Amino acid dipepetide frequency for Streptomyces regalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.928AlaAla: 19.928 ± 0.125	1.084AlaCys: 1.084 ± 0.022	8.201AlaAsp: 8.201 ± 0.056	8.761AlaGlu: 8.761 ± 0.07	3.47AlaPhe: 3.47 ± 0.043	12.236AlaGly: 12.236 ± 0.079	2.866AlaHis: 2.866 ± 0.029	3.611AlaIle: 3.611 ± 0.04	2.987AlaLys: 2.987 ± 0.045	14.182AlaLeu: 14.182 ± 0.09	2.496AlaMet: 2.496 ± 0.032	2.025AlaAsn: 2.025 ± 0.03	6.606AlaPro: 6.606 ± 0.061	3.907AlaGln: 3.907 ± 0.045	9.753AlaArg: 9.753 ± 0.07	5.976AlaSer: 5.976 ± 0.052	7.036AlaThr: 7.036 ± 0.057	11.842AlaVal: 11.842 ± 0.091	1.897AlaTrp: 1.897 ± 0.027	2.85AlaTyr: 2.85 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.088CysAla: 1.088 ± 0.024	0.108CysCys: 0.108 ± 0.006	0.483CysAsp: 0.483 ± 0.014	0.436CysGlu: 0.436 ± 0.012	0.228CysPhe: 0.228 ± 0.009	0.951CysGly: 0.951 ± 0.022	0.2CysHis: 0.2 ± 0.009	0.173CysIle: 0.173 ± 0.008	0.126CysLys: 0.126 ± 0.007	0.789CysLeu: 0.789 ± 0.019	0.13CysMet: 0.13 ± 0.007	0.148CysAsn: 0.148 ± 0.008	0.495CysPro: 0.495 ± 0.012	0.18CysGln: 0.18 ± 0.007	0.622CysArg: 0.622 ± 0.015	0.45CysSer: 0.45 ± 0.013	0.548CysThr: 0.548 ± 0.012	0.671CysVal: 0.671 ± 0.014	0.131CysTrp: 0.131 ± 0.007	0.159CysTyr: 0.159 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.49AspAla: 7.49 ± 0.053	0.461AspCys: 0.461 ± 0.014	3.688AspAsp: 3.688 ± 0.042	3.973AspGlu: 3.973 ± 0.04	1.764AspPhe: 1.764 ± 0.026	6.466AspGly: 6.466 ± 0.057	1.431AspHis: 1.431 ± 0.022	2.028AspIle: 2.028 ± 0.028	1.368AspLys: 1.368 ± 0.028	6.202AspLeu: 6.202 ± 0.052	0.865AspMet: 0.865 ± 0.017	1.062AspAsn: 1.062 ± 0.021	4.359AspPro: 4.359 ± 0.039	1.616AspGln: 1.616 ± 0.024	4.75AspArg: 4.75 ± 0.049	2.694AspSer: 2.694 ± 0.036	3.247AspThr: 3.247 ± 0.039	4.803AspVal: 4.803 ± 0.043	1.084AspTrp: 1.084 ± 0.022	1.18AspTyr: 1.18 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	7.509GluAla: 7.509 ± 0.067	0.381GluCys: 0.381 ± 0.013	2.905GluAsp: 2.905 ± 0.038	3.643GluGlu: 3.643 ± 0.049	1.528GluPhe: 1.528 ± 0.026	4.346GluGly: 4.346 ± 0.042	1.554GluHis: 1.554 ± 0.024	2.28GluIle: 2.28 ± 0.029	1.54GluLys: 1.54 ± 0.024	6.95GluLeu: 6.95 ± 0.057	0.932GluMet: 0.932 ± 0.02	1.07GluAsn: 1.07 ± 0.02	3.364GluPro: 3.364 ± 0.041	2.367GluGln: 2.367 ± 0.031	5.308GluArg: 5.308 ± 0.046	2.664GluSer: 2.664 ± 0.037	2.964GluThr: 2.964 ± 0.038	4.56GluVal: 4.56 ± 0.044	0.815GluTrp: 0.815 ± 0.019	1.194GluTyr: 1.194 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.653PheAla: 3.653 ± 0.037	0.253PheCys: 0.253 ± 0.009	1.953PheAsp: 1.953 ± 0.028	1.502PheGlu: 1.502 ± 0.021	0.901PhePhe: 0.901 ± 0.021	3.001PheGly: 3.001 ± 0.034	0.614PheHis: 0.614 ± 0.014	0.762PheIle: 0.762 ± 0.019	0.572PheLys: 0.572 ± 0.014	2.615PheLeu: 2.615 ± 0.032	0.419PheMet: 0.419 ± 0.014	0.61PheAsn: 0.61 ± 0.017	1.355PhePro: 1.355 ± 0.025	0.729PheGln: 0.729 ± 0.015	1.822PheArg: 1.822 ± 0.025	1.498PheSer: 1.498 ± 0.023	2.086PheThr: 2.086 ± 0.032	2.247PheVal: 2.247 ± 0.029	0.446PheTrp: 0.446 ± 0.014	0.605PheTyr: 0.605 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.45GlyAla: 10.45 ± 0.072	0.827GlyCys: 0.827 ± 0.017	5.194GlyAsp: 5.194 ± 0.052	5.115GlyGlu: 5.115 ± 0.046	2.844GlyPhe: 2.844 ± 0.037	8.592GlyGly: 8.592 ± 0.077	2.315GlyHis: 2.315 ± 0.027	3.583GlyIle: 3.583 ± 0.037	2.598GlyLys: 2.598 ± 0.041	9.153GlyLeu: 9.153 ± 0.067	1.999GlyMet: 1.999 ± 0.024	1.85GlyAsn: 1.85 ± 0.03	4.804GlyPro: 4.804 ± 0.044	2.774GlyGln: 2.774 ± 0.034	7.366GlyArg: 7.366 ± 0.057	5.396GlySer: 5.396 ± 0.052	6.329GlyThr: 6.329 ± 0.057	7.399GlyVal: 7.399 ± 0.062	1.723GlyTrp: 1.723 ± 0.024	2.295GlyTyr: 2.295 ± 0.027	0.0GlyXaa: 0.0 ± 0.0
His	2.677HisAla: 2.677 ± 0.027	0.227HisCys: 0.227 ± 0.009	1.375HisAsp: 1.375 ± 0.027	1.273HisGlu: 1.273 ± 0.02	0.671HisPhe: 0.671 ± 0.014	2.349HisGly: 2.349 ± 0.03	0.693HisHis: 0.693 ± 0.017	0.741HisIle: 0.741 ± 0.016	0.387HisLys: 0.387 ± 0.012	2.407HisLeu: 2.407 ± 0.029	0.361HisMet: 0.361 ± 0.013	0.407HisAsn: 0.407 ± 0.011	1.81HisPro: 1.81 ± 0.022	0.663HisGln: 0.663 ± 0.016	2.103HisArg: 2.103 ± 0.028	1.053HisSer: 1.053 ± 0.021	1.391HisThr: 1.391 ± 0.021	1.709HisVal: 1.709 ± 0.026	0.386HisTrp: 0.386 ± 0.013	0.498HisTyr: 0.498 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.923IleAla: 4.923 ± 0.046	0.299IleCys: 0.299 ± 0.009	2.337IleAsp: 2.337 ± 0.027	2.09IleGlu: 2.09 ± 0.031	0.726IlePhe: 0.726 ± 0.016	3.566IleGly: 3.566 ± 0.041	0.684IleHis: 0.684 ± 0.015	0.906IleIle: 0.906 ± 0.02	0.815IleLys: 0.815 ± 0.02	2.572IleLeu: 2.572 ± 0.033	0.46IleMet: 0.46 ± 0.015	0.749IleAsn: 0.749 ± 0.019	1.925IlePro: 1.925 ± 0.029	0.806IleGln: 0.806 ± 0.018	2.38IleArg: 2.38 ± 0.03	1.766IleSer: 1.766 ± 0.025	2.329IleThr: 2.329 ± 0.03	2.805IleVal: 2.805 ± 0.035	0.397IleTrp: 0.397 ± 0.012	0.572IleTyr: 0.572 ± 0.014	0.0IleXaa: 0.0 ± 0.0
Lys	3.147LysAla: 3.147 ± 0.042	0.134LysCys: 0.134 ± 0.008	1.464LysAsp: 1.464 ± 0.027	1.32LysGlu: 1.32 ± 0.026	0.511LysPhe: 0.511 ± 0.015	1.973LysGly: 1.973 ± 0.031	0.471LysHis: 0.471 ± 0.012	0.93LysIle: 0.93 ± 0.021	0.944LysLys: 0.944 ± 0.027	2.184LysLeu: 2.184 ± 0.029	0.407LysMet: 0.407 ± 0.013	0.575LysAsn: 0.575 ± 0.019	1.446LysPro: 1.446 ± 0.025	0.806LysGln: 0.806 ± 0.019	1.481LysArg: 1.481 ± 0.022	1.301LysSer: 1.301 ± 0.025	1.406LysThr: 1.406 ± 0.024	2.074LysVal: 2.074 ± 0.033	0.312LysTrp: 0.312 ± 0.011	0.528LysTyr: 0.528 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	14.714LeuAla: 14.714 ± 0.107	0.853LeuCys: 0.853 ± 0.017	6.658LeuAsp: 6.658 ± 0.057	4.717LeuGlu: 4.717 ± 0.049	2.606LeuPhe: 2.606 ± 0.033	9.09LeuGly: 9.09 ± 0.063	2.304LeuHis: 2.304 ± 0.03	3.411LeuIle: 3.411 ± 0.043	2.251LeuLys: 2.251 ± 0.031	11.25LeuLeu: 11.25 ± 0.077	1.707LeuMet: 1.707 ± 0.03	1.78LeuAsn: 1.78 ± 0.025	6.359LeuPro: 6.359 ± 0.059	2.377LeuGln: 2.377 ± 0.031	8.456LeuArg: 8.456 ± 0.067	5.326LeuSer: 5.326 ± 0.048	6.976LeuThr: 6.976 ± 0.053	8.665LeuVal: 8.665 ± 0.06	1.354LeuTrp: 1.354 ± 0.025	1.957LeuTyr: 1.957 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.266MetAla: 2.266 ± 0.031	0.141MetCys: 0.141 ± 0.007	0.938MetAsp: 0.938 ± 0.017	0.767MetGlu: 0.767 ± 0.015	0.459MetPhe: 0.459 ± 0.012	1.358MetGly: 1.358 ± 0.027	0.364MetHis: 0.364 ± 0.012	0.679MetIle: 0.679 ± 0.019	0.449MetLys: 0.449 ± 0.013	1.702MetLeu: 1.702 ± 0.024	0.309MetMet: 0.309 ± 0.011	0.433MetAsn: 0.433 ± 0.014	1.145MetPro: 1.145 ± 0.019	0.495MetGln: 0.495 ± 0.014	1.459MetArg: 1.459 ± 0.026	1.312MetSer: 1.312 ± 0.026	1.584MetThr: 1.584 ± 0.022	1.285MetVal: 1.285 ± 0.024	0.226MetTrp: 0.226 ± 0.009	0.329MetTyr: 0.329 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.254AsnAla: 2.254 ± 0.032	0.183AsnCys: 0.183 ± 0.008	1.008AsnAsp: 1.008 ± 0.021	0.859AsnGlu: 0.859 ± 0.017	0.507AsnPhe: 0.507 ± 0.013	2.024AsnGly: 2.024 ± 0.033	0.415AsnHis: 0.415 ± 0.012	0.706AsnIle: 0.706 ± 0.016	0.49AsnLys: 0.49 ± 0.015	1.732AsnLeu: 1.732 ± 0.029	0.316AsnMet: 0.316 ± 0.012	0.505AsnAsn: 0.505 ± 0.017	1.44AsnPro: 1.44 ± 0.023	0.575AsnGln: 0.575 ± 0.016	1.329AsnArg: 1.329 ± 0.023	1.073AsnSer: 1.073 ± 0.022	1.182AsnThr: 1.182 ± 0.023	1.435AsnVal: 1.435 ± 0.024	0.341AsnTrp: 0.341 ± 0.011	0.459AsnTyr: 0.459 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	7.834ProAla: 7.834 ± 0.06	0.35ProCys: 0.35 ± 0.01	4.517ProAsp: 4.517 ± 0.044	4.365ProGlu: 4.365 ± 0.04	1.509ProPhe: 1.509 ± 0.021	6.133ProGly: 6.133 ± 0.06	1.408ProHis: 1.408 ± 0.022	1.385ProIle: 1.385 ± 0.026	1.279ProLys: 1.279 ± 0.024	5.262ProLeu: 5.262 ± 0.04	0.984ProMet: 0.984 ± 0.018	0.952ProAsn: 0.952 ± 0.02	3.24ProPro: 3.24 ± 0.045	1.851ProGln: 1.851 ± 0.033	3.705ProArg: 3.705 ± 0.04	3.23ProSer: 3.23 ± 0.038	3.374ProThr: 3.374 ± 0.044	5.255ProVal: 5.255 ± 0.041	0.912ProTrp: 0.912 ± 0.018	1.487ProTyr: 1.487 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.849GlnAla: 3.849 ± 0.041	0.196GlnCys: 0.196 ± 0.008	1.496GlnAsp: 1.496 ± 0.023	1.58GlnGlu: 1.58 ± 0.028	0.725GlnPhe: 0.725 ± 0.017	2.428GlnGly: 2.428 ± 0.033	0.703GlnHis: 0.703 ± 0.016	1.145GlnIle: 1.145 ± 0.021	0.677GlnLys: 0.677 ± 0.016	3.222GlnLeu: 3.222 ± 0.032	0.549GlnMet: 0.549 ± 0.015	0.553GlnAsn: 0.553 ± 0.016	1.791GlnPro: 1.791 ± 0.035	1.336GlnGln: 1.336 ± 0.035	2.399GlnArg: 2.399 ± 0.03	1.363GlnSer: 1.363 ± 0.026	1.476GlnThr: 1.476 ± 0.026	2.498GlnVal: 2.498 ± 0.031	0.517GlnTrp: 0.517 ± 0.016	0.666GlnTyr: 0.666 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.338ArgAla: 9.338 ± 0.067	0.566ArgCys: 0.566 ± 0.015	4.212ArgAsp: 4.212 ± 0.045	4.708ArgGlu: 4.708 ± 0.048	2.332ArgPhe: 2.332 ± 0.028	5.533ArgGly: 5.533 ± 0.045	2.086ArgHis: 2.086 ± 0.03	3.295ArgIle: 3.295 ± 0.033	1.745ArgLys: 1.745 ± 0.026	8.687ArgLeu: 8.687 ± 0.07	1.691ArgMet: 1.691 ± 0.023	1.372ArgAsn: 1.372 ± 0.025	4.655ArgPro: 4.655 ± 0.043	2.33ArgGln: 2.33 ± 0.028	7.442ArgArg: 7.442 ± 0.068	3.95ArgSer: 3.95 ± 0.038	5.282ArgThr: 5.282 ± 0.043	5.682ArgVal: 5.682 ± 0.046	1.355ArgTrp: 1.355 ± 0.023	1.841ArgTyr: 1.841 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.789SerAla: 6.789 ± 0.055	0.435SerCys: 0.435 ± 0.013	2.847SerAsp: 2.847 ± 0.034	2.523SerGlu: 2.523 ± 0.031	1.545SerPhe: 1.545 ± 0.025	5.992SerGly: 5.992 ± 0.06	1.059SerHis: 1.059 ± 0.019	1.51SerIle: 1.51 ± 0.023	1.158SerLys: 1.158 ± 0.024	4.871SerLeu: 4.871 ± 0.044	1.097SerMet: 1.097 ± 0.019	0.987SerAsn: 0.987 ± 0.022	3.179SerPro: 3.179 ± 0.034	1.33SerGln: 1.33 ± 0.024	3.632SerArg: 3.632 ± 0.039	3.049SerSer: 3.049 ± 0.051	3.207SerThr: 3.207 ± 0.04	4.35SerVal: 4.35 ± 0.044	0.922SerTrp: 0.922 ± 0.021	1.343SerTyr: 1.343 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	8.834ThrAla: 8.834 ± 0.061	0.482ThrCys: 0.482 ± 0.014	3.826ThrAsp: 3.826 ± 0.038	3.356ThrGlu: 3.356 ± 0.034	1.677ThrPhe: 1.677 ± 0.023	6.589ThrGly: 6.589 ± 0.06	1.257ThrHis: 1.257 ± 0.019	1.808ThrIle: 1.808 ± 0.027	1.304ThrLys: 1.304 ± 0.025	5.828ThrLeu: 5.828 ± 0.047	0.96ThrMet: 0.96 ± 0.021	1.105ThrAsn: 1.105 ± 0.024	4.142ThrPro: 4.142 ± 0.043	1.489ThrGln: 1.489 ± 0.024	3.87ThrArg: 3.87 ± 0.039	3.372ThrSer: 3.372 ± 0.039	4.004ThrThr: 4.004 ± 0.046	6.112ThrVal: 6.112 ± 0.052	1.009ThrTrp: 1.009 ± 0.02	1.482ThrTyr: 1.482 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.431ValAla: 10.431 ± 0.076	0.783ValCys: 0.783 ± 0.016	4.863ValAsp: 4.863 ± 0.042	4.777ValGlu: 4.777 ± 0.045	2.44ValPhe: 2.44 ± 0.029	6.466ValGly: 6.466 ± 0.053	1.967ValHis: 1.967 ± 0.027	3.023ValIle: 3.023 ± 0.037	1.859ValLys: 1.859 ± 0.027	9.259ValLeu: 9.259 ± 0.066	1.443ValMet: 1.443 ± 0.022	1.721ValAsn: 1.721 ± 0.024	5.067ValPro: 5.067 ± 0.039	2.179ValGln: 2.179 ± 0.025	7.018ValArg: 7.018 ± 0.059	4.359ValSer: 4.359 ± 0.043	5.713ValThr: 5.713 ± 0.048	7.892ValVal: 7.892 ± 0.065	1.191ValTrp: 1.191 ± 0.019	1.635ValTyr: 1.635 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.679TrpAla: 1.679 ± 0.024	0.159TrpCys: 0.159 ± 0.008	0.882TrpAsp: 0.882 ± 0.017	0.752TrpGlu: 0.752 ± 0.018	0.509TrpPhe: 0.509 ± 0.016	1.123TrpGly: 1.123 ± 0.02	0.381TrpHis: 0.381 ± 0.011	0.591TrpIle: 0.591 ± 0.013	0.403TrpLys: 0.403 ± 0.011	1.81TrpLeu: 1.81 ± 0.025	0.298TrpMet: 0.298 ± 0.011	0.461TrpAsn: 0.461 ± 0.015	0.793TrpPro: 0.793 ± 0.017	0.705TrpGln: 0.705 ± 0.016	1.34TrpArg: 1.34 ± 0.022	0.972TrpSer: 0.972 ± 0.019	1.106TrpThr: 1.106 ± 0.02	1.034TrpVal: 1.034 ± 0.022	0.364TrpTrp: 0.364 ± 0.011	0.404TrpTyr: 0.404 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.858TyrAla: 2.858 ± 0.032	0.194TyrCys: 0.194 ± 0.009	1.683TyrAsp: 1.683 ± 0.034	1.357TyrGlu: 1.357 ± 0.022	0.691TyrPhe: 0.691 ± 0.017	2.388TyrGly: 2.388 ± 0.034	0.406TyrHis: 0.406 ± 0.011	0.54TyrIle: 0.54 ± 0.013	0.466TyrLys: 0.466 ± 0.015	2.137TyrLeu: 2.137 ± 0.026	0.274TyrMet: 0.274 ± 0.01	0.467TyrAsn: 0.467 ± 0.014	1.058TyrPro: 1.058 ± 0.023	0.655TyrGln: 0.655 ± 0.017	1.867TyrArg: 1.867 ± 0.027	1.021TyrSer: 1.021 ± 0.019	1.266TyrThr: 1.266 ± 0.024	1.768TyrVal: 1.768 ± 0.025	0.387TyrTrp: 0.387 ± 0.012	0.492TyrTyr: 0.492 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9110 proteins (2933057 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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