Amino acid dipepetide frequency for Eubacterium sp. CAG:841

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.13AlaAla: 8.13 ± 0.149
1.417AlaCys: 1.417 ± 0.059
5.041AlaAsp: 5.041 ± 0.097
6.813AlaGlu: 6.813 ± 0.133
3.608AlaPhe: 3.608 ± 0.097
5.986AlaGly: 5.986 ± 0.121
1.203AlaHis: 1.203 ± 0.051
5.475AlaIle: 5.475 ± 0.107
5.816AlaLys: 5.816 ± 0.117
7.995AlaLeu: 7.995 ± 0.137
2.17AlaMet: 2.17 ± 0.061
2.451AlaAsn: 2.451 ± 0.077
2.428AlaPro: 2.428 ± 0.072
1.898AlaGln: 1.898 ± 0.058
3.211AlaArg: 3.211 ± 0.082
4.962AlaSer: 4.962 ± 0.098
3.728AlaThr: 3.728 ± 0.109
7.207AlaVal: 7.207 ± 0.139
0.542AlaTrp: 0.542 ± 0.036
2.87AlaTyr: 2.87 ± 0.072
0.002AlaXaa: 0.002 ± 0.002
Cys
1.66CysAla: 1.66 ± 0.058
0.266CysCys: 0.266 ± 0.024
1.425CysAsp: 1.425 ± 0.047
1.402CysGlu: 1.402 ± 0.054
0.81CysPhe: 0.81 ± 0.04
2.422CysGly: 2.422 ± 0.072
0.332CysHis: 0.332 ± 0.026
1.167CysIle: 1.167 ± 0.048
1.065CysLys: 1.065 ± 0.046
1.132CysLeu: 1.132 ± 0.044
0.324CysMet: 0.324 ± 0.026
0.607CysAsn: 0.607 ± 0.039
0.769CysPro: 0.769 ± 0.047
0.247CysGln: 0.247 ± 0.02
0.962CysArg: 0.962 ± 0.042
1.157CysSer: 1.157 ± 0.044
0.904CysThr: 0.904 ± 0.049
1.277CysVal: 1.277 ± 0.049
0.098CysTrp: 0.098 ± 0.016
0.559CysTyr: 0.559 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
4.54AspAla: 4.54 ± 0.111
1.072AspCys: 1.072 ± 0.047
3.49AspAsp: 3.49 ± 0.101
5.174AspGlu: 5.174 ± 0.105
3.068AspPhe: 3.068 ± 0.088
5.531AspGly: 5.531 ± 0.121
0.694AspHis: 0.694 ± 0.036
5.236AspIle: 5.236 ± 0.106
4.119AspLys: 4.119 ± 0.108
3.562AspLeu: 3.562 ± 0.08
1.863AspMet: 1.863 ± 0.056
2.008AspAsn: 2.008 ± 0.069
1.824AspPro: 1.824 ± 0.061
0.725AspGln: 0.725 ± 0.037
2.513AspArg: 2.513 ± 0.066
3.23AspSer: 3.23 ± 0.09
3.172AspThr: 3.172 ± 0.072
3.948AspVal: 3.948 ± 0.094
0.405AspTrp: 0.405 ± 0.031
2.544AspTyr: 2.544 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
5.278GluAla: 5.278 ± 0.1
0.955GluCys: 0.955 ± 0.042
3.41GluAsp: 3.41 ± 0.092
5.209GluGlu: 5.209 ± 0.116
2.522GluPhe: 2.522 ± 0.077
3.969GluGly: 3.969 ± 0.094
1.124GluHis: 1.124 ± 0.047
5.465GluIle: 5.465 ± 0.111
7.789GluLys: 7.789 ± 0.146
6.404GluLeu: 6.404 ± 0.114
2.09GluMet: 2.09 ± 0.059
4.594GluAsn: 4.594 ± 0.105
1.653GluPro: 1.653 ± 0.056
1.751GluGln: 1.751 ± 0.063
3.315GluArg: 3.315 ± 0.094
3.797GluSer: 3.797 ± 0.089
3.84GluThr: 3.84 ± 0.089
3.645GluVal: 3.645 ± 0.095
0.523GluTrp: 0.523 ± 0.032
3.244GluTyr: 3.244 ± 0.082
0.0GluXaa: 0.0 ± 0.0
Phe
3.814PheAla: 3.814 ± 0.097
0.999PheCys: 0.999 ± 0.046
3.311PheAsp: 3.311 ± 0.086
2.97PheGlu: 2.97 ± 0.067
2.083PhePhe: 2.083 ± 0.085
3.778PheGly: 3.778 ± 0.103
0.526PheHis: 0.526 ± 0.035
3.28PheIle: 3.28 ± 0.085
1.739PheLys: 1.739 ± 0.057
3.276PheLeu: 3.276 ± 0.088
1.005PheMet: 1.005 ± 0.045
1.379PheAsn: 1.379 ± 0.056
1.502PhePro: 1.502 ± 0.05
0.671PheGln: 0.671 ± 0.038
1.863PheArg: 1.863 ± 0.062
3.944PheSer: 3.944 ± 0.103
2.517PheThr: 2.517 ± 0.07
2.956PheVal: 2.956 ± 0.084
0.357PheTrp: 0.357 ± 0.026
1.668PheTyr: 1.668 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
6.086GlyAla: 6.086 ± 0.13
1.448GlyCys: 1.448 ± 0.056
4.289GlyAsp: 4.289 ± 0.104
5.506GlyGlu: 5.506 ± 0.116
3.255GlyPhe: 3.255 ± 0.082
5.862GlyGly: 5.862 ± 0.116
1.065GlyHis: 1.065 ± 0.05
5.969GlyIle: 5.969 ± 0.118
6.63GlyLys: 6.63 ± 0.122
5.313GlyLeu: 5.313 ± 0.085
2.073GlyMet: 2.073 ± 0.061
2.887GlyAsn: 2.887 ± 0.083
1.028GlyPro: 1.028 ± 0.046
1.495GlyGln: 1.495 ± 0.055
3.059GlyArg: 3.059 ± 0.078
4.086GlySer: 4.086 ± 0.102
4.659GlyThr: 4.659 ± 0.093
4.989GlyVal: 4.989 ± 0.107
0.619GlyTrp: 0.619 ± 0.039
3.188GlyTyr: 3.188 ± 0.081
0.0GlyXaa: 0.0 ± 0.0
His
1.03HisAla: 1.03 ± 0.047
0.283HisCys: 0.283 ± 0.023
0.868HisAsp: 0.868 ± 0.044
0.829HisGlu: 0.829 ± 0.037
0.775HisPhe: 0.775 ± 0.032
1.363HisGly: 1.363 ± 0.049
0.307HisHis: 0.307 ± 0.028
1.321HisIle: 1.321 ± 0.058
0.872HisLys: 0.872 ± 0.045
1.161HisLeu: 1.161 ± 0.052
0.388HisMet: 0.388 ± 0.028
0.604HisAsn: 0.604 ± 0.027
0.843HisPro: 0.843 ± 0.043
0.307HisGln: 0.307 ± 0.022
0.715HisArg: 0.715 ± 0.041
0.93HisSer: 0.93 ± 0.046
0.87HisThr: 0.87 ± 0.041
0.777HisVal: 0.777 ± 0.04
0.118HisTrp: 0.118 ± 0.016
0.631HisTyr: 0.631 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.503IleAla: 6.503 ± 0.131
1.699IleCys: 1.699 ± 0.062
4.36IleAsp: 4.36 ± 0.095
4.595IleGlu: 4.595 ± 0.105
3.236IlePhe: 3.236 ± 0.098
5.126IleGly: 5.126 ± 0.101
0.941IleHis: 0.941 ± 0.046
6.046IleIle: 6.046 ± 0.125
5.162IleLys: 5.162 ± 0.091
5.612IleLeu: 5.612 ± 0.106
1.884IleMet: 1.884 ± 0.063
3.08IleAsn: 3.08 ± 0.084
2.947IlePro: 2.947 ± 0.076
1.184IleGln: 1.184 ± 0.059
3.167IleArg: 3.167 ± 0.091
6.269IleSer: 6.269 ± 0.125
4.767IleThr: 4.767 ± 0.111
5.051IleVal: 5.051 ± 0.113
0.505IleTrp: 0.505 ± 0.033
2.858IleTyr: 2.858 ± 0.075
0.0IleXaa: 0.0 ± 0.0
Lys
5.548LysAla: 5.548 ± 0.12
0.991LysCys: 0.991 ± 0.05
3.546LysAsp: 3.546 ± 0.092
4.894LysGlu: 4.894 ± 0.102
2.37LysPhe: 2.37 ± 0.07
3.868LysGly: 3.868 ± 0.095
0.995LysHis: 0.995 ± 0.041
5.658LysIle: 5.658 ± 0.108
6.647LysLys: 6.647 ± 0.12
6.177LysLeu: 6.177 ± 0.108
2.438LysMet: 2.438 ± 0.079
4.218LysAsn: 4.218 ± 0.079
2.114LysPro: 2.114 ± 0.063
1.714LysGln: 1.714 ± 0.056
3.3LysArg: 3.3 ± 0.086
4.343LysSer: 4.343 ± 0.084
4.864LysThr: 4.864 ± 0.09
3.944LysVal: 3.944 ± 0.091
0.573LysTrp: 0.573 ± 0.035
3.46LysTyr: 3.46 ± 0.091
0.0LysXaa: 0.0 ± 0.0
Leu
6.996LeuAla: 6.996 ± 0.123
2.314LeuCys: 2.314 ± 0.077
4.665LeuAsp: 4.665 ± 0.1
4.833LeuGlu: 4.833 ± 0.115
4.075LeuPhe: 4.075 ± 0.102
5.889LeuGly: 5.889 ± 0.111
1.248LeuHis: 1.248 ± 0.06
5.922LeuIle: 5.922 ± 0.124
4.892LeuLys: 4.892 ± 0.108
7.56LeuLeu: 7.56 ± 0.154
2.168LeuMet: 2.168 ± 0.068
2.438LeuAsn: 2.438 ± 0.074
3.583LeuPro: 3.583 ± 0.093
1.302LeuGln: 1.302 ± 0.049
4.206LeuArg: 4.206 ± 0.107
8.171LeuSer: 8.171 ± 0.151
4.902LeuThr: 4.902 ± 0.107
5.033LeuVal: 5.033 ± 0.113
0.652LeuTrp: 0.652 ± 0.035
3.357LeuTyr: 3.357 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.033MetAla: 2.033 ± 0.06
0.417MetCys: 0.417 ± 0.026
1.234MetAsp: 1.234 ± 0.052
1.493MetGlu: 1.493 ± 0.059
1.057MetPhe: 1.057 ± 0.052
1.705MetGly: 1.705 ± 0.059
0.422MetHis: 0.422 ± 0.03
2.027MetIle: 2.027 ± 0.067
2.47MetLys: 2.47 ± 0.066
2.738MetLeu: 2.738 ± 0.071
0.789MetMet: 0.789 ± 0.038
1.265MetAsn: 1.265 ± 0.049
1.157MetPro: 1.157 ± 0.051
0.71MetGln: 0.71 ± 0.038
1.392MetArg: 1.392 ± 0.057
1.718MetSer: 1.718 ± 0.054
1.901MetThr: 1.901 ± 0.064
1.333MetVal: 1.333 ± 0.052
0.199MetTrp: 0.199 ± 0.021
0.887MetTyr: 0.887 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.292AsnAla: 3.292 ± 0.084
0.644AsnCys: 0.644 ± 0.033
2.008AsnAsp: 2.008 ± 0.064
2.368AsnGlu: 2.368 ± 0.073
1.709AsnPhe: 1.709 ± 0.059
3.469AsnGly: 3.469 ± 0.099
0.596AsnHis: 0.596 ± 0.031
3.404AsnIle: 3.404 ± 0.089
2.393AsnLys: 2.393 ± 0.069
2.931AsnLeu: 2.931 ± 0.082
1.153AsnMet: 1.153 ± 0.053
1.554AsnAsn: 1.554 ± 0.068
1.863AsnPro: 1.863 ± 0.058
0.752AsnGln: 0.752 ± 0.041
1.747AsnArg: 1.747 ± 0.06
2.382AsnSer: 2.382 ± 0.075
2.268AsnThr: 2.268 ± 0.06
2.781AsnVal: 2.781 ± 0.08
0.357AsnTrp: 0.357 ± 0.028
1.711AsnTyr: 1.711 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
2.609ProAla: 2.609 ± 0.07
0.634ProCys: 0.634 ± 0.038
2.654ProAsp: 2.654 ± 0.087
3.329ProGlu: 3.329 ± 0.079
1.473ProPhe: 1.473 ± 0.062
1.944ProGly: 1.944 ± 0.063
0.602ProHis: 0.602 ± 0.032
2.013ProIle: 2.013 ± 0.065
2.179ProLys: 2.179 ± 0.068
2.632ProLeu: 2.632 ± 0.078
0.831ProMet: 0.831 ± 0.041
1.07ProAsn: 1.07 ± 0.049
0.958ProPro: 0.958 ± 0.052
0.97ProGln: 0.97 ± 0.045
1.167ProArg: 1.167 ± 0.049
2.374ProSer: 2.374 ± 0.08
1.826ProThr: 1.826 ± 0.063
2.601ProVal: 2.601 ± 0.066
0.216ProTrp: 0.216 ± 0.02
1.462ProTyr: 1.462 ± 0.06
0.002ProXaa: 0.002 ± 0.002
Gln
1.556GlnAla: 1.556 ± 0.05
0.309GlnCys: 0.309 ± 0.027
0.829GlnAsp: 0.829 ± 0.034
0.949GlnGlu: 0.949 ± 0.044
0.721GlnPhe: 0.721 ± 0.038
1.163GlnGly: 1.163 ± 0.048
0.328GlnHis: 0.328 ± 0.022
1.709GlnIle: 1.709 ± 0.066
1.788GlnLys: 1.788 ± 0.059
1.834GlnLeu: 1.834 ± 0.069
0.683GlnMet: 0.683 ± 0.036
1.122GlnAsn: 1.122 ± 0.048
0.633GlnPro: 0.633 ± 0.04
0.579GlnGln: 0.579 ± 0.043
1.068GlnArg: 1.068 ± 0.05
1.406GlnSer: 1.406 ± 0.05
1.323GlnThr: 1.323 ± 0.056
1.107GlnVal: 1.107 ± 0.047
0.195GlnTrp: 0.195 ± 0.022
0.904GlnTyr: 0.904 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.55ArgAla: 3.55 ± 0.087
0.683ArgCys: 0.683 ± 0.04
2.515ArgAsp: 2.515 ± 0.08
3.519ArgGlu: 3.519 ± 0.103
2.017ArgPhe: 2.017 ± 0.069
2.846ArgGly: 2.846 ± 0.077
0.841ArgHis: 0.841 ± 0.044
3.568ArgIle: 3.568 ± 0.092
3.126ArgLys: 3.126 ± 0.085
4.221ArgLeu: 4.221 ± 0.127
1.184ArgMet: 1.184 ± 0.049
1.718ArgAsn: 1.718 ± 0.063
1.29ArgPro: 1.29 ± 0.052
1.144ArgGln: 1.144 ± 0.051
2.704ArgArg: 2.704 ± 0.092
2.424ArgSer: 2.424 ± 0.061
2.441ArgThr: 2.441 ± 0.073
2.526ArgVal: 2.526 ± 0.079
0.312ArgTrp: 0.312 ± 0.022
1.83ArgTyr: 1.83 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
6.356SerAla: 6.356 ± 0.135
1.136SerCys: 1.136 ± 0.049
4.756SerAsp: 4.756 ± 0.105
5.384SerGlu: 5.384 ± 0.114
3.049SerPhe: 3.049 ± 0.082
6.028SerGly: 6.028 ± 0.116
1.107SerHis: 1.107 ± 0.044
3.992SerIle: 3.992 ± 0.089
3.905SerLys: 3.905 ± 0.085
6.026SerLeu: 6.026 ± 0.11
1.583SerMet: 1.583 ± 0.058
2.042SerAsn: 2.042 ± 0.071
2.335SerPro: 2.335 ± 0.065
1.433SerGln: 1.433 ± 0.058
2.949SerArg: 2.949 ± 0.08
4.613SerSer: 4.613 ± 0.111
2.983SerThr: 2.983 ± 0.099
5.494SerVal: 5.494 ± 0.108
0.463SerTrp: 0.463 ± 0.029
2.432SerTyr: 2.432 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
5.195ThrAla: 5.195 ± 0.102
0.696ThrCys: 0.696 ± 0.046
3.739ThrAsp: 3.739 ± 0.087
4.63ThrGlu: 4.63 ± 0.084
2.438ThrPhe: 2.438 ± 0.071
4.511ThrGly: 4.511 ± 0.099
0.912ThrHis: 0.912 ± 0.042
3.506ThrIle: 3.506 ± 0.085
3.357ThrLys: 3.357 ± 0.076
5.346ThrLeu: 5.346 ± 0.102
1.294ThrMet: 1.294 ± 0.045
1.716ThrAsn: 1.716 ± 0.045
2.293ThrPro: 2.293 ± 0.061
1.151ThrGln: 1.151 ± 0.052
1.811ThrArg: 1.811 ± 0.056
3.435ThrSer: 3.435 ± 0.099
3.492ThrThr: 3.492 ± 0.174
5.754ThrVal: 5.754 ± 0.102
0.405ThrTrp: 0.405 ± 0.026
2.193ThrTyr: 2.193 ± 0.106
0.002ThrXaa: 0.002 ± 0.002
Val
5.043ValAla: 5.043 ± 0.109
1.728ValCys: 1.728 ± 0.074
3.294ValAsp: 3.294 ± 0.085
3.705ValGlu: 3.705 ± 0.091
3.238ValPhe: 3.238 ± 0.086
4.445ValGly: 4.445 ± 0.101
0.881ValHis: 0.881 ± 0.043
5.504ValIle: 5.504 ± 0.105
4.69ValLys: 4.69 ± 0.088
6.273ValLeu: 6.273 ± 0.117
1.88ValMet: 1.88 ± 0.064
2.47ValAsn: 2.47 ± 0.071
2.682ValPro: 2.682 ± 0.079
1.144ValGln: 1.144 ± 0.048
3.14ValArg: 3.14 ± 0.088
5.423ValSer: 5.423 ± 0.128
4.568ValThr: 4.568 ± 0.115
4.227ValVal: 4.227 ± 0.098
0.609ValTrp: 0.609 ± 0.035
2.609ValTyr: 2.609 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.569TrpAla: 0.569 ± 0.032
0.145TrpCys: 0.145 ± 0.018
0.424TrpAsp: 0.424 ± 0.032
0.526TrpGlu: 0.526 ± 0.03
0.303TrpPhe: 0.303 ± 0.026
0.49TrpGly: 0.49 ± 0.029
0.206TrpHis: 0.206 ± 0.021
0.534TrpIle: 0.534 ± 0.038
0.494TrpLys: 0.494 ± 0.033
0.768TrpLeu: 0.768 ± 0.039
0.21TrpMet: 0.21 ± 0.02
0.422TrpAsn: 0.422 ± 0.03
0.141TrpPro: 0.141 ± 0.017
0.287TrpGln: 0.287 ± 0.024
0.345TrpArg: 0.345 ± 0.03
0.447TrpSer: 0.447 ± 0.031
0.388TrpThr: 0.388 ± 0.027
0.38TrpVal: 0.38 ± 0.03
0.106TrpTrp: 0.106 ± 0.015
0.336TrpTyr: 0.336 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.163TyrAla: 3.163 ± 0.072
0.75TyrCys: 0.75 ± 0.04
2.86TyrAsp: 2.86 ± 0.106
2.447TyrGlu: 2.447 ± 0.074
1.832TyrPhe: 1.832 ± 0.07
3.107TyrGly: 3.107 ± 0.077
0.66TyrHis: 0.66 ± 0.037
3.197TyrIle: 3.197 ± 0.073
2.526TyrLys: 2.526 ± 0.07
3.242TyrLeu: 3.242 ± 0.093
0.935TyrMet: 0.935 ± 0.047
1.736TyrAsn: 1.736 ± 0.074
1.502TyrPro: 1.502 ± 0.061
0.742TyrGln: 0.742 ± 0.037
1.828TyrArg: 1.828 ± 0.062
2.956TyrSer: 2.956 ± 0.081
2.463TyrThr: 2.463 ± 0.086
2.526TyrVal: 2.526 ± 0.08
0.268TyrTrp: 0.268 ± 0.023
1.867TyrTyr: 1.867 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.002XaaLeu: 0.002 ± 0.002
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.002XaaPro: 0.002 ± 0.002
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.006XaaXaa: 0.006 ± 0.004
Statistics based on 1649 proteins (518552 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski