Amino acid dipepetide frequency for Rhizomicrobium sp. SCGC AG-212-E05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.276AlaAla: 17.276 ± 0.336
1.106AlaCys: 1.106 ± 0.06
6.54AlaAsp: 6.54 ± 0.155
6.48AlaGlu: 6.48 ± 0.139
4.308AlaPhe: 4.308 ± 0.128
10.496AlaGly: 10.496 ± 0.191
2.391AlaHis: 2.391 ± 0.093
6.242AlaIle: 6.242 ± 0.148
5.014AlaLys: 5.014 ± 0.134
13.882AlaLeu: 13.882 ± 0.247
3.446AlaMet: 3.446 ± 0.112
3.005AlaAsn: 3.005 ± 0.088
6.302AlaPro: 6.302 ± 0.157
4.925AlaGln: 4.925 ± 0.112
8.59AlaArg: 8.59 ± 0.196
6.231AlaSer: 6.231 ± 0.152
5.463AlaThr: 5.463 ± 0.127
8.498AlaVal: 8.498 ± 0.142
1.496AlaTrp: 1.496 ± 0.067
2.607AlaTyr: 2.607 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
1.057CysAla: 1.057 ± 0.058
0.135CysCys: 0.135 ± 0.02
0.622CysAsp: 0.622 ± 0.042
0.435CysGlu: 0.435 ± 0.033
0.333CysPhe: 0.333 ± 0.027
0.974CysGly: 0.974 ± 0.057
0.208CysHis: 0.208 ± 0.027
0.381CysIle: 0.381 ± 0.031
0.243CysLys: 0.243 ± 0.026
0.695CysLeu: 0.695 ± 0.047
0.124CysMet: 0.124 ± 0.02
0.235CysAsn: 0.235 ± 0.025
0.414CysPro: 0.414 ± 0.037
0.257CysGln: 0.257 ± 0.025
0.546CysArg: 0.546 ± 0.042
0.449CysSer: 0.449 ± 0.037
0.441CysThr: 0.441 ± 0.039
0.692CysVal: 0.692 ± 0.044
0.111CysTrp: 0.111 ± 0.017
0.206CysTyr: 0.206 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
6.842AspAla: 6.842 ± 0.151
0.457AspCys: 0.457 ± 0.038
2.642AspAsp: 2.642 ± 0.073
2.888AspGlu: 2.888 ± 0.109
2.261AspPhe: 2.261 ± 0.094
5.212AspGly: 5.212 ± 0.131
1.163AspHis: 1.163 ± 0.051
3.324AspIle: 3.324 ± 0.093
1.961AspLys: 1.961 ± 0.071
5.12AspLeu: 5.12 ± 0.124
1.493AspMet: 1.493 ± 0.061
1.471AspAsn: 1.471 ± 0.07
3.218AspPro: 3.218 ± 0.099
1.666AspGln: 1.666 ± 0.073
3.743AspArg: 3.743 ± 0.095
2.491AspSer: 2.491 ± 0.071
2.45AspThr: 2.45 ± 0.079
3.927AspVal: 3.927 ± 0.106
0.879AspTrp: 0.879 ± 0.052
1.693AspTyr: 1.693 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
6.585GluAla: 6.585 ± 0.155
0.36GluCys: 0.36 ± 0.031
2.515GluAsp: 2.515 ± 0.097
2.591GluGlu: 2.591 ± 0.091
1.704GluPhe: 1.704 ± 0.067
4.13GluGly: 4.13 ± 0.105
1.009GluHis: 1.009 ± 0.057
3.373GluIle: 3.373 ± 0.102
2.713GluLys: 2.713 ± 0.087
4.801GluLeu: 4.801 ± 0.12
1.474GluMet: 1.474 ± 0.077
1.59GluAsn: 1.59 ± 0.063
2.164GluPro: 2.164 ± 0.08
1.793GluGln: 1.793 ± 0.072
3.889GluArg: 3.889 ± 0.106
2.402GluSer: 2.402 ± 0.085
2.688GluThr: 2.688 ± 0.08
3.343GluVal: 3.343 ± 0.1
0.679GluTrp: 0.679 ± 0.044
1.063GluTyr: 1.063 ± 0.061
0.0GluXaa: 0.0 ± 0.0
Phe
4.909PheAla: 4.909 ± 0.139
0.408PheCys: 0.408 ± 0.035
2.569PheAsp: 2.569 ± 0.09
2.088PheGlu: 2.088 ± 0.081
1.606PhePhe: 1.606 ± 0.088
3.594PheGly: 3.594 ± 0.094
0.847PheHis: 0.847 ± 0.054
1.725PheIle: 1.725 ± 0.066
1.139PheLys: 1.139 ± 0.053
3.497PheLeu: 3.497 ± 0.102
0.806PheMet: 0.806 ± 0.047
1.266PheAsn: 1.266 ± 0.062
1.642PhePro: 1.642 ± 0.058
1.109PheGln: 1.109 ± 0.054
2.191PheArg: 2.191 ± 0.091
2.307PheSer: 2.307 ± 0.073
2.258PheThr: 2.258 ± 0.088
2.859PheVal: 2.859 ± 0.093
0.549PheTrp: 0.549 ± 0.041
1.055PheTyr: 1.055 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
9.769GlyAla: 9.769 ± 0.177
0.825GlyCys: 0.825 ± 0.047
4.63GlyAsp: 4.63 ± 0.101
4.408GlyGlu: 4.408 ± 0.101
3.743GlyPhe: 3.743 ± 0.122
7.892GlyGly: 7.892 ± 0.21
1.877GlyHis: 1.877 ± 0.072
4.636GlyIle: 4.636 ± 0.113
4.387GlyLys: 4.387 ± 0.133
8.695GlyLeu: 8.695 ± 0.156
2.358GlyMet: 2.358 ± 0.085
2.629GlyAsn: 2.629 ± 0.098
3.556GlyPro: 3.556 ± 0.095
2.851GlyGln: 2.851 ± 0.096
5.698GlyArg: 5.698 ± 0.109
4.43GlySer: 4.43 ± 0.132
4.73GlyThr: 4.73 ± 0.131
6.074GlyVal: 6.074 ± 0.14
1.515GlyTrp: 1.515 ± 0.077
2.415GlyTyr: 2.415 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
2.345HisAla: 2.345 ± 0.099
0.214HisCys: 0.214 ± 0.027
1.12HisAsp: 1.12 ± 0.056
0.99HisGlu: 0.99 ± 0.049
0.944HisPhe: 0.944 ± 0.052
1.996HisGly: 1.996 ± 0.07
0.592HisHis: 0.592 ± 0.039
1.014HisIle: 1.014 ± 0.046
0.684HisLys: 0.684 ± 0.05
1.915HisLeu: 1.915 ± 0.071
0.416HisMet: 0.416 ± 0.032
0.657HisAsn: 0.657 ± 0.04
1.166HisPro: 1.166 ± 0.047
0.636HisGln: 0.636 ± 0.044
1.444HisArg: 1.444 ± 0.066
1.022HisSer: 1.022 ± 0.053
0.901HisThr: 0.901 ± 0.059
1.59HisVal: 1.59 ± 0.061
0.306HisTrp: 0.306 ± 0.028
0.6HisTyr: 0.6 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
7.367IleAla: 7.367 ± 0.157
0.508IleCys: 0.508 ± 0.033
3.105IleAsp: 3.105 ± 0.088
3.029IleGlu: 3.029 ± 0.096
1.863IlePhe: 1.863 ± 0.077
4.552IleGly: 4.552 ± 0.123
0.982IleHis: 0.982 ± 0.052
2.134IleIle: 2.134 ± 0.079
1.939IleLys: 1.939 ± 0.071
4.698IleLeu: 4.698 ± 0.132
0.92IleMet: 0.92 ± 0.055
1.471IleAsn: 1.471 ± 0.072
2.499IlePro: 2.499 ± 0.085
1.374IleGln: 1.374 ± 0.064
3.086IleArg: 3.086 ± 0.097
3.037IleSer: 3.037 ± 0.105
2.986IleThr: 2.986 ± 0.079
4.095IleVal: 4.095 ± 0.115
0.609IleTrp: 0.609 ± 0.043
1.22IleTyr: 1.22 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.876LysAla: 4.876 ± 0.128
0.181LysCys: 0.181 ± 0.021
2.21LysAsp: 2.21 ± 0.095
1.88LysGlu: 1.88 ± 0.074
1.374LysPhe: 1.374 ± 0.07
3.54LysGly: 3.54 ± 0.105
0.679LysHis: 0.679 ± 0.042
2.285LysIle: 2.285 ± 0.098
2.218LysLys: 2.218 ± 0.104
4.054LysLeu: 4.054 ± 0.12
1.133LysMet: 1.133 ± 0.051
1.249LysAsn: 1.249 ± 0.067
2.58LysPro: 2.58 ± 0.091
1.287LysGln: 1.287 ± 0.066
2.686LysArg: 2.686 ± 0.088
2.331LysSer: 2.331 ± 0.079
2.531LysThr: 2.531 ± 0.085
2.94LysVal: 2.94 ± 0.089
0.392LysTrp: 0.392 ± 0.032
0.887LysTyr: 0.887 ± 0.047
0.0LysXaa: 0.0 ± 0.0
Leu
13.114LeuAla: 13.114 ± 0.25
0.898LeuCys: 0.898 ± 0.055
5.409LeuAsp: 5.409 ± 0.123
4.984LeuGlu: 4.984 ± 0.127
3.738LeuPhe: 3.738 ± 0.113
8.414LeuGly: 8.414 ± 0.156
1.869LeuHis: 1.869 ± 0.073
4.544LeuIle: 4.544 ± 0.106
4.841LeuLys: 4.841 ± 0.123
9.536LeuLeu: 9.536 ± 0.238
2.553LeuMet: 2.553 ± 0.082
2.618LeuAsn: 2.618 ± 0.081
5.425LeuPro: 5.425 ± 0.116
2.686LeuGln: 2.686 ± 0.087
6.074LeuArg: 6.074 ± 0.147
6.247LeuSer: 6.247 ± 0.114
5.666LeuThr: 5.666 ± 0.109
7.064LeuVal: 7.064 ± 0.162
1.22LeuTrp: 1.22 ± 0.06
2.096LeuTyr: 2.096 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
3.267MetAla: 3.267 ± 0.085
0.173MetCys: 0.173 ± 0.022
1.252MetAsp: 1.252 ± 0.057
1.141MetGlu: 1.141 ± 0.062
0.682MetPhe: 0.682 ± 0.047
1.95MetGly: 1.95 ± 0.079
0.514MetHis: 0.514 ± 0.034
1.295MetIle: 1.295 ± 0.052
1.268MetLys: 1.268 ± 0.058
2.68MetLeu: 2.68 ± 0.101
0.714MetMet: 0.714 ± 0.052
0.855MetAsn: 0.855 ± 0.051
1.444MetPro: 1.444 ± 0.068
0.795MetGln: 0.795 ± 0.048
1.839MetArg: 1.839 ± 0.079
1.577MetSer: 1.577 ± 0.06
1.834MetThr: 1.834 ± 0.073
1.858MetVal: 1.858 ± 0.064
0.265MetTrp: 0.265 ± 0.026
0.411MetTyr: 0.411 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.446AsnAla: 3.446 ± 0.115
0.289AsnCys: 0.289 ± 0.032
1.49AsnAsp: 1.49 ± 0.06
1.114AsnGlu: 1.114 ± 0.055
1.347AsnPhe: 1.347 ± 0.066
2.615AsnGly: 2.615 ± 0.093
0.587AsnHis: 0.587 ± 0.044
1.582AsnIle: 1.582 ± 0.074
0.909AsnLys: 0.909 ± 0.055
2.826AsnLeu: 2.826 ± 0.101
0.784AsnMet: 0.784 ± 0.052
0.976AsnAsn: 0.976 ± 0.063
2.02AsnPro: 2.02 ± 0.08
0.784AsnGln: 0.784 ± 0.051
1.874AsnArg: 1.874 ± 0.077
1.469AsnSer: 1.469 ± 0.077
1.32AsnThr: 1.32 ± 0.078
2.118AsnVal: 2.118 ± 0.088
0.538AsnTrp: 0.538 ± 0.04
0.876AsnTyr: 0.876 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
6.631ProAla: 6.631 ± 0.149
0.395ProCys: 0.395 ± 0.029
3.608ProAsp: 3.608 ± 0.105
3.286ProGlu: 3.286 ± 0.099
1.999ProPhe: 1.999 ± 0.079
4.922ProGly: 4.922 ± 0.13
1.139ProHis: 1.139 ± 0.058
2.077ProIle: 2.077 ± 0.065
1.92ProLys: 1.92 ± 0.079
4.638ProLeu: 4.638 ± 0.109
1.309ProMet: 1.309 ± 0.07
1.515ProAsn: 1.515 ± 0.071
2.78ProPro: 2.78 ± 0.107
1.928ProGln: 1.928 ± 0.083
3.216ProArg: 3.216 ± 0.109
2.631ProSer: 2.631 ± 0.079
2.407ProThr: 2.407 ± 0.079
4.165ProVal: 4.165 ± 0.102
0.571ProTrp: 0.571 ± 0.046
1.282ProTyr: 1.282 ± 0.057
0.0ProXaa: 0.0 ± 0.0
Gln
4.165GlnAla: 4.165 ± 0.109
0.262GlnCys: 0.262 ± 0.03
1.579GlnAsp: 1.579 ± 0.065
1.368GlnGlu: 1.368 ± 0.053
1.279GlnPhe: 1.279 ± 0.059
2.642GlnGly: 2.642 ± 0.083
0.668GlnHis: 0.668 ± 0.045
1.853GlnIle: 1.853 ± 0.077
1.431GlnLys: 1.431 ± 0.061
2.824GlnLeu: 2.824 ± 0.096
1.079GlnMet: 1.079 ± 0.051
1.039GlnAsn: 1.039 ± 0.059
1.923GlnPro: 1.923 ± 0.076
1.396GlnGln: 1.396 ± 0.096
2.307GlnArg: 2.307 ± 0.093
1.861GlnSer: 1.861 ± 0.073
1.855GlnThr: 1.855 ± 0.075
2.35GlnVal: 2.35 ± 0.086
0.425GlnTrp: 0.425 ± 0.036
0.728GlnTyr: 0.728 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
7.965ArgAla: 7.965 ± 0.147
0.481ArgCys: 0.481 ± 0.04
3.995ArgAsp: 3.995 ± 0.125
3.792ArgGlu: 3.792 ± 0.102
2.761ArgPhe: 2.761 ± 0.089
4.976ArgGly: 4.976 ± 0.123
1.531ArgHis: 1.531 ± 0.066
3.765ArgIle: 3.765 ± 0.1
2.756ArgLys: 2.756 ± 0.094
7.205ArgLeu: 7.205 ± 0.158
1.855ArgMet: 1.855 ± 0.073
1.888ArgAsn: 1.888 ± 0.083
3.251ArgPro: 3.251 ± 0.083
2.402ArgGln: 2.402 ± 0.084
4.841ArgArg: 4.841 ± 0.15
3.229ArgSer: 3.229 ± 0.113
3.348ArgThr: 3.348 ± 0.097
4.349ArgVal: 4.349 ± 0.095
0.876ArgTrp: 0.876 ± 0.05
1.753ArgTyr: 1.753 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
6.085SerAla: 6.085 ± 0.145
0.433SerCys: 0.433 ± 0.036
3.159SerAsp: 3.159 ± 0.092
2.569SerGlu: 2.569 ± 0.086
2.334SerPhe: 2.334 ± 0.099
5.412SerGly: 5.412 ± 0.123
1.209SerHis: 1.209 ± 0.059
2.634SerIle: 2.634 ± 0.084
1.918SerLys: 1.918 ± 0.075
5.455SerLeu: 5.455 ± 0.125
1.171SerMet: 1.171 ± 0.056
1.588SerAsn: 1.588 ± 0.083
2.875SerPro: 2.875 ± 0.081
1.85SerGln: 1.85 ± 0.075
3.665SerArg: 3.665 ± 0.085
2.961SerSer: 2.961 ± 0.101
2.54SerThr: 2.54 ± 0.095
3.678SerVal: 3.678 ± 0.095
0.844SerTrp: 0.844 ± 0.052
1.588SerTyr: 1.588 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
6.21ThrAla: 6.21 ± 0.162
0.484ThrCys: 0.484 ± 0.034
2.629ThrAsp: 2.629 ± 0.093
2.072ThrGlu: 2.072 ± 0.082
1.961ThrPhe: 1.961 ± 0.061
5.368ThrGly: 5.368 ± 0.141
1.041ThrHis: 1.041 ± 0.059
2.845ThrIle: 2.845 ± 0.086
1.75ThrLys: 1.75 ± 0.076
5.423ThrLeu: 5.423 ± 0.123
1.201ThrMet: 1.201 ± 0.065
1.574ThrAsn: 1.574 ± 0.074
3.527ThrPro: 3.527 ± 0.087
1.777ThrGln: 1.777 ± 0.078
3.47ThrArg: 3.47 ± 0.104
2.742ThrSer: 2.742 ± 0.097
2.526ThrThr: 2.526 ± 0.103
4.151ThrVal: 4.151 ± 0.134
0.668ThrTrp: 0.668 ± 0.046
1.304ThrTyr: 1.304 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
8.425ValAla: 8.425 ± 0.156
0.606ValCys: 0.606 ± 0.039
3.538ValAsp: 3.538 ± 0.102
3.97ValGlu: 3.97 ± 0.103
2.702ValPhe: 2.702 ± 0.084
5.079ValGly: 5.079 ± 0.136
1.387ValHis: 1.387 ± 0.062
4.041ValIle: 4.041 ± 0.113
2.848ValLys: 2.848 ± 0.094
7.137ValLeu: 7.137 ± 0.136
2.093ValMet: 2.093 ± 0.085
2.074ValAsn: 2.074 ± 0.083
3.765ValPro: 3.765 ± 0.115
2.142ValGln: 2.142 ± 0.073
4.638ValArg: 4.638 ± 0.119
4.319ValSer: 4.319 ± 0.119
4.911ValThr: 4.911 ± 0.118
5.401ValVal: 5.401 ± 0.156
1.028ValTrp: 1.028 ± 0.056
1.574ValTyr: 1.574 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
1.179TrpAla: 1.179 ± 0.065
0.084TrpCys: 0.084 ± 0.014
0.706TrpAsp: 0.706 ± 0.046
0.541TrpGlu: 0.541 ± 0.035
0.506TrpPhe: 0.506 ± 0.044
1.044TrpGly: 1.044 ± 0.05
0.327TrpHis: 0.327 ± 0.03
0.673TrpIle: 0.673 ± 0.047
0.679TrpLys: 0.679 ± 0.043
1.571TrpLeu: 1.571 ± 0.063
0.422TrpMet: 0.422 ± 0.035
0.519TrpAsn: 0.519 ± 0.04
0.673TrpPro: 0.673 ± 0.043
0.511TrpGln: 0.511 ± 0.039
1.206TrpArg: 1.206 ± 0.065
0.849TrpSer: 0.849 ± 0.051
0.744TrpThr: 0.744 ± 0.045
0.795TrpVal: 0.795 ± 0.053
0.181TrpTrp: 0.181 ± 0.022
0.311TrpTyr: 0.311 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.783TyrAla: 2.783 ± 0.09
0.26TyrCys: 0.26 ± 0.025
1.588TyrAsp: 1.588 ± 0.068
1.236TyrGlu: 1.236 ± 0.056
0.979TyrPhe: 0.979 ± 0.051
2.31TyrGly: 2.31 ± 0.092
0.533TyrHis: 0.533 ± 0.04
1.049TyrIle: 1.049 ± 0.052
0.698TyrLys: 0.698 ± 0.045
2.345TyrLeu: 2.345 ± 0.08
0.46TyrMet: 0.46 ± 0.033
0.746TyrAsn: 0.746 ± 0.059
1.195TyrPro: 1.195 ± 0.057
0.865TyrGln: 0.865 ± 0.049
2.015TyrArg: 2.015 ± 0.09
1.379TyrSer: 1.379 ± 0.058
1.122TyrThr: 1.122 ± 0.058
1.731TyrVal: 1.731 ± 0.066
0.373TyrTrp: 0.373 ± 0.029
0.698TyrTyr: 0.698 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1220 proteins (369753 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski