Amino acid dipepetide frequency for Melaminivora sp. SC2-9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.78AlaAla: 20.78 ± 0.224	1.469AlaCys: 1.469 ± 0.042	6.377AlaAsp: 6.377 ± 0.081	6.841AlaGlu: 6.841 ± 0.1	3.879AlaPhe: 3.879 ± 0.059	11.799AlaGly: 11.799 ± 0.117	3.179AlaHis: 3.179 ± 0.061	5.001AlaIle: 5.001 ± 0.066	3.194AlaLys: 3.194 ± 0.076	17.235AlaLeu: 17.235 ± 0.187	3.497AlaMet: 3.497 ± 0.059	2.46AlaAsn: 2.46 ± 0.059	7.75AlaPro: 7.75 ± 0.129	7.763AlaGln: 7.763 ± 0.118	11.185AlaArg: 11.185 ± 0.131	7.184AlaSer: 7.184 ± 0.087	6.026AlaThr: 6.026 ± 0.088	9.109AlaVal: 9.109 ± 0.108	2.273AlaTrp: 2.273 ± 0.05	2.277AlaTyr: 2.277 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.274CysAla: 1.274 ± 0.035	0.128CysCys: 0.128 ± 0.013	0.5CysAsp: 0.5 ± 0.021	0.53CysGlu: 0.53 ± 0.022	0.273CysPhe: 0.273 ± 0.017	0.933CysGly: 0.933 ± 0.03	0.3CysHis: 0.3 ± 0.017	0.375CysIle: 0.375 ± 0.018	0.204CysLys: 0.204 ± 0.014	0.867CysLeu: 0.867 ± 0.027	0.239CysMet: 0.239 ± 0.014	0.221CysAsn: 0.221 ± 0.015	0.52CysPro: 0.52 ± 0.024	0.321CysGln: 0.321 ± 0.017	0.584CysArg: 0.584 ± 0.022	0.468CysSer: 0.468 ± 0.022	0.48CysThr: 0.48 ± 0.022	0.673CysVal: 0.673 ± 0.029	0.128CysTrp: 0.128 ± 0.012	0.2CysTyr: 0.2 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.816AspAla: 7.816 ± 0.106	0.439AspCys: 0.439 ± 0.019	2.55AspAsp: 2.55 ± 0.054	3.349AspGlu: 3.349 ± 0.055	1.909AspPhe: 1.909 ± 0.042	4.572AspGly: 4.572 ± 0.072	1.033AspHis: 1.033 ± 0.03	2.157AspIle: 2.157 ± 0.05	1.638AspLys: 1.638 ± 0.046	5.034AspLeu: 5.034 ± 0.077	1.237AspMet: 1.237 ± 0.034	1.069AspAsn: 1.069 ± 0.033	2.636AspPro: 2.636 ± 0.046	1.559AspGln: 1.559 ± 0.04	2.919AspArg: 2.919 ± 0.053	2.125AspSer: 2.125 ± 0.04	2.272AspThr: 2.272 ± 0.05	4.034AspVal: 4.034 ± 0.059	1.053AspTrp: 1.053 ± 0.035	1.281AspTyr: 1.281 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.722GluAla: 6.722 ± 0.092	0.399GluCys: 0.399 ± 0.019	2.365GluAsp: 2.365 ± 0.053	2.469GluGlu: 2.469 ± 0.055	1.691GluPhe: 1.691 ± 0.039	4.118GluGly: 4.118 ± 0.067	1.493GluHis: 1.493 ± 0.04	2.321GluIle: 2.321 ± 0.05	1.59GluLys: 1.59 ± 0.052	6.325GluLeu: 6.325 ± 0.094	1.138GluMet: 1.138 ± 0.038	1.087GluAsn: 1.087 ± 0.032	2.692GluPro: 2.692 ± 0.049	3.007GluGln: 3.007 ± 0.058	5.364GluArg: 5.364 ± 0.08	2.149GluSer: 2.149 ± 0.048	2.07GluThr: 2.07 ± 0.046	4.034GluVal: 4.034 ± 0.077	0.674GluTrp: 0.674 ± 0.024	1.041GluTyr: 1.041 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.295PheAla: 4.295 ± 0.074	0.364PheCys: 0.364 ± 0.02	2.317PheAsp: 2.317 ± 0.049	1.887PheGlu: 1.887 ± 0.037	1.287PhePhe: 1.287 ± 0.038	3.155PheGly: 3.155 ± 0.054	0.679PheHis: 0.679 ± 0.025	1.499PheIle: 1.499 ± 0.039	1.012PheLys: 1.012 ± 0.036	2.773PheLeu: 2.773 ± 0.057	0.78PheMet: 0.78 ± 0.029	0.969PheAsn: 0.969 ± 0.034	1.331PhePro: 1.331 ± 0.036	1.028PheGln: 1.028 ± 0.03	1.673PheArg: 1.673 ± 0.037	1.872PheSer: 1.872 ± 0.044	1.794PheThr: 1.794 ± 0.041	2.474PheVal: 2.474 ± 0.048	0.525PheTrp: 0.525 ± 0.024	0.777PheTyr: 0.777 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.677GlyAla: 10.677 ± 0.123	0.925GlyCys: 0.925 ± 0.03	4.039GlyAsp: 4.039 ± 0.063	4.721GlyGlu: 4.721 ± 0.075	2.965GlyPhe: 2.965 ± 0.053	7.534GlyGly: 7.534 ± 0.117	1.978GlyHis: 1.978 ± 0.044	3.526GlyIle: 3.526 ± 0.064	2.85GlyLys: 2.85 ± 0.056	8.889GlyLeu: 8.889 ± 0.097	2.417GlyMet: 2.417 ± 0.05	1.971GlyAsn: 1.971 ± 0.047	3.062GlyPro: 3.062 ± 0.058	3.83GlyGln: 3.83 ± 0.068	5.992GlyArg: 5.992 ± 0.077	4.574GlySer: 4.574 ± 0.073	4.081GlyThr: 4.081 ± 0.067	6.563GlyVal: 6.563 ± 0.081	1.526GlyTrp: 1.526 ± 0.039	2.203GlyTyr: 2.203 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	3.282HisAla: 3.282 ± 0.066	0.306HisCys: 0.306 ± 0.018	1.255HisAsp: 1.255 ± 0.033	1.346HisGlu: 1.346 ± 0.037	0.876HisPhe: 0.876 ± 0.029	2.379HisGly: 2.379 ± 0.049	0.609HisHis: 0.609 ± 0.025	0.951HisIle: 0.951 ± 0.028	0.564HisLys: 0.564 ± 0.026	2.42HisLeu: 2.42 ± 0.056	0.508HisMet: 0.508 ± 0.024	0.491HisAsn: 0.491 ± 0.022	1.577HisPro: 1.577 ± 0.039	0.874HisGln: 0.874 ± 0.028	1.473HisArg: 1.473 ± 0.044	1.016HisSer: 1.016 ± 0.026	1.11HisThr: 1.11 ± 0.034	1.594HisVal: 1.594 ± 0.036	0.436HisTrp: 0.436 ± 0.022	0.691HisTyr: 0.691 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.993IleAla: 5.993 ± 0.076	0.334IleCys: 0.334 ± 0.015	2.785IleAsp: 2.785 ± 0.054	2.816IleGlu: 2.816 ± 0.06	1.181IlePhe: 1.181 ± 0.039	3.585IleGly: 3.585 ± 0.059	0.838IleHis: 0.838 ± 0.029	1.417IleIle: 1.417 ± 0.045	1.234IleLys: 1.234 ± 0.038	2.993IleLeu: 2.993 ± 0.062	0.723IleMet: 0.723 ± 0.028	1.226IleAsn: 1.226 ± 0.038	1.733IlePro: 1.733 ± 0.046	1.237IleGln: 1.237 ± 0.038	2.387IleArg: 2.387 ± 0.045	1.959IleSer: 1.959 ± 0.048	2.279IleThr: 2.279 ± 0.046	3.287IleVal: 3.287 ± 0.055	0.453IleTrp: 0.453 ± 0.022	0.855IleTyr: 0.855 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	3.433LysAla: 3.433 ± 0.067	0.149LysCys: 0.149 ± 0.012	1.477LysAsp: 1.477 ± 0.04	1.307LysGlu: 1.307 ± 0.036	0.754LysPhe: 0.754 ± 0.026	2.174LysGly: 2.174 ± 0.052	0.516LysHis: 0.516 ± 0.02	1.2LysIle: 1.2 ± 0.042	1.27LysLys: 1.27 ± 0.042	2.864LysLeu: 2.864 ± 0.065	0.71LysMet: 0.71 ± 0.026	0.852LysAsn: 0.852 ± 0.031	1.713LysPro: 1.713 ± 0.041	0.967LysGln: 0.967 ± 0.034	1.934LysArg: 1.934 ± 0.052	1.568LysSer: 1.568 ± 0.041	1.662LysThr: 1.662 ± 0.045	2.104LysVal: 2.104 ± 0.059	0.286LysTrp: 0.286 ± 0.016	0.555LysTyr: 0.555 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	17.569LeuAla: 17.569 ± 0.177	0.991LeuCys: 0.991 ± 0.031	5.883LeuAsp: 5.883 ± 0.075	5.166LeuGlu: 5.166 ± 0.075	3.21LeuPhe: 3.21 ± 0.063	8.677LeuGly: 8.677 ± 0.099	2.739LeuHis: 2.739 ± 0.055	4.048LeuIle: 4.048 ± 0.069	3.137LeuLys: 3.137 ± 0.065	12.451LeuLeu: 12.451 ± 0.176	2.453LeuMet: 2.453 ± 0.052	2.359LeuAsn: 2.359 ± 0.045	6.687LeuPro: 6.687 ± 0.081	4.988LeuGln: 4.988 ± 0.077	8.612LeuArg: 8.612 ± 0.108	5.659LeuSer: 5.659 ± 0.073	5.194LeuThr: 5.194 ± 0.068	7.906LeuVal: 7.906 ± 0.11	1.522LeuTrp: 1.522 ± 0.046	2.091LeuTyr: 2.091 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.106MetAla: 3.106 ± 0.048	0.152MetCys: 0.152 ± 0.011	1.113MetAsp: 1.113 ± 0.033	1.036MetGlu: 1.036 ± 0.032	0.671MetPhe: 0.671 ± 0.027	1.898MetGly: 1.898 ± 0.052	0.586MetHis: 0.586 ± 0.026	0.807MetIle: 0.807 ± 0.025	0.884MetLys: 0.884 ± 0.033	2.547MetLeu: 2.547 ± 0.047	0.504MetMet: 0.504 ± 0.023	0.77MetAsn: 0.77 ± 0.025	1.545MetPro: 1.545 ± 0.036	1.308MetGln: 1.308 ± 0.038	1.784MetArg: 1.784 ± 0.043	1.479MetSer: 1.479 ± 0.037	1.418MetThr: 1.418 ± 0.03	1.631MetVal: 1.631 ± 0.038	0.188MetTrp: 0.188 ± 0.013	0.372MetTyr: 0.372 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.938AsnAla: 2.938 ± 0.059	0.217AsnCys: 0.217 ± 0.015	1.099AsnAsp: 1.099 ± 0.037	1.038AsnGlu: 1.038 ± 0.03	0.836AsnPhe: 0.836 ± 0.03	1.747AsnGly: 1.747 ± 0.043	0.463AsnHis: 0.463 ± 0.019	1.027AsnIle: 1.027 ± 0.032	0.663AsnLys: 0.663 ± 0.029	2.378AsnLeu: 2.378 ± 0.047	0.531AsnMet: 0.531 ± 0.023	0.645AsnAsn: 0.645 ± 0.029	1.689AsnPro: 1.689 ± 0.037	0.888AsnGln: 0.888 ± 0.032	1.44AsnArg: 1.44 ± 0.043	0.98AsnSer: 0.98 ± 0.029	1.154AsnThr: 1.154 ± 0.041	1.714AsnVal: 1.714 ± 0.036	0.382AsnTrp: 0.382 ± 0.019	0.575AsnTyr: 0.575 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	8.31ProAla: 8.31 ± 0.125	0.372ProCys: 0.372 ± 0.02	3.033ProAsp: 3.033 ± 0.054	3.502ProGlu: 3.502 ± 0.055	1.697ProPhe: 1.697 ± 0.041	4.899ProGly: 4.899 ± 0.079	1.281ProHis: 1.281 ± 0.034	1.733ProIle: 1.733 ± 0.041	1.25ProLys: 1.25 ± 0.038	5.859ProLeu: 5.859 ± 0.078	1.32ProMet: 1.32 ± 0.04	1.015ProAsn: 1.015 ± 0.028	3.253ProPro: 3.253 ± 0.08	2.783ProGln: 2.783 ± 0.058	3.464ProArg: 3.464 ± 0.062	2.48ProSer: 2.48 ± 0.049	2.405ProThr: 2.405 ± 0.048	4.15ProVal: 4.15 ± 0.068	0.831ProTrp: 0.831 ± 0.032	1.085ProTyr: 1.085 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	7.07GlnAla: 7.07 ± 0.1	0.37GlnCys: 0.37 ± 0.019	2.184GlnAsp: 2.184 ± 0.048	2.078GlnGlu: 2.078 ± 0.05	1.321GlnPhe: 1.321 ± 0.035	3.661GlnGly: 3.661 ± 0.064	1.181GlnHis: 1.181 ± 0.031	1.724GlnIle: 1.724 ± 0.044	1.029GlnLys: 1.029 ± 0.036	5.129GlnLeu: 5.129 ± 0.08	1.051GlnMet: 1.051 ± 0.032	0.788GlnAsn: 0.788 ± 0.024	2.839GlnPro: 2.839 ± 0.053	2.581GlnGln: 2.581 ± 0.054	4.233GlnArg: 4.233 ± 0.074	2.037GlnSer: 2.037 ± 0.045	1.876GlnThr: 1.876 ± 0.043	3.395GlnVal: 3.395 ± 0.055	0.833GlnTrp: 0.833 ± 0.024	0.814GlnTyr: 0.814 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	9.725ArgAla: 9.725 ± 0.119	0.649ArgCys: 0.649 ± 0.025	3.514ArgAsp: 3.514 ± 0.061	4.59ArgGlu: 4.59 ± 0.078	2.673ArgPhe: 2.673 ± 0.039	5.31ArgGly: 5.31 ± 0.083	2.026ArgHis: 2.026 ± 0.048	3.296ArgIle: 3.296 ± 0.057	1.862ArgLys: 1.862 ± 0.044	8.802ArgLeu: 8.802 ± 0.1	1.958ArgMet: 1.958 ± 0.039	1.612ArgAsn: 1.612 ± 0.04	3.621ArgPro: 3.621 ± 0.061	3.606ArgGln: 3.606 ± 0.064	5.864ArgArg: 5.864 ± 0.104	3.597ArgSer: 3.597 ± 0.06	3.313ArgThr: 3.313 ± 0.052	5.358ArgVal: 5.358 ± 0.071	1.377ArgTrp: 1.377 ± 0.037	1.789ArgTyr: 1.789 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.584SerAla: 6.584 ± 0.086	0.413SerCys: 0.413 ± 0.021	2.38SerAsp: 2.38 ± 0.05	2.367SerGlu: 2.367 ± 0.047	1.842SerPhe: 1.842 ± 0.039	5.088SerGly: 5.088 ± 0.072	1.101SerHis: 1.101 ± 0.033	2.065SerIle: 2.065 ± 0.048	1.202SerLys: 1.202 ± 0.036	5.155SerLeu: 5.155 ± 0.062	1.225SerMet: 1.225 ± 0.031	1.132SerAsn: 1.132 ± 0.041	2.67SerPro: 2.67 ± 0.051	1.924SerGln: 1.924 ± 0.043	3.497SerArg: 3.497 ± 0.057	2.831SerSer: 2.831 ± 0.057	2.569SerThr: 2.569 ± 0.055	3.838SerVal: 3.838 ± 0.062	0.703SerTrp: 0.703 ± 0.028	1.201SerTyr: 1.201 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.816ThrAla: 5.816 ± 0.08	0.409ThrCys: 0.409 ± 0.022	2.23ThrAsp: 2.23 ± 0.046	2.15ThrGlu: 2.15 ± 0.051	1.543ThrPhe: 1.543 ± 0.04	4.33ThrGly: 4.33 ± 0.068	1.157ThrHis: 1.157 ± 0.032	1.868ThrIle: 1.868 ± 0.042	1.015ThrLys: 1.015 ± 0.035	6.067ThrLeu: 6.067 ± 0.075	0.934ThrMet: 0.934 ± 0.033	0.986ThrAsn: 0.986 ± 0.03	3.385ThrPro: 3.385 ± 0.057	2.063ThrGln: 2.063 ± 0.043	3.422ThrArg: 3.422 ± 0.057	2.347ThrSer: 2.347 ± 0.048	2.414ThrThr: 2.414 ± 0.051	3.666ThrVal: 3.666 ± 0.062	0.669ThrTrp: 0.669 ± 0.025	0.964ThrTyr: 0.964 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	9.679ValAla: 9.679 ± 0.102	0.725ValCys: 0.725 ± 0.024	3.773ValAsp: 3.773 ± 0.063	3.825ValGlu: 3.825 ± 0.062	2.513ValPhe: 2.513 ± 0.056	5.43ValGly: 5.43 ± 0.07	1.707ValHis: 1.707 ± 0.036	2.992ValIle: 2.992 ± 0.059	1.942ValLys: 1.942 ± 0.049	8.787ValLeu: 8.787 ± 0.097	1.754ValMet: 1.754 ± 0.036	1.877ValAsn: 1.877 ± 0.042	4.112ValPro: 4.112 ± 0.059	3.685ValGln: 3.685 ± 0.059	5.668ValArg: 5.668 ± 0.075	3.584ValSer: 3.584 ± 0.06	3.563ValThr: 3.563 ± 0.063	5.819ValVal: 5.819 ± 0.069	1.004ValTrp: 1.004 ± 0.033	1.429ValTyr: 1.429 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.605TrpAla: 1.605 ± 0.044	0.179TrpCys: 0.179 ± 0.012	0.657TrpAsp: 0.657 ± 0.026	0.57TrpGlu: 0.57 ± 0.023	0.526TrpPhe: 0.526 ± 0.023	1.075TrpGly: 1.075 ± 0.032	0.435TrpHis: 0.435 ± 0.023	0.596TrpIle: 0.596 ± 0.024	0.367TrpLys: 0.367 ± 0.02	2.429TrpLeu: 2.429 ± 0.053	0.428TrpMet: 0.428 ± 0.022	0.373TrpAsn: 0.373 ± 0.018	0.824TrpPro: 0.824 ± 0.032	0.931TrpGln: 0.931 ± 0.029	1.456TrpArg: 1.456 ± 0.045	0.844TrpSer: 0.844 ± 0.026	0.676TrpThr: 0.676 ± 0.025	0.976TrpVal: 0.976 ± 0.028	0.332TrpTrp: 0.332 ± 0.017	0.279TrpTyr: 0.279 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.606TyrAla: 2.606 ± 0.045	0.226TyrCys: 0.226 ± 0.014	1.152TyrAsp: 1.152 ± 0.033	1.161TyrGlu: 1.161 ± 0.033	0.843TyrPhe: 0.843 ± 0.028	1.962TyrGly: 1.962 ± 0.049	0.456TyrHis: 0.456 ± 0.023	0.71TyrIle: 0.71 ± 0.025	0.588TyrLys: 0.588 ± 0.024	2.337TyrLeu: 2.337 ± 0.048	0.395TyrMet: 0.395 ± 0.018	0.5TyrAsn: 0.5 ± 0.022	1.082TyrPro: 1.082 ± 0.036	0.853TyrGln: 0.853 ± 0.027	1.591TyrArg: 1.591 ± 0.04	1.034TyrSer: 1.034 ± 0.032	1.078TyrThr: 1.078 ± 0.033	1.542TyrVal: 1.542 ± 0.04	0.363TyrTrp: 0.363 ± 0.019	0.566TyrTyr: 0.566 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3389 proteins (1115108 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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