Amino acid dipepetide frequency for Achromobacter phage vB_AxyP_19-32_Axy12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.659AlaAla: 10.659 ± 1.198
0.658AlaCys: 0.658 ± 0.211
4.43AlaAsp: 4.43 ± 0.554
6.668AlaGlu: 6.668 ± 0.777
3.553AlaPhe: 3.553 ± 0.434
6.711AlaGly: 6.711 ± 0.899
1.404AlaHis: 1.404 ± 0.193
5.088AlaIle: 5.088 ± 0.539
5.132AlaLys: 5.132 ± 0.598
9.08AlaLeu: 9.08 ± 1.145
2.895AlaMet: 2.895 ± 0.281
4.474AlaAsn: 4.474 ± 0.483
4.474AlaPro: 4.474 ± 0.473
5.132AlaGln: 5.132 ± 0.663
3.772AlaArg: 3.772 ± 0.467
4.562AlaSer: 4.562 ± 0.41
6.053AlaThr: 6.053 ± 0.617
6.492AlaVal: 6.492 ± 0.814
1.404AlaTrp: 1.404 ± 0.264
3.158AlaTyr: 3.158 ± 0.337
0.0AlaXaa: 0.0 ± 0.0
Cys
0.395CysAla: 0.395 ± 0.179
0.132CysCys: 0.132 ± 0.082
0.439CysAsp: 0.439 ± 0.164
0.263CysGlu: 0.263 ± 0.114
0.351CysPhe: 0.351 ± 0.168
0.746CysGly: 0.746 ± 0.192
0.175CysHis: 0.175 ± 0.085
0.439CysIle: 0.439 ± 0.152
0.702CysLys: 0.702 ± 0.181
0.702CysLeu: 0.702 ± 0.23
0.044CysMet: 0.044 ± 0.043
0.307CysAsn: 0.307 ± 0.153
0.307CysPro: 0.307 ± 0.127
0.483CysGln: 0.483 ± 0.174
0.483CysArg: 0.483 ± 0.173
0.351CysSer: 0.351 ± 0.126
0.395CysThr: 0.395 ± 0.124
0.307CysVal: 0.307 ± 0.128
0.219CysTrp: 0.219 ± 0.101
0.175CysTyr: 0.175 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
6.492AspAla: 6.492 ± 0.89
0.57AspCys: 0.57 ± 0.161
2.72AspAsp: 2.72 ± 0.384
3.334AspGlu: 3.334 ± 0.37
2.895AspPhe: 2.895 ± 0.383
4.65AspGly: 4.65 ± 0.518
0.921AspHis: 0.921 ± 0.26
3.114AspIle: 3.114 ± 0.398
2.807AspLys: 2.807 ± 0.324
5.088AspLeu: 5.088 ± 0.414
2.193AspMet: 2.193 ± 0.324
1.755AspAsn: 1.755 ± 0.299
3.202AspPro: 3.202 ± 0.398
2.807AspGln: 2.807 ± 0.334
2.807AspArg: 2.807 ± 0.351
2.895AspSer: 2.895 ± 0.325
3.158AspThr: 3.158 ± 0.354
3.334AspVal: 3.334 ± 0.445
0.833AspTrp: 0.833 ± 0.191
2.588AspTyr: 2.588 ± 0.414
0.0AspXaa: 0.0 ± 0.0
Glu
7.194GluAla: 7.194 ± 0.744
0.395GluCys: 0.395 ± 0.143
3.597GluAsp: 3.597 ± 0.358
5.308GluGlu: 5.308 ± 0.682
1.974GluPhe: 1.974 ± 0.302
4.211GluGly: 4.211 ± 0.476
1.316GluHis: 1.316 ± 0.233
2.807GluIle: 2.807 ± 0.371
4.036GluLys: 4.036 ± 0.567
6.273GluLeu: 6.273 ± 0.583
1.974GluMet: 1.974 ± 0.297
2.325GluAsn: 2.325 ± 0.278
2.193GluPro: 2.193 ± 0.345
3.027GluGln: 3.027 ± 0.382
3.509GluArg: 3.509 ± 0.44
2.851GluSer: 2.851 ± 0.314
2.939GluThr: 2.939 ± 0.315
4.299GluVal: 4.299 ± 0.517
0.79GluTrp: 0.79 ± 0.177
2.193GluTyr: 2.193 ± 0.27
0.0GluXaa: 0.0 ± 0.0
Phe
2.895PheAla: 2.895 ± 0.436
0.395PheCys: 0.395 ± 0.152
2.149PheAsp: 2.149 ± 0.331
1.755PheGlu: 1.755 ± 0.29
1.491PhePhe: 1.491 ± 0.228
3.29PheGly: 3.29 ± 0.343
0.57PheHis: 0.57 ± 0.167
2.062PheIle: 2.062 ± 0.276
2.149PheLys: 2.149 ± 0.398
2.895PheLeu: 2.895 ± 0.307
1.448PheMet: 1.448 ± 0.262
1.93PheAsn: 1.93 ± 0.27
1.097PhePro: 1.097 ± 0.176
1.448PheGln: 1.448 ± 0.244
2.106PheArg: 2.106 ± 0.299
2.149PheSer: 2.149 ± 0.431
2.413PheThr: 2.413 ± 0.362
2.106PheVal: 2.106 ± 0.301
0.395PheTrp: 0.395 ± 0.151
1.097PheTyr: 1.097 ± 0.194
0.0PheXaa: 0.0 ± 0.0
Gly
6.229GlyAla: 6.229 ± 0.684
0.483GlyCys: 0.483 ± 0.169
4.211GlyAsp: 4.211 ± 0.436
4.255GlyGlu: 4.255 ± 0.398
2.72GlyPhe: 2.72 ± 0.343
5.176GlyGly: 5.176 ± 0.903
1.535GlyHis: 1.535 ± 0.334
4.079GlyIle: 4.079 ± 0.339
5.045GlyLys: 5.045 ± 0.548
4.957GlyLeu: 4.957 ± 0.607
3.422GlyMet: 3.422 ± 0.334
4.123GlyAsn: 4.123 ± 0.369
1.886GlyPro: 1.886 ± 0.33
3.202GlyGln: 3.202 ± 0.425
4.167GlyArg: 4.167 ± 0.515
4.737GlySer: 4.737 ± 0.563
4.299GlyThr: 4.299 ± 0.41
4.255GlyVal: 4.255 ± 0.433
1.184GlyTrp: 1.184 ± 0.263
2.983GlyTyr: 2.983 ± 0.353
0.0GlyXaa: 0.0 ± 0.0
His
1.579HisAla: 1.579 ± 0.31
0.219HisCys: 0.219 ± 0.106
1.272HisAsp: 1.272 ± 0.245
1.491HisGlu: 1.491 ± 0.31
0.57HisPhe: 0.57 ± 0.141
1.053HisGly: 1.053 ± 0.261
0.702HisHis: 0.702 ± 0.209
1.141HisIle: 1.141 ± 0.291
1.448HisLys: 1.448 ± 0.288
1.755HisLeu: 1.755 ± 0.326
0.658HisMet: 0.658 ± 0.167
0.746HisAsn: 0.746 ± 0.125
1.009HisPro: 1.009 ± 0.31
0.921HisGln: 0.921 ± 0.193
1.316HisArg: 1.316 ± 0.262
0.526HisSer: 0.526 ± 0.194
0.877HisThr: 0.877 ± 0.18
1.009HisVal: 1.009 ± 0.327
0.483HisTrp: 0.483 ± 0.147
1.053HisTyr: 1.053 ± 0.224
0.0HisXaa: 0.0 ± 0.0
Ile
5.22IleAla: 5.22 ± 0.425
0.219IleCys: 0.219 ± 0.102
3.597IleAsp: 3.597 ± 0.385
4.079IleGlu: 4.079 ± 0.589
1.491IlePhe: 1.491 ± 0.255
3.202IleGly: 3.202 ± 0.375
1.491IleHis: 1.491 ± 0.243
2.588IleIle: 2.588 ± 0.442
2.983IleLys: 2.983 ± 0.299
3.729IleLeu: 3.729 ± 0.437
1.272IleMet: 1.272 ± 0.219
2.325IleAsn: 2.325 ± 0.312
2.851IlePro: 2.851 ± 0.305
2.764IleGln: 2.764 ± 0.317
2.325IleArg: 2.325 ± 0.346
2.5IleSer: 2.5 ± 0.274
3.378IleThr: 3.378 ± 0.409
3.027IleVal: 3.027 ± 0.374
0.439IleTrp: 0.439 ± 0.158
1.535IleTyr: 1.535 ± 0.269
0.0IleXaa: 0.0 ± 0.0
Lys
5.878LysAla: 5.878 ± 0.594
0.219LysCys: 0.219 ± 0.117
3.772LysAsp: 3.772 ± 0.375
3.641LysGlu: 3.641 ± 0.539
1.491LysPhe: 1.491 ± 0.271
3.948LysGly: 3.948 ± 0.371
1.535LysHis: 1.535 ± 0.325
2.413LysIle: 2.413 ± 0.271
4.255LysLys: 4.255 ± 0.578
5.615LysLeu: 5.615 ± 0.466
2.193LysMet: 2.193 ± 0.327
2.544LysAsn: 2.544 ± 0.272
2.544LysPro: 2.544 ± 0.399
3.597LysGln: 3.597 ± 0.339
2.851LysArg: 2.851 ± 0.454
3.685LysSer: 3.685 ± 0.449
3.246LysThr: 3.246 ± 0.419
3.465LysVal: 3.465 ± 0.403
0.614LysTrp: 0.614 ± 0.138
1.404LysTyr: 1.404 ± 0.264
0.0LysXaa: 0.0 ± 0.0
Leu
7.501LeuAla: 7.501 ± 0.911
0.79LeuCys: 0.79 ± 0.214
5.088LeuAsp: 5.088 ± 0.357
4.694LeuGlu: 4.694 ± 0.413
2.983LeuPhe: 2.983 ± 0.339
6.624LeuGly: 6.624 ± 0.577
2.018LeuHis: 2.018 ± 0.411
3.465LeuIle: 3.465 ± 0.309
4.913LeuLys: 4.913 ± 0.429
6.141LeuLeu: 6.141 ± 0.599
2.72LeuMet: 2.72 ± 0.327
4.299LeuAsn: 4.299 ± 0.433
4.211LeuPro: 4.211 ± 0.377
3.685LeuGln: 3.685 ± 0.387
4.299LeuArg: 4.299 ± 0.48
4.913LeuSer: 4.913 ± 0.473
6.053LeuThr: 6.053 ± 0.498
5.922LeuVal: 5.922 ± 0.394
1.053LeuTrp: 1.053 ± 0.231
2.456LeuTyr: 2.456 ± 0.296
0.0LeuXaa: 0.0 ± 0.0
Met
2.764MetAla: 2.764 ± 0.352
0.219MetCys: 0.219 ± 0.11
2.281MetAsp: 2.281 ± 0.318
2.149MetGlu: 2.149 ± 0.278
0.877MetPhe: 0.877 ± 0.214
2.456MetGly: 2.456 ± 0.372
0.746MetHis: 0.746 ± 0.203
2.281MetIle: 2.281 ± 0.271
1.798MetLys: 1.798 ± 0.338
3.027MetLeu: 3.027 ± 0.351
0.746MetMet: 0.746 ± 0.177
1.623MetAsn: 1.623 ± 0.232
1.535MetPro: 1.535 ± 0.277
1.93MetGln: 1.93 ± 0.258
1.842MetArg: 1.842 ± 0.27
2.369MetSer: 2.369 ± 0.259
2.193MetThr: 2.193 ± 0.232
1.93MetVal: 1.93 ± 0.321
0.395MetTrp: 0.395 ± 0.144
0.79MetTyr: 0.79 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
4.123AsnAla: 4.123 ± 0.43
0.263AsnCys: 0.263 ± 0.13
2.149AsnAsp: 2.149 ± 0.293
2.456AsnGlu: 2.456 ± 0.34
1.404AsnPhe: 1.404 ± 0.225
3.334AsnGly: 3.334 ± 0.526
0.702AsnHis: 0.702 ± 0.154
1.755AsnIle: 1.755 ± 0.369
1.886AsnLys: 1.886 ± 0.326
4.43AsnLeu: 4.43 ± 0.441
1.711AsnMet: 1.711 ± 0.326
2.281AsnAsn: 2.281 ± 0.475
3.553AsnPro: 3.553 ± 0.465
2.895AsnGln: 2.895 ± 0.273
2.413AsnArg: 2.413 ± 0.327
3.114AsnSer: 3.114 ± 0.413
2.939AsnThr: 2.939 ± 0.488
2.764AsnVal: 2.764 ± 0.314
0.833AsnTrp: 0.833 ± 0.217
1.535AsnTyr: 1.535 ± 0.195
0.0AsnXaa: 0.0 ± 0.0
Pro
3.685ProAla: 3.685 ± 0.454
0.439ProCys: 0.439 ± 0.149
2.764ProAsp: 2.764 ± 0.405
3.553ProGlu: 3.553 ± 0.451
1.711ProPhe: 1.711 ± 0.32
3.158ProGly: 3.158 ± 0.379
0.439ProHis: 0.439 ± 0.111
2.062ProIle: 2.062 ± 0.293
3.071ProLys: 3.071 ± 0.411
3.904ProLeu: 3.904 ± 0.409
1.491ProMet: 1.491 ± 0.236
1.448ProAsn: 1.448 ± 0.257
1.842ProPro: 1.842 ± 0.381
2.018ProGln: 2.018 ± 0.265
1.272ProArg: 1.272 ± 0.279
3.114ProSer: 3.114 ± 0.351
4.079ProThr: 4.079 ± 0.313
3.992ProVal: 3.992 ± 0.474
0.57ProTrp: 0.57 ± 0.199
1.36ProTyr: 1.36 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
6.404GlnAla: 6.404 ± 0.833
0.132GlnCys: 0.132 ± 0.096
2.544GlnAsp: 2.544 ± 0.352
3.729GlnGlu: 3.729 ± 0.371
1.842GlnPhe: 1.842 ± 0.298
3.685GlnGly: 3.685 ± 0.425
0.746GlnHis: 0.746 ± 0.158
2.281GlnIle: 2.281 ± 0.394
2.413GlnLys: 2.413 ± 0.321
3.509GlnLeu: 3.509 ± 0.336
2.237GlnMet: 2.237 ± 0.281
2.106GlnAsn: 2.106 ± 0.281
1.755GlnPro: 1.755 ± 0.281
2.851GlnGln: 2.851 ± 0.461
2.5GlnArg: 2.5 ± 0.342
2.5GlnSer: 2.5 ± 0.5
2.281GlnThr: 2.281 ± 0.248
3.685GlnVal: 3.685 ± 0.283
0.965GlnTrp: 0.965 ± 0.208
1.316GlnTyr: 1.316 ± 0.225
0.0GlnXaa: 0.0 ± 0.0
Arg
4.825ArgAla: 4.825 ± 0.602
0.439ArgCys: 0.439 ± 0.136
2.807ArgAsp: 2.807 ± 0.321
2.895ArgGlu: 2.895 ± 0.313
2.281ArgPhe: 2.281 ± 0.381
2.588ArgGly: 2.588 ± 0.378
0.746ArgHis: 0.746 ± 0.247
2.807ArgIle: 2.807 ± 0.321
2.413ArgLys: 2.413 ± 0.322
4.869ArgLeu: 4.869 ± 0.454
1.798ArgMet: 1.798 ± 0.235
2.413ArgAsn: 2.413 ± 0.239
2.281ArgPro: 2.281 ± 0.308
2.281ArgGln: 2.281 ± 0.36
2.193ArgArg: 2.193 ± 0.376
2.983ArgSer: 2.983 ± 0.375
2.369ArgThr: 2.369 ± 0.282
3.729ArgVal: 3.729 ± 0.404
0.921ArgTrp: 0.921 ± 0.214
1.404ArgTyr: 1.404 ± 0.251
0.0ArgXaa: 0.0 ± 0.0
Ser
4.343SerAla: 4.343 ± 0.52
0.439SerCys: 0.439 ± 0.158
3.465SerAsp: 3.465 ± 0.336
2.676SerGlu: 2.676 ± 0.297
1.93SerPhe: 1.93 ± 0.233
4.781SerGly: 4.781 ± 0.608
1.141SerHis: 1.141 ± 0.199
2.939SerIle: 2.939 ± 0.425
3.29SerLys: 3.29 ± 0.322
5.045SerLeu: 5.045 ± 0.685
1.842SerMet: 1.842 ± 0.288
2.676SerAsn: 2.676 ± 0.344
2.764SerPro: 2.764 ± 0.367
2.193SerGln: 2.193 ± 0.314
3.158SerArg: 3.158 ± 0.405
3.378SerSer: 3.378 ± 0.426
3.29SerThr: 3.29 ± 0.393
3.465SerVal: 3.465 ± 0.441
0.79SerTrp: 0.79 ± 0.205
2.325SerTyr: 2.325 ± 0.29
0.0SerXaa: 0.0 ± 0.0
Thr
6.097ThrAla: 6.097 ± 0.596
0.307ThrCys: 0.307 ± 0.121
3.641ThrAsp: 3.641 ± 0.357
3.597ThrGlu: 3.597 ± 0.341
2.106ThrPhe: 2.106 ± 0.315
5.132ThrGly: 5.132 ± 0.562
0.877ThrHis: 0.877 ± 0.233
3.422ThrIle: 3.422 ± 0.415
4.079ThrLys: 4.079 ± 0.376
4.123ThrLeu: 4.123 ± 0.364
1.667ThrMet: 1.667 ± 0.286
2.851ThrAsn: 2.851 ± 0.4
3.597ThrPro: 3.597 ± 0.415
2.237ThrGln: 2.237 ± 0.365
2.149ThrArg: 2.149 ± 0.32
3.29ThrSer: 3.29 ± 0.347
3.114ThrThr: 3.114 ± 0.395
4.343ThrVal: 4.343 ± 0.674
0.921ThrTrp: 0.921 ± 0.259
1.535ThrTyr: 1.535 ± 0.296
0.0ThrXaa: 0.0 ± 0.0
Val
6.229ValAla: 6.229 ± 0.737
0.833ValCys: 0.833 ± 0.225
3.509ValAsp: 3.509 ± 0.35
3.86ValGlu: 3.86 ± 0.355
2.149ValPhe: 2.149 ± 0.391
4.387ValGly: 4.387 ± 0.596
1.491ValHis: 1.491 ± 0.254
3.29ValIle: 3.29 ± 0.626
3.509ValLys: 3.509 ± 0.377
5.571ValLeu: 5.571 ± 0.525
2.149ValMet: 2.149 ± 0.273
3.597ValAsn: 3.597 ± 0.379
3.114ValPro: 3.114 ± 0.454
3.509ValGln: 3.509 ± 0.422
3.378ValArg: 3.378 ± 0.338
3.86ValSer: 3.86 ± 0.435
3.992ValThr: 3.992 ± 0.493
5.132ValVal: 5.132 ± 0.579
0.833ValTrp: 0.833 ± 0.195
1.93ValTyr: 1.93 ± 0.372
0.0ValXaa: 0.0 ± 0.0
Trp
1.272TrpAla: 1.272 ± 0.241
0.132TrpCys: 0.132 ± 0.076
1.228TrpAsp: 1.228 ± 0.314
0.877TrpGlu: 0.877 ± 0.236
0.79TrpPhe: 0.79 ± 0.183
1.141TrpGly: 1.141 ± 0.339
0.263TrpHis: 0.263 ± 0.103
0.746TrpIle: 0.746 ± 0.187
1.009TrpLys: 1.009 ± 0.148
0.965TrpLeu: 0.965 ± 0.27
0.439TrpMet: 0.439 ± 0.161
0.746TrpAsn: 0.746 ± 0.195
0.439TrpPro: 0.439 ± 0.145
0.439TrpGln: 0.439 ± 0.14
0.833TrpArg: 0.833 ± 0.189
0.658TrpSer: 0.658 ± 0.186
0.658TrpThr: 0.658 ± 0.209
1.097TrpVal: 1.097 ± 0.225
0.351TrpTrp: 0.351 ± 0.174
0.526TrpTyr: 0.526 ± 0.172
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.018TyrAla: 2.018 ± 0.247
0.132TyrCys: 0.132 ± 0.079
2.5TyrAsp: 2.5 ± 0.283
1.974TyrGlu: 1.974 ± 0.347
1.228TyrPhe: 1.228 ± 0.231
2.676TyrGly: 2.676 ± 0.422
1.009TyrHis: 1.009 ± 0.273
2.237TyrIle: 2.237 ± 0.466
1.974TyrLys: 1.974 ± 0.327
2.149TyrLeu: 2.149 ± 0.388
1.009TyrMet: 1.009 ± 0.213
1.974TyrAsn: 1.974 ± 0.3
1.316TyrPro: 1.316 ± 0.378
2.062TyrGln: 2.062 ± 0.267
1.667TyrArg: 1.667 ± 0.287
1.491TyrSer: 1.491 ± 0.192
1.36TyrThr: 1.36 ± 0.298
1.974TyrVal: 1.974 ± 0.252
0.614TyrTrp: 0.614 ± 0.175
0.746TyrTyr: 0.746 ± 0.151
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 82 proteins (22798 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski