Amino acid dipepetide frequency for Prevotella ruminicola (strain ATCC 19189 / JCM 8958 / 23)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.388AlaAla: 6.388 ± 0.109	1.064AlaCys: 1.064 ± 0.033	4.942AlaAsp: 4.942 ± 0.074	5.037AlaGlu: 5.037 ± 0.084	3.136AlaPhe: 3.136 ± 0.075	5.12AlaGly: 5.12 ± 0.082	1.401AlaHis: 1.401 ± 0.041	5.102AlaIle: 5.102 ± 0.076	4.872AlaLys: 4.872 ± 0.086	6.806AlaLeu: 6.806 ± 0.1	2.269AlaMet: 2.269 ± 0.047	3.508AlaAsn: 3.508 ± 0.07	2.503AlaPro: 2.503 ± 0.053	3.489AlaGln: 3.489 ± 0.064	3.188AlaArg: 3.188 ± 0.055	4.086AlaSer: 4.086 ± 0.075	4.316AlaThr: 4.316 ± 0.064	4.78AlaVal: 4.78 ± 0.072	0.965AlaTrp: 0.965 ± 0.032	2.983AlaTyr: 2.983 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.897CysAla: 0.897 ± 0.028	0.239CysCys: 0.239 ± 0.016	0.767CysAsp: 0.767 ± 0.028	0.784CysGlu: 0.784 ± 0.026	0.572CysPhe: 0.572 ± 0.025	1.186CysGly: 1.186 ± 0.038	0.357CysHis: 0.357 ± 0.018	0.909CysIle: 0.909 ± 0.027	0.749CysLys: 0.749 ± 0.03	1.11CysLeu: 1.11 ± 0.032	0.365CysMet: 0.365 ± 0.018	0.611CysAsn: 0.611 ± 0.025	0.596CysPro: 0.596 ± 0.024	0.478CysGln: 0.478 ± 0.026	0.583CysArg: 0.583 ± 0.025	0.803CysSer: 0.803 ± 0.03	0.717CysThr: 0.717 ± 0.032	0.878CysVal: 0.878 ± 0.029	0.194CysTrp: 0.194 ± 0.013	0.585CysTyr: 0.585 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.661AspAla: 4.661 ± 0.071	0.711AspCys: 0.711 ± 0.028	3.441AspAsp: 3.441 ± 0.064	4.534AspGlu: 4.534 ± 0.069	3.076AspPhe: 3.076 ± 0.054	4.804AspGly: 4.804 ± 0.081	1.038AspHis: 1.038 ± 0.033	4.082AspIle: 4.082 ± 0.066	3.785AspLys: 3.785 ± 0.071	4.595AspLeu: 4.595 ± 0.063	1.806AspMet: 1.806 ± 0.038	2.888AspAsn: 2.888 ± 0.051	2.01AspPro: 2.01 ± 0.049	1.674AspGln: 1.674 ± 0.039	2.527AspArg: 2.527 ± 0.049	3.04AspSer: 3.04 ± 0.069	2.883AspThr: 2.883 ± 0.055	3.967AspVal: 3.967 ± 0.065	0.925AspTrp: 0.925 ± 0.031	3.114AspTyr: 3.114 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.211GluAla: 5.211 ± 0.078	0.736GluCys: 0.736 ± 0.028	3.252GluAsp: 3.252 ± 0.06	4.191GluGlu: 4.191 ± 0.076	2.443GluPhe: 2.443 ± 0.05	4.135GluGly: 4.135 ± 0.056	1.389GluHis: 1.389 ± 0.04	4.02GluIle: 4.02 ± 0.068	4.496GluLys: 4.496 ± 0.083	5.784GluLeu: 5.784 ± 0.083	2.064GluMet: 2.064 ± 0.039	3.159GluAsn: 3.159 ± 0.056	2.076GluPro: 2.076 ± 0.066	2.957GluGln: 2.957 ± 0.061	3.251GluArg: 3.251 ± 0.058	2.814GluSer: 2.814 ± 0.053	3.049GluThr: 3.049 ± 0.062	4.095GluVal: 4.095 ± 0.068	0.93GluTrp: 0.93 ± 0.031	2.602GluTyr: 2.602 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.102PheAla: 3.102 ± 0.048	0.737PheCys: 0.737 ± 0.026	2.955PheAsp: 2.955 ± 0.056	2.535PheGlu: 2.535 ± 0.052	1.914PhePhe: 1.914 ± 0.053	3.344PheGly: 3.344 ± 0.057	0.839PheHis: 0.839 ± 0.033	2.614PheIle: 2.614 ± 0.057	2.441PheLys: 2.441 ± 0.05	3.29PheLeu: 3.29 ± 0.055	1.23PheMet: 1.23 ± 0.036	2.148PheAsn: 2.148 ± 0.051	1.473PhePro: 1.473 ± 0.04	1.195PheGln: 1.195 ± 0.032	1.907PheArg: 1.907 ± 0.043	2.888PheSer: 2.888 ± 0.053	2.736PheThr: 2.736 ± 0.054	2.928PheVal: 2.928 ± 0.055	0.63PheTrp: 0.63 ± 0.026	1.838PheTyr: 1.838 ± 0.044	0.0PheXaa: 0.0 ± 0.0
Gly	4.744GlyAla: 4.744 ± 0.083	1.093GlyCys: 1.093 ± 0.044	3.971GlyAsp: 3.971 ± 0.07	3.999GlyGlu: 3.999 ± 0.067	3.134GlyPhe: 3.134 ± 0.057	5.129GlyGly: 5.129 ± 0.101	1.489GlyHis: 1.489 ± 0.042	5.054GlyIle: 5.054 ± 0.068	5.011GlyLys: 5.011 ± 0.069	5.816GlyLeu: 5.816 ± 0.074	2.152GlyMet: 2.152 ± 0.053	3.484GlyAsn: 3.484 ± 0.068	1.472GlyPro: 1.472 ± 0.037	2.444GlyGln: 2.444 ± 0.048	3.069GlyArg: 3.069 ± 0.053	3.947GlySer: 3.947 ± 0.072	4.268GlyThr: 4.268 ± 0.071	4.834GlyVal: 4.834 ± 0.079	1.11GlyTrp: 1.11 ± 0.037	3.357GlyTyr: 3.357 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.274HisAla: 1.274 ± 0.037	0.346HisCys: 0.346 ± 0.018	1.138HisAsp: 1.138 ± 0.038	1.186HisGlu: 1.186 ± 0.031	1.051HisPhe: 1.051 ± 0.035	1.404HisGly: 1.404 ± 0.039	0.643HisHis: 0.643 ± 0.026	1.455HisIle: 1.455 ± 0.037	1.077HisLys: 1.077 ± 0.034	1.922HisLeu: 1.922 ± 0.048	0.442HisMet: 0.442 ± 0.021	1.011HisAsn: 1.011 ± 0.026	1.148HisPro: 1.148 ± 0.036	0.888HisGln: 0.888 ± 0.034	1.037HisArg: 1.037 ± 0.033	1.115HisSer: 1.115 ± 0.035	1.102HisThr: 1.102 ± 0.033	1.236HisVal: 1.236 ± 0.03	0.291HisTrp: 0.291 ± 0.016	1.035HisTyr: 1.035 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.207IleAla: 5.207 ± 0.08	0.985IleCys: 0.985 ± 0.034	4.561IleAsp: 4.561 ± 0.067	4.338IleGlu: 4.338 ± 0.078	2.456IlePhe: 2.456 ± 0.055	4.711IleGly: 4.711 ± 0.078	1.257IleHis: 1.257 ± 0.034	4.25IleIle: 4.25 ± 0.075	4.011IleLys: 4.011 ± 0.066	5.074IleLeu: 5.074 ± 0.075	1.567IleMet: 1.567 ± 0.037	3.252IleAsn: 3.252 ± 0.063	2.835IlePro: 2.835 ± 0.056	2.24IleGln: 2.24 ± 0.042	3.097IleArg: 3.097 ± 0.057	4.124IleSer: 4.124 ± 0.073	3.967IleThr: 3.967 ± 0.07	4.259IleVal: 4.259 ± 0.072	0.763IleTrp: 0.763 ± 0.026	2.475IleTyr: 2.475 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.428LysAla: 5.428 ± 0.08	0.631LysCys: 0.631 ± 0.023	3.928LysAsp: 3.928 ± 0.068	4.576LysGlu: 4.576 ± 0.077	2.227LysPhe: 2.227 ± 0.046	4.289LysGly: 4.289 ± 0.059	1.35LysHis: 1.35 ± 0.036	3.77LysIle: 3.77 ± 0.077	4.69LysLys: 4.69 ± 0.074	5.287LysLeu: 5.287 ± 0.073	2.274LysMet: 2.274 ± 0.048	3.315LysAsn: 3.315 ± 0.051	2.342LysPro: 2.342 ± 0.053	2.804LysGln: 2.804 ± 0.062	3.045LysArg: 3.045 ± 0.061	3.185LysSer: 3.185 ± 0.052	3.467LysThr: 3.467 ± 0.053	4.213LysVal: 4.213 ± 0.068	0.868LysTrp: 0.868 ± 0.027	2.858LysTyr: 2.858 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	6.582LeuAla: 6.582 ± 0.099	1.319LeuCys: 1.319 ± 0.034	4.817LeuAsp: 4.817 ± 0.067	4.651LeuGlu: 4.651 ± 0.08	3.787LeuPhe: 3.787 ± 0.075	5.693LeuGly: 5.693 ± 0.087	1.904LeuHis: 1.904 ± 0.037	4.985LeuIle: 4.985 ± 0.074	6.163LeuLys: 6.163 ± 0.076	7.98LeuLeu: 7.98 ± 0.125	2.84LeuMet: 2.84 ± 0.055	4.422LeuAsn: 4.422 ± 0.082	3.788LeuPro: 3.788 ± 0.059	3.491LeuGln: 3.491 ± 0.063	4.14LeuArg: 4.14 ± 0.073	5.764LeuSer: 5.764 ± 0.087	5.45LeuThr: 5.45 ± 0.081	5.138LeuVal: 5.138 ± 0.075	1.086LeuTrp: 1.086 ± 0.036	3.481LeuTyr: 3.481 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.625MetAla: 2.625 ± 0.058	0.329MetCys: 0.329 ± 0.016	1.574MetAsp: 1.574 ± 0.041	1.705MetGlu: 1.705 ± 0.044	1.065MetPhe: 1.065 ± 0.032	1.911MetGly: 1.911 ± 0.045	0.587MetHis: 0.587 ± 0.025	1.695MetIle: 1.695 ± 0.046	2.423MetLys: 2.423 ± 0.047	2.799MetLeu: 2.799 ± 0.056	1.102MetMet: 1.102 ± 0.036	1.566MetAsn: 1.566 ± 0.04	1.401MetPro: 1.401 ± 0.043	1.323MetGln: 1.323 ± 0.032	1.434MetArg: 1.434 ± 0.035	1.56MetSer: 1.56 ± 0.042	1.737MetThr: 1.737 ± 0.046	1.912MetVal: 1.912 ± 0.047	0.3MetTrp: 0.3 ± 0.018	0.918MetTyr: 0.918 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.598AsnAla: 3.598 ± 0.063	0.618AsnCys: 0.618 ± 0.026	2.945AsnAsp: 2.945 ± 0.052	2.978AsnGlu: 2.978 ± 0.052	2.063AsnPhe: 2.063 ± 0.05	3.934AsnGly: 3.934 ± 0.077	1.132AsnHis: 1.132 ± 0.031	3.477AsnIle: 3.477 ± 0.069	2.849AsnLys: 2.849 ± 0.06	4.136AsnLeu: 4.136 ± 0.076	1.269AsnMet: 1.269 ± 0.035	2.564AsnAsn: 2.564 ± 0.063	2.477AsnPro: 2.477 ± 0.045	1.903AsnGln: 1.903 ± 0.049	2.279AsnArg: 2.279 ± 0.051	2.62AsnSer: 2.62 ± 0.058	2.772AsnThr: 2.772 ± 0.063	3.102AsnVal: 3.102 ± 0.061	0.686AsnTrp: 0.686 ± 0.028	2.393AsnTyr: 2.393 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.859ProAla: 2.859 ± 0.053	0.404ProCys: 0.404 ± 0.019	2.584ProAsp: 2.584 ± 0.051	3.214ProGlu: 3.214 ± 0.07	1.673ProPhe: 1.673 ± 0.037	2.299ProGly: 2.299 ± 0.058	0.715ProHis: 0.715 ± 0.028	2.322ProIle: 2.322 ± 0.042	2.249ProLys: 2.249 ± 0.055	3.113ProLeu: 3.113 ± 0.054	1.085ProMet: 1.085 ± 0.033	1.778ProAsn: 1.778 ± 0.04	0.721ProPro: 0.721 ± 0.03	1.602ProGln: 1.602 ± 0.042	1.363ProArg: 1.363 ± 0.038	2.087ProSer: 2.087 ± 0.036	2.149ProThr: 2.149 ± 0.044	2.718ProVal: 2.718 ± 0.059	0.521ProTrp: 0.521 ± 0.022	1.785ProTyr: 1.785 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.944GlnAla: 2.944 ± 0.056	0.373GlnCys: 0.373 ± 0.02	1.811GlnAsp: 1.811 ± 0.04	2.351GlnGlu: 2.351 ± 0.053	1.606GlnPhe: 1.606 ± 0.039	2.32GlnGly: 2.32 ± 0.053	0.939GlnHis: 0.939 ± 0.028	2.432GlnIle: 2.432 ± 0.043	2.664GlnLys: 2.664 ± 0.056	4.145GlnLeu: 4.145 ± 0.066	1.429GlnMet: 1.429 ± 0.036	1.984GlnAsn: 1.984 ± 0.048	1.552GlnPro: 1.552 ± 0.041	2.342GlnGln: 2.342 ± 0.056	2.006GlnArg: 2.006 ± 0.048	1.979GlnSer: 1.979 ± 0.044	2.153GlnThr: 2.153 ± 0.046	2.379GlnVal: 2.379 ± 0.047	0.608GlnTrp: 0.608 ± 0.025	1.643GlnTyr: 1.643 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.911ArgAla: 2.911 ± 0.057	0.519ArgCys: 0.519 ± 0.021	2.424ArgAsp: 2.424 ± 0.051	2.934ArgGlu: 2.934 ± 0.059	2.072ArgPhe: 2.072 ± 0.043	2.551ArgGly: 2.551 ± 0.048	1.103ArgHis: 1.103 ± 0.034	3.405ArgIle: 3.405 ± 0.059	3.105ArgLys: 3.105 ± 0.059	4.459ArgLeu: 4.459 ± 0.075	1.57ArgMet: 1.57 ± 0.046	2.268ArgAsn: 2.268 ± 0.044	1.65ArgPro: 1.65 ± 0.043	2.177ArgGln: 2.177 ± 0.049	2.338ArgArg: 2.338 ± 0.051	2.202ArgSer: 2.202 ± 0.045	2.408ArgThr: 2.408 ± 0.042	2.728ArgVal: 2.728 ± 0.049	0.722ArgTrp: 0.722 ± 0.026	2.244ArgTyr: 2.244 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.14SerAla: 4.14 ± 0.07	0.797SerCys: 0.797 ± 0.029	3.324SerAsp: 3.324 ± 0.055	3.26SerGlu: 3.26 ± 0.063	2.696SerPhe: 2.696 ± 0.054	4.073SerGly: 4.073 ± 0.08	1.182SerHis: 1.182 ± 0.04	3.942SerIle: 3.942 ± 0.067	3.305SerLys: 3.305 ± 0.054	5.097SerLeu: 5.097 ± 0.088	1.565SerMet: 1.565 ± 0.043	2.572SerAsn: 2.572 ± 0.054	2.005SerPro: 2.005 ± 0.041	2.004SerGln: 2.004 ± 0.043	2.33SerArg: 2.33 ± 0.048	3.33SerSer: 3.33 ± 0.072	3.156SerThr: 3.156 ± 0.056	3.868SerVal: 3.868 ± 0.061	0.853SerTrp: 0.853 ± 0.029	2.519SerTyr: 2.519 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.424ThrAla: 4.424 ± 0.065	0.644ThrCys: 0.644 ± 0.025	3.646ThrAsp: 3.646 ± 0.053	3.13ThrGlu: 3.13 ± 0.054	2.564ThrPhe: 2.564 ± 0.052	4.177ThrGly: 4.177 ± 0.061	1.032ThrHis: 1.032 ± 0.039	4.211ThrIle: 4.211 ± 0.073	3.132ThrLys: 3.132 ± 0.057	5.397ThrLeu: 5.397 ± 0.08	1.473ThrMet: 1.473 ± 0.039	2.635ThrAsn: 2.635 ± 0.059	2.624ThrPro: 2.624 ± 0.045	1.926ThrGln: 1.926 ± 0.043	2.265ThrArg: 2.265 ± 0.051	3.19ThrSer: 3.19 ± 0.062	3.454ThrThr: 3.454 ± 0.068	3.841ThrVal: 3.841 ± 0.064	0.771ThrTrp: 0.771 ± 0.026	2.42ThrTyr: 2.42 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.934ValAla: 4.934 ± 0.078	1.024ValCys: 1.024 ± 0.036	3.846ValAsp: 3.846 ± 0.068	4.073ValGlu: 4.073 ± 0.064	2.734ValPhe: 2.734 ± 0.05	4.339ValGly: 4.339 ± 0.066	1.131ValHis: 1.131 ± 0.033	4.312ValIle: 4.312 ± 0.068	4.263ValLys: 4.263 ± 0.069	5.572ValLeu: 5.572 ± 0.085	1.872ValMet: 1.872 ± 0.046	3.357ValAsn: 3.357 ± 0.061	2.479ValPro: 2.479 ± 0.051	2.004ValGln: 2.004 ± 0.043	2.966ValArg: 2.966 ± 0.057	4.081ValSer: 4.081 ± 0.069	3.861ValThr: 3.861 ± 0.077	4.685ValVal: 4.685 ± 0.082	0.797ValTrp: 0.797 ± 0.03	2.58ValTyr: 2.58 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.945TrpAla: 0.945 ± 0.033	0.199TrpCys: 0.199 ± 0.014	0.833TrpAsp: 0.833 ± 0.029	0.735TrpGlu: 0.735 ± 0.026	0.57TrpPhe: 0.57 ± 0.023	1.075TrpGly: 1.075 ± 0.039	0.334TrpHis: 0.334 ± 0.017	0.769TrpIle: 0.769 ± 0.028	0.821TrpLys: 0.821 ± 0.031	1.44TrpLeu: 1.44 ± 0.036	0.489TrpMet: 0.489 ± 0.022	0.82TrpAsn: 0.82 ± 0.034	0.362TrpPro: 0.362 ± 0.022	0.751TrpGln: 0.751 ± 0.029	0.686TrpArg: 0.686 ± 0.025	0.753TrpSer: 0.753 ± 0.027	0.702TrpThr: 0.702 ± 0.025	0.754TrpVal: 0.754 ± 0.03	0.247TrpTrp: 0.247 ± 0.018	0.604TrpTyr: 0.604 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.082TyrAla: 3.082 ± 0.049	0.611TyrCys: 0.611 ± 0.022	2.799TyrAsp: 2.799 ± 0.054	2.444TyrGlu: 2.444 ± 0.046	1.904TyrPhe: 1.904 ± 0.044	3.082TyrGly: 3.082 ± 0.066	0.98TyrHis: 0.98 ± 0.031	2.622TyrIle: 2.622 ± 0.056	2.444TyrLys: 2.444 ± 0.051	3.661TyrLeu: 3.661 ± 0.07	1.102TyrMet: 1.102 ± 0.032	2.453TyrAsn: 2.453 ± 0.058	1.73TyrPro: 1.73 ± 0.045	1.965TyrGln: 1.965 ± 0.045	2.281TyrArg: 2.281 ± 0.05	2.45TyrSer: 2.45 ± 0.057	2.608TyrThr: 2.608 ± 0.05	2.593TyrVal: 2.593 ± 0.048	0.622TyrTrp: 0.622 ± 0.027	2.207TyrTyr: 2.207 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2761 proteins (1065923 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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