Amino acid dipepetide frequency for Pseudobacteroides cellulosolvens ATCC 35603 = DSM 2933

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.836AlaAla: 4.836 ± 0.072	0.74AlaCys: 0.74 ± 0.023	3.294AlaAsp: 3.294 ± 0.049	3.538AlaGlu: 3.538 ± 0.048	2.691AlaPhe: 2.691 ± 0.052	4.392AlaGly: 4.392 ± 0.066	0.786AlaHis: 0.786 ± 0.019	5.034AlaIle: 5.034 ± 0.058	4.35AlaLys: 4.35 ± 0.055	5.408AlaLeu: 5.408 ± 0.061	1.464AlaMet: 1.464 ± 0.027	2.854AlaAsn: 2.854 ± 0.045	1.717AlaPro: 1.717 ± 0.041	1.671AlaGln: 1.671 ± 0.028	2.128AlaArg: 2.128 ± 0.041	4.109AlaSer: 4.109 ± 0.08	3.002AlaThr: 3.002 ± 0.081	4.731AlaVal: 4.731 ± 0.06	0.568AlaTrp: 0.568 ± 0.023	2.307AlaTyr: 2.307 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.596CysAla: 0.596 ± 0.019	0.192CysCys: 0.192 ± 0.011	0.744CysAsp: 0.744 ± 0.021	0.718CysGlu: 0.718 ± 0.02	0.571CysPhe: 0.571 ± 0.019	0.979CysGly: 0.979 ± 0.029	0.223CysHis: 0.223 ± 0.01	1.097CysIle: 1.097 ± 0.026	0.877CysLys: 0.877 ± 0.024	0.96CysLeu: 0.96 ± 0.024	0.291CysMet: 0.291 ± 0.013	0.639CysAsn: 0.639 ± 0.019	0.501CysPro: 0.501 ± 0.018	0.277CysGln: 0.277 ± 0.013	0.471CysArg: 0.471 ± 0.017	0.915CysSer: 0.915 ± 0.024	0.588CysThr: 0.588 ± 0.023	0.656CysVal: 0.656 ± 0.019	0.12CysTrp: 0.12 ± 0.008	0.479CysTyr: 0.479 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.061AspAla: 3.061 ± 0.055	0.67AspCys: 0.67 ± 0.019	3.115AspAsp: 3.115 ± 0.048	4.148AspGlu: 4.148 ± 0.059	2.791AspPhe: 2.791 ± 0.037	4.267AspGly: 4.267 ± 0.065	0.688AspHis: 0.688 ± 0.018	6.118AspIle: 6.118 ± 0.067	5.008AspLys: 5.008 ± 0.06	4.663AspLeu: 4.663 ± 0.051	1.652AspMet: 1.652 ± 0.034	3.581AspAsn: 3.581 ± 0.048	1.73AspPro: 1.73 ± 0.037	1.164AspGln: 1.164 ± 0.025	2.049AspArg: 2.049 ± 0.043	3.77AspSer: 3.77 ± 0.041	2.905AspThr: 2.905 ± 0.047	3.76AspVal: 3.76 ± 0.049	0.659AspTrp: 0.659 ± 0.023	2.812AspTyr: 2.812 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.021GluAla: 4.021 ± 0.053	0.686GluCys: 0.686 ± 0.018	3.565GluAsp: 3.565 ± 0.054	4.718GluGlu: 4.718 ± 0.073	2.862GluPhe: 2.862 ± 0.044	3.773GluGly: 3.773 ± 0.054	0.902GluHis: 0.902 ± 0.022	6.166GluIle: 6.166 ± 0.066	6.103GluLys: 6.103 ± 0.073	5.969GluLeu: 5.969 ± 0.066	1.83GluMet: 1.83 ± 0.031	4.204GluAsn: 4.204 ± 0.056	1.628GluPro: 1.628 ± 0.033	1.817GluGln: 1.817 ± 0.035	2.553GluArg: 2.553 ± 0.045	3.723GluSer: 3.723 ± 0.051	2.876GluThr: 2.876 ± 0.046	4.165GluVal: 4.165 ± 0.055	0.62GluTrp: 0.62 ± 0.018	2.866GluTyr: 2.866 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.407PheAla: 2.407 ± 0.037	0.574PheCys: 0.574 ± 0.016	2.807PheAsp: 2.807 ± 0.044	2.769PheGlu: 2.769 ± 0.043	1.945PhePhe: 1.945 ± 0.04	2.891PheGly: 2.891 ± 0.04	0.613PheHis: 0.613 ± 0.019	4.123PheIle: 4.123 ± 0.062	3.468PheLys: 3.468 ± 0.051	3.636PheLeu: 3.636 ± 0.06	1.091PheMet: 1.091 ± 0.03	2.848PheAsn: 2.848 ± 0.04	1.263PhePro: 1.263 ± 0.031	1.006PheGln: 1.006 ± 0.022	1.447PheArg: 1.447 ± 0.029	3.368PheSer: 3.368 ± 0.052	2.521PheThr: 2.521 ± 0.046	2.628PheVal: 2.628 ± 0.036	0.398PheTrp: 0.398 ± 0.015	1.861PheTyr: 1.861 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	3.66GlyAla: 3.66 ± 0.056	0.953GlyCys: 0.953 ± 0.028	3.684GlyAsp: 3.684 ± 0.05	3.794GlyGlu: 3.794 ± 0.051	3.115GlyPhe: 3.115 ± 0.044	4.111GlyGly: 4.111 ± 0.063	1.026GlyHis: 1.026 ± 0.025	6.193GlyIle: 6.193 ± 0.061	5.566GlyLys: 5.566 ± 0.055	5.341GlyLeu: 5.341 ± 0.079	1.766GlyMet: 1.766 ± 0.033	3.808GlyAsn: 3.808 ± 0.071	1.316GlyPro: 1.316 ± 0.028	1.813GlyGln: 1.813 ± 0.04	2.446GlyArg: 2.446 ± 0.043	4.465GlySer: 4.465 ± 0.054	4.262GlyThr: 4.262 ± 0.089	4.339GlyVal: 4.339 ± 0.055	0.709GlyTrp: 0.709 ± 0.021	3.302GlyTyr: 3.302 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	0.757HisAla: 0.757 ± 0.022	0.224HisCys: 0.224 ± 0.011	0.784HisAsp: 0.784 ± 0.019	0.884HisGlu: 0.884 ± 0.023	0.75HisPhe: 0.75 ± 0.021	0.994HisGly: 0.994 ± 0.02	0.349HisHis: 0.349 ± 0.014	1.309HisIle: 1.309 ± 0.025	1.039HisLys: 1.039 ± 0.027	1.234HisLeu: 1.234 ± 0.027	0.373HisMet: 0.373 ± 0.014	0.792HisAsn: 0.792 ± 0.018	0.61HisPro: 0.61 ± 0.018	0.409HisGln: 0.409 ± 0.015	0.552HisArg: 0.552 ± 0.019	0.996HisSer: 0.996 ± 0.023	0.761HisThr: 0.761 ± 0.021	0.77HisVal: 0.77 ± 0.019	0.191HisTrp: 0.191 ± 0.011	0.644HisTyr: 0.644 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.423IleAla: 5.423 ± 0.061	1.079IleCys: 1.079 ± 0.025	5.65IleAsp: 5.65 ± 0.059	5.978IleGlu: 5.978 ± 0.068	3.456IlePhe: 3.456 ± 0.057	5.415IleGly: 5.415 ± 0.055	1.181IleHis: 1.181 ± 0.026	7.82IleIle: 7.82 ± 0.089	7.66IleLys: 7.66 ± 0.074	7.623IleLeu: 7.623 ± 0.085	2.165IleMet: 2.165 ± 0.04	5.851IleAsn: 5.851 ± 0.058	3.504IlePro: 3.504 ± 0.052	2.156IleGln: 2.156 ± 0.044	3.228IleArg: 3.228 ± 0.046	6.998IleSer: 6.998 ± 0.072	4.957IleThr: 4.957 ± 0.06	5.443IleVal: 5.443 ± 0.062	0.674IleTrp: 0.674 ± 0.021	3.368IleTyr: 3.368 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.975LysAla: 4.975 ± 0.064	0.879LysCys: 0.879 ± 0.022	5.309LysAsp: 5.309 ± 0.057	6.246LysGlu: 6.246 ± 0.067	2.836LysPhe: 2.836 ± 0.04	4.906LysGly: 4.906 ± 0.054	1.208LysHis: 1.208 ± 0.028	6.915LysIle: 6.915 ± 0.062	6.607LysLys: 6.607 ± 0.074	6.92LysLeu: 6.92 ± 0.06	2.078LysMet: 2.078 ± 0.035	5.266LysAsn: 5.266 ± 0.064	2.628LysPro: 2.628 ± 0.041	2.199LysGln: 2.199 ± 0.038	3.023LysArg: 3.023 ± 0.049	5.343LysSer: 5.343 ± 0.06	4.226LysThr: 4.226 ± 0.056	5.58LysVal: 5.58 ± 0.058	0.78LysTrp: 0.78 ± 0.024	3.688LysTyr: 3.688 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	5.206LeuAla: 5.206 ± 0.065	1.039LeuCys: 1.039 ± 0.026	4.747LeuAsp: 4.747 ± 0.051	5.616LeuGlu: 5.616 ± 0.065	3.734LeuPhe: 3.734 ± 0.063	5.378LeuGly: 5.378 ± 0.057	1.227LeuHis: 1.227 ± 0.024	7.083LeuIle: 7.083 ± 0.089	7.879LeuLys: 7.879 ± 0.07	7.573LeuLeu: 7.573 ± 0.094	2.169LeuMet: 2.169 ± 0.036	5.183LeuAsn: 5.183 ± 0.062	3.023LeuPro: 3.023 ± 0.042	2.231LeuGln: 2.231 ± 0.04	3.288LeuArg: 3.288 ± 0.048	6.707LeuSer: 6.707 ± 0.07	4.675LeuThr: 4.675 ± 0.061	5.197LeuVal: 5.197 ± 0.059	0.756LeuTrp: 0.756 ± 0.024	3.286LeuTyr: 3.286 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.782MetAla: 1.782 ± 0.032	0.256MetCys: 0.256 ± 0.011	1.663MetAsp: 1.663 ± 0.029	1.821MetGlu: 1.821 ± 0.034	0.991MetPhe: 0.991 ± 0.023	1.725MetGly: 1.725 ± 0.033	0.387MetHis: 0.387 ± 0.016	1.948MetIle: 1.948 ± 0.036	2.209MetLys: 2.209 ± 0.034	2.343MetLeu: 2.343 ± 0.04	0.664MetMet: 0.664 ± 0.022	1.501MetAsn: 1.501 ± 0.03	1.055MetPro: 1.055 ± 0.024	0.717MetGln: 0.717 ± 0.021	0.879MetArg: 0.879 ± 0.021	1.722MetSer: 1.722 ± 0.034	1.217MetThr: 1.217 ± 0.028	1.75MetVal: 1.75 ± 0.029	0.195MetTrp: 0.195 ± 0.011	0.861MetTyr: 0.861 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.189AsnAla: 3.189 ± 0.041	0.693AsnCys: 0.693 ± 0.022	3.369AsnAsp: 3.369 ± 0.045	3.722AsnGlu: 3.722 ± 0.044	2.372AsnPhe: 2.372 ± 0.039	4.344AsnGly: 4.344 ± 0.07	0.835AsnHis: 0.835 ± 0.018	5.918AsnIle: 5.918 ± 0.07	4.851AsnLys: 4.851 ± 0.056	4.814AsnLeu: 4.814 ± 0.055	1.758AsnMet: 1.758 ± 0.036	4.021AsnAsn: 4.021 ± 0.066	2.267AsnPro: 2.267 ± 0.038	1.646AsnGln: 1.646 ± 0.031	2.098AsnArg: 2.098 ± 0.041	4.284AsnSer: 4.284 ± 0.06	3.36AsnThr: 3.36 ± 0.06	3.674AsnVal: 3.674 ± 0.059	0.597AsnTrp: 0.597 ± 0.018	2.527AsnTyr: 2.527 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	1.948ProAla: 1.948 ± 0.035	0.335ProCys: 0.335 ± 0.014	2.246ProAsp: 2.246 ± 0.036	2.587ProGlu: 2.587 ± 0.036	1.503ProPhe: 1.503 ± 0.032	2.206ProGly: 2.206 ± 0.033	0.515ProHis: 0.515 ± 0.019	2.555ProIle: 2.555 ± 0.042	2.159ProLys: 2.159 ± 0.029	2.681ProLeu: 2.681 ± 0.037	0.721ProMet: 0.721 ± 0.02	1.664ProAsn: 1.664 ± 0.034	0.921ProPro: 0.921 ± 0.029	1.043ProGln: 1.043 ± 0.023	0.831ProArg: 0.831 ± 0.02	2.364ProSer: 2.364 ± 0.044	2.501ProThr: 2.501 ± 0.104	2.747ProVal: 2.747 ± 0.046	0.301ProTrp: 0.301 ± 0.012	1.43ProTyr: 1.43 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	1.64GlnAla: 1.64 ± 0.037	0.289GlnCys: 0.289 ± 0.015	1.366GlnAsp: 1.366 ± 0.025	1.658GlnGlu: 1.658 ± 0.029	1.033GlnPhe: 1.033 ± 0.024	1.576GlnGly: 1.576 ± 0.028	0.408GlnHis: 0.408 ± 0.013	2.374GlnIle: 2.374 ± 0.035	2.377GlnLys: 2.377 ± 0.041	2.424GlnLeu: 2.424 ± 0.044	0.803GlnMet: 0.803 ± 0.02	1.794GlnAsn: 1.794 ± 0.036	0.843GlnPro: 0.843 ± 0.025	0.865GlnGln: 0.865 ± 0.026	1.074GlnArg: 1.074 ± 0.029	1.689GlnSer: 1.689 ± 0.033	1.338GlnThr: 1.338 ± 0.029	1.63GlnVal: 1.63 ± 0.032	0.29GlnTrp: 0.29 ± 0.013	1.215GlnTyr: 1.215 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.91ArgAla: 1.91 ± 0.033	0.409ArgCys: 0.409 ± 0.016	1.99ArgAsp: 1.99 ± 0.034	2.478ArgGlu: 2.478 ± 0.041	1.766ArgPhe: 1.766 ± 0.033	1.951ArgGly: 1.951 ± 0.039	0.581ArgHis: 0.581 ± 0.018	3.461ArgIle: 3.461 ± 0.054	3.03ArgLys: 3.03 ± 0.054	3.361ArgLeu: 3.361 ± 0.056	1.003ArgMet: 1.003 ± 0.023	2.18ArgAsn: 2.18 ± 0.037	1.061ArgPro: 1.061 ± 0.027	1.123ArgGln: 1.123 ± 0.028	1.429ArgArg: 1.429 ± 0.033	2.046ArgSer: 2.046 ± 0.035	1.766ArgThr: 1.766 ± 0.034	2.322ArgVal: 2.322 ± 0.033	0.364ArgTrp: 0.364 ± 0.015	1.646ArgTyr: 1.646 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	3.771SerAla: 3.771 ± 0.059	0.802SerCys: 0.802 ± 0.026	4.118SerAsp: 4.118 ± 0.055	4.122SerGlu: 4.122 ± 0.051	3.312SerPhe: 3.312 ± 0.048	5.383SerGly: 5.383 ± 0.075	1.023SerHis: 1.023 ± 0.025	6.66SerIle: 6.66 ± 0.063	5.329SerLys: 5.329 ± 0.057	6.055SerLeu: 6.055 ± 0.065	1.722SerMet: 1.722 ± 0.031	4.046SerAsn: 4.046 ± 0.056	2.182SerPro: 2.182 ± 0.04	2.033SerGln: 2.033 ± 0.037	2.412SerArg: 2.412 ± 0.035	5.256SerSer: 5.256 ± 0.07	3.869SerThr: 3.869 ± 0.064	4.51SerVal: 4.51 ± 0.065	0.731SerTrp: 0.731 ± 0.027	2.87SerTyr: 2.87 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.848ThrAla: 3.848 ± 0.078	0.53ThrCys: 0.53 ± 0.022	3.086ThrAsp: 3.086 ± 0.07	2.949ThrGlu: 2.949 ± 0.045	2.32ThrPhe: 2.32 ± 0.04	4.335ThrGly: 4.335 ± 0.079	0.804ThrHis: 0.804 ± 0.021	4.634ThrIle: 4.634 ± 0.052	3.584ThrLys: 3.584 ± 0.053	4.609ThrLeu: 4.609 ± 0.052	1.188ThrMet: 1.188 ± 0.028	2.947ThrAsn: 2.947 ± 0.062	2.963ThrPro: 2.963 ± 0.104	1.443ThrGln: 1.443 ± 0.048	1.705ThrArg: 1.705 ± 0.036	3.786ThrSer: 3.786 ± 0.057	2.975ThrThr: 2.975 ± 0.07	3.988ThrVal: 3.988 ± 0.089	0.518ThrTrp: 0.518 ± 0.022	2.204ThrTyr: 2.204 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	3.743ValAla: 3.743 ± 0.055	0.85ValCys: 0.85 ± 0.02	3.702ValAsp: 3.702 ± 0.044	4.068ValGlu: 4.068 ± 0.054	3.097ValPhe: 3.097 ± 0.044	3.696ValGly: 3.696 ± 0.055	0.87ValHis: 0.87 ± 0.024	5.776ValIle: 5.776 ± 0.061	5.343ValLys: 5.343 ± 0.061	6.006ValLeu: 6.006 ± 0.065	1.633ValMet: 1.633 ± 0.026	3.76ValAsn: 3.76 ± 0.049	2.411ValPro: 2.411 ± 0.048	1.619ValGln: 1.619 ± 0.031	2.253ValArg: 2.253 ± 0.039	4.893ValSer: 4.893 ± 0.055	3.764ValThr: 3.764 ± 0.072	4.373ValVal: 4.373 ± 0.061	0.599ValTrp: 0.599 ± 0.02	2.743ValTyr: 2.743 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.669TrpAla: 0.669 ± 0.025	0.116TrpCys: 0.116 ± 0.01	0.627TrpAsp: 0.627 ± 0.022	0.602TrpGlu: 0.602 ± 0.018	0.401TrpPhe: 0.401 ± 0.016	0.72TrpGly: 0.72 ± 0.025	0.191TrpHis: 0.191 ± 0.011	0.719TrpIle: 0.719 ± 0.02	0.73TrpLys: 0.73 ± 0.02	0.825TrpLeu: 0.825 ± 0.023	0.264TrpMet: 0.264 ± 0.011	0.66TrpAsn: 0.66 ± 0.023	0.208TrpPro: 0.208 ± 0.012	0.305TrpGln: 0.305 ± 0.015	0.334TrpArg: 0.334 ± 0.013	0.633TrpSer: 0.633 ± 0.021	0.523TrpThr: 0.523 ± 0.025	0.584TrpVal: 0.584 ± 0.02	0.133TrpTrp: 0.133 ± 0.009	0.373TrpTyr: 0.373 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.183TyrAla: 2.183 ± 0.034	0.578TyrCys: 0.578 ± 0.02	2.746TyrAsp: 2.746 ± 0.078	2.632TyrGlu: 2.632 ± 0.04	2.117TyrPhe: 2.117 ± 0.04	2.628TyrGly: 2.628 ± 0.033	0.607TyrHis: 0.607 ± 0.017	3.726TyrIle: 3.726 ± 0.047	3.443TyrLys: 3.443 ± 0.05	3.553TyrLeu: 3.553 ± 0.049	1.049TyrMet: 1.049 ± 0.025	2.742TyrAsn: 2.742 ± 0.044	1.426TyrPro: 1.426 ± 0.031	1.147TyrGln: 1.147 ± 0.025	1.675TyrArg: 1.675 ± 0.036	3.138TyrSer: 3.138 ± 0.044	2.331TyrThr: 2.331 ± 0.049	2.351TyrVal: 2.351 ± 0.039	0.412TyrTrp: 0.412 ± 0.016	2.059TyrTyr: 2.059 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5771 proteins (1943841 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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