Amino acid dipepetide frequency for Trichinella sp. T8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.566AlaAla: 5.566 ± 0.049
1.522AlaCys: 1.522 ± 0.015
3.588AlaAsp: 3.588 ± 0.022
4.467AlaGlu: 4.467 ± 0.033
2.781AlaPhe: 2.781 ± 0.02
3.354AlaGly: 3.354 ± 0.027
1.308AlaHis: 1.308 ± 0.012
3.425AlaIle: 3.425 ± 0.025
3.608AlaLys: 3.608 ± 0.025
6.198AlaLeu: 6.198 ± 0.034
1.59AlaMet: 1.59 ± 0.016
2.965AlaAsn: 2.965 ± 0.022
2.363AlaPro: 2.363 ± 0.021
2.306AlaGln: 2.306 ± 0.021
3.004AlaArg: 3.004 ± 0.025
5.226AlaSer: 5.226 ± 0.032
3.543AlaThr: 3.543 ± 0.025
5.051AlaVal: 5.051 ± 0.029
0.692AlaTrp: 0.692 ± 0.01
1.855AlaTyr: 1.855 ± 0.016
0.003AlaXaa: 0.003 ± 0.001
Cys
1.434CysAla: 1.434 ± 0.017
0.882CysCys: 0.882 ± 0.015
1.327CysAsp: 1.327 ± 0.016
1.463CysGlu: 1.463 ± 0.021
1.294CysPhe: 1.294 ± 0.014
1.43CysGly: 1.43 ± 0.016
0.675CysHis: 0.675 ± 0.01
1.514CysIle: 1.514 ± 0.018
1.463CysLys: 1.463 ± 0.019
2.581CysLeu: 2.581 ± 0.023
0.571CysMet: 0.571 ± 0.009
1.195CysAsn: 1.195 ± 0.014
1.23CysPro: 1.23 ± 0.022
1.127CysGln: 1.127 ± 0.014
1.613CysArg: 1.613 ± 0.018
2.435CysSer: 2.435 ± 0.025
1.363CysThr: 1.363 ± 0.018
1.492CysVal: 1.492 ± 0.018
0.346CysTrp: 0.346 ± 0.007
0.773CysTyr: 0.773 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
3.288AspAla: 3.288 ± 0.023
1.348AspCys: 1.348 ± 0.019
3.976AspAsp: 3.976 ± 0.038
4.222AspGlu: 4.222 ± 0.031
2.36AspPhe: 2.36 ± 0.018
3.119AspGly: 3.119 ± 0.027
1.216AspHis: 1.216 ± 0.014
2.786AspIle: 2.786 ± 0.02
2.541AspLys: 2.541 ± 0.019
4.632AspLeu: 4.632 ± 0.028
1.166AspMet: 1.166 ± 0.013
2.333AspAsn: 2.333 ± 0.017
2.051AspPro: 2.051 ± 0.019
2.048AspGln: 2.048 ± 0.018
2.76AspArg: 2.76 ± 0.018
4.124AspSer: 4.124 ± 0.027
2.157AspThr: 2.157 ± 0.017
3.679AspVal: 3.679 ± 0.022
0.684AspTrp: 0.684 ± 0.009
1.632AspTyr: 1.632 ± 0.015
0.001AspXaa: 0.001 ± 0.0
Glu
3.878GluAla: 3.878 ± 0.03
1.314GluCys: 1.314 ± 0.018
3.165GluAsp: 3.165 ± 0.023
5.435GluGlu: 5.435 ± 0.045
2.455GluPhe: 2.455 ± 0.022
2.282GluGly: 2.282 ± 0.022
1.421GluHis: 1.421 ± 0.016
3.953GluIle: 3.953 ± 0.035
4.923GluLys: 4.923 ± 0.038
5.802GluLeu: 5.802 ± 0.037
1.945GluMet: 1.945 ± 0.017
4.042GluAsn: 4.042 ± 0.029
2.122GluPro: 2.122 ± 0.023
3.055GluGln: 3.055 ± 0.025
3.581GluArg: 3.581 ± 0.025
4.477GluSer: 4.477 ± 0.031
3.311GluThr: 3.311 ± 0.024
3.436GluVal: 3.436 ± 0.025
0.7GluTrp: 0.7 ± 0.01
1.746GluTyr: 1.746 ± 0.018
0.001GluXaa: 0.001 ± 0.0
Phe
2.777PheAla: 2.777 ± 0.024
1.426PheCys: 1.426 ± 0.016
2.613PheAsp: 2.613 ± 0.018
2.627PheGlu: 2.627 ± 0.02
2.185PhePhe: 2.185 ± 0.022
2.604PheGly: 2.604 ± 0.022
1.346PheHis: 1.346 ± 0.013
2.557PheIle: 2.557 ± 0.021
2.195PheLys: 2.195 ± 0.018
4.372PheLeu: 4.372 ± 0.032
0.921PheMet: 0.921 ± 0.012
2.09PheAsn: 2.09 ± 0.019
2.017PhePro: 2.017 ± 0.02
1.941PheGln: 1.941 ± 0.016
2.378PheArg: 2.378 ± 0.02
3.911PheSer: 3.911 ± 0.026
2.413PheThr: 2.413 ± 0.02
3.089PheVal: 3.089 ± 0.021
0.615PheTrp: 0.615 ± 0.009
1.685PheTyr: 1.685 ± 0.017
0.001PheXaa: 0.001 ± 0.0
Gly
2.731GlyAla: 2.731 ± 0.022
1.255GlyCys: 1.255 ± 0.017
2.594GlyAsp: 2.594 ± 0.022
2.881GlyGlu: 2.881 ± 0.025
2.27GlyPhe: 2.27 ± 0.022
3.288GlyGly: 3.288 ± 0.037
1.293GlyHis: 1.293 ± 0.014
2.926GlyIle: 2.926 ± 0.026
3.383GlyLys: 3.383 ± 0.023
4.017GlyLeu: 4.017 ± 0.033
1.22GlyMet: 1.22 ± 0.015
2.539GlyAsn: 2.539 ± 0.019
1.788GlyPro: 1.788 ± 0.03
2.046GlyGln: 2.046 ± 0.019
3.263GlyArg: 3.263 ± 0.027
4.245GlySer: 4.245 ± 0.031
2.601GlyThr: 2.601 ± 0.024
3.057GlyVal: 3.057 ± 0.022
0.66GlyTrp: 0.66 ± 0.01
1.724GlyTyr: 1.724 ± 0.021
0.001GlyXaa: 0.001 ± 0.0
His
1.452HisAla: 1.452 ± 0.013
0.893HisCys: 0.893 ± 0.012
1.018HisAsp: 1.018 ± 0.013
1.235HisGlu: 1.235 ± 0.014
1.402HisPhe: 1.402 ± 0.013
1.318HisGly: 1.318 ± 0.013
0.992HisHis: 0.992 ± 0.016
1.301HisIle: 1.301 ± 0.012
0.981HisLys: 0.981 ± 0.011
2.723HisLeu: 2.723 ± 0.02
0.554HisMet: 0.554 ± 0.009
0.973HisAsn: 0.973 ± 0.012
1.237HisPro: 1.237 ± 0.014
1.126HisGln: 1.126 ± 0.014
1.58HisArg: 1.58 ± 0.014
2.075HisSer: 2.075 ± 0.017
1.103HisThr: 1.103 ± 0.013
1.598HisVal: 1.598 ± 0.013
0.349HisTrp: 0.349 ± 0.008
0.874HisTyr: 0.874 ± 0.009
0.0HisXaa: 0.0 ± 0.0
Ile
3.708IleAla: 3.708 ± 0.023
1.679IleCys: 1.679 ± 0.019
2.991IleAsp: 2.991 ± 0.021
3.296IleGlu: 3.296 ± 0.025
2.823IlePhe: 2.823 ± 0.025
2.886IleGly: 2.886 ± 0.022
1.327IleHis: 1.327 ± 0.014
3.14IleIle: 3.14 ± 0.025
2.842IleLys: 2.842 ± 0.023
5.34IleLeu: 5.34 ± 0.042
1.178IleMet: 1.178 ± 0.014
2.48IleAsn: 2.48 ± 0.019
2.539IlePro: 2.539 ± 0.02
2.174IleGln: 2.174 ± 0.019
3.209IleArg: 3.209 ± 0.023
4.768IleSer: 4.768 ± 0.028
2.854IleThr: 2.854 ± 0.023
3.68IleVal: 3.68 ± 0.022
0.676IleTrp: 0.676 ± 0.009
1.918IleTyr: 1.918 ± 0.018
0.002IleXaa: 0.002 ± 0.0
Lys
3.59LysAla: 3.59 ± 0.028
1.478LysCys: 1.478 ± 0.019
2.598LysAsp: 2.598 ± 0.024
3.922LysGlu: 3.922 ± 0.033
2.523LysPhe: 2.523 ± 0.018
2.281LysGly: 2.281 ± 0.022
1.507LysHis: 1.507 ± 0.015
3.594LysIle: 3.594 ± 0.026
4.607LysLys: 4.607 ± 0.046
6.114LysLeu: 6.114 ± 0.038
1.742LysMet: 1.742 ± 0.017
3.151LysAsn: 3.151 ± 0.024
2.414LysPro: 2.414 ± 0.022
2.863LysGln: 2.863 ± 0.024
3.906LysArg: 3.906 ± 0.027
4.633LysSer: 4.633 ± 0.03
3.049LysThr: 3.049 ± 0.025
3.377LysVal: 3.377 ± 0.025
0.746LysTrp: 0.746 ± 0.01
1.888LysTyr: 1.888 ± 0.017
0.001LysXaa: 0.001 ± 0.0
Leu
6.054LeuAla: 6.054 ± 0.033
2.468LeuCys: 2.468 ± 0.019
4.518LeuAsp: 4.518 ± 0.023
5.786LeuGlu: 5.786 ± 0.036
4.608LeuPhe: 4.608 ± 0.033
3.846LeuGly: 3.846 ± 0.024
2.73LeuHis: 2.73 ± 0.02
5.41LeuIle: 5.41 ± 0.033
6.586LeuLys: 6.586 ± 0.039
10.691LeuLeu: 10.691 ± 0.057
2.24LeuMet: 2.24 ± 0.018
4.965LeuAsn: 4.965 ± 0.026
4.823LeuPro: 4.823 ± 0.028
4.524LeuGln: 4.524 ± 0.028
5.504LeuArg: 5.504 ± 0.032
7.663LeuSer: 7.663 ± 0.033
5.038LeuThr: 5.038 ± 0.026
5.463LeuVal: 5.463 ± 0.033
1.093LeuTrp: 1.093 ± 0.014
2.916LeuTyr: 2.916 ± 0.021
0.002LeuXaa: 0.002 ± 0.0
Met
1.629MetAla: 1.629 ± 0.015
0.495MetCys: 0.495 ± 0.009
1.271MetAsp: 1.271 ± 0.012
1.648MetGlu: 1.648 ± 0.016
1.022MetPhe: 1.022 ± 0.011
0.928MetGly: 0.928 ± 0.012
0.67MetHis: 0.67 ± 0.011
1.319MetIle: 1.319 ± 0.014
1.766MetLys: 1.766 ± 0.016
2.483MetLeu: 2.483 ± 0.017
0.683MetMet: 0.683 ± 0.011
1.376MetAsn: 1.376 ± 0.013
1.157MetPro: 1.157 ± 0.012
1.193MetGln: 1.193 ± 0.013
1.263MetArg: 1.263 ± 0.014
1.698MetSer: 1.698 ± 0.017
1.271MetThr: 1.271 ± 0.012
1.379MetVal: 1.379 ± 0.014
0.237MetTrp: 0.237 ± 0.006
0.686MetTyr: 0.686 ± 0.01
0.001MetXaa: 0.001 ± 0.0
Asn
3.259AsnAla: 3.259 ± 0.024
1.425AsnCys: 1.425 ± 0.015
2.767AsnAsp: 2.767 ± 0.019
3.246AsnGlu: 3.246 ± 0.023
2.54AsnPhe: 2.54 ± 0.02
2.999AsnGly: 2.999 ± 0.027
1.051AsnHis: 1.051 ± 0.01
2.726AsnIle: 2.726 ± 0.022
2.515AsnLys: 2.515 ± 0.021
4.521AsnLeu: 4.521 ± 0.028
1.154AsnMet: 1.154 ± 0.011
2.969AsnAsn: 2.969 ± 0.033
1.928AsnPro: 1.928 ± 0.02
1.823AsnGln: 1.823 ± 0.016
2.667AsnArg: 2.667 ± 0.019
4.266AsnSer: 4.266 ± 0.032
2.261AsnThr: 2.261 ± 0.018
3.433AsnVal: 3.433 ± 0.02
0.614AsnTrp: 0.614 ± 0.01
1.723AsnTyr: 1.723 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
2.875ProAla: 2.875 ± 0.023
0.945ProCys: 0.945 ± 0.016
2.26ProAsp: 2.26 ± 0.019
2.587ProGlu: 2.587 ± 0.025
1.982ProPhe: 1.982 ± 0.018
2.346ProGly: 2.346 ± 0.059
0.931ProHis: 0.931 ± 0.012
2.16ProIle: 2.16 ± 0.019
2.343ProLys: 2.343 ± 0.019
4.045ProLeu: 4.045 ± 0.026
0.955ProMet: 0.955 ± 0.011
2.064ProAsn: 2.064 ± 0.019
2.95ProPro: 2.95 ± 0.04
1.505ProGln: 1.505 ± 0.017
1.974ProArg: 1.974 ± 0.017
3.835ProSer: 3.835 ± 0.031
2.681ProThr: 2.681 ± 0.022
3.16ProVal: 3.16 ± 0.025
0.485ProTrp: 0.485 ± 0.009
1.368ProTyr: 1.368 ± 0.016
0.001ProXaa: 0.001 ± 0.0
Gln
2.59GlnAla: 2.59 ± 0.022
1.147GlnCys: 1.147 ± 0.016
1.467GlnAsp: 1.467 ± 0.016
2.161GlnGlu: 2.161 ± 0.02
1.944GlnPhe: 1.944 ± 0.017
1.476GlnGly: 1.476 ± 0.015
1.225GlnHis: 1.225 ± 0.015
2.424GlnIle: 2.424 ± 0.019
2.536GlnLys: 2.536 ± 0.021
4.881GlnLeu: 4.881 ± 0.032
1.201GlnMet: 1.201 ± 0.012
2.117GlnAsn: 2.117 ± 0.017
1.886GlnPro: 1.886 ± 0.02
3.617GlnGln: 3.617 ± 0.077
2.699GlnArg: 2.699 ± 0.02
3.315GlnSer: 3.315 ± 0.026
2.139GlnThr: 2.139 ± 0.017
2.134GlnVal: 2.134 ± 0.018
0.613GlnTrp: 0.613 ± 0.01
1.302GlnTyr: 1.302 ± 0.013
0.001GlnXaa: 0.001 ± 0.0
Arg
3.044ArgAla: 3.044 ± 0.024
1.606ArgCys: 1.606 ± 0.017
2.431ArgAsp: 2.431 ± 0.021
3.035ArgGlu: 3.035 ± 0.028
2.648ArgPhe: 2.648 ± 0.017
2.531ArgGly: 2.531 ± 0.023
1.575ArgHis: 1.575 ± 0.013
3.265ArgIle: 3.265 ± 0.022
3.76ArgLys: 3.76 ± 0.024
5.952ArgLeu: 5.952 ± 0.035
1.477ArgMet: 1.477 ± 0.014
2.705ArgAsn: 2.705 ± 0.021
2.4ArgPro: 2.4 ± 0.018
2.626ArgGln: 2.626 ± 0.018
4.86ArgArg: 4.86 ± 0.035
4.565ArgSer: 4.565 ± 0.032
2.827ArgThr: 2.827 ± 0.021
3.023ArgVal: 3.023 ± 0.025
0.838ArgTrp: 0.838 ± 0.012
1.744ArgTyr: 1.744 ± 0.017
0.001ArgXaa: 0.001 ± 0.0
Ser
5.564SerAla: 5.564 ± 0.032
2.092SerCys: 2.092 ± 0.02
4.459SerAsp: 4.459 ± 0.031
4.859SerGlu: 4.859 ± 0.032
3.607SerPhe: 3.607 ± 0.024
4.577SerGly: 4.577 ± 0.027
1.66SerHis: 1.66 ± 0.014
4.219SerIle: 4.219 ± 0.027
4.723SerLys: 4.723 ± 0.031
7.432SerLeu: 7.432 ± 0.033
1.827SerMet: 1.827 ± 0.016
4.186SerAsn: 4.186 ± 0.03
3.529SerPro: 3.529 ± 0.029
2.87SerGln: 2.87 ± 0.02
4.418SerArg: 4.418 ± 0.028
9.567SerSer: 9.567 ± 0.074
5.268SerThr: 5.268 ± 0.034
5.634SerVal: 5.634 ± 0.026
0.939SerTrp: 0.939 ± 0.012
2.227SerTyr: 2.227 ± 0.018
0.001SerXaa: 0.001 ± 0.0
Thr
4.183ThrAla: 4.183 ± 0.03
1.324ThrCys: 1.324 ± 0.017
2.809ThrAsp: 2.809 ± 0.02
3.166ThrGlu: 3.166 ± 0.023
2.402ThrPhe: 2.402 ± 0.019
2.899ThrGly: 2.899 ± 0.023
0.942ThrHis: 0.942 ± 0.011
2.858ThrIle: 2.858 ± 0.023
2.775ThrLys: 2.775 ± 0.018
5.036ThrLeu: 5.036 ± 0.028
1.263ThrMet: 1.263 ± 0.013
2.458ThrAsn: 2.458 ± 0.019
2.395ThrPro: 2.395 ± 0.023
1.531ThrGln: 1.531 ± 0.015
2.287ThrArg: 2.287 ± 0.018
4.54ThrSer: 4.54 ± 0.028
3.864ThrThr: 3.864 ± 0.043
4.425ThrVal: 4.425 ± 0.026
0.568ThrTrp: 0.568 ± 0.01
1.398ThrTyr: 1.398 ± 0.014
0.0ThrXaa: 0.0 ± 0.0
Val
4.291ValAla: 4.291 ± 0.024
1.643ValCys: 1.643 ± 0.02
4.098ValAsp: 4.098 ± 0.023
4.634ValGlu: 4.634 ± 0.028
2.582ValPhe: 2.582 ± 0.023
3.422ValGly: 3.422 ± 0.025
1.774ValHis: 1.774 ± 0.016
3.518ValIle: 3.518 ± 0.024
3.796ValLys: 3.796 ± 0.026
5.765ValLeu: 5.765 ± 0.032
1.421ValMet: 1.421 ± 0.015
3.027ValAsn: 3.027 ± 0.02
2.764ValPro: 2.764 ± 0.02
2.781ValGln: 2.781 ± 0.021
3.38ValArg: 3.38 ± 0.024
4.788ValSer: 4.788 ± 0.028
3.246ValThr: 3.246 ± 0.022
4.642ValVal: 4.642 ± 0.031
0.719ValTrp: 0.719 ± 0.01
1.866ValTyr: 1.866 ± 0.015
0.001ValXaa: 0.001 ± 0.0
Trp
0.635TrpAla: 0.635 ± 0.01
0.279TrpCys: 0.279 ± 0.006
0.546TrpAsp: 0.546 ± 0.01
0.564TrpGlu: 0.564 ± 0.009
0.565TrpPhe: 0.565 ± 0.01
0.402TrpGly: 0.402 ± 0.007
0.329TrpHis: 0.329 ± 0.007
0.818TrpIle: 0.818 ± 0.012
0.961TrpLys: 0.961 ± 0.011
1.317TrpLeu: 1.317 ± 0.015
0.357TrpMet: 0.357 ± 0.008
0.765TrpAsn: 0.765 ± 0.01
0.534TrpPro: 0.534 ± 0.009
0.548TrpGln: 0.548 ± 0.01
0.764TrpArg: 0.764 ± 0.01
1.017TrpSer: 1.017 ± 0.013
0.685TrpThr: 0.685 ± 0.01
0.504TrpVal: 0.504 ± 0.008
0.194TrpTrp: 0.194 ± 0.006
0.421TrpTyr: 0.421 ± 0.009
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.866TyrAla: 1.866 ± 0.017
0.983TyrCys: 0.983 ± 0.013
1.628TyrAsp: 1.628 ± 0.017
1.805TyrGlu: 1.805 ± 0.017
1.77TyrPhe: 1.77 ± 0.02
1.794TyrGly: 1.794 ± 0.017
0.811TyrHis: 0.811 ± 0.011
1.593TyrIle: 1.593 ± 0.016
1.679TyrLys: 1.679 ± 0.018
3.022TyrLeu: 3.022 ± 0.023
0.711TyrMet: 0.711 ± 0.009
1.488TyrAsn: 1.488 ± 0.014
1.327TyrPro: 1.327 ± 0.014
1.172TyrGln: 1.172 ± 0.012
1.802TyrArg: 1.802 ± 0.016
2.511TyrSer: 2.511 ± 0.018
1.449TyrThr: 1.449 ± 0.016
1.899TyrVal: 1.899 ± 0.017
0.438TyrTrp: 0.438 ± 0.008
1.224TyrTyr: 1.224 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.001XaaHis: 0.001 ± 0.0
0.002XaaIle: 0.002 ± 0.001
0.002XaaLys: 0.002 ± 0.0
0.003XaaLeu: 0.003 ± 0.001
0.001XaaMet: 0.001 ± 0.0
0.001XaaAsn: 0.001 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.002XaaArg: 0.002 ± 0.0
0.002XaaSer: 0.002 ± 0.0
0.001XaaThr: 0.001 ± 0.0
0.001XaaVal: 0.001 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.017XaaXaa: 0.017 ± 0.003
Statistics based on 18039 proteins (8199004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski