
2.629AsnLys: 2.629 ± 0.511
3.816AsnLeu: 3.816 ± 0.848
0.763AsnMet: 0.763 ± 0.26
2.713AsnAsn: 2.713 ± 0.464
2.798AsnPro: 2.798 ± 0.494
2.205AsnGln: 2.205 ± 0.38
1.866AsnArg: 1.866 ± 0.464
2.544AsnSer: 2.544 ± 0.447
3.561AsnThr: 3.561 ± 0.917
2.12AsnVal: 2.12 ± 0.388
0.594AsnTrp: 0.594 ± 0.234
1.442AsnTyr: 1.442 ± 0.324
0.0AsnXaa: 0.0 ± 0.0
Pro
5.003ProAla: 5.003 ± 0.666
0.254ProCys: 0.254 ± 0.164
2.968ProAsp: 2.968 ± 0.542
2.374ProGlu: 2.374 ± 0.724
0.763ProPhe: 0.763 ± 0.244
2.968ProGly: 2.968 ± 0.452
0.678ProHis: 0.678 ± 0.245
1.272ProIle: 1.272 ± 0.292
2.968ProLys: 2.968 ± 0.622
2.713ProLeu: 2.713 ± 0.526
1.187ProMet: 1.187 ± 0.278
2.205ProAsn: 2.205 ± 0.473
1.526ProPro: 1.526 ± 0.342
1.781ProGln: 1.781 ± 0.467
1.611ProArg: 1.611 ± 0.437
3.137ProSer: 3.137 ± 0.363
3.392ProThr: 3.392 ± 0.579
2.289ProVal: 2.289 ± 0.423
0.509ProTrp: 0.509 ± 0.198
1.357ProTyr: 1.357 ± 0.312
0.0ProXaa: 0.0 ± 0.0
Gln
5.512GlnAla: 5.512 ± 0.951
0.085GlnCys: 0.085 ± 0.086
2.035GlnAsp: 2.035 ± 0.364
2.289GlnGlu: 2.289 ± 0.436
1.272GlnPhe: 1.272 ± 0.4
2.713GlnGly: 2.713 ± 0.527
0.17GlnHis: 0.17 ± 0.098
2.035GlnIle: 2.035 ± 0.365
2.035GlnLys: 2.035 ± 0.372
2.798GlnLeu: 2.798 ± 0.588
0.594GlnMet: 0.594 ± 0.259
1.272GlnAsn: 1.272 ± 0.312
1.781GlnPro: 1.781 ± 0.429
1.102GlnGln: 1.102 ± 0.258
1.866GlnArg: 1.866 ± 0.402
2.459GlnSer: 2.459 ± 0.562
2.713GlnThr: 2.713 ± 0.54
2.713GlnVal: 2.713 ± 0.476
0.509GlnTrp: 0.509 ± 0.245
1.018GlnTyr: 1.018 ± 0.291
0.0GlnXaa: 0.0 ± 0.0
Arg
4.579ArgAla: 4.579 ± 0.672
0.085ArgCys: 0.085 ± 0.085
3.137ArgAsp: 3.137 ± 0.452
2.205ArgGlu: 2.205 ± 0.437
2.544ArgPhe: 2.544 ± 0.536
3.816ArgGly: 3.816 ± 0.692
0.594ArgHis: 0.594 ± 0.219
2.374ArgIle: 2.374 ± 0.487
3.222ArgLys: 3.222 ± 0.543
4.155ArgLeu: 4.155 ± 0.618
1.357ArgMet: 1.357 ± 0.338
1.781ArgAsn: 1.781 ± 0.542
1.866ArgPro: 1.866 ± 0.557
2.12ArgGln: 2.12 ± 0.382
2.205ArgArg: 2.205 ± 0.427
2.713ArgSer: 2.713 ± 0.421
3.053ArgThr: 3.053 ± 0.509
2.035ArgVal: 2.035 ± 0.369
0.848ArgTrp: 0.848 ± 0.286
1.95ArgTyr: 1.95 ± 0.462
0.0ArgXaa: 0.0 ± 0.0
Ser
11.447SerAla: 11.447 ± 3.455
0.254SerCys: 0.254 ± 0.146
2.883SerAsp: 2.883 ± 0.578
3.646SerGlu: 3.646 ± 0.529
2.544SerPhe: 2.544 ± 0.437
7.123SerGly: 7.123 ± 1.591
0.848SerHis: 0.848 ± 0.359
3.901SerIle: 3.901 ± 0.603
3.985SerLys: 3.985 ± 0.742
5.257SerLeu: 5.257 ± 0.63
1.611SerMet: 1.611 ± 0.352
3.137SerAsn: 3.137 ± 0.488
2.459SerPro: 2.459 ± 0.499
2.374SerGln: 2.374 ± 0.427
2.968SerArg: 2.968 ± 0.501
5.173SerSer: 5.173 ± 0.958
5.851SerThr: 5.851 ± 0.997
4.409SerVal: 4.409 ± 0.539
1.018SerTrp: 1.018 ± 0.295
1.95SerTyr: 1.95 ± 0.379
0.0SerXaa: 0.0 ± 0.0
Thr
9.582ThrAla: 9.582 ± 1.801
0.509ThrCys: 0.509 ± 0.214
3.307ThrAsp: 3.307 ± 0.412
3.392ThrGlu: 3.392 ± 0.602
1.95ThrPhe: 1.95 ± 0.352
5.088ThrGly: 5.088 ± 0.926
0.933ThrHis: 0.933 ± 0.273
5.342ThrIle: 5.342 ± 0.915
4.07ThrLys: 4.07 ± 0.789
3.307ThrLeu: 3.307 ± 0.718
1.611ThrMet: 1.611 ± 0.369
2.459ThrAsn: 2.459 ± 0.46
3.731ThrPro: 3.731 ± 0.599
2.374ThrGln: 2.374 ± 0.369
3.053ThrArg: 3.053 ± 0.359
7.038ThrSer: 7.038 ± 2.048
7.632ThrThr: 7.632 ± 1.512
4.579ThrVal: 4.579 ± 0.732
0.763ThrTrp: 0.763 ± 0.224
2.713ThrTyr: 2.713 ± 0.552
0.0ThrXaa: 0.0 ± 0.0
Val
5.851ValAla: 5.851 ± 0.756
0.254ValCys: 0.254 ± 0.154
5.342ValAsp: 5.342 ± 0.872
4.664ValGlu: 4.664 ± 0.794
1.781ValPhe: 1.781 ± 0.442
3.731ValGly: 3.731 ± 0.473
0.509ValHis: 0.509 ± 0.19
3.222ValIle: 3.222 ± 0.505
3.646ValLys: 3.646 ± 0.608
4.325ValLeu: 4.325 ± 0.601
1.696ValMet: 1.696 ± 0.4
2.798ValAsn: 2.798 ± 0.499
2.713ValPro: 2.713 ± 0.531
1.95ValGln: 1.95 ± 0.454
3.816ValArg: 3.816 ± 0.499
5.512ValSer: 5.512 ± 0.748
4.494ValThr: 4.494 ± 0.543
4.749ValVal: 4.749 ± 0.585
1.272ValTrp: 1.272 ± 0.391
1.866ValTyr: 1.866 ± 0.329
0.0ValXaa: 0.0 ± 0.0
Trp
1.442TrpAla: 1.442 ± 0.325
0.17TrpCys: 0.17 ± 0.126
1.102TrpAsp: 1.102 ± 0.34
0.848TrpGlu: 0.848 ± 0.273
0.933TrpPhe: 0.933 ± 0.279
1.272TrpGly: 1.272 ± 0.356
0.085TrpHis: 0.085 ± 0.085
0.424TrpIle: 0.424 ± 0.204
0.763TrpLys: 0.763 ± 0.257
0.678TrpLeu: 0.678 ± 0.249
0.594TrpMet: 0.594 ± 0.198
1.018TrpAsn: 1.018 ± 0.332
0.0TrpPro: 0.0 ± 0.0
1.187TrpGln: 1.187 ± 0.377
0.763TrpArg: 0.763 ± 0.278
1.442TrpSer: 1.442 ± 0.33
1.187TrpThr: 1.187 ± 0.297
0.594TrpVal: 0.594 ± 0.253
0.254TrpTrp: 0.254 ± 0.133
0.933TrpTyr: 0.933 ± 0.247
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.07TyrAla: 4.07 ± 0.563
0.085TyrCys: 0.085 ± 0.088
2.12TyrAsp: 2.12 ± 0.326
2.205TyrGlu: 2.205 ± 0.461
0.763TyrPhe: 0.763 ± 0.248
3.646TyrGly: 3.646 ± 0.66
0.254TyrHis: 0.254 ± 0.134
1.611TyrIle: 1.611 ± 0.39
2.035TyrLys: 2.035 ± 0.329
2.629TyrLeu: 2.629 ± 0.499
0.848TyrMet: 0.848 ± 0.273
1.442TyrAsn: 1.442 ± 0.339
1.526TyrPro: 1.526 ± 0.374
1.187TyrGln: 1.187 ± 0.293
2.12TyrArg: 2.12 ± 0.373
2.035TyrSer: 2.035 ± 0.45
2.798TyrThr: 2.798 ± 0.558
2.289TyrVal: 2.289 ± 0.448
0.678TyrTrp: 0.678 ± 0.206
1.187TyrTyr: 1.187 ± 0.366
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (11794 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski