Amino acid dipepetide frequency for Wuchereria bancrofti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.778AlaAla: 4.778 ± 0.051	1.16AlaCys: 1.16 ± 0.018	2.98AlaAsp: 2.98 ± 0.027	4.097AlaGlu: 4.097 ± 0.035	2.547AlaPhe: 2.547 ± 0.022	2.829AlaGly: 2.829 ± 0.03	1.33AlaHis: 1.33 ± 0.018	4.065AlaIle: 4.065 ± 0.035	3.663AlaLys: 3.663 ± 0.035	5.897AlaLeu: 5.897 ± 0.04	1.506AlaMet: 1.506 ± 0.018	2.892AlaAsn: 2.892 ± 0.025	2.138AlaPro: 2.138 ± 0.025	2.33AlaGln: 2.33 ± 0.026	3.049AlaArg: 3.049 ± 0.032	4.576AlaSer: 4.576 ± 0.034	3.642AlaThr: 3.642 ± 0.033	4.496AlaVal: 4.496 ± 0.037	0.556AlaTrp: 0.556 ± 0.013	1.772AlaTyr: 1.772 ± 0.022	0.004AlaXaa: 0.004 ± 0.001
Cys	1.273CysAla: 1.273 ± 0.016	0.667CysCys: 0.667 ± 0.015	1.252CysAsp: 1.252 ± 0.022	1.289CysGlu: 1.289 ± 0.02	1.03CysPhe: 1.03 ± 0.018	1.313CysGly: 1.313 ± 0.024	0.572CysHis: 0.572 ± 0.013	1.479CysIle: 1.479 ± 0.021	1.236CysLys: 1.236 ± 0.018	1.986CysLeu: 1.986 ± 0.025	0.523CysMet: 0.523 ± 0.01	1.129CysAsn: 1.129 ± 0.017	1.018CysPro: 1.018 ± 0.021	0.836CysGln: 0.836 ± 0.016	1.29CysArg: 1.29 ± 0.02	1.932CysSer: 1.932 ± 0.025	1.148CysThr: 1.148 ± 0.016	1.208CysVal: 1.208 ± 0.019	0.255CysTrp: 0.255 ± 0.008	0.74CysTyr: 0.74 ± 0.013	0.001CysXaa: 0.001 ± 0.001
Asp	3.135AspAla: 3.135 ± 0.028	1.104AspCys: 1.104 ± 0.02	4.165AspAsp: 4.165 ± 0.047	4.701AspGlu: 4.701 ± 0.047	2.411AspPhe: 2.411 ± 0.027	3.207AspGly: 3.207 ± 0.032	1.111AspHis: 1.111 ± 0.015	3.627AspIle: 3.627 ± 0.032	2.957AspLys: 2.957 ± 0.03	4.755AspLeu: 4.755 ± 0.037	1.272AspMet: 1.272 ± 0.018	2.687AspAsn: 2.687 ± 0.025	1.976AspPro: 1.976 ± 0.025	1.801AspGln: 1.801 ± 0.023	2.756AspArg: 2.756 ± 0.027	3.996AspSer: 3.996 ± 0.032	2.454AspThr: 2.454 ± 0.024	3.377AspVal: 3.377 ± 0.028	0.624AspTrp: 0.624 ± 0.013	1.82AspTyr: 1.82 ± 0.021	0.003AspXaa: 0.003 ± 0.001
Glu	3.856GluAla: 3.856 ± 0.038	1.306GluCys: 1.306 ± 0.019	3.251GluAsp: 3.251 ± 0.034	5.551GluGlu: 5.551 ± 0.053	2.314GluPhe: 2.314 ± 0.025	2.678GluGly: 2.678 ± 0.027	1.442GluHis: 1.442 ± 0.018	4.632GluIle: 4.632 ± 0.035	5.499GluLys: 5.499 ± 0.051	6.077GluLeu: 6.077 ± 0.043	2.101GluMet: 2.101 ± 0.022	3.952GluAsn: 3.952 ± 0.03	2.006GluPro: 2.006 ± 0.025	3.201GluGln: 3.201 ± 0.032	4.147GluArg: 4.147 ± 0.035	4.393GluSer: 4.393 ± 0.035	3.531GluThr: 3.531 ± 0.034	3.587GluVal: 3.587 ± 0.03	0.757GluTrp: 0.757 ± 0.015	1.99GluTyr: 1.99 ± 0.023	0.003GluXaa: 0.003 ± 0.001
Phe	2.708PheAla: 2.708 ± 0.024	1.13PheCys: 1.13 ± 0.019	2.548PheAsp: 2.548 ± 0.027	2.579PheGlu: 2.579 ± 0.029	2.143PhePhe: 2.143 ± 0.027	2.665PheGly: 2.665 ± 0.029	1.157PheHis: 1.157 ± 0.018	3.029PheIle: 3.029 ± 0.031	2.024PheLys: 2.024 ± 0.024	4.141PheLeu: 4.141 ± 0.032	1.086PheMet: 1.086 ± 0.017	1.934PheAsn: 1.934 ± 0.022	1.743PhePro: 1.743 ± 0.021	1.541PheGln: 1.541 ± 0.021	2.271PheArg: 2.271 ± 0.023	3.449PheSer: 3.449 ± 0.028	2.383PheThr: 2.383 ± 0.025	2.794PheVal: 2.794 ± 0.028	0.546PheTrp: 0.546 ± 0.011	1.546PheTyr: 1.546 ± 0.022	0.003PheXaa: 0.003 ± 0.001
Gly	2.755GlyAla: 2.755 ± 0.03	1.087GlyCys: 1.087 ± 0.019	2.694GlyAsp: 2.694 ± 0.027	2.968GlyGlu: 2.968 ± 0.03	2.184GlyPhe: 2.184 ± 0.023	2.945GlyGly: 2.945 ± 0.042	1.209GlyHis: 1.209 ± 0.018	3.515GlyIle: 3.515 ± 0.032	3.253GlyLys: 3.253 ± 0.033	3.991GlyLeu: 3.991 ± 0.032	1.239GlyMet: 1.239 ± 0.02	2.674GlyAsn: 2.674 ± 0.028	1.633GlyPro: 1.633 ± 0.025	1.856GlyGln: 1.856 ± 0.026	3.0GlyArg: 3.0 ± 0.031	4.038GlySer: 4.038 ± 0.04	3.005GlyThr: 3.005 ± 0.03	2.747GlyVal: 2.747 ± 0.026	0.608GlyTrp: 0.608 ± 0.012	1.736GlyTyr: 1.736 ± 0.021	0.005GlyXaa: 0.005 ± 0.001
His	1.303HisAla: 1.303 ± 0.018	0.686HisCys: 0.686 ± 0.012	1.092HisAsp: 1.092 ± 0.017	1.363HisGlu: 1.363 ± 0.017	1.31HisPhe: 1.31 ± 0.019	1.202HisGly: 1.202 ± 0.019	0.736HisHis: 0.736 ± 0.016	1.603HisIle: 1.603 ± 0.018	1.151HisLys: 1.151 ± 0.018	2.484HisLeu: 2.484 ± 0.026	0.6HisMet: 0.6 ± 0.012	1.064HisAsn: 1.064 ± 0.017	1.114HisPro: 1.114 ± 0.016	1.023HisGln: 1.023 ± 0.016	1.482HisArg: 1.482 ± 0.021	2.039HisSer: 2.039 ± 0.024	1.105HisThr: 1.105 ± 0.016	1.31HisVal: 1.31 ± 0.018	0.321HisTrp: 0.321 ± 0.01	0.922HisTyr: 0.922 ± 0.016	0.003HisXaa: 0.003 ± 0.001
Ile	4.453IleAla: 4.453 ± 0.037	1.706IleCys: 1.706 ± 0.024	3.856IleAsp: 3.856 ± 0.036	4.064IleGlu: 4.064 ± 0.033	3.009IlePhe: 3.009 ± 0.027	3.397IleGly: 3.397 ± 0.032	1.556IleHis: 1.556 ± 0.02	4.569IleIle: 4.569 ± 0.044	3.524IleLys: 3.524 ± 0.03	5.915IleLeu: 5.915 ± 0.042	1.509IleMet: 1.509 ± 0.018	3.377IleAsn: 3.377 ± 0.032	3.049IlePro: 3.049 ± 0.031	2.403IleGln: 2.403 ± 0.022	3.766IleArg: 3.766 ± 0.028	5.934IleSer: 5.934 ± 0.039	3.961IleThr: 3.961 ± 0.032	3.997IleVal: 3.997 ± 0.034	0.735IleTrp: 0.735 ± 0.013	2.143IleTyr: 2.143 ± 0.022	0.006IleXaa: 0.006 ± 0.001
Lys	3.386LysAla: 3.386 ± 0.033	1.417LysCys: 1.417 ± 0.024	3.002LysAsp: 3.002 ± 0.031	4.579LysGlu: 4.579 ± 0.047	2.426LysPhe: 2.426 ± 0.024	2.576LysGly: 2.576 ± 0.029	1.534LysHis: 1.534 ± 0.02	4.238LysIle: 4.238 ± 0.04	5.265LysLys: 5.265 ± 0.065	6.098LysLeu: 6.098 ± 0.046	1.867LysMet: 1.867 ± 0.026	3.411LysAsn: 3.411 ± 0.031	2.301LysPro: 2.301 ± 0.029	2.929LysGln: 2.929 ± 0.03	4.143LysArg: 4.143 ± 0.034	4.338LysSer: 4.338 ± 0.033	3.321LysThr: 3.321 ± 0.033	3.348LysVal: 3.348 ± 0.026	0.758LysTrp: 0.758 ± 0.012	2.135LysTyr: 2.135 ± 0.022	0.002LysXaa: 0.002 ± 0.001
Leu	5.63LeuAla: 5.63 ± 0.035	2.105LeuCys: 2.105 ± 0.025	4.63LeuAsp: 4.63 ± 0.039	5.829LeuGlu: 5.829 ± 0.051	4.214LeuPhe: 4.214 ± 0.034	3.724LeuGly: 3.724 ± 0.033	2.505LeuHis: 2.505 ± 0.025	6.021LeuIle: 6.021 ± 0.045	6.207LeuLys: 6.207 ± 0.044	10.034LeuLeu: 10.034 ± 0.067	2.368LeuMet: 2.368 ± 0.024	4.758LeuAsn: 4.758 ± 0.039	4.466LeuPro: 4.466 ± 0.036	4.304LeuGln: 4.304 ± 0.043	5.61LeuArg: 5.61 ± 0.04	7.955LeuSer: 7.955 ± 0.055	4.991LeuThr: 4.991 ± 0.037	4.833LeuVal: 4.833 ± 0.038	0.99LeuTrp: 0.99 ± 0.015	2.856LeuTyr: 2.856 ± 0.029	0.006LeuXaa: 0.006 ± 0.001
Met	1.535MetAla: 1.535 ± 0.021	0.461MetCys: 0.461 ± 0.011	1.459MetAsp: 1.459 ± 0.018	1.96MetGlu: 1.96 ± 0.026	0.966MetPhe: 0.966 ± 0.017	1.027MetGly: 1.027 ± 0.016	0.658MetHis: 0.658 ± 0.013	1.693MetIle: 1.693 ± 0.02	1.966MetLys: 1.966 ± 0.021	2.463MetLeu: 2.463 ± 0.024	0.73MetMet: 0.73 ± 0.014	1.434MetAsn: 1.434 ± 0.019	1.016MetPro: 1.016 ± 0.015	1.231MetGln: 1.231 ± 0.019	1.426MetArg: 1.426 ± 0.019	1.797MetSer: 1.797 ± 0.021	1.326MetThr: 1.326 ± 0.018	1.388MetVal: 1.388 ± 0.02	0.233MetTrp: 0.233 ± 0.008	0.675MetTyr: 0.675 ± 0.012	0.001MetXaa: 0.001 ± 0.0
Asn	3.198AsnAla: 3.198 ± 0.029	1.19AsnCys: 1.19 ± 0.019	3.454AsnAsp: 3.454 ± 0.032	3.978AsnGlu: 3.978 ± 0.031	2.333AsnPhe: 2.333 ± 0.026	3.175AsnGly: 3.175 ± 0.034	1.119AsnHis: 1.119 ± 0.016	3.597AsnIle: 3.597 ± 0.034	2.838AsnLys: 2.838 ± 0.024	4.524AsnLeu: 4.524 ± 0.035	1.237AsnMet: 1.237 ± 0.018	3.009AsnAsn: 3.009 ± 0.039	1.873AsnPro: 1.873 ± 0.021	1.795AsnGln: 1.795 ± 0.023	2.681AsnArg: 2.681 ± 0.024	4.194AsnSer: 4.194 ± 0.038	2.529AsnThr: 2.529 ± 0.027	3.27AsnVal: 3.27 ± 0.032	0.566AsnTrp: 0.566 ± 0.011	1.747AsnTyr: 1.747 ± 0.022	0.002AsnXaa: 0.002 ± 0.001
Pro	2.214ProAla: 2.214 ± 0.027	0.746ProCys: 0.746 ± 0.015	2.023ProAsp: 2.023 ± 0.025	2.664ProGlu: 2.664 ± 0.033	1.815ProPhe: 1.815 ± 0.019	1.987ProGly: 1.987 ± 0.033	0.882ProHis: 0.882 ± 0.015	2.576ProIle: 2.576 ± 0.027	2.311ProLys: 2.311 ± 0.03	3.743ProLeu: 3.743 ± 0.031	0.878ProMet: 0.878 ± 0.017	2.028ProAsn: 2.028 ± 0.021	2.577ProPro: 2.577 ± 0.043	1.577ProGln: 1.577 ± 0.021	1.898ProArg: 1.898 ± 0.022	3.756ProSer: 3.756 ± 0.035	2.415ProThr: 2.415 ± 0.028	2.715ProVal: 2.715 ± 0.022	0.408ProTrp: 0.408 ± 0.011	1.393ProTyr: 1.393 ± 0.016	0.002ProXaa: 0.002 ± 0.001
Gln	2.11GlnAla: 2.11 ± 0.029	0.976GlnCys: 0.976 ± 0.016	1.415GlnAsp: 1.415 ± 0.017	2.336GlnGlu: 2.336 ± 0.029	1.763GlnPhe: 1.763 ± 0.022	1.383GlnGly: 1.383 ± 0.018	1.103GlnHis: 1.103 ± 0.019	2.878GlnIle: 2.878 ± 0.031	2.939GlnLys: 2.939 ± 0.032	4.468GlnLeu: 4.468 ± 0.037	1.272GlnMet: 1.272 ± 0.019	2.25GlnAsn: 2.25 ± 0.025	1.611GlnPro: 1.611 ± 0.023	3.31GlnGln: 3.31 ± 0.065	2.55GlnArg: 2.55 ± 0.029	2.989GlnSer: 2.989 ± 0.026	2.167GlnThr: 2.167 ± 0.024	2.029GlnVal: 2.029 ± 0.024	0.514GlnTrp: 0.514 ± 0.011	1.378GlnTyr: 1.378 ± 0.019	0.003GlnXaa: 0.003 ± 0.001
Arg	2.956ArgAla: 2.956 ± 0.03	1.335ArgCys: 1.335 ± 0.02	2.649ArgAsp: 2.649 ± 0.029	3.513ArgGlu: 3.513 ± 0.031	2.418ArgPhe: 2.418 ± 0.027	2.436ArgGly: 2.436 ± 0.032	1.478ArgHis: 1.478 ± 0.019	3.879ArgIle: 3.879 ± 0.029	4.358ArgLys: 4.358 ± 0.038	5.385ArgLeu: 5.385 ± 0.04	1.465ArgMet: 1.465 ± 0.021	3.331ArgAsn: 3.331 ± 0.03	2.094ArgPro: 2.094 ± 0.028	2.5ArgGln: 2.5 ± 0.027	4.318ArgArg: 4.318 ± 0.046	4.398ArgSer: 4.398 ± 0.04	3.0ArgThr: 3.0 ± 0.029	2.774ArgVal: 2.774 ± 0.024	0.67ArgTrp: 0.67 ± 0.014	1.911ArgTyr: 1.911 ± 0.022	0.003ArgXaa: 0.003 ± 0.001
Ser	4.909SerAla: 4.909 ± 0.04	1.641SerCys: 1.641 ± 0.021	4.497SerAsp: 4.497 ± 0.038	4.775SerGlu: 4.775 ± 0.042	3.586SerPhe: 3.586 ± 0.031	4.467SerGly: 4.467 ± 0.041	1.755SerHis: 1.755 ± 0.021	4.868SerIle: 4.868 ± 0.038	4.614SerLys: 4.614 ± 0.038	7.475SerLeu: 7.475 ± 0.048	1.881SerMet: 1.881 ± 0.023	4.303SerAsn: 4.303 ± 0.039	3.3SerPro: 3.3 ± 0.038	2.887SerGln: 2.887 ± 0.029	4.183SerArg: 4.183 ± 0.039	8.928SerSer: 8.928 ± 0.083	5.052SerThr: 5.052 ± 0.045	5.124SerVal: 5.124 ± 0.037	0.779SerTrp: 0.779 ± 0.013	2.298SerTyr: 2.298 ± 0.026	0.005SerXaa: 0.005 ± 0.001
Thr	3.837ThrAla: 3.837 ± 0.036	1.106ThrCys: 1.106 ± 0.018	3.052ThrAsp: 3.052 ± 0.028	3.397ThrGlu: 3.397 ± 0.029	2.39ThrPhe: 2.39 ± 0.024	2.918ThrGly: 2.918 ± 0.027	1.147ThrHis: 1.147 ± 0.018	3.75ThrIle: 3.75 ± 0.035	3.164ThrLys: 3.164 ± 0.034	4.965ThrLeu: 4.965 ± 0.035	1.286ThrMet: 1.286 ± 0.018	2.939ThrAsn: 2.939 ± 0.031	2.366ThrPro: 2.366 ± 0.026	1.776ThrGln: 1.776 ± 0.024	2.481ThrArg: 2.481 ± 0.028	4.919ThrSer: 4.919 ± 0.041	4.201ThrThr: 4.201 ± 0.057	4.063ThrVal: 4.063 ± 0.031	0.487ThrTrp: 0.487 ± 0.01	1.624ThrTyr: 1.624 ± 0.022	0.003ThrXaa: 0.003 ± 0.001
Val	3.876ValAla: 3.876 ± 0.034	1.286ValCys: 1.286 ± 0.019	3.461ValAsp: 3.461 ± 0.028	4.082ValGlu: 4.082 ± 0.039	2.42ValPhe: 2.42 ± 0.025	2.875ValGly: 2.875 ± 0.031	1.435ValHis: 1.435 ± 0.018	4.097ValIle: 4.097 ± 0.033	3.549ValLys: 3.549 ± 0.035	5.493ValLeu: 5.493 ± 0.045	1.49ValMet: 1.49 ± 0.02	2.884ValAsn: 2.884 ± 0.029	2.602ValPro: 2.602 ± 0.025	2.419ValGln: 2.419 ± 0.026	3.127ValArg: 3.127 ± 0.03	4.437ValSer: 4.437 ± 0.033	3.494ValThr: 3.494 ± 0.03	3.985ValVal: 3.985 ± 0.048	0.61ValTrp: 0.61 ± 0.011	1.797ValTyr: 1.797 ± 0.023	0.003ValXaa: 0.003 ± 0.001
Trp	0.541TrpAla: 0.541 ± 0.011	0.234TrpCys: 0.234 ± 0.006	0.552TrpAsp: 0.552 ± 0.013	0.586TrpGlu: 0.586 ± 0.013	0.519TrpPhe: 0.519 ± 0.011	0.401TrpGly: 0.401 ± 0.011	0.29TrpHis: 0.29 ± 0.009	0.802TrpIle: 0.802 ± 0.014	0.854TrpLys: 0.854 ± 0.016	1.128TrpLeu: 1.128 ± 0.017	0.33TrpMet: 0.33 ± 0.009	0.704TrpAsn: 0.704 ± 0.016	0.426TrpPro: 0.426 ± 0.011	0.446TrpGln: 0.446 ± 0.011	0.705TrpArg: 0.705 ± 0.013	0.836TrpSer: 0.836 ± 0.015	0.625TrpThr: 0.625 ± 0.012	0.465TrpVal: 0.465 ± 0.01	0.171TrpTrp: 0.171 ± 0.007	0.382TrpTyr: 0.382 ± 0.01	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.849TyrAla: 1.849 ± 0.02	0.835TyrCys: 0.835 ± 0.018	1.905TyrAsp: 1.905 ± 0.025	1.956TyrGlu: 1.956 ± 0.021	1.62TyrPhe: 1.62 ± 0.019	1.934TyrGly: 1.934 ± 0.023	0.893TyrHis: 0.893 ± 0.016	2.008TyrIle: 2.008 ± 0.023	1.697TyrLys: 1.697 ± 0.024	3.009TyrLeu: 3.009 ± 0.029	0.803TyrMet: 0.803 ± 0.014	1.549TyrAsn: 1.549 ± 0.021	1.293TyrPro: 1.293 ± 0.018	1.275TyrGln: 1.275 ± 0.018	1.988TyrArg: 1.988 ± 0.019	2.42TyrSer: 2.42 ± 0.028	1.515TyrThr: 1.515 ± 0.021	1.909TyrVal: 1.909 ± 0.022	0.409TyrTrp: 0.409 ± 0.011	1.307TyrTyr: 1.307 ± 0.021	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.004XaaAla: 0.004 ± 0.001	0.002XaaCys: 0.002 ± 0.001	0.003XaaAsp: 0.003 ± 0.001	0.004XaaGlu: 0.004 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.003XaaGly: 0.003 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.005XaaIle: 0.005 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.007XaaLeu: 0.007 ± 0.001	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.003XaaPro: 0.003 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.003XaaArg: 0.003 ± 0.001	0.007XaaSer: 0.007 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.258XaaXaa: 0.258 ± 0.028

Statistics based on 13000 proteins (4298790 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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