human papillomavirus 164

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Gammapapillomavirus; Gammapapillomavirus 8

Average proteome isoelectric point is 6.02

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|K4MN90|K4MN90_9PAPI Major capsid protein L1 OS=human papillomavirus 164 OX=1315261 GN=L1 PE=3 SV=1
MM1 pKa = 7.8IGPQPTKK8 pKa = 10.84EE9 pKa = 4.12NLDD12 pKa = 3.27IDD14 pKa = 4.48LEE16 pKa = 4.31EE17 pKa = 4.86LVLPQNLIAEE27 pKa = 4.67EE28 pKa = 4.24SLSPDD33 pKa = 2.83VDD35 pKa = 3.68PEE37 pKa = 4.1EE38 pKa = 5.19EE39 pKa = 3.94EE40 pKa = 4.51RR41 pKa = 11.84QPFWVDD47 pKa = 3.63TYY49 pKa = 11.39CGTCNASVRR58 pKa = 11.84VSILATASAVCLLRR72 pKa = 11.84VLLQGEE78 pKa = 4.62LCFVCTGCSKK88 pKa = 10.75GRR90 pKa = 11.84LRR92 pKa = 11.84NGRR95 pKa = 11.84SNN97 pKa = 3.19

Molecular weight: 10.67 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|K4MYW1|K4MYW1_9PAPI Protein E6 OS=human papillomavirus 164 OX=1315261 GN=E6 PE=3 SV=1
MM1 pKa = 7.7VEE3 pKa = 4.04TQEE6 pKa = 4.39TLTQRR11 pKa = 11.84FNALQEE17 pKa = 4.35EE18 pKa = 4.43ILNIIEE24 pKa = 4.81EE25 pKa = 4.61SPTDD29 pKa = 3.72LNSIIKK35 pKa = 9.41YY36 pKa = 7.1WQLTRR41 pKa = 11.84KK42 pKa = 9.82EE43 pKa = 4.33YY44 pKa = 9.19VTLYY48 pKa = 10.12YY49 pKa = 10.54ARR51 pKa = 11.84KK52 pKa = 9.74EE53 pKa = 4.05NITRR57 pKa = 11.84LGLQPVPTLTVSEE70 pKa = 4.64YY71 pKa = 9.63KK72 pKa = 10.64AKK74 pKa = 10.42EE75 pKa = 4.24AIHH78 pKa = 5.68MQLLLTSLSRR88 pKa = 11.84SRR90 pKa = 11.84FASEE94 pKa = 3.23TWTLQDD100 pKa = 4.89CSAEE104 pKa = 4.5LINTQPKK111 pKa = 10.05NCFKK115 pKa = 11.24KK116 pKa = 9.46MGYY119 pKa = 7.46TVDD122 pKa = 2.43VWFDD126 pKa = 3.35HH127 pKa = 7.05DD128 pKa = 4.02RR129 pKa = 11.84SKK131 pKa = 11.56AFPYY135 pKa = 9.93TNWKK139 pKa = 9.34LIYY142 pKa = 9.95YY143 pKa = 9.7QDD145 pKa = 5.93SNDD148 pKa = 3.03QWQKK152 pKa = 9.41TKK154 pKa = 11.51GEE156 pKa = 3.96VDD158 pKa = 3.6EE159 pKa = 5.86NGLFYY164 pKa = 11.44NEE166 pKa = 4.48LNGDD170 pKa = 3.44RR171 pKa = 11.84VYY173 pKa = 10.39FTLFEE178 pKa = 5.13ADD180 pKa = 3.19SAKK183 pKa = 10.89YY184 pKa = 9.72GVSGEE189 pKa = 4.19WTVHH193 pKa = 4.93YY194 pKa = 10.25EE195 pKa = 3.72NTTVVSSSSSNRR207 pKa = 11.84RR208 pKa = 11.84LEE210 pKa = 4.13QPSQTTFDD218 pKa = 3.86EE219 pKa = 5.12PSTSRR224 pKa = 11.84DD225 pKa = 3.24TEE227 pKa = 3.9AQSPKK232 pKa = 9.9RR233 pKa = 11.84RR234 pKa = 11.84RR235 pKa = 11.84QEE237 pKa = 3.73ATSTSSSPSSSTSNLRR253 pKa = 11.84AGRR256 pKa = 11.84RR257 pKa = 11.84GQQQGEE263 pKa = 4.12RR264 pKa = 11.84AAPVPKK270 pKa = 9.89RR271 pKa = 11.84RR272 pKa = 11.84RR273 pKa = 11.84TATSTTQSPEE283 pKa = 3.57RR284 pKa = 11.84FAVPTPSEE292 pKa = 3.84VGTRR296 pKa = 11.84HH297 pKa = 6.69RR298 pKa = 11.84LPPQQGLGRR307 pKa = 11.84LRR309 pKa = 11.84QLQAEE314 pKa = 4.13AWDD317 pKa = 4.45PYY319 pKa = 11.59LLILKK324 pKa = 10.35GSANNLKK331 pKa = 10.18CWRR334 pKa = 11.84NKK336 pKa = 9.63HH337 pKa = 4.94KK338 pKa = 10.56HH339 pKa = 6.01KK340 pKa = 10.86NWFSNSSNVFRR351 pKa = 11.84WLGHH355 pKa = 5.81GCTQSRR361 pKa = 11.84MLLVFDD367 pKa = 4.64TPLQRR372 pKa = 11.84EE373 pKa = 4.11RR374 pKa = 11.84FVMNVRR380 pKa = 11.84LPKK383 pKa = 9.48NTTYY387 pKa = 11.03AYY389 pKa = 10.59GSLDD393 pKa = 3.38SLL395 pKa = 4.41

Molecular weight: 45.66 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2443

97

600

349.0

39.57

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.69 ± 0.51

2.415 ± 0.861

6.427 ± 0.542

6.427 ± 0.778

4.748 ± 0.533

4.953 ± 0.607

1.76 ± 0.262

5.158 ± 0.942

5.158 ± 0.756

9.742 ± 0.541

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.433 ± 0.289

5.239 ± 0.376

6.181 ± 1.141

4.544 ± 0.7

5.813 ± 0.67

7.327 ± 0.594

6.222 ± 0.927

6.099 ± 0.63

1.31 ± 0.403

3.357 ± 0.228
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski