Amino acid dipepetide frequency for Streptococcus satellite phage Javan81

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.926AlaAla: 2.926 ± 0.853
0.732AlaCys: 0.732 ± 0.386
5.486AlaAsp: 5.486 ± 1.679
5.486AlaGlu: 5.486 ± 1.266
2.195AlaPhe: 2.195 ± 0.723
4.389AlaGly: 4.389 ± 1.313
0.366AlaHis: 0.366 ± 0.398
6.584AlaIle: 6.584 ± 1.495
6.95AlaLys: 6.95 ± 1.361
9.876AlaLeu: 9.876 ± 2.325
1.829AlaMet: 1.829 ± 0.661
2.195AlaAsn: 2.195 ± 0.929
1.829AlaPro: 1.829 ± 0.689
2.56AlaGln: 2.56 ± 0.857
3.292AlaArg: 3.292 ± 0.793
3.292AlaSer: 3.292 ± 1.148
3.292AlaThr: 3.292 ± 0.748
2.56AlaVal: 2.56 ± 0.902
0.366AlaTrp: 0.366 ± 0.367
2.926AlaTyr: 2.926 ± 1.113
0.0AlaXaa: 0.0 ± 0.0
Cys
1.097CysAla: 1.097 ± 0.494
0.0CysCys: 0.0 ± 0.0
0.366CysAsp: 0.366 ± 0.376
0.366CysGlu: 0.366 ± 0.352
0.0CysPhe: 0.0 ± 0.0
0.732CysGly: 0.732 ± 0.418
0.366CysHis: 0.366 ± 0.387
0.732CysIle: 0.732 ± 0.436
1.097CysLys: 1.097 ± 0.459
0.366CysLeu: 0.366 ± 0.387
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.366CysGln: 0.366 ± 0.42
0.366CysArg: 0.366 ± 0.352
0.366CysSer: 0.366 ± 0.352
0.366CysThr: 0.366 ± 0.367
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.366CysTyr: 0.366 ± 0.376
0.0CysXaa: 0.0 ± 0.0
Asp
2.195AspAla: 2.195 ± 0.708
0.732AspCys: 0.732 ± 0.483
2.195AspAsp: 2.195 ± 0.726
3.658AspGlu: 3.658 ± 0.764
2.195AspPhe: 2.195 ± 0.845
2.56AspGly: 2.56 ± 1.039
0.732AspHis: 0.732 ± 0.422
6.584AspIle: 6.584 ± 1.372
6.95AspLys: 6.95 ± 1.24
5.121AspLeu: 5.121 ± 1.246
2.56AspMet: 2.56 ± 1.011
4.389AspAsn: 4.389 ± 1.508
0.732AspPro: 0.732 ± 0.503
1.097AspGln: 1.097 ± 0.46
1.097AspArg: 1.097 ± 0.597
2.195AspSer: 2.195 ± 0.961
2.56AspThr: 2.56 ± 0.838
2.56AspVal: 2.56 ± 1.076
0.732AspTrp: 0.732 ± 0.5
2.56AspTyr: 2.56 ± 1.143
0.0AspXaa: 0.0 ± 0.0
Glu
6.218GluAla: 6.218 ± 1.664
0.366GluCys: 0.366 ± 0.336
2.926GluAsp: 2.926 ± 1.131
4.755GluGlu: 4.755 ± 1.564
2.56GluPhe: 2.56 ± 1.159
2.195GluGly: 2.195 ± 0.911
0.366GluHis: 0.366 ± 0.367
7.315GluIle: 7.315 ± 1.879
9.876GluLys: 9.876 ± 1.204
10.241GluLeu: 10.241 ± 2.121
3.658GluMet: 3.658 ± 1.096
2.56GluAsn: 2.56 ± 0.876
1.097GluPro: 1.097 ± 0.558
5.852GluGln: 5.852 ± 1.874
6.584GluArg: 6.584 ± 2.164
3.292GluSer: 3.292 ± 0.959
4.389GluThr: 4.389 ± 0.781
2.195GluVal: 2.195 ± 0.721
1.097GluTrp: 1.097 ± 0.519
2.926GluTyr: 2.926 ± 1.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.56PheAla: 2.56 ± 0.768
0.732PheCys: 0.732 ± 0.497
2.926PheAsp: 2.926 ± 0.987
4.023PheGlu: 4.023 ± 1.199
1.829PhePhe: 1.829 ± 0.637
2.926PheGly: 2.926 ± 0.818
1.097PheHis: 1.097 ± 0.546
3.292PheIle: 3.292 ± 0.887
2.56PheLys: 2.56 ± 0.898
2.926PheLeu: 2.926 ± 0.968
0.366PheMet: 0.366 ± 0.298
1.097PheAsn: 1.097 ± 0.638
1.097PhePro: 1.097 ± 0.58
1.463PheGln: 1.463 ± 0.618
2.56PheArg: 2.56 ± 0.812
2.195PheSer: 2.195 ± 1.121
1.829PheThr: 1.829 ± 0.84
1.463PheVal: 1.463 ± 0.593
0.366PheTrp: 0.366 ± 0.311
1.463PheTyr: 1.463 ± 0.637
0.0PheXaa: 0.0 ± 0.0
Gly
2.56GlyAla: 2.56 ± 0.753
0.0GlyCys: 0.0 ± 0.0
0.732GlyAsp: 0.732 ± 0.509
2.56GlyGlu: 2.56 ± 1.071
1.829GlyPhe: 1.829 ± 0.794
2.926GlyGly: 2.926 ± 1.227
0.732GlyHis: 0.732 ± 0.415
4.389GlyIle: 4.389 ± 1.171
4.023GlyLys: 4.023 ± 0.976
8.778GlyLeu: 8.778 ± 1.608
1.829GlyMet: 1.829 ± 0.88
1.463GlyAsn: 1.463 ± 0.858
0.0GlyPro: 0.0 ± 0.0
1.829GlyGln: 1.829 ± 0.804
2.195GlyArg: 2.195 ± 0.675
2.926GlySer: 2.926 ± 0.908
1.463GlyThr: 1.463 ± 0.54
2.926GlyVal: 2.926 ± 0.994
1.097GlyTrp: 1.097 ± 0.606
3.292GlyTyr: 3.292 ± 0.988
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.867
0.0HisCys: 0.0 ± 0.0
0.366HisAsp: 0.366 ± 0.336
0.366HisGlu: 0.366 ± 0.397
0.366HisPhe: 0.366 ± 0.397
2.195HisGly: 2.195 ± 0.927
1.829HisHis: 1.829 ± 1.105
1.463HisIle: 1.463 ± 0.579
1.097HisLys: 1.097 ± 0.705
3.292HisLeu: 3.292 ± 0.871
0.0HisMet: 0.0 ± 0.0
0.732HisAsn: 0.732 ± 0.507
0.732HisPro: 0.732 ± 0.496
0.0HisGln: 0.0 ± 0.0
0.0HisArg: 0.0 ± 0.0
0.0HisSer: 0.0 ± 0.0
1.097HisThr: 1.097 ± 0.473
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
0.732HisTyr: 0.732 ± 0.508
0.0HisXaa: 0.0 ± 0.0
Ile
4.389IleAla: 4.389 ± 1.122
1.463IleCys: 1.463 ± 0.787
7.315IleAsp: 7.315 ± 1.232
5.486IleGlu: 5.486 ± 1.651
2.926IlePhe: 2.926 ± 1.093
1.829IleGly: 1.829 ± 0.8
1.097IleHis: 1.097 ± 0.612
4.389IleIle: 4.389 ± 1.116
4.389IleLys: 4.389 ± 1.233
8.778IleLeu: 8.778 ± 2.294
0.732IleMet: 0.732 ± 0.613
2.195IleAsn: 2.195 ± 0.864
2.56IlePro: 2.56 ± 0.951
3.292IleGln: 3.292 ± 1.231
5.852IleArg: 5.852 ± 1.058
4.389IleSer: 4.389 ± 1.553
5.852IleThr: 5.852 ± 1.5
1.829IleVal: 1.829 ± 0.743
1.829IleTrp: 1.829 ± 0.794
2.926IleTyr: 2.926 ± 0.794
0.0IleXaa: 0.0 ± 0.0
Lys
10.607LysAla: 10.607 ± 1.931
0.366LysCys: 0.366 ± 0.311
3.292LysAsp: 3.292 ± 1.507
11.339LysGlu: 11.339 ± 2.118
3.658LysPhe: 3.658 ± 0.844
3.292LysGly: 3.292 ± 1.031
1.097LysHis: 1.097 ± 0.739
4.389LysIle: 4.389 ± 0.905
9.51LysLys: 9.51 ± 1.895
6.95LysLeu: 6.95 ± 1.51
2.195LysMet: 2.195 ± 0.841
7.681LysAsn: 7.681 ± 1.518
3.658LysPro: 3.658 ± 1.014
5.486LysGln: 5.486 ± 1.206
3.658LysArg: 3.658 ± 1.047
3.658LysSer: 3.658 ± 1.268
8.047LysThr: 8.047 ± 1.482
5.852LysVal: 5.852 ± 1.477
0.366LysTrp: 0.366 ± 0.367
1.463LysTyr: 1.463 ± 0.838
0.0LysXaa: 0.0 ± 0.0
Leu
9.144LeuAla: 9.144 ± 1.97
0.732LeuCys: 0.732 ± 0.529
8.047LeuAsp: 8.047 ± 1.325
13.168LeuGlu: 13.168 ± 2.28
5.121LeuPhe: 5.121 ± 1.521
6.584LeuGly: 6.584 ± 1.613
0.732LeuHis: 0.732 ± 0.463
5.121LeuIle: 5.121 ± 1.239
13.533LeuLys: 13.533 ± 2.905
14.265LeuLeu: 14.265 ± 2.047
2.926LeuMet: 2.926 ± 0.846
4.023LeuAsn: 4.023 ± 1.089
2.56LeuPro: 2.56 ± 0.943
5.486LeuGln: 5.486 ± 1.038
3.292LeuArg: 3.292 ± 1.013
5.486LeuSer: 5.486 ± 1.243
8.778LeuThr: 8.778 ± 1.369
2.926LeuVal: 2.926 ± 0.983
0.732LeuTrp: 0.732 ± 0.773
3.658LeuTyr: 3.658 ± 1.253
0.0LeuXaa: 0.0 ± 0.0
Met
3.292MetAla: 3.292 ± 0.968
0.0MetCys: 0.0 ± 0.0
1.463MetAsp: 1.463 ± 0.697
2.195MetGlu: 2.195 ± 0.782
0.0MetPhe: 0.0 ± 0.0
0.366MetGly: 0.366 ± 0.33
0.0MetHis: 0.0 ± 0.0
1.829MetIle: 1.829 ± 0.735
1.463MetLys: 1.463 ± 0.711
2.56MetLeu: 2.56 ± 0.942
0.0MetMet: 0.0 ± 0.0
1.829MetAsn: 1.829 ± 0.97
0.732MetPro: 0.732 ± 0.557
0.366MetGln: 0.366 ± 0.33
1.463MetArg: 1.463 ± 0.584
0.732MetSer: 0.732 ± 0.443
2.56MetThr: 2.56 ± 0.819
1.097MetVal: 1.097 ± 0.71
0.366MetTrp: 0.366 ± 0.376
1.097MetTyr: 1.097 ± 0.659
0.0MetXaa: 0.0 ± 0.0
Asn
2.56AsnAla: 2.56 ± 0.862
0.0AsnCys: 0.0 ± 0.0
1.829AsnAsp: 1.829 ± 0.985
2.926AsnGlu: 2.926 ± 0.952
2.56AsnPhe: 2.56 ± 0.909
2.56AsnGly: 2.56 ± 0.934
0.732AsnHis: 0.732 ± 0.496
2.195AsnIle: 2.195 ± 0.69
5.486AsnLys: 5.486 ± 0.752
4.389AsnLeu: 4.389 ± 1.029
0.732AsnMet: 0.732 ± 0.415
3.292AsnAsn: 3.292 ± 0.858
0.732AsnPro: 0.732 ± 0.421
2.195AsnGln: 2.195 ± 0.703
2.195AsnArg: 2.195 ± 1.001
2.56AsnSer: 2.56 ± 1.081
2.195AsnThr: 2.195 ± 1.259
0.732AsnVal: 0.732 ± 0.785
0.366AsnTrp: 0.366 ± 0.42
1.829AsnTyr: 1.829 ± 0.699
0.0AsnXaa: 0.0 ± 0.0
Pro
2.195ProAla: 2.195 ± 0.843
0.0ProCys: 0.0 ± 0.0
1.829ProAsp: 1.829 ± 0.644
1.463ProGlu: 1.463 ± 0.906
0.732ProPhe: 0.732 ± 0.446
0.366ProGly: 0.366 ± 0.311
0.366ProHis: 0.366 ± 0.336
0.732ProIle: 0.732 ± 0.541
2.56ProLys: 2.56 ± 1.012
2.56ProLeu: 2.56 ± 1.028
0.0ProMet: 0.0 ± 0.0
0.0ProAsn: 0.0 ± 0.0
0.366ProPro: 0.366 ± 0.357
2.56ProGln: 2.56 ± 1.073
2.195ProArg: 2.195 ± 0.786
1.463ProSer: 1.463 ± 0.564
1.463ProThr: 1.463 ± 0.547
0.732ProVal: 0.732 ± 0.421
0.366ProTrp: 0.366 ± 0.43
1.463ProTyr: 1.463 ± 0.686
0.0ProXaa: 0.0 ± 0.0
Gln
3.658GlnAla: 3.658 ± 1.331
0.366GlnCys: 0.366 ± 0.352
2.195GlnAsp: 2.195 ± 0.941
3.292GlnGlu: 3.292 ± 0.868
0.732GlnPhe: 0.732 ± 0.661
2.926GlnGly: 2.926 ± 0.773
1.097GlnHis: 1.097 ± 0.755
3.658GlnIle: 3.658 ± 1.312
3.658GlnLys: 3.658 ± 1.158
7.681GlnLeu: 7.681 ± 1.523
0.366GlnMet: 0.366 ± 0.33
1.829GlnAsn: 1.829 ± 0.639
2.195GlnPro: 2.195 ± 1.191
3.658GlnGln: 3.658 ± 1.019
2.56GlnArg: 2.56 ± 0.628
2.56GlnSer: 2.56 ± 0.68
4.389GlnThr: 4.389 ± 1.377
3.658GlnVal: 3.658 ± 0.984
0.366GlnTrp: 0.366 ± 0.33
0.732GlnTyr: 0.732 ± 0.578
0.0GlnXaa: 0.0 ± 0.0
Arg
2.926ArgAla: 2.926 ± 0.829
0.366ArgCys: 0.366 ± 0.289
2.195ArgAsp: 2.195 ± 0.728
5.121ArgGlu: 5.121 ± 1.067
1.829ArgPhe: 1.829 ± 0.716
2.926ArgGly: 2.926 ± 1.006
0.366ArgHis: 0.366 ± 0.289
3.292ArgIle: 3.292 ± 1.131
2.926ArgLys: 2.926 ± 0.767
4.755ArgLeu: 4.755 ± 0.873
0.366ArgMet: 0.366 ± 0.363
1.829ArgAsn: 1.829 ± 0.7
1.097ArgPro: 1.097 ± 0.794
5.121ArgGln: 5.121 ± 1.356
3.658ArgArg: 3.658 ± 0.93
2.56ArgSer: 2.56 ± 0.931
2.195ArgThr: 2.195 ± 0.93
2.195ArgVal: 2.195 ± 0.826
0.732ArgTrp: 0.732 ± 0.461
2.56ArgTyr: 2.56 ± 0.766
0.0ArgXaa: 0.0 ± 0.0
Ser
2.926SerAla: 2.926 ± 0.88
0.0SerCys: 0.0 ± 0.0
4.755SerAsp: 4.755 ± 0.866
4.755SerGlu: 4.755 ± 1.548
0.732SerPhe: 0.732 ± 0.747
1.097SerGly: 1.097 ± 0.548
1.097SerHis: 1.097 ± 0.581
5.121SerIle: 5.121 ± 1.212
4.389SerLys: 4.389 ± 1.656
4.755SerLeu: 4.755 ± 0.891
0.732SerMet: 0.732 ± 0.46
1.829SerAsn: 1.829 ± 0.776
0.366SerPro: 0.366 ± 0.33
1.463SerGln: 1.463 ± 0.695
1.829SerArg: 1.829 ± 0.741
1.829SerSer: 1.829 ± 0.718
3.292SerThr: 3.292 ± 1.302
4.389SerVal: 4.389 ± 1.184
0.732SerTrp: 0.732 ± 0.539
4.023SerTyr: 4.023 ± 1.1
0.0SerXaa: 0.0 ± 0.0
Thr
2.926ThrAla: 2.926 ± 1.007
0.366ThrCys: 0.366 ± 0.311
2.926ThrAsp: 2.926 ± 0.977
3.658ThrGlu: 3.658 ± 0.997
2.195ThrPhe: 2.195 ± 0.64
4.755ThrGly: 4.755 ± 1.539
1.097ThrHis: 1.097 ± 0.651
5.852ThrIle: 5.852 ± 1.369
6.584ThrLys: 6.584 ± 1.426
7.681ThrLeu: 7.681 ± 1.22
2.56ThrMet: 2.56 ± 1.268
1.829ThrAsn: 1.829 ± 0.786
1.463ThrPro: 1.463 ± 0.559
4.755ThrGln: 4.755 ± 1.582
2.56ThrArg: 2.56 ± 0.884
2.56ThrSer: 2.56 ± 1.15
3.658ThrThr: 3.658 ± 1.02
5.486ThrVal: 5.486 ± 1.68
0.366ThrTrp: 0.366 ± 0.33
2.195ThrTyr: 2.195 ± 0.865
0.0ThrXaa: 0.0 ± 0.0
Val
2.195ValAla: 2.195 ± 0.68
0.0ValCys: 0.0 ± 0.0
1.463ValAsp: 1.463 ± 0.711
2.56ValGlu: 2.56 ± 1.101
2.926ValPhe: 2.926 ± 1.146
1.463ValGly: 1.463 ± 0.753
0.366ValHis: 0.366 ± 0.417
3.292ValIle: 3.292 ± 1.017
5.121ValLys: 5.121 ± 1.618
4.023ValLeu: 4.023 ± 1.127
0.366ValMet: 0.366 ± 0.367
1.829ValAsn: 1.829 ± 0.771
1.097ValPro: 1.097 ± 0.512
1.463ValGln: 1.463 ± 0.522
1.463ValArg: 1.463 ± 0.904
3.658ValSer: 3.658 ± 0.841
5.121ValThr: 5.121 ± 1.348
2.56ValVal: 2.56 ± 0.951
0.366ValTrp: 0.366 ± 0.347
3.292ValTyr: 3.292 ± 1.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.463TrpAla: 1.463 ± 0.802
0.366TrpCys: 0.366 ± 0.387
0.0TrpAsp: 0.0 ± 0.0
1.463TrpGlu: 1.463 ± 0.74
0.366TrpPhe: 0.366 ± 0.387
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.366TrpIle: 0.366 ± 0.42
1.097TrpLys: 1.097 ± 0.547
2.195TrpLeu: 2.195 ± 0.694
0.366TrpMet: 0.366 ± 0.387
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.366TrpGln: 0.366 ± 0.311
0.0TrpArg: 0.0 ± 0.0
0.732TrpSer: 0.732 ± 0.5
0.732TrpThr: 0.732 ± 0.421
0.732TrpVal: 0.732 ± 0.557
0.0TrpTrp: 0.0 ± 0.0
0.366TrpTyr: 0.366 ± 0.352
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.195TyrAla: 2.195 ± 0.844
0.366TyrCys: 0.366 ± 0.387
1.097TyrAsp: 1.097 ± 0.696
1.829TyrGlu: 1.829 ± 0.886
4.023TyrPhe: 4.023 ± 1.206
1.463TyrGly: 1.463 ± 0.562
1.829TyrHis: 1.829 ± 0.641
2.926TyrIle: 2.926 ± 1.032
3.658TyrLys: 3.658 ± 1.24
5.121TyrLeu: 5.121 ± 1.119
1.463TyrMet: 1.463 ± 0.567
1.463TyrAsn: 1.463 ± 0.546
1.097TyrPro: 1.097 ± 0.584
2.195TyrGln: 2.195 ± 0.792
2.195TyrArg: 2.195 ± 0.776
3.658TyrSer: 3.658 ± 1.184
2.195TyrThr: 2.195 ± 0.799
0.732TyrVal: 0.732 ± 0.386
0.366TyrTrp: 0.366 ± 0.392
1.829TyrTyr: 1.829 ± 0.559
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 18 proteins (2735 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski