Amino acid dipepetide frequency for Firmicutes bacterium CAG:882

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.763AlaAla: 7.763 ± 0.144
1.162AlaCys: 1.162 ± 0.04
5.55AlaAsp: 5.55 ± 0.073
5.357AlaGlu: 5.357 ± 0.091
2.945AlaPhe: 2.945 ± 0.061
6.38AlaGly: 6.38 ± 0.098
1.183AlaHis: 1.183 ± 0.046
4.725AlaIle: 4.725 ± 0.086
4.643AlaLys: 4.643 ± 0.076
6.497AlaLeu: 6.497 ± 0.089
2.369AlaMet: 2.369 ± 0.052
2.497AlaAsn: 2.497 ± 0.061
1.876AlaPro: 1.876 ± 0.049
2.209AlaGln: 2.209 ± 0.053
2.897AlaArg: 2.897 ± 0.056
4.146AlaSer: 4.146 ± 0.077
3.057AlaThr: 3.057 ± 0.068
7.136AlaVal: 7.136 ± 0.113
0.57AlaTrp: 0.57 ± 0.029
3.179AlaTyr: 3.179 ± 0.065
0.001AlaXaa: 0.001 ± 0.001
Cys
1.129CysAla: 1.129 ± 0.04
0.275CysCys: 0.275 ± 0.019
0.955CysAsp: 0.955 ± 0.038
1.001CysGlu: 1.001 ± 0.039
0.64CysPhe: 0.64 ± 0.029
1.414CysGly: 1.414 ± 0.045
0.316CysHis: 0.316 ± 0.018
1.21CysIle: 1.21 ± 0.038
0.69CysLys: 0.69 ± 0.028
1.066CysLeu: 1.066 ± 0.035
0.487CysMet: 0.487 ± 0.022
0.667CysAsn: 0.667 ± 0.031
0.528CysPro: 0.528 ± 0.026
0.336CysGln: 0.336 ± 0.023
0.793CysArg: 0.793 ± 0.032
0.975CysSer: 0.975 ± 0.034
0.748CysThr: 0.748 ± 0.029
1.148CysVal: 1.148 ± 0.037
0.099CysTrp: 0.099 ± 0.012
0.616CysTyr: 0.616 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.796AspAla: 4.796 ± 0.086
0.857AspCys: 0.857 ± 0.037
3.947AspAsp: 3.947 ± 0.088
5.895AspGlu: 5.895 ± 0.092
2.815AspPhe: 2.815 ± 0.06
5.295AspGly: 5.295 ± 0.102
0.645AspHis: 0.645 ± 0.028
5.434AspIle: 5.434 ± 0.079
4.543AspLys: 4.543 ± 0.069
3.543AspLeu: 3.543 ± 0.069
2.276AspMet: 2.276 ± 0.05
3.342AspAsn: 3.342 ± 0.07
1.138AspPro: 1.138 ± 0.04
0.643AspGln: 0.643 ± 0.026
2.552AspArg: 2.552 ± 0.057
3.549AspSer: 3.549 ± 0.072
3.432AspThr: 3.432 ± 0.076
4.354AspVal: 4.354 ± 0.078
0.557AspTrp: 0.557 ± 0.023
3.232AspTyr: 3.232 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
5.207GluAla: 5.207 ± 0.088
0.995GluCys: 0.995 ± 0.033
3.811GluAsp: 3.811 ± 0.066
5.616GluGlu: 5.616 ± 0.1
2.578GluPhe: 2.578 ± 0.055
4.085GluGly: 4.085 ± 0.081
1.488GluHis: 1.488 ± 0.045
5.033GluIle: 5.033 ± 0.085
6.017GluLys: 6.017 ± 0.087
7.463GluLeu: 7.463 ± 0.116
1.975GluMet: 1.975 ± 0.042
4.523GluAsn: 4.523 ± 0.078
1.883GluPro: 1.883 ± 0.057
2.629GluGln: 2.629 ± 0.062
3.283GluArg: 3.283 ± 0.07
3.594GluSer: 3.594 ± 0.074
3.277GluThr: 3.277 ± 0.092
4.228GluVal: 4.228 ± 0.083
0.66GluTrp: 0.66 ± 0.03
3.824GluTyr: 3.824 ± 0.07
0.0GluXaa: 0.0 ± 0.0
Phe
2.98PheAla: 2.98 ± 0.067
0.701PheCys: 0.701 ± 0.028
2.802PheAsp: 2.802 ± 0.064
2.59PheGlu: 2.59 ± 0.054
1.767PhePhe: 1.767 ± 0.059
3.005PheGly: 3.005 ± 0.062
0.647PheHis: 0.647 ± 0.026
3.347PheIle: 3.347 ± 0.071
2.348PheLys: 2.348 ± 0.055
3.321PheLeu: 3.321 ± 0.063
1.333PheMet: 1.333 ± 0.042
1.984PheAsn: 1.984 ± 0.047
1.258PhePro: 1.258 ± 0.042
0.74PheGln: 0.74 ± 0.03
1.556PheArg: 1.556 ± 0.04
2.822PheSer: 2.822 ± 0.057
2.448PheThr: 2.448 ± 0.061
2.865PheVal: 2.865 ± 0.069
0.384PheTrp: 0.384 ± 0.022
1.804PheTyr: 1.804 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.887GlyAla: 4.887 ± 0.088
1.246GlyCys: 1.246 ± 0.039
3.812GlyAsp: 3.812 ± 0.061
4.576GlyGlu: 4.576 ± 0.082
3.083GlyPhe: 3.083 ± 0.06
4.706GlyGly: 4.706 ± 0.117
1.252GlyHis: 1.252 ± 0.045
6.224GlyIle: 6.224 ± 0.093
4.975GlyLys: 4.975 ± 0.094
5.445GlyLeu: 5.445 ± 0.085
2.53GlyMet: 2.53 ± 0.062
3.447GlyAsn: 3.447 ± 0.067
1.023GlyPro: 1.023 ± 0.04
1.929GlyGln: 1.929 ± 0.051
3.545GlyArg: 3.545 ± 0.073
4.285GlySer: 4.285 ± 0.083
4.09GlyThr: 4.09 ± 0.087
5.181GlyVal: 5.181 ± 0.087
0.734GlyTrp: 0.734 ± 0.036
3.643GlyTyr: 3.643 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.015HisAla: 1.015 ± 0.034
0.277HisCys: 0.277 ± 0.021
0.999HisAsp: 0.999 ± 0.04
1.092HisGlu: 1.092 ± 0.038
0.85HisPhe: 0.85 ± 0.03
1.231HisGly: 1.231 ± 0.037
0.355HisHis: 0.355 ± 0.036
1.429HisIle: 1.429 ± 0.045
0.852HisLys: 0.852 ± 0.033
1.187HisLeu: 1.187 ± 0.035
0.407HisMet: 0.407 ± 0.021
0.855HisAsn: 0.855 ± 0.032
0.703HisPro: 0.703 ± 0.032
0.389HisGln: 0.389 ± 0.024
0.748HisArg: 0.748 ± 0.031
1.014HisSer: 1.014 ± 0.035
0.855HisThr: 0.855 ± 0.029
1.04HisVal: 1.04 ± 0.032
0.16HisTrp: 0.16 ± 0.014
0.793HisTyr: 0.793 ± 0.032
0.0HisXaa: 0.0 ± 0.0
Ile
5.945IleAla: 5.945 ± 0.09
1.292IleCys: 1.292 ± 0.042
4.724IleAsp: 4.724 ± 0.074
5.208IleGlu: 5.208 ± 0.087
2.932IlePhe: 2.932 ± 0.071
5.007IleGly: 5.007 ± 0.075
1.157IleHis: 1.157 ± 0.038
5.874IleIle: 5.874 ± 0.114
4.915IleLys: 4.915 ± 0.082
6.062IleLeu: 6.062 ± 0.094
2.29IleMet: 2.29 ± 0.055
3.686IleAsn: 3.686 ± 0.069
2.846IlePro: 2.846 ± 0.057
1.748IleGln: 1.748 ± 0.047
3.356IleArg: 3.356 ± 0.063
4.991IleSer: 4.991 ± 0.093
4.376IleThr: 4.376 ± 0.073
5.526IleVal: 5.526 ± 0.1
0.589IleTrp: 0.589 ± 0.026
3.153IleTyr: 3.153 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.916LysAla: 4.916 ± 0.082
0.777LysCys: 0.777 ± 0.036
4.027LysAsp: 4.027 ± 0.066
5.442LysGlu: 5.442 ± 0.084
1.888LysPhe: 1.888 ± 0.052
3.871LysGly: 3.871 ± 0.079
1.112LysHis: 1.112 ± 0.037
4.446LysIle: 4.446 ± 0.078
5.959LysLys: 5.959 ± 0.098
6.361LysLeu: 6.361 ± 0.094
1.992LysMet: 1.992 ± 0.05
4.12LysAsn: 4.12 ± 0.073
1.958LysPro: 1.958 ± 0.052
1.963LysGln: 1.963 ± 0.056
3.146LysArg: 3.146 ± 0.063
3.602LysSer: 3.602 ± 0.068
3.295LysThr: 3.295 ± 0.063
4.186LysVal: 4.186 ± 0.077
0.519LysTrp: 0.519 ± 0.027
3.164LysTyr: 3.164 ± 0.065
0.0LysXaa: 0.0 ± 0.0
Leu
6.61LeuAla: 6.61 ± 0.09
1.461LeuCys: 1.461 ± 0.048
5.325LeuAsp: 5.325 ± 0.082
5.606LeuGlu: 5.606 ± 0.088
3.56LeuPhe: 3.56 ± 0.069
5.555LeuGly: 5.555 ± 0.082
1.364LeuHis: 1.364 ± 0.039
5.954LeuIle: 5.954 ± 0.085
5.712LeuLys: 5.712 ± 0.096
7.383LeuLeu: 7.383 ± 0.112
2.672LeuMet: 2.672 ± 0.061
3.88LeuAsn: 3.88 ± 0.07
3.001LeuPro: 3.001 ± 0.07
1.919LeuGln: 1.919 ± 0.047
3.507LeuArg: 3.507 ± 0.061
6.1LeuSer: 6.1 ± 0.1
4.79LeuThr: 4.79 ± 0.077
5.621LeuVal: 5.621 ± 0.083
0.708LeuTrp: 0.708 ± 0.029
3.693LeuTyr: 3.693 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.473MetAla: 2.473 ± 0.056
0.469MetCys: 0.469 ± 0.023
1.798MetAsp: 1.798 ± 0.051
2.186MetGlu: 2.186 ± 0.049
1.157MetPhe: 1.157 ± 0.045
2.018MetGly: 2.018 ± 0.055
0.447MetHis: 0.447 ± 0.024
1.959MetIle: 1.959 ± 0.046
2.318MetLys: 2.318 ± 0.052
3.098MetLeu: 3.098 ± 0.071
0.92MetMet: 0.92 ± 0.037
1.621MetAsn: 1.621 ± 0.049
1.167MetPro: 1.167 ± 0.037
0.953MetGln: 0.953 ± 0.035
1.37MetArg: 1.37 ± 0.042
2.046MetSer: 2.046 ± 0.053
1.776MetThr: 1.776 ± 0.047
2.071MetVal: 2.071 ± 0.048
0.252MetTrp: 0.252 ± 0.019
1.245MetTyr: 1.245 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.659AsnAla: 3.659 ± 0.065
0.622AsnCys: 0.622 ± 0.028
2.856AsnAsp: 2.856 ± 0.056
3.302AsnGlu: 3.302 ± 0.072
1.811AsnPhe: 1.811 ± 0.047
3.829AsnGly: 3.829 ± 0.083
0.719AsnHis: 0.719 ± 0.03
4.308AsnIle: 4.308 ± 0.07
3.033AsnLys: 3.033 ± 0.067
3.59AsnLeu: 3.59 ± 0.069
1.687AsnMet: 1.687 ± 0.048
2.558AsnAsn: 2.558 ± 0.062
1.92AsnPro: 1.92 ± 0.048
1.134AsnGln: 1.134 ± 0.034
2.124AsnArg: 2.124 ± 0.051
2.83AsnSer: 2.83 ± 0.058
2.655AsnThr: 2.655 ± 0.076
3.678AsnVal: 3.678 ± 0.069
0.372AsnTrp: 0.372 ± 0.025
2.148AsnTyr: 2.148 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.163ProAla: 2.163 ± 0.056
0.437ProCys: 0.437 ± 0.024
2.382ProAsp: 2.382 ± 0.051
2.725ProGlu: 2.725 ± 0.067
1.332ProPhe: 1.332 ± 0.041
2.092ProGly: 2.092 ± 0.051
0.511ProHis: 0.511 ± 0.025
1.872ProIle: 1.872 ± 0.044
1.609ProLys: 1.609 ± 0.048
2.336ProLeu: 2.336 ± 0.059
0.809ProMet: 0.809 ± 0.031
1.05ProAsn: 1.05 ± 0.035
0.595ProPro: 0.595 ± 0.032
0.922ProGln: 0.922 ± 0.038
0.891ProArg: 0.891 ± 0.036
1.671ProSer: 1.671 ± 0.048
1.387ProThr: 1.387 ± 0.052
2.668ProVal: 2.668 ± 0.063
0.275ProTrp: 0.275 ± 0.019
1.437ProTyr: 1.437 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
1.994GlnAla: 1.994 ± 0.055
0.31GlnCys: 0.31 ± 0.02
1.367GlnAsp: 1.367 ± 0.044
1.802GlnGlu: 1.802 ± 0.049
0.982GlnPhe: 0.982 ± 0.038
1.625GlnGly: 1.625 ± 0.045
0.404GlnHis: 0.404 ± 0.023
2.01GlnIle: 2.01 ± 0.043
1.831GlnLys: 1.831 ± 0.047
2.579GlnLeu: 2.579 ± 0.049
0.909GlnMet: 0.909 ± 0.037
1.382GlnAsn: 1.382 ± 0.043
0.791GlnPro: 0.791 ± 0.036
0.845GlnGln: 0.845 ± 0.031
1.105GlnArg: 1.105 ± 0.042
1.515GlnSer: 1.515 ± 0.045
1.442GlnThr: 1.442 ± 0.047
1.696GlnVal: 1.696 ± 0.047
0.223GlnTrp: 0.223 ± 0.017
1.257GlnTyr: 1.257 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.823ArgAla: 2.823 ± 0.064
0.605ArgCys: 0.605 ± 0.026
2.459ArgAsp: 2.459 ± 0.06
3.367ArgGlu: 3.367 ± 0.076
1.901ArgPhe: 1.901 ± 0.051
2.469ArgGly: 2.469 ± 0.065
0.819ArgHis: 0.819 ± 0.037
3.669ArgIle: 3.669 ± 0.066
3.096ArgLys: 3.096 ± 0.061
4.126ArgLeu: 4.126 ± 0.073
1.559ArgMet: 1.559 ± 0.047
2.155ArgAsn: 2.155 ± 0.05
1.174ArgPro: 1.174 ± 0.042
1.499ArgGln: 1.499 ± 0.047
2.348ArgArg: 2.348 ± 0.062
2.078ArgSer: 2.078 ± 0.05
2.277ArgThr: 2.277 ± 0.059
2.693ArgVal: 2.693 ± 0.064
0.363ArgTrp: 0.363 ± 0.02
2.086ArgTyr: 2.086 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.389SerAla: 4.389 ± 0.095
0.861SerCys: 0.861 ± 0.034
4.129SerAsp: 4.129 ± 0.076
4.225SerGlu: 4.225 ± 0.074
2.767SerPhe: 2.767 ± 0.059
5.111SerGly: 5.111 ± 0.075
0.979SerHis: 0.979 ± 0.035
4.418SerIle: 4.418 ± 0.083
3.27SerLys: 3.27 ± 0.071
4.869SerLeu: 4.869 ± 0.08
1.865SerMet: 1.865 ± 0.054
2.35SerAsn: 2.35 ± 0.059
1.558SerPro: 1.558 ± 0.045
1.623SerGln: 1.623 ± 0.047
2.747SerArg: 2.747 ± 0.064
3.744SerSer: 3.744 ± 0.088
3.16SerThr: 3.16 ± 0.069
4.76SerVal: 4.76 ± 0.076
0.498SerTrp: 0.498 ± 0.025
2.739SerTyr: 2.739 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
4.779ThrAla: 4.779 ± 0.085
0.61ThrCys: 0.61 ± 0.027
3.687ThrAsp: 3.687 ± 0.06
3.678ThrGlu: 3.678 ± 0.074
2.175ThrPhe: 2.175 ± 0.056
4.64ThrGly: 4.64 ± 0.077
0.876ThrHis: 0.876 ± 0.032
3.889ThrIle: 3.889 ± 0.073
2.726ThrLys: 2.726 ± 0.055
4.445ThrLeu: 4.445 ± 0.074
1.439ThrMet: 1.439 ± 0.039
2.023ThrAsn: 2.023 ± 0.054
1.87ThrPro: 1.87 ± 0.049
1.559ThrGln: 1.559 ± 0.048
1.865ThrArg: 1.865 ± 0.049
2.992ThrSer: 2.992 ± 0.068
3.013ThrThr: 3.013 ± 0.101
4.493ThrVal: 4.493 ± 0.093
0.417ThrTrp: 0.417 ± 0.026
2.216ThrTyr: 2.216 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
4.99ValAla: 4.99 ± 0.09
1.323ValCys: 1.323 ± 0.039
4.412ValAsp: 4.412 ± 0.069
4.54ValGlu: 4.54 ± 0.072
3.109ValPhe: 3.109 ± 0.072
4.479ValGly: 4.479 ± 0.089
1.066ValHis: 1.066 ± 0.032
5.673ValIle: 5.673 ± 0.091
4.934ValLys: 4.934 ± 0.081
6.587ValLeu: 6.587 ± 0.095
2.193ValMet: 2.193 ± 0.047
3.551ValAsn: 3.551 ± 0.068
2.33ValPro: 2.33 ± 0.05
1.686ValGln: 1.686 ± 0.051
3.148ValArg: 3.148 ± 0.066
4.706ValSer: 4.706 ± 0.069
4.298ValThr: 4.298 ± 0.077
5.298ValVal: 5.298 ± 0.095
0.644ValTrp: 0.644 ± 0.031
3.316ValTyr: 3.316 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.491TrpAla: 0.491 ± 0.027
0.141TrpCys: 0.141 ± 0.014
0.543TrpAsp: 0.543 ± 0.025
0.553TrpGlu: 0.553 ± 0.03
0.391TrpPhe: 0.391 ± 0.019
0.632TrpGly: 0.632 ± 0.03
0.18TrpHis: 0.18 ± 0.013
0.556TrpIle: 0.556 ± 0.029
0.579TrpLys: 0.579 ± 0.023
0.824TrpLeu: 0.824 ± 0.034
0.239TrpMet: 0.239 ± 0.016
0.582TrpAsn: 0.582 ± 0.025
0.151TrpPro: 0.151 ± 0.014
0.301TrpGln: 0.301 ± 0.018
0.383TrpArg: 0.383 ± 0.022
0.527TrpSer: 0.527 ± 0.029
0.385TrpThr: 0.385 ± 0.023
0.518TrpVal: 0.518 ± 0.027
0.113TrpTrp: 0.113 ± 0.012
0.413TrpTyr: 0.413 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.133TyrAla: 3.133 ± 0.068
0.674TyrCys: 0.674 ± 0.032
3.258TyrAsp: 3.258 ± 0.068
3.409TyrGlu: 3.409 ± 0.069
2.017TyrPhe: 2.017 ± 0.053
3.168TyrGly: 3.168 ± 0.059
0.731TyrHis: 0.731 ± 0.03
3.648TyrIle: 3.648 ± 0.071
2.693TyrLys: 2.693 ± 0.056
3.641TyrLeu: 3.641 ± 0.067
1.393TyrMet: 1.393 ± 0.037
2.564TyrAsn: 2.564 ± 0.054
1.395TyrPro: 1.395 ± 0.042
1.043TyrGln: 1.043 ± 0.038
2.201TyrArg: 2.201 ± 0.058
2.875TyrSer: 2.875 ± 0.06
2.633TyrThr: 2.633 ± 0.063
3.121TyrVal: 3.121 ± 0.059
0.364TyrTrp: 0.364 ± 0.023
2.175TyrTyr: 2.175 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.001XaaAsp: 0.001 ± 0.001
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 2572 proteins (845954 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski