Amino acid dipepetide frequency for Methylomagnum ishizawai

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.941AlaAla: 15.941 ± 0.232	1.251AlaCys: 1.251 ± 0.03	6.411AlaAsp: 6.411 ± 0.08	7.966AlaGlu: 7.966 ± 0.093	3.68AlaPhe: 3.68 ± 0.055	10.365AlaGly: 10.365 ± 0.126	2.403AlaHis: 2.403 ± 0.046	5.12AlaIle: 5.12 ± 0.061	3.914AlaLys: 3.914 ± 0.07	14.567AlaLeu: 14.567 ± 0.17	2.667AlaMet: 2.667 ± 0.052	2.877AlaAsn: 2.877 ± 0.06	5.367AlaPro: 5.367 ± 0.094	4.879AlaGln: 4.879 ± 0.103	7.809AlaArg: 7.809 ± 0.093	5.096AlaSer: 5.096 ± 0.063	5.64AlaThr: 5.64 ± 0.073	8.3AlaVal: 8.3 ± 0.083	1.906AlaTrp: 1.906 ± 0.042	2.948AlaTyr: 2.948 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.139CysAla: 1.139 ± 0.031	0.136CysCys: 0.136 ± 0.009	0.503CysAsp: 0.503 ± 0.022	0.513CysGlu: 0.513 ± 0.019	0.33CysPhe: 0.33 ± 0.015	1.05CysGly: 1.05 ± 0.028	0.327CysHis: 0.327 ± 0.017	0.299CysIle: 0.299 ± 0.014	0.258CysLys: 0.258 ± 0.012	1.122CysLeu: 1.122 ± 0.031	0.145CysMet: 0.145 ± 0.011	0.224CysAsn: 0.224 ± 0.012	0.569CysPro: 0.569 ± 0.019	0.366CysGln: 0.366 ± 0.016	0.773CysArg: 0.773 ± 0.023	0.446CysSer: 0.446 ± 0.019	0.37CysThr: 0.37 ± 0.017	0.629CysVal: 0.629 ± 0.019	0.149CysTrp: 0.149 ± 0.01	0.28CysTyr: 0.28 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.218AspAla: 6.218 ± 0.077	0.556AspCys: 0.556 ± 0.021	2.676AspAsp: 2.676 ± 0.066	3.012AspGlu: 3.012 ± 0.056	2.41AspPhe: 2.41 ± 0.038	5.122AspGly: 5.122 ± 0.095	1.224AspHis: 1.224 ± 0.027	3.163AspIle: 3.163 ± 0.048	1.908AspLys: 1.908 ± 0.056	5.973AspLeu: 5.973 ± 0.081	1.043AspMet: 1.043 ± 0.029	1.505AspAsn: 1.505 ± 0.042	3.82AspPro: 3.82 ± 0.063	1.865AspGln: 1.865 ± 0.039	3.822AspArg: 3.822 ± 0.062	2.669AspSer: 2.669 ± 0.051	2.933AspThr: 2.933 ± 0.063	2.95AspVal: 2.95 ± 0.047	1.124AspTrp: 1.124 ± 0.029	1.921AspTyr: 1.921 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.585GluAla: 7.585 ± 0.1	0.51GluCys: 0.51 ± 0.018	2.765GluAsp: 2.765 ± 0.048	3.176GluGlu: 3.176 ± 0.063	2.166GluPhe: 2.166 ± 0.044	4.014GluGly: 4.014 ± 0.059	1.3GluHis: 1.3 ± 0.027	3.346GluIle: 3.346 ± 0.049	2.096GluLys: 2.096 ± 0.053	6.204GluLeu: 6.204 ± 0.075	1.173GluMet: 1.173 ± 0.029	1.642GluAsn: 1.642 ± 0.033	3.166GluPro: 3.166 ± 0.057	2.615GluGln: 2.615 ± 0.046	5.203GluArg: 5.203 ± 0.077	2.823GluSer: 2.823 ± 0.049	3.454GluThr: 3.454 ± 0.055	3.898GluVal: 3.898 ± 0.062	0.825GluTrp: 0.825 ± 0.025	1.463GluTyr: 1.463 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.823PheAla: 3.823 ± 0.053	0.398PheCys: 0.398 ± 0.017	2.466PheAsp: 2.466 ± 0.044	2.108PheGlu: 2.108 ± 0.034	1.383PhePhe: 1.383 ± 0.03	3.327PheGly: 3.327 ± 0.046	0.904PheHis: 0.904 ± 0.024	1.596PheIle: 1.596 ± 0.036	1.339PheLys: 1.339 ± 0.037	3.696PheLeu: 3.696 ± 0.065	0.769PheMet: 0.769 ± 0.024	1.139PheAsn: 1.139 ± 0.03	1.824PhePro: 1.824 ± 0.036	1.38PheGln: 1.38 ± 0.028	2.359PheArg: 2.359 ± 0.039	2.092PheSer: 2.092 ± 0.04	1.804PheThr: 1.804 ± 0.038	2.395PheVal: 2.395 ± 0.045	0.558PheTrp: 0.558 ± 0.017	1.013PheTyr: 1.013 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	7.76GlyAla: 7.76 ± 0.091	1.003GlyCys: 1.003 ± 0.03	4.594GlyAsp: 4.594 ± 0.105	4.767GlyGlu: 4.767 ± 0.066	3.822GlyPhe: 3.822 ± 0.059	7.976GlyGly: 7.976 ± 0.156	2.033GlyHis: 2.033 ± 0.042	4.137GlyIle: 4.137 ± 0.054	3.665GlyLys: 3.665 ± 0.053	9.843GlyLeu: 9.843 ± 0.104	2.077GlyMet: 2.077 ± 0.036	2.488GlyAsn: 2.488 ± 0.09	3.398GlyPro: 3.398 ± 0.053	3.564GlyGln: 3.564 ± 0.049	5.941GlyArg: 5.941 ± 0.081	4.359GlySer: 4.359 ± 0.077	4.411GlyThr: 4.411 ± 0.084	5.955GlyVal: 5.955 ± 0.081	1.523GlyTrp: 1.523 ± 0.029	2.722GlyTyr: 2.722 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.386HisAla: 2.386 ± 0.05	0.292HisCys: 0.292 ± 0.014	1.161HisAsp: 1.161 ± 0.031	1.119HisGlu: 1.119 ± 0.032	0.908HisPhe: 0.908 ± 0.026	2.183HisGly: 2.183 ± 0.041	0.707HisHis: 0.707 ± 0.026	1.116HisIle: 1.116 ± 0.029	0.662HisLys: 0.662 ± 0.022	2.41HisLeu: 2.41 ± 0.047	0.422HisMet: 0.422 ± 0.018	0.573HisAsn: 0.573 ± 0.018	1.77HisPro: 1.77 ± 0.036	0.762HisGln: 0.762 ± 0.021	1.752HisArg: 1.752 ± 0.038	1.134HisSer: 1.134 ± 0.027	1.072HisThr: 1.072 ± 0.027	1.18HisVal: 1.18 ± 0.028	0.432HisTrp: 0.432 ± 0.015	0.749HisTyr: 0.749 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.812IleAla: 5.812 ± 0.063	0.393IleCys: 0.393 ± 0.015	3.175IleAsp: 3.175 ± 0.052	3.252IleGlu: 3.252 ± 0.051	1.368IlePhe: 1.368 ± 0.034	4.0IleGly: 4.0 ± 0.056	1.15IleHis: 1.15 ± 0.033	1.735IleIle: 1.735 ± 0.042	1.699IleLys: 1.699 ± 0.043	4.384IleLeu: 4.384 ± 0.062	0.721IleMet: 0.721 ± 0.024	1.444IleAsn: 1.444 ± 0.037	2.694IlePro: 2.694 ± 0.042	1.664IleGln: 1.664 ± 0.035	3.006IleArg: 3.006 ± 0.05	2.259IleSer: 2.259 ± 0.042	2.217IleThr: 2.217 ± 0.044	3.087IleVal: 3.087 ± 0.051	0.469IleTrp: 0.469 ± 0.017	1.117IleTyr: 1.117 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.009LysAla: 4.009 ± 0.066	0.206LysCys: 0.206 ± 0.01	1.813LysAsp: 1.813 ± 0.042	1.753LysGlu: 1.753 ± 0.045	1.013LysPhe: 1.013 ± 0.025	2.363LysGly: 2.363 ± 0.048	0.803LysHis: 0.803 ± 0.023	1.803LysIle: 1.803 ± 0.045	1.455LysLys: 1.455 ± 0.042	4.032LysLeu: 4.032 ± 0.067	0.664LysMet: 0.664 ± 0.021	1.068LysAsn: 1.068 ± 0.029	2.4LysPro: 2.4 ± 0.043	1.397LysGln: 1.397 ± 0.031	2.381LysArg: 2.381 ± 0.048	1.835LysSer: 1.835 ± 0.048	2.265LysThr: 2.265 ± 0.055	2.281LysVal: 2.281 ± 0.046	0.306LysTrp: 0.306 ± 0.014	0.756LysTyr: 0.756 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	15.346LeuAla: 15.346 ± 0.155	1.096LeuCys: 1.096 ± 0.029	7.345LeuAsp: 7.345 ± 0.097	6.726LeuGlu: 6.726 ± 0.079	3.897LeuPhe: 3.897 ± 0.055	9.598LeuGly: 9.598 ± 0.09	2.205LeuHis: 2.205 ± 0.038	4.523LeuIle: 4.523 ± 0.07	4.106LeuLys: 4.106 ± 0.069	11.593LeuLeu: 11.593 ± 0.145	2.084LeuMet: 2.084 ± 0.041	3.068LeuAsn: 3.068 ± 0.054	6.437LeuPro: 6.437 ± 0.079	3.109LeuGln: 3.109 ± 0.054	8.049LeuArg: 8.049 ± 0.107	6.01LeuSer: 6.01 ± 0.065	4.855LeuThr: 4.855 ± 0.1	7.117LeuVal: 7.117 ± 0.089	1.564LeuTrp: 1.564 ± 0.041	2.536LeuTyr: 2.536 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.559MetAla: 2.559 ± 0.043	0.125MetCys: 0.125 ± 0.008	1.162MetAsp: 1.162 ± 0.029	1.121MetGlu: 1.121 ± 0.034	0.529MetPhe: 0.529 ± 0.018	1.591MetGly: 1.591 ± 0.036	0.376MetHis: 0.376 ± 0.016	0.927MetIle: 0.927 ± 0.025	0.879MetLys: 0.879 ± 0.025	1.953MetLeu: 1.953 ± 0.038	0.403MetMet: 0.403 ± 0.017	0.864MetAsn: 0.864 ± 0.025	1.194MetPro: 1.194 ± 0.028	0.673MetGln: 0.673 ± 0.023	1.336MetArg: 1.336 ± 0.029	1.132MetSer: 1.132 ± 0.03	1.09MetThr: 1.09 ± 0.024	1.337MetVal: 1.337 ± 0.033	0.15MetTrp: 0.15 ± 0.01	0.304MetTyr: 0.304 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.893AsnAla: 2.893 ± 0.048	0.252AsnCys: 0.252 ± 0.012	1.339AsnAsp: 1.339 ± 0.056	1.19AsnGlu: 1.19 ± 0.027	0.951AsnPhe: 0.951 ± 0.025	2.385AsnGly: 2.385 ± 0.067	0.693AsnHis: 0.693 ± 0.021	1.499AsnIle: 1.499 ± 0.042	0.854AsnLys: 0.854 ± 0.027	3.261AsnLeu: 3.261 ± 0.05	0.467AsnMet: 0.467 ± 0.018	0.86AsnAsn: 0.86 ± 0.032	2.418AsnPro: 2.418 ± 0.043	1.117AsnGln: 1.117 ± 0.027	1.857AsnArg: 1.857 ± 0.038	1.346AsnSer: 1.346 ± 0.04	1.506AsnThr: 1.506 ± 0.039	1.547AsnVal: 1.547 ± 0.038	0.361AsnTrp: 0.361 ± 0.014	0.776AsnTyr: 0.776 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	6.966ProAla: 6.966 ± 0.093	0.461ProCys: 0.461 ± 0.02	3.799ProAsp: 3.799 ± 0.057	4.688ProGlu: 4.688 ± 0.074	1.804ProPhe: 1.804 ± 0.033	5.53ProGly: 5.53 ± 0.074	1.15ProHis: 1.15 ± 0.03	2.127ProIle: 2.127 ± 0.04	1.867ProLys: 1.867 ± 0.043	5.361ProLeu: 5.361 ± 0.068	1.222ProMet: 1.222 ± 0.029	1.388ProAsn: 1.388 ± 0.03	3.982ProPro: 3.982 ± 0.084	1.834ProGln: 1.834 ± 0.038	3.012ProArg: 3.012 ± 0.047	2.66ProSer: 2.66 ± 0.045	2.707ProThr: 2.707 ± 0.052	4.397ProVal: 4.397 ± 0.063	0.918ProTrp: 0.918 ± 0.026	1.312ProTyr: 1.312 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	5.398GlnAla: 5.398 ± 0.073	0.282GlnCys: 0.282 ± 0.012	1.909GlnAsp: 1.909 ± 0.035	1.917GlnGlu: 1.917 ± 0.039	1.238GlnPhe: 1.238 ± 0.031	3.214GlnGly: 3.214 ± 0.054	0.835GlnHis: 0.835 ± 0.026	1.799GlnIle: 1.799 ± 0.037	1.222GlnLys: 1.222 ± 0.031	3.281GlnLeu: 3.281 ± 0.052	0.696GlnMet: 0.696 ± 0.021	0.955GlnAsn: 0.955 ± 0.028	2.213GlnPro: 2.213 ± 0.04	1.476GlnGln: 1.476 ± 0.04	2.973GlnArg: 2.973 ± 0.051	1.82GlnSer: 1.82 ± 0.039	1.99GlnThr: 1.99 ± 0.041	2.684GlnVal: 2.684 ± 0.074	0.519GlnTrp: 0.519 ± 0.021	0.909GlnTyr: 0.909 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.143ArgAla: 7.143 ± 0.096	0.665ArgCys: 0.665 ± 0.024	3.775ArgAsp: 3.775 ± 0.056	4.604ArgGlu: 4.604 ± 0.073	2.941ArgPhe: 2.941 ± 0.046	4.742ArgGly: 4.742 ± 0.066	1.995ArgHis: 1.995 ± 0.041	3.733ArgIle: 3.733 ± 0.052	2.441ArgLys: 2.441 ± 0.049	8.787ArgLeu: 8.787 ± 0.106	1.521ArgMet: 1.521 ± 0.033	1.846ArgAsn: 1.846 ± 0.035	3.599ArgPro: 3.599 ± 0.065	2.956ArgGln: 2.956 ± 0.049	5.654ArgArg: 5.654 ± 0.081	2.894ArgSer: 2.894 ± 0.044	2.762ArgThr: 2.762 ± 0.045	4.658ArgVal: 4.658 ± 0.058	1.289ArgTrp: 1.289 ± 0.034	2.265ArgTyr: 2.265 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	5.621SerAla: 5.621 ± 0.065	0.428SerCys: 0.428 ± 0.017	2.356SerAsp: 2.356 ± 0.049	2.438SerGlu: 2.438 ± 0.05	1.911SerPhe: 1.911 ± 0.036	5.011SerGly: 5.011 ± 0.084	1.132SerHis: 1.132 ± 0.029	2.29SerIle: 2.29 ± 0.042	1.532SerLys: 1.532 ± 0.037	5.768SerLeu: 5.768 ± 0.073	0.95SerMet: 0.95 ± 0.025	1.312SerAsn: 1.312 ± 0.036	2.867SerPro: 2.867 ± 0.043	1.705SerGln: 1.705 ± 0.036	3.137SerArg: 3.137 ± 0.044	2.487SerSer: 2.487 ± 0.053	2.427SerThr: 2.427 ± 0.047	3.272SerVal: 3.272 ± 0.053	0.701SerTrp: 0.701 ± 0.023	1.324SerTyr: 1.324 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.138ThrAla: 6.138 ± 0.135	0.411ThrCys: 0.411 ± 0.017	2.585ThrAsp: 2.585 ± 0.048	2.444ThrGlu: 2.444 ± 0.043	1.469ThrPhe: 1.469 ± 0.04	4.939ThrGly: 4.939 ± 0.07	1.146ThrHis: 1.146 ± 0.026	1.799ThrIle: 1.799 ± 0.039	1.053ThrLys: 1.053 ± 0.03	6.518ThrLeu: 6.518 ± 0.079	0.686ThrMet: 0.686 ± 0.024	1.127ThrAsn: 1.127 ± 0.029	3.591ThrPro: 3.591 ± 0.055	2.013ThrGln: 2.013 ± 0.043	2.872ThrArg: 2.872 ± 0.043	2.04ThrSer: 2.04 ± 0.047	2.621ThrThr: 2.621 ± 0.119	3.899ThrVal: 3.899 ± 0.061	0.647ThrTrp: 0.647 ± 0.021	1.172ThrTyr: 1.172 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.143ValAla: 8.143 ± 0.119	0.698ValCys: 0.698 ± 0.02	3.941ValAsp: 3.941 ± 0.048	4.578ValGlu: 4.578 ± 0.069	2.834ValPhe: 2.834 ± 0.046	5.33ValGly: 5.33 ± 0.067	1.398ValHis: 1.398 ± 0.029	2.882ValIle: 2.882 ± 0.044	2.395ValLys: 2.395 ± 0.049	7.293ValLeu: 7.293 ± 0.078	1.288ValMet: 1.288 ± 0.034	1.984ValAsn: 1.984 ± 0.038	3.645ValPro: 3.645 ± 0.05	2.151ValGln: 2.151 ± 0.037	4.629ValArg: 4.629 ± 0.06	3.439ValSer: 3.439 ± 0.051	2.899ValThr: 2.899 ± 0.06	5.437ValVal: 5.437 ± 0.078	0.958ValTrp: 0.958 ± 0.028	1.804ValTyr: 1.804 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.353TrpAla: 1.353 ± 0.032	0.148TrpCys: 0.148 ± 0.01	0.701TrpAsp: 0.701 ± 0.022	0.776TrpGlu: 0.776 ± 0.023	0.591TrpPhe: 0.591 ± 0.021	0.93TrpGly: 0.93 ± 0.029	0.391TrpHis: 0.391 ± 0.014	0.696TrpIle: 0.696 ± 0.021	0.497TrpLys: 0.497 ± 0.02	2.105TrpLeu: 2.105 ± 0.045	0.329TrpMet: 0.329 ± 0.017	0.537TrpAsn: 0.537 ± 0.019	0.782TrpPro: 0.782 ± 0.026	0.645TrpGln: 0.645 ± 0.019	1.345TrpArg: 1.345 ± 0.034	0.781TrpSer: 0.781 ± 0.024	0.779TrpThr: 0.779 ± 0.028	1.102TrpVal: 1.102 ± 0.029	0.225TrpTrp: 0.225 ± 0.012	0.343TrpTyr: 0.343 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.873TyrAla: 2.873 ± 0.047	0.317TyrCys: 0.317 ± 0.014	1.437TyrAsp: 1.437 ± 0.036	1.275TyrGlu: 1.275 ± 0.028	1.129TyrPhe: 1.129 ± 0.028	2.371TyrGly: 2.371 ± 0.05	0.617TyrHis: 0.617 ± 0.02	1.054TyrIle: 1.054 ± 0.029	0.761TyrLys: 0.761 ± 0.023	3.112TyrLeu: 3.112 ± 0.046	0.374TyrMet: 0.374 ± 0.017	0.671TyrAsn: 0.671 ± 0.024	1.448TyrPro: 1.448 ± 0.032	1.161TyrGln: 1.161 ± 0.027	2.361TyrArg: 2.361 ± 0.043	1.347TyrSer: 1.347 ± 0.03	1.371TyrThr: 1.371 ± 0.037	1.6TyrVal: 1.6 ± 0.037	0.434TyrTrp: 0.434 ± 0.015	0.821TyrTyr: 0.821 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4600 proteins (1591077 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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