Amino acid dipepetide frequency for Nitrincola sp. A-D6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.324AlaAla: 9.324 ± 0.142
1.093AlaCys: 1.093 ± 0.043
5.691AlaAsp: 5.691 ± 0.094
6.539AlaGlu: 6.539 ± 0.118
3.514AlaPhe: 3.514 ± 0.07
7.263AlaGly: 7.263 ± 0.124
1.897AlaHis: 1.897 ± 0.055
5.263AlaIle: 5.263 ± 0.096
3.313AlaLys: 3.313 ± 0.082
11.166AlaLeu: 11.166 ± 0.146
2.727AlaMet: 2.727 ± 0.058
2.889AlaAsn: 2.889 ± 0.07
3.037AlaPro: 3.037 ± 0.075
4.27AlaGln: 4.27 ± 0.088
5.126AlaArg: 5.126 ± 0.097
5.707AlaSer: 5.707 ± 0.106
4.506AlaThr: 4.506 ± 0.1
6.669AlaVal: 6.669 ± 0.11
1.109AlaTrp: 1.109 ± 0.044
2.431AlaTyr: 2.431 ± 0.068
0.001AlaXaa: 0.001 ± 0.002
Cys
0.822CysAla: 0.822 ± 0.036
0.176CysCys: 0.176 ± 0.018
0.596CysAsp: 0.596 ± 0.028
0.622CysGlu: 0.622 ± 0.026
0.489CysPhe: 0.489 ± 0.027
0.89CysGly: 0.89 ± 0.037
0.328CysHis: 0.328 ± 0.021
0.596CysIle: 0.596 ± 0.03
0.366CysLys: 0.366 ± 0.023
1.098CysLeu: 1.098 ± 0.042
0.235CysMet: 0.235 ± 0.02
0.361CysAsn: 0.361 ± 0.02
0.513CysPro: 0.513 ± 0.024
0.485CysGln: 0.485 ± 0.03
0.615CysArg: 0.615 ± 0.031
0.641CysSer: 0.641 ± 0.036
0.479CysThr: 0.479 ± 0.026
0.669CysVal: 0.669 ± 0.033
0.154CysTrp: 0.154 ± 0.015
0.371CysTyr: 0.371 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
5.234AspAla: 5.234 ± 0.093
0.545AspCys: 0.545 ± 0.026
2.985AspAsp: 2.985 ± 0.071
3.837AspGlu: 3.837 ± 0.075
2.283AspPhe: 2.283 ± 0.057
3.748AspGly: 3.748 ± 0.085
1.192AspHis: 1.192 ± 0.039
3.483AspIle: 3.483 ± 0.081
2.304AspLys: 2.304 ± 0.06
6.01AspLeu: 6.01 ± 0.091
1.417AspMet: 1.417 ± 0.047
1.942AspAsn: 1.942 ± 0.064
2.615AspPro: 2.615 ± 0.065
2.838AspGln: 2.838 ± 0.065
2.969AspArg: 2.969 ± 0.065
3.272AspSer: 3.272 ± 0.071
2.944AspThr: 2.944 ± 0.072
3.547AspVal: 3.547 ± 0.077
1.002AspTrp: 1.002 ± 0.04
1.926AspTyr: 1.926 ± 0.055
0.0AspXaa: 0.0 ± 0.0
Glu
6.356GluAla: 6.356 ± 0.104
0.459GluCys: 0.459 ± 0.024
2.794GluAsp: 2.794 ± 0.066
3.516GluGlu: 3.516 ± 0.089
2.156GluPhe: 2.156 ± 0.056
3.782GluGly: 3.782 ± 0.084
1.506GluHis: 1.506 ± 0.051
3.512GluIle: 3.512 ± 0.076
2.819GluLys: 2.819 ± 0.076
7.059GluLeu: 7.059 ± 0.101
1.751GluMet: 1.751 ± 0.056
2.029GluAsn: 2.029 ± 0.051
2.428GluPro: 2.428 ± 0.084
4.039GluGln: 4.039 ± 0.092
4.048GluArg: 4.048 ± 0.081
3.582GluSer: 3.582 ± 0.066
3.301GluThr: 3.301 ± 0.072
4.319GluVal: 4.319 ± 0.08
0.706GluTrp: 0.706 ± 0.034
1.553GluTyr: 1.553 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
3.413PheAla: 3.413 ± 0.07
0.516PheCys: 0.516 ± 0.028
2.507PheAsp: 2.507 ± 0.062
2.344PheGlu: 2.344 ± 0.062
1.629PhePhe: 1.629 ± 0.053
2.755PheGly: 2.755 ± 0.065
0.804PheHis: 0.804 ± 0.038
2.405PheIle: 2.405 ± 0.061
1.381PheLys: 1.381 ± 0.04
3.364PheLeu: 3.364 ± 0.081
1.043PheMet: 1.043 ± 0.038
1.672PheAsn: 1.672 ± 0.046
1.563PhePro: 1.563 ± 0.052
1.347PheGln: 1.347 ± 0.039
1.898PheArg: 1.898 ± 0.048
3.104PheSer: 3.104 ± 0.073
2.192PheThr: 2.192 ± 0.061
2.453PheVal: 2.453 ± 0.068
0.53PheTrp: 0.53 ± 0.03
1.216PheTyr: 1.216 ± 0.048
0.0PheXaa: 0.0 ± 0.0
Gly
5.573GlyAla: 5.573 ± 0.105
0.957GlyCys: 0.957 ± 0.041
3.885GlyAsp: 3.885 ± 0.087
4.194GlyGlu: 4.194 ± 0.091
3.27GlyPhe: 3.27 ± 0.074
4.985GlyGly: 4.985 ± 0.105
1.608GlyHis: 1.608 ± 0.052
4.564GlyIle: 4.564 ± 0.078
3.044GlyLys: 3.044 ± 0.084
7.629GlyLeu: 7.629 ± 0.109
2.203GlyMet: 2.203 ± 0.055
2.43GlyAsn: 2.43 ± 0.069
1.962GlyPro: 1.962 ± 0.063
3.222GlyGln: 3.222 ± 0.08
4.109GlyArg: 4.109 ± 0.085
4.345GlySer: 4.345 ± 0.089
3.302GlyThr: 3.302 ± 0.077
5.4GlyVal: 5.4 ± 0.089
1.174GlyTrp: 1.174 ± 0.051
2.427GlyTyr: 2.427 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.901HisAla: 1.901 ± 0.048
0.322HisCys: 0.322 ± 0.02
1.157HisAsp: 1.157 ± 0.045
1.193HisGlu: 1.193 ± 0.046
1.026HisPhe: 1.026 ± 0.034
1.493HisGly: 1.493 ± 0.049
0.715HisHis: 0.715 ± 0.032
1.27HisIle: 1.27 ± 0.044
0.788HisLys: 0.788 ± 0.033
2.673HisLeu: 2.673 ± 0.063
0.562HisMet: 0.562 ± 0.031
0.838HisAsn: 0.838 ± 0.04
1.355HisPro: 1.355 ± 0.049
1.41HisGln: 1.41 ± 0.05
1.275HisArg: 1.275 ± 0.045
1.334HisSer: 1.334 ± 0.04
1.119HisThr: 1.119 ± 0.04
1.181HisVal: 1.181 ± 0.048
0.453HisTrp: 0.453 ± 0.026
0.88HisTyr: 0.88 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
5.747IleAla: 5.747 ± 0.095
0.714IleCys: 0.714 ± 0.033
3.891IleAsp: 3.891 ± 0.073
3.975IleGlu: 3.975 ± 0.085
1.965IlePhe: 1.965 ± 0.056
4.16IleGly: 4.16 ± 0.089
1.24IleHis: 1.24 ± 0.04
3.149IleIle: 3.149 ± 0.071
2.254IleLys: 2.254 ± 0.066
5.361IleLeu: 5.361 ± 0.098
1.238IleMet: 1.238 ± 0.044
2.644IleAsn: 2.644 ± 0.064
2.536IlePro: 2.536 ± 0.061
2.312IleGln: 2.312 ± 0.064
3.578IleArg: 3.578 ± 0.066
4.138IleSer: 4.138 ± 0.081
3.541IleThr: 3.541 ± 0.071
3.455IleVal: 3.455 ± 0.078
0.626IleTrp: 0.626 ± 0.035
1.53IleTyr: 1.53 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
3.942LysAla: 3.942 ± 0.082
0.251LysCys: 0.251 ± 0.02
2.05LysAsp: 2.05 ± 0.061
2.076LysGlu: 2.076 ± 0.064
0.989LysPhe: 0.989 ± 0.045
2.603LysGly: 2.603 ± 0.063
0.931LysHis: 0.931 ± 0.042
2.153LysIle: 2.153 ± 0.061
1.783LysLys: 1.783 ± 0.061
3.988LysLeu: 3.988 ± 0.07
0.95LysMet: 0.95 ± 0.038
1.363LysAsn: 1.363 ± 0.052
2.018LysPro: 2.018 ± 0.052
2.14LysGln: 2.14 ± 0.06
2.491LysArg: 2.491 ± 0.068
2.376LysSer: 2.376 ± 0.064
2.235LysThr: 2.235 ± 0.064
2.826LysVal: 2.826 ± 0.07
0.342LysTrp: 0.342 ± 0.021
0.877LysTyr: 0.877 ± 0.039
0.0LysXaa: 0.0 ± 0.0
Leu
10.775LeuAla: 10.775 ± 0.159
1.132LeuCys: 1.132 ± 0.039
6.179LeuAsp: 6.179 ± 0.095
6.677LeuGlu: 6.677 ± 0.11
3.952LeuPhe: 3.952 ± 0.083
7.406LeuGly: 7.406 ± 0.127
2.468LeuHis: 2.468 ± 0.06
6.849LeuIle: 6.849 ± 0.116
4.787LeuLys: 4.787 ± 0.096
13.202LeuLeu: 13.202 ± 0.221
3.085LeuMet: 3.085 ± 0.068
4.363LeuAsn: 4.363 ± 0.085
5.713LeuPro: 5.713 ± 0.108
5.365LeuGln: 5.365 ± 0.092
6.083LeuArg: 6.083 ± 0.095
8.166LeuSer: 8.166 ± 0.135
6.156LeuThr: 6.156 ± 0.098
7.283LeuVal: 7.283 ± 0.119
1.192LeuTrp: 1.192 ± 0.045
2.578LeuTyr: 2.578 ± 0.059
0.001LeuXaa: 0.001 ± 0.002
Met
2.638MetAla: 2.638 ± 0.061
0.195MetCys: 0.195 ± 0.021
1.412MetAsp: 1.412 ± 0.042
1.273MetGlu: 1.273 ± 0.042
0.76MetPhe: 0.76 ± 0.03
1.76MetGly: 1.76 ± 0.051
0.609MetHis: 0.609 ± 0.033
1.474MetIle: 1.474 ± 0.043
1.231MetLys: 1.231 ± 0.043
3.018MetLeu: 3.018 ± 0.075
0.688MetMet: 0.688 ± 0.032
1.059MetAsn: 1.059 ± 0.039
1.374MetPro: 1.374 ± 0.053
1.512MetGln: 1.512 ± 0.046
1.591MetArg: 1.591 ± 0.048
1.865MetSer: 1.865 ± 0.054
1.707MetThr: 1.707 ± 0.045
1.669MetVal: 1.669 ± 0.047
0.173MetTrp: 0.173 ± 0.016
0.438MetTyr: 0.438 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.391AsnAla: 3.391 ± 0.072
0.331AsnCys: 0.331 ± 0.023
1.749AsnAsp: 1.749 ± 0.051
1.926AsnGlu: 1.926 ± 0.046
1.27AsnPhe: 1.27 ± 0.048
2.267AsnGly: 2.267 ± 0.058
0.817AsnHis: 0.817 ± 0.039
2.147AsnIle: 2.147 ± 0.058
1.35AsnLys: 1.35 ± 0.047
3.91AsnLeu: 3.91 ± 0.083
0.889AsnMet: 0.889 ± 0.035
1.407AsnAsn: 1.407 ± 0.055
2.159AsnPro: 2.159 ± 0.067
1.739AsnGln: 1.739 ± 0.054
2.134AsnArg: 2.134 ± 0.064
2.179AsnSer: 2.179 ± 0.057
2.085AsnThr: 2.085 ± 0.059
1.927AsnVal: 1.927 ± 0.056
0.53AsnTrp: 0.53 ± 0.028
1.026AsnTyr: 1.026 ± 0.039
0.0AsnXaa: 0.0 ± 0.0
Pro
4.312ProAla: 4.312 ± 0.092
0.387ProCys: 0.387 ± 0.021
3.253ProAsp: 3.253 ± 0.067
3.841ProGlu: 3.841 ± 0.089
1.742ProPhe: 1.742 ± 0.047
3.457ProGly: 3.457 ± 0.074
0.861ProHis: 0.861 ± 0.037
2.074ProIle: 2.074 ± 0.048
1.358ProLys: 1.358 ± 0.046
4.709ProLeu: 4.709 ± 0.097
1.053ProMet: 1.053 ± 0.04
1.315ProAsn: 1.315 ± 0.044
1.607ProPro: 1.607 ± 0.058
1.744ProGln: 1.744 ± 0.053
1.857ProArg: 1.857 ± 0.049
2.422ProSer: 2.422 ± 0.064
1.955ProThr: 1.955 ± 0.059
3.787ProVal: 3.787 ± 0.062
0.615ProTrp: 0.615 ± 0.03
1.123ProTyr: 1.123 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
5.149GlnAla: 5.149 ± 0.103
0.406GlnCys: 0.406 ± 0.025
2.16GlnAsp: 2.16 ± 0.062
2.344GlnGlu: 2.344 ± 0.057
1.471GlnPhe: 1.471 ± 0.043
3.54GlnGly: 3.54 ± 0.077
1.331GlnHis: 1.331 ± 0.049
2.698GlnIle: 2.698 ± 0.064
1.564GlnLys: 1.564 ± 0.053
6.324GlnLeu: 6.324 ± 0.133
1.216GlnMet: 1.216 ± 0.046
1.343GlnAsn: 1.343 ± 0.052
2.328GlnPro: 2.328 ± 0.064
3.776GlnGln: 3.776 ± 0.101
3.313GlnArg: 3.313 ± 0.083
2.823GlnSer: 2.823 ± 0.069
2.422GlnThr: 2.422 ± 0.055
3.629GlnVal: 3.629 ± 0.072
0.647GlnTrp: 0.647 ± 0.029
1.093GlnTyr: 1.093 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
4.347ArgAla: 4.347 ± 0.083
0.623ArgCys: 0.623 ± 0.031
2.934ArgAsp: 2.934 ± 0.063
3.786ArgGlu: 3.786 ± 0.091
2.698ArgPhe: 2.698 ± 0.064
3.243ArgGly: 3.243 ± 0.071
1.467ArgHis: 1.467 ± 0.049
3.878ArgIle: 3.878 ± 0.07
2.376ArgLys: 2.376 ± 0.063
6.998ArgLeu: 6.998 ± 0.111
1.688ArgMet: 1.688 ± 0.048
1.999ArgAsn: 1.999 ± 0.057
2.192ArgPro: 2.192 ± 0.057
3.164ArgGln: 3.164 ± 0.084
3.532ArgArg: 3.532 ± 0.075
3.353ArgSer: 3.353 ± 0.067
2.497ArgThr: 2.497 ± 0.066
4.104ArgVal: 4.104 ± 0.086
0.808ArgTrp: 0.808 ± 0.038
2.009ArgTyr: 2.009 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.894SerAla: 5.894 ± 0.101
0.666SerCys: 0.666 ± 0.035
3.683SerAsp: 3.683 ± 0.079
3.825SerGlu: 3.825 ± 0.08
2.54SerPhe: 2.54 ± 0.068
5.47SerGly: 5.47 ± 0.098
1.473SerHis: 1.473 ± 0.053
3.573SerIle: 3.573 ± 0.071
2.118SerLys: 2.118 ± 0.061
7.281SerLeu: 7.281 ± 0.117
1.736SerMet: 1.736 ± 0.048
2.023SerAsn: 2.023 ± 0.058
2.612SerPro: 2.612 ± 0.066
2.842SerGln: 2.842 ± 0.07
3.642SerArg: 3.642 ± 0.087
3.904SerSer: 3.904 ± 0.084
3.026SerThr: 3.026 ± 0.08
4.618SerVal: 4.618 ± 0.081
0.859SerTrp: 0.859 ± 0.037
1.745SerTyr: 1.745 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
4.994ThrAla: 4.994 ± 0.091
0.526ThrCys: 0.526 ± 0.028
3.221ThrAsp: 3.221 ± 0.078
3.406ThrGlu: 3.406 ± 0.074
1.844ThrPhe: 1.844 ± 0.051
4.444ThrGly: 4.444 ± 0.092
1.24ThrHis: 1.24 ± 0.039
2.443ThrIle: 2.443 ± 0.064
1.321ThrLys: 1.321 ± 0.051
7.251ThrLeu: 7.251 ± 0.124
0.915ThrMet: 0.915 ± 0.034
1.522ThrAsn: 1.522 ± 0.045
2.903ThrPro: 2.903 ± 0.076
2.443ThrGln: 2.443 ± 0.065
2.959ThrArg: 2.959 ± 0.075
2.906ThrSer: 2.906 ± 0.07
2.787ThrThr: 2.787 ± 0.071
3.148ThrVal: 3.148 ± 0.077
0.586ThrTrp: 0.586 ± 0.028
1.278ThrTyr: 1.278 ± 0.045
0.0ThrXaa: 0.0 ± 0.0
Val
6.357ValAla: 6.357 ± 0.108
0.762ValCys: 0.762 ± 0.031
3.942ValAsp: 3.942 ± 0.073
4.29ValGlu: 4.29 ± 0.077
2.782ValPhe: 2.782 ± 0.067
4.418ValGly: 4.418 ± 0.09
1.381ValHis: 1.381 ± 0.047
4.299ValIle: 4.299 ± 0.078
2.763ValLys: 2.763 ± 0.071
7.231ValLeu: 7.231 ± 0.11
2.05ValMet: 2.05 ± 0.059
2.634ValAsn: 2.634 ± 0.062
2.702ValPro: 2.702 ± 0.064
2.479ValGln: 2.479 ± 0.062
3.736ValArg: 3.736 ± 0.081
4.912ValSer: 4.912 ± 0.072
3.905ValThr: 3.905 ± 0.075
5.123ValVal: 5.123 ± 0.098
0.82ValTrp: 0.82 ± 0.035
1.77ValTyr: 1.77 ± 0.046
0.001ValXaa: 0.001 ± 0.002
Trp
0.867TrpAla: 0.867 ± 0.039
0.153TrpCys: 0.153 ± 0.016
0.549TrpAsp: 0.549 ± 0.03
0.599TrpGlu: 0.599 ± 0.032
0.568TrpPhe: 0.568 ± 0.033
0.743TrpGly: 0.743 ± 0.04
0.393TrpHis: 0.393 ± 0.026
0.744TrpIle: 0.744 ± 0.032
0.489TrpLys: 0.489 ± 0.028
1.927TrpLeu: 1.927 ± 0.068
0.411TrpMet: 0.411 ± 0.023
0.465TrpAsn: 0.465 ± 0.024
0.54TrpPro: 0.54 ± 0.028
0.918TrpGln: 0.918 ± 0.037
0.822TrpArg: 0.822 ± 0.036
0.797TrpSer: 0.797 ± 0.031
0.539TrpThr: 0.539 ± 0.03
0.9TrpVal: 0.9 ± 0.034
0.192TrpTrp: 0.192 ± 0.018
0.355TrpTyr: 0.355 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.497TyrAla: 2.497 ± 0.068
0.293TyrCys: 0.293 ± 0.022
1.455TyrAsp: 1.455 ± 0.049
1.452TyrGlu: 1.452 ± 0.045
1.187TyrPhe: 1.187 ± 0.056
1.859TyrGly: 1.859 ± 0.054
0.685TyrHis: 0.685 ± 0.03
1.479TyrIle: 1.479 ± 0.054
0.973TyrLys: 0.973 ± 0.039
3.215TyrLeu: 3.215 ± 0.068
0.587TyrMet: 0.587 ± 0.028
0.935TyrAsn: 0.935 ± 0.039
1.317TyrPro: 1.317 ± 0.041
1.532TyrGln: 1.532 ± 0.052
1.918TyrArg: 1.918 ± 0.046
1.701TyrSer: 1.701 ± 0.049
1.438TyrThr: 1.438 ± 0.051
1.65TyrVal: 1.65 ± 0.049
0.452TyrTrp: 0.452 ± 0.025
0.889TyrTyr: 0.889 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.003XaaMet: 0.003 ± 0.002
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.002
Statistics based on 2517 proteins (686487 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski