Amino acid dipepetide frequency for Helicobacter phage 1961P

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.456AlaAla: 1.456 ± 0.428
0.607AlaCys: 0.607 ± 0.278
2.427AlaAsp: 2.427 ± 0.419
3.156AlaGlu: 3.156 ± 0.761
3.763AlaPhe: 3.763 ± 0.656
3.277AlaGly: 3.277 ± 0.639
0.607AlaHis: 0.607 ± 0.3
6.918AlaIle: 6.918 ± 0.943
7.768AlaLys: 7.768 ± 1.189
10.438AlaLeu: 10.438 ± 1.489
1.335AlaMet: 1.335 ± 0.47
5.462AlaAsn: 5.462 ± 0.819
1.456AlaPro: 1.456 ± 0.404
2.913AlaGln: 2.913 ± 0.573
3.277AlaArg: 3.277 ± 0.692
3.398AlaSer: 3.398 ± 0.587
2.185AlaThr: 2.185 ± 0.461
2.063AlaVal: 2.063 ± 0.444
0.364AlaTrp: 0.364 ± 0.188
2.306AlaTyr: 2.306 ± 0.543
0.0AlaXaa: 0.0 ± 0.0
Cys
0.607CysAla: 0.607 ± 0.302
0.0CysCys: 0.0 ± 0.0
0.485CysAsp: 0.485 ± 0.312
0.85CysGlu: 0.85 ± 0.286
0.728CysPhe: 0.728 ± 0.428
0.485CysGly: 0.485 ± 0.364
0.0CysHis: 0.0 ± 0.0
0.728CysIle: 0.728 ± 0.335
0.121CysLys: 0.121 ± 0.111
1.214CysLeu: 1.214 ± 0.533
0.0CysMet: 0.0 ± 0.0
0.364CysAsn: 0.364 ± 0.237
0.364CysPro: 0.364 ± 0.167
0.243CysGln: 0.243 ± 0.142
0.243CysArg: 0.243 ± 0.216
0.121CysSer: 0.121 ± 0.114
0.364CysThr: 0.364 ± 0.198
0.364CysVal: 0.364 ± 0.219
0.0CysTrp: 0.0 ± 0.0
0.243CysTyr: 0.243 ± 0.157
0.0CysXaa: 0.0 ± 0.0
Asp
2.185AspAla: 2.185 ± 0.501
0.364AspCys: 0.364 ± 0.239
2.306AspAsp: 2.306 ± 0.456
4.369AspGlu: 4.369 ± 0.672
4.369AspPhe: 4.369 ± 0.826
1.456AspGly: 1.456 ± 0.351
0.728AspHis: 0.728 ± 0.221
2.913AspIle: 2.913 ± 0.831
6.797AspLys: 6.797 ± 1.302
6.918AspLeu: 6.918 ± 0.859
1.578AspMet: 1.578 ± 0.472
4.734AspAsn: 4.734 ± 0.61
1.699AspPro: 1.699 ± 0.34
1.214AspGln: 1.214 ± 0.48
1.335AspArg: 1.335 ± 0.377
2.427AspSer: 2.427 ± 0.621
1.456AspThr: 1.456 ± 0.425
1.214AspVal: 1.214 ± 0.437
0.0AspTrp: 0.0 ± 0.0
3.034AspTyr: 3.034 ± 0.521
0.0AspXaa: 0.0 ± 0.0
Glu
6.918GluAla: 6.918 ± 0.948
0.364GluCys: 0.364 ± 0.194
2.185GluAsp: 2.185 ± 0.469
4.976GluGlu: 4.976 ± 0.894
3.884GluPhe: 3.884 ± 0.794
1.456GluGly: 1.456 ± 0.39
1.699GluHis: 1.699 ± 0.48
7.404GluIle: 7.404 ± 0.884
8.496GluLys: 8.496 ± 0.828
7.161GluLeu: 7.161 ± 0.754
1.214GluMet: 1.214 ± 0.268
7.161GluAsn: 7.161 ± 0.848
1.821GluPro: 1.821 ± 0.54
5.34GluGln: 5.34 ± 0.681
6.19GluArg: 6.19 ± 0.959
6.554GluSer: 6.554 ± 0.822
4.491GluThr: 4.491 ± 0.59
4.005GluVal: 4.005 ± 0.787
0.607GluTrp: 0.607 ± 0.237
2.063GluTyr: 2.063 ± 0.356
0.0GluXaa: 0.0 ± 0.0
Phe
0.728PheAla: 0.728 ± 0.3
0.728PheCys: 0.728 ± 0.345
3.156PheAsp: 3.156 ± 0.674
3.763PheGlu: 3.763 ± 0.611
3.52PhePhe: 3.52 ± 0.578
1.821PheGly: 1.821 ± 0.399
0.971PheHis: 0.971 ± 0.269
3.398PheIle: 3.398 ± 0.411
6.311PheLys: 6.311 ± 0.71
6.19PheLeu: 6.19 ± 0.85
0.485PheMet: 0.485 ± 0.311
3.763PheAsn: 3.763 ± 0.565
0.485PhePro: 0.485 ± 0.225
0.485PheGln: 0.485 ± 0.225
1.821PheArg: 1.821 ± 0.5
4.855PheSer: 4.855 ± 0.762
2.67PheThr: 2.67 ± 0.542
1.456PheVal: 1.456 ± 0.407
0.0PheTrp: 0.0 ± 0.0
1.942PheTyr: 1.942 ± 0.632
0.0PheXaa: 0.0 ± 0.0
Gly
2.063GlyAla: 2.063 ± 0.633
0.485GlyCys: 0.485 ± 0.239
1.578GlyAsp: 1.578 ± 0.359
2.185GlyGlu: 2.185 ± 0.532
2.67GlyPhe: 2.67 ± 0.566
3.398GlyGly: 3.398 ± 0.788
0.364GlyHis: 0.364 ± 0.177
3.277GlyIle: 3.277 ± 0.553
2.792GlyLys: 2.792 ± 0.722
6.311GlyLeu: 6.311 ± 1.13
1.456GlyMet: 1.456 ± 0.355
3.52GlyAsn: 3.52 ± 0.609
0.121GlyPro: 0.121 ± 0.114
1.214GlyGln: 1.214 ± 0.255
0.971GlyArg: 0.971 ± 0.303
2.427GlySer: 2.427 ± 0.419
1.092GlyThr: 1.092 ± 0.21
4.127GlyVal: 4.127 ± 0.899
0.243GlyTrp: 0.243 ± 0.182
2.063GlyTyr: 2.063 ± 0.491
0.0GlyXaa: 0.0 ± 0.0
His
1.578HisAla: 1.578 ± 0.405
0.121HisCys: 0.121 ± 0.111
1.092HisAsp: 1.092 ± 0.557
1.578HisGlu: 1.578 ± 0.393
1.092HisPhe: 1.092 ± 0.323
0.364HisGly: 0.364 ± 0.171
0.121HisHis: 0.121 ± 0.117
0.728HisIle: 0.728 ± 0.366
1.456HisLys: 1.456 ± 0.398
1.092HisLeu: 1.092 ± 0.253
0.243HisMet: 0.243 ± 0.171
1.214HisAsn: 1.214 ± 0.45
0.243HisPro: 0.243 ± 0.166
0.243HisGln: 0.243 ± 0.138
0.485HisArg: 0.485 ± 0.2
0.85HisSer: 0.85 ± 0.294
0.607HisThr: 0.607 ± 0.265
0.485HisVal: 0.485 ± 0.211
0.0HisTrp: 0.0 ± 0.0
0.243HisTyr: 0.243 ± 0.152
0.0HisXaa: 0.0 ± 0.0
Ile
4.491IleAla: 4.491 ± 0.593
0.85IleCys: 0.85 ± 0.354
4.005IleAsp: 4.005 ± 0.707
6.676IleGlu: 6.676 ± 1.164
2.185IlePhe: 2.185 ± 0.516
2.063IleGly: 2.063 ± 0.577
0.971IleHis: 0.971 ± 0.401
4.491IleIle: 4.491 ± 0.786
9.589IleLys: 9.589 ± 1.131
6.797IleLeu: 6.797 ± 0.71
1.699IleMet: 1.699 ± 0.414
5.583IleAsn: 5.583 ± 1.041
1.092IlePro: 1.092 ± 0.355
3.277IleGln: 3.277 ± 0.646
4.005IleArg: 4.005 ± 0.566
5.462IleSer: 5.462 ± 0.514
3.398IleThr: 3.398 ± 0.735
4.005IleVal: 4.005 ± 0.56
0.243IleTrp: 0.243 ± 0.161
1.821IleTyr: 1.821 ± 0.455
0.0IleXaa: 0.0 ± 0.0
Lys
9.224LysAla: 9.224 ± 1.237
0.485LysCys: 0.485 ± 0.296
7.404LysAsp: 7.404 ± 1.281
13.958LysGlu: 13.958 ± 1.34
2.549LysPhe: 2.549 ± 0.404
3.52LysGly: 3.52 ± 0.557
2.427LysHis: 2.427 ± 0.724
8.375LysIle: 8.375 ± 1.221
10.924LysLys: 10.924 ± 1.584
8.253LysLeu: 8.253 ± 0.971
1.456LysMet: 1.456 ± 0.446
8.982LysAsn: 8.982 ± 1.112
3.641LysPro: 3.641 ± 0.487
5.947LysGln: 5.947 ± 1.077
4.491LysArg: 4.491 ± 0.635
6.433LysSer: 6.433 ± 1.016
4.976LysThr: 4.976 ± 0.879
4.248LysVal: 4.248 ± 0.771
0.85LysTrp: 0.85 ± 0.285
2.427LysTyr: 2.427 ± 0.565
0.0LysXaa: 0.0 ± 0.0
Leu
6.069LeuAla: 6.069 ± 0.734
1.335LeuCys: 1.335 ± 0.502
4.855LeuAsp: 4.855 ± 0.783
11.409LeuGlu: 11.409 ± 1.183
4.127LeuPhe: 4.127 ± 0.712
5.705LeuGly: 5.705 ± 0.891
0.364LeuHis: 0.364 ± 0.205
5.826LeuIle: 5.826 ± 0.716
16.021LeuLys: 16.021 ± 1.596
8.132LeuLeu: 8.132 ± 1.195
1.456LeuMet: 1.456 ± 0.461
11.166LeuAsn: 11.166 ± 1.399
2.306LeuPro: 2.306 ± 0.488
4.248LeuGln: 4.248 ± 0.879
3.763LeuArg: 3.763 ± 0.609
6.433LeuSer: 6.433 ± 0.542
4.248LeuThr: 4.248 ± 0.881
3.156LeuVal: 3.156 ± 0.514
0.85LeuTrp: 0.85 ± 0.411
2.063LeuTyr: 2.063 ± 0.494
0.0LeuXaa: 0.0 ± 0.0
Met
1.092MetAla: 1.092 ± 0.342
0.121MetCys: 0.121 ± 0.116
1.578MetAsp: 1.578 ± 0.382
1.092MetGlu: 1.092 ± 0.258
1.092MetPhe: 1.092 ± 0.504
1.578MetGly: 1.578 ± 0.454
0.364MetHis: 0.364 ± 0.173
1.578MetIle: 1.578 ± 0.488
1.578MetLys: 1.578 ± 0.519
1.821MetLeu: 1.821 ± 0.431
0.243MetMet: 0.243 ± 0.166
1.578MetAsn: 1.578 ± 0.349
0.485MetPro: 0.485 ± 0.174
1.699MetGln: 1.699 ± 0.414
0.607MetArg: 0.607 ± 0.239
0.971MetSer: 0.971 ± 0.221
0.243MetThr: 0.243 ± 0.17
0.364MetVal: 0.364 ± 0.244
0.243MetTrp: 0.243 ± 0.152
0.485MetTyr: 0.485 ± 0.218
0.0MetXaa: 0.0 ± 0.0
Asn
10.317AsnAla: 10.317 ± 1.444
0.243AsnCys: 0.243 ± 0.155
3.884AsnAsp: 3.884 ± 0.6
6.797AsnGlu: 6.797 ± 0.764
4.248AsnPhe: 4.248 ± 0.646
2.549AsnGly: 2.549 ± 0.41
0.971AsnHis: 0.971 ± 0.379
4.369AsnIle: 4.369 ± 0.705
8.375AsnLys: 8.375 ± 0.77
7.04AsnLeu: 7.04 ± 0.835
1.335AsnMet: 1.335 ± 0.322
7.525AsnAsn: 7.525 ± 1.073
2.185AsnPro: 2.185 ± 0.585
4.734AsnGln: 4.734 ± 0.999
3.277AsnArg: 3.277 ± 0.628
4.491AsnSer: 4.491 ± 0.744
3.763AsnThr: 3.763 ± 0.69
1.456AsnVal: 1.456 ± 0.486
0.243AsnTrp: 0.243 ± 0.15
5.219AsnTyr: 5.219 ± 0.996
0.0AsnXaa: 0.0 ± 0.0
Pro
0.728ProAla: 0.728 ± 0.352
0.0ProCys: 0.0 ± 0.0
0.85ProAsp: 0.85 ± 0.185
0.971ProGlu: 0.971 ± 0.34
2.306ProPhe: 2.306 ± 0.4
0.243ProGly: 0.243 ± 0.234
0.121ProHis: 0.121 ± 0.103
2.549ProIle: 2.549 ± 0.43
3.763ProLys: 3.763 ± 0.654
2.427ProLeu: 2.427 ± 0.402
0.485ProMet: 0.485 ± 0.184
3.034ProAsn: 3.034 ± 0.602
0.485ProPro: 0.485 ± 0.232
0.85ProGln: 0.85 ± 0.25
0.364ProArg: 0.364 ± 0.186
2.427ProSer: 2.427 ± 0.453
1.335ProThr: 1.335 ± 0.355
0.607ProVal: 0.607 ± 0.234
0.243ProTrp: 0.243 ± 0.234
0.728ProTyr: 0.728 ± 0.267
0.0ProXaa: 0.0 ± 0.0
Gln
4.491GlnAla: 4.491 ± 0.745
0.243GlnCys: 0.243 ± 0.166
1.578GlnAsp: 1.578 ± 0.383
4.855GlnGlu: 4.855 ± 0.774
1.456GlnPhe: 1.456 ± 0.389
2.427GlnGly: 2.427 ± 0.583
0.607GlnHis: 0.607 ± 0.255
3.034GlnIle: 3.034 ± 0.401
4.976GlnLys: 4.976 ± 0.728
3.641GlnLeu: 3.641 ± 0.601
0.728GlnMet: 0.728 ± 0.25
4.491GlnAsn: 4.491 ± 0.848
0.971GlnPro: 0.971 ± 0.311
3.156GlnGln: 3.156 ± 0.88
1.578GlnArg: 1.578 ± 0.453
2.185GlnSer: 2.185 ± 0.472
2.063GlnThr: 2.063 ± 0.449
2.306GlnVal: 2.306 ± 0.551
0.121GlnTrp: 0.121 ± 0.108
0.85GlnTyr: 0.85 ± 0.322
0.0GlnXaa: 0.0 ± 0.0
Arg
3.52ArgAla: 3.52 ± 0.682
0.243ArgCys: 0.243 ± 0.158
2.427ArgAsp: 2.427 ± 0.475
3.641ArgGlu: 3.641 ± 0.642
2.185ArgPhe: 2.185 ± 0.528
1.335ArgGly: 1.335 ± 0.315
0.485ArgHis: 0.485 ± 0.201
2.549ArgIle: 2.549 ± 0.536
3.398ArgLys: 3.398 ± 0.717
5.705ArgLeu: 5.705 ± 0.896
0.85ArgMet: 0.85 ± 0.337
2.185ArgAsn: 2.185 ± 0.617
1.092ArgPro: 1.092 ± 0.337
1.214ArgGln: 1.214 ± 0.475
0.728ArgArg: 0.728 ± 0.34
2.427ArgSer: 2.427 ± 0.54
1.821ArgThr: 1.821 ± 0.481
2.427ArgVal: 2.427 ± 0.46
0.243ArgTrp: 0.243 ± 0.152
2.063ArgTyr: 2.063 ± 0.445
0.0ArgXaa: 0.0 ± 0.0
Ser
3.398SerAla: 3.398 ± 0.662
0.364SerCys: 0.364 ± 0.277
5.34SerAsp: 5.34 ± 0.751
5.462SerGlu: 5.462 ± 0.81
3.398SerPhe: 3.398 ± 0.824
4.005SerGly: 4.005 ± 0.447
0.728SerHis: 0.728 ± 0.281
2.913SerIle: 2.913 ± 0.542
6.554SerLys: 6.554 ± 0.761
8.496SerLeu: 8.496 ± 1.24
1.456SerMet: 1.456 ± 0.383
3.763SerAsn: 3.763 ± 0.432
1.699SerPro: 1.699 ± 0.459
2.67SerGln: 2.67 ± 0.587
1.699SerArg: 1.699 ± 0.354
1.942SerSer: 1.942 ± 0.513
2.063SerThr: 2.063 ± 0.529
4.369SerVal: 4.369 ± 0.765
0.485SerTrp: 0.485 ± 0.258
3.034SerTyr: 3.034 ± 0.455
0.0SerXaa: 0.0 ± 0.0
Thr
1.699ThrAla: 1.699 ± 0.395
0.243ThrCys: 0.243 ± 0.15
2.306ThrAsp: 2.306 ± 0.446
2.185ThrGlu: 2.185 ± 0.482
1.214ThrPhe: 1.214 ± 0.342
2.549ThrGly: 2.549 ± 0.71
1.092ThrHis: 1.092 ± 0.313
4.005ThrIle: 4.005 ± 0.782
3.763ThrLys: 3.763 ± 0.786
3.763ThrLeu: 3.763 ± 0.454
0.85ThrMet: 0.85 ± 0.255
3.52ThrAsn: 3.52 ± 0.464
2.792ThrPro: 2.792 ± 0.432
3.277ThrGln: 3.277 ± 0.787
1.942ThrArg: 1.942 ± 0.371
2.792ThrSer: 2.792 ± 0.616
2.913ThrThr: 2.913 ± 0.432
0.364ThrVal: 0.364 ± 0.177
0.485ThrTrp: 0.485 ± 0.2
1.456ThrTyr: 1.456 ± 0.358
0.0ThrXaa: 0.0 ± 0.0
Val
2.427ValAla: 2.427 ± 0.489
0.364ValCys: 0.364 ± 0.225
2.185ValAsp: 2.185 ± 0.449
1.821ValGlu: 1.821 ± 0.445
2.063ValPhe: 2.063 ± 0.608
3.034ValGly: 3.034 ± 0.686
0.121ValHis: 0.121 ± 0.106
4.005ValIle: 4.005 ± 0.716
3.763ValLys: 3.763 ± 0.762
4.248ValLeu: 4.248 ± 0.735
0.728ValMet: 0.728 ± 0.298
1.699ValAsn: 1.699 ± 0.365
0.728ValPro: 0.728 ± 0.334
0.85ValGln: 0.85 ± 0.345
2.063ValArg: 2.063 ± 0.567
4.491ValSer: 4.491 ± 0.872
1.821ValThr: 1.821 ± 0.374
2.306ValVal: 2.306 ± 0.577
0.243ValTrp: 0.243 ± 0.177
1.214ValTyr: 1.214 ± 0.486
0.0ValXaa: 0.0 ± 0.0
Trp
0.121TrpAla: 0.121 ± 0.113
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.971TrpGlu: 0.971 ± 0.371
0.0TrpPhe: 0.0 ± 0.0
0.364TrpGly: 0.364 ± 0.179
0.243TrpHis: 0.243 ± 0.149
0.485TrpIle: 0.485 ± 0.22
0.121TrpLys: 0.121 ± 0.108
0.364TrpLeu: 0.364 ± 0.198
0.243TrpMet: 0.243 ± 0.168
0.607TrpAsn: 0.607 ± 0.307
0.0TrpPro: 0.0 ± 0.0
0.243TrpGln: 0.243 ± 0.147
0.243TrpArg: 0.243 ± 0.15
0.728TrpSer: 0.728 ± 0.3
0.121TrpThr: 0.121 ± 0.126
0.485TrpVal: 0.485 ± 0.244
0.0TrpTrp: 0.0 ± 0.0
0.243TrpTyr: 0.243 ± 0.208
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.063TyrAla: 2.063 ± 0.46
0.364TyrCys: 0.364 ± 0.26
1.456TyrAsp: 1.456 ± 0.397
3.277TyrGlu: 3.277 ± 0.578
1.699TyrPhe: 1.699 ± 0.505
0.728TyrGly: 0.728 ± 0.249
0.85TyrHis: 0.85 ± 0.258
3.156TyrIle: 3.156 ± 0.535
4.005TyrLys: 4.005 ± 0.68
3.641TyrLeu: 3.641 ± 0.716
0.85TyrMet: 0.85 ± 0.315
2.67TyrAsn: 2.67 ± 0.471
0.85TyrPro: 0.85 ± 0.283
1.942TyrGln: 1.942 ± 0.31
1.456TyrArg: 1.456 ± 0.257
2.427TyrSer: 2.427 ± 0.559
1.578TyrThr: 1.578 ± 0.415
0.364TyrVal: 0.364 ± 0.208
0.121TyrTrp: 0.121 ± 0.124
1.699TyrTyr: 1.699 ± 0.502
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 33 proteins (8240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski