Amino acid dipepetide frequency for Rhodovulum sp. PH10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.434AlaAla: 21.434 ± 0.215
1.329AlaCys: 1.329 ± 0.032
7.567AlaAsp: 7.567 ± 0.097
8.651AlaGlu: 8.651 ± 0.109
4.495AlaPhe: 4.495 ± 0.06
12.05AlaGly: 12.05 ± 0.122
2.475AlaHis: 2.475 ± 0.045
6.014AlaIle: 6.014 ± 0.07
4.161AlaLys: 4.161 ± 0.077
14.199AlaLeu: 14.199 ± 0.134
3.348AlaMet: 3.348 ± 0.056
2.324AlaAsn: 2.324 ± 0.048
7.096AlaPro: 7.096 ± 0.093
3.335AlaGln: 3.335 ± 0.06
10.628AlaArg: 10.628 ± 0.125
6.336AlaSer: 6.336 ± 0.087
7.033AlaThr: 7.033 ± 0.087
10.775AlaVal: 10.775 ± 0.101
1.591AlaTrp: 1.591 ± 0.042
2.336AlaTyr: 2.336 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.062CysAla: 1.062 ± 0.03
0.125CysCys: 0.125 ± 0.01
0.555CysAsp: 0.555 ± 0.02
0.492CysGlu: 0.492 ± 0.021
0.331CysPhe: 0.331 ± 0.017
1.027CysGly: 1.027 ± 0.033
0.244CysHis: 0.244 ± 0.017
0.359CysIle: 0.359 ± 0.018
0.19CysLys: 0.19 ± 0.012
0.763CysLeu: 0.763 ± 0.025
0.161CysMet: 0.161 ± 0.01
0.199CysAsn: 0.199 ± 0.012
0.588CysPro: 0.588 ± 0.023
0.186CysGln: 0.186 ± 0.012
0.85CysArg: 0.85 ± 0.024
0.443CysSer: 0.443 ± 0.018
0.464CysThr: 0.464 ± 0.019
0.64CysVal: 0.64 ± 0.024
0.105CysTrp: 0.105 ± 0.008
0.172CysTyr: 0.172 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.409AspAla: 7.409 ± 0.093
0.459AspCys: 0.459 ± 0.019
3.5AspAsp: 3.5 ± 0.073
3.509AspGlu: 3.509 ± 0.068
1.911AspPhe: 1.911 ± 0.041
5.413AspGly: 5.413 ± 0.075
1.247AspHis: 1.247 ± 0.03
2.421AspIle: 2.421 ± 0.044
1.482AspLys: 1.482 ± 0.035
6.121AspLeu: 6.121 ± 0.071
1.042AspMet: 1.042 ± 0.029
0.964AspAsn: 0.964 ± 0.027
4.071AspPro: 4.071 ± 0.051
1.511AspGln: 1.511 ± 0.043
4.966AspArg: 4.966 ± 0.072
1.781AspSer: 1.781 ± 0.04
2.888AspThr: 2.888 ± 0.056
4.296AspVal: 4.296 ± 0.062
0.838AspTrp: 0.838 ± 0.027
1.275AspTyr: 1.275 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
8.009GluAla: 8.009 ± 0.098
0.356GluCys: 0.356 ± 0.016
2.439GluAsp: 2.439 ± 0.057
3.033GluGlu: 3.033 ± 0.058
1.513GluPhe: 1.513 ± 0.032
4.032GluGly: 4.032 ± 0.058
1.244GluHis: 1.244 ± 0.031
3.397GluIle: 3.397 ± 0.057
2.287GluLys: 2.287 ± 0.05
4.696GluLeu: 4.696 ± 0.069
1.405GluMet: 1.405 ± 0.028
1.345GluAsn: 1.345 ± 0.034
3.294GluPro: 3.294 ± 0.063
1.895GluGln: 1.895 ± 0.049
5.627GluArg: 5.627 ± 0.09
2.262GluSer: 2.262 ± 0.053
3.919GluThr: 3.919 ± 0.06
4.25GluVal: 4.25 ± 0.057
0.636GluTrp: 0.636 ± 0.02
0.841GluTyr: 0.841 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
4.661PheAla: 4.661 ± 0.06
0.427PheCys: 0.427 ± 0.019
2.398PheAsp: 2.398 ± 0.048
2.016PheGlu: 2.016 ± 0.038
1.395PhePhe: 1.395 ± 0.032
3.63PheGly: 3.63 ± 0.057
0.653PheHis: 0.653 ± 0.022
1.049PheIle: 1.049 ± 0.03
0.744PheLys: 0.744 ± 0.026
3.273PheLeu: 3.273 ± 0.055
0.64PheMet: 0.64 ± 0.021
0.677PheAsn: 0.677 ± 0.022
1.602PhePro: 1.602 ± 0.035
0.778PheGln: 0.778 ± 0.023
2.552PheArg: 2.552 ± 0.044
2.086PheSer: 2.086 ± 0.045
1.799PheThr: 1.799 ± 0.038
3.23PheVal: 3.23 ± 0.054
0.477PheTrp: 0.477 ± 0.021
0.769PheTyr: 0.769 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
10.225GlyAla: 10.225 ± 0.103
0.971GlyCys: 0.971 ± 0.029
4.514GlyAsp: 4.514 ± 0.074
4.926GlyGlu: 4.926 ± 0.071
3.663GlyPhe: 3.663 ± 0.057
7.554GlyGly: 7.554 ± 0.089
1.997GlyHis: 1.997 ± 0.041
4.112GlyIle: 4.112 ± 0.058
2.943GlyLys: 2.943 ± 0.056
8.954GlyLeu: 8.954 ± 0.094
2.093GlyMet: 2.093 ± 0.043
1.715GlyAsn: 1.715 ± 0.041
4.186GlyPro: 4.186 ± 0.063
2.195GlyGln: 2.195 ± 0.044
7.717GlyArg: 7.717 ± 0.086
4.388GlySer: 4.388 ± 0.063
5.12GlyThr: 5.12 ± 0.057
6.573GlyVal: 6.573 ± 0.066
1.355GlyTrp: 1.355 ± 0.033
2.003GlyTyr: 2.003 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.597HisAla: 2.597 ± 0.049
0.227HisCys: 0.227 ± 0.013
1.357HisAsp: 1.357 ± 0.033
1.125HisGlu: 1.125 ± 0.029
0.713HisPhe: 0.713 ± 0.024
2.187HisGly: 2.187 ± 0.039
0.606HisHis: 0.606 ± 0.025
0.694HisIle: 0.694 ± 0.026
0.405HisLys: 0.405 ± 0.02
1.932HisLeu: 1.932 ± 0.04
0.412HisMet: 0.412 ± 0.016
0.35HisAsn: 0.35 ± 0.015
1.449HisPro: 1.449 ± 0.034
0.512HisGln: 0.512 ± 0.02
1.816HisArg: 1.816 ± 0.046
0.735HisSer: 0.735 ± 0.023
0.899HisThr: 0.899 ± 0.029
1.671HisVal: 1.671 ± 0.034
0.325HisTrp: 0.325 ± 0.015
0.446HisTyr: 0.446 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
7.186IleAla: 7.186 ± 0.078
0.399IleCys: 0.399 ± 0.016
3.418IleAsp: 3.418 ± 0.053
3.284IleGlu: 3.284 ± 0.058
1.234IlePhe: 1.234 ± 0.034
4.932IleGly: 4.932 ± 0.068
0.748IleHis: 0.748 ± 0.026
1.227IleIle: 1.227 ± 0.039
1.13IleLys: 1.13 ± 0.03
3.55IleLeu: 3.55 ± 0.049
0.697IleMet: 0.697 ± 0.023
0.908IleAsn: 0.908 ± 0.029
2.053IlePro: 2.053 ± 0.039
0.853IleGln: 0.853 ± 0.028
2.961IleArg: 2.961 ± 0.051
2.087IleSer: 2.087 ± 0.043
2.376IleThr: 2.376 ± 0.051
4.492IleVal: 4.492 ± 0.059
0.412IleTrp: 0.412 ± 0.017
0.843IleTyr: 0.843 ± 0.029
0.0IleXaa: 0.0 ± 0.0
Lys
4.08LysAla: 4.08 ± 0.071
0.168LysCys: 0.168 ± 0.01
1.451LysAsp: 1.451 ± 0.036
1.371LysGlu: 1.371 ± 0.035
0.804LysPhe: 0.804 ± 0.027
2.213LysGly: 2.213 ± 0.046
0.536LysHis: 0.536 ± 0.021
1.608LysIle: 1.608 ± 0.039
1.221LysLys: 1.221 ± 0.039
2.98LysLeu: 2.98 ± 0.053
0.662LysMet: 0.662 ± 0.026
0.85LysAsn: 0.85 ± 0.026
2.111LysPro: 2.111 ± 0.053
0.732LysGln: 0.732 ± 0.026
2.277LysArg: 2.277 ± 0.044
1.58LysSer: 1.58 ± 0.039
1.984LysThr: 1.984 ± 0.039
2.33LysVal: 2.33 ± 0.047
0.251LysTrp: 0.251 ± 0.013
0.543LysTyr: 0.543 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
15.707LeuAla: 15.707 ± 0.148
0.846LeuCys: 0.846 ± 0.027
6.356LeuAsp: 6.356 ± 0.079
4.929LeuGlu: 4.929 ± 0.072
3.452LeuPhe: 3.452 ± 0.061
8.645LeuGly: 8.645 ± 0.085
1.83LeuHis: 1.83 ± 0.037
4.211LeuIle: 4.211 ± 0.075
2.928LeuLys: 2.928 ± 0.05
9.29LeuLeu: 9.29 ± 0.107
2.111LeuMet: 2.111 ± 0.046
1.719LeuAsn: 1.719 ± 0.037
5.766LeuPro: 5.766 ± 0.071
2.232LeuGln: 2.232 ± 0.044
6.956LeuArg: 6.956 ± 0.072
5.279LeuSer: 5.279 ± 0.066
5.013LeuThr: 5.013 ± 0.064
8.741LeuVal: 8.741 ± 0.099
1.099LeuTrp: 1.099 ± 0.033
1.883LeuTyr: 1.883 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
2.729MetAla: 2.729 ± 0.043
0.159MetCys: 0.159 ± 0.011
0.902MetAsp: 0.902 ± 0.028
0.906MetGlu: 0.906 ± 0.028
0.67MetPhe: 0.67 ± 0.024
1.541MetGly: 1.541 ± 0.035
0.432MetHis: 0.432 ± 0.018
1.148MetIle: 1.148 ± 0.034
0.781MetLys: 0.781 ± 0.025
2.332MetLeu: 2.332 ± 0.046
0.584MetMet: 0.584 ± 0.02
0.534MetAsn: 0.534 ± 0.019
1.515MetPro: 1.515 ± 0.035
0.712MetGln: 0.712 ± 0.028
1.907MetArg: 1.907 ± 0.042
1.413MetSer: 1.413 ± 0.036
1.668MetThr: 1.668 ± 0.037
1.757MetVal: 1.757 ± 0.039
0.225MetTrp: 0.225 ± 0.012
0.304MetTyr: 0.304 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.602AsnAla: 2.602 ± 0.045
0.202AsnCys: 0.202 ± 0.013
1.079AsnAsp: 1.079 ± 0.028
0.969AsnGlu: 0.969 ± 0.025
0.71AsnPhe: 0.71 ± 0.025
1.935AsnGly: 1.935 ± 0.041
0.394AsnHis: 0.394 ± 0.019
0.92AsnIle: 0.92 ± 0.024
0.497AsnLys: 0.497 ± 0.02
2.077AsnLeu: 2.077 ± 0.039
0.416AsnMet: 0.416 ± 0.018
0.44AsnAsn: 0.44 ± 0.019
1.549AsnPro: 1.549 ± 0.031
0.497AsnGln: 0.497 ± 0.021
1.519AsnArg: 1.519 ± 0.032
0.739AsnSer: 0.739 ± 0.027
0.978AsnThr: 0.978 ± 0.025
1.672AsnVal: 1.672 ± 0.037
0.291AsnTrp: 0.291 ± 0.015
0.469AsnTyr: 0.469 ± 0.017
0.0AsnXaa: 0.0 ± 0.0
Pro
8.269ProAla: 8.269 ± 0.119
0.433ProCys: 0.433 ± 0.017
4.177ProAsp: 4.177 ± 0.066
3.807ProGlu: 3.807 ± 0.056
2.086ProPhe: 2.086 ± 0.042
5.164ProGly: 5.164 ± 0.072
1.238ProHis: 1.238 ± 0.033
2.266ProIle: 2.266 ± 0.044
1.753ProLys: 1.753 ± 0.046
5.154ProLeu: 5.154 ± 0.064
1.255ProMet: 1.255 ± 0.031
1.195ProAsn: 1.195 ± 0.029
3.959ProPro: 3.959 ± 0.079
1.493ProGln: 1.493 ± 0.035
3.916ProArg: 3.916 ± 0.06
3.085ProSer: 3.085 ± 0.052
2.834ProThr: 2.834 ± 0.05
4.853ProVal: 4.853 ± 0.075
0.771ProTrp: 0.771 ± 0.024
1.13ProTyr: 1.13 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.526GlnAla: 3.526 ± 0.06
0.183GlnCys: 0.183 ± 0.012
1.165GlnAsp: 1.165 ± 0.029
1.24GlnGlu: 1.24 ± 0.034
0.796GlnPhe: 0.796 ± 0.025
1.962GlnGly: 1.962 ± 0.038
0.504GlnHis: 0.504 ± 0.019
1.38GlnIle: 1.38 ± 0.032
0.995GlnLys: 0.995 ± 0.031
2.086GlnLeu: 2.086 ± 0.045
0.66GlnMet: 0.66 ± 0.023
0.7GlnAsn: 0.7 ± 0.024
1.469GlnPro: 1.469 ± 0.033
0.959GlnGln: 0.959 ± 0.035
2.154GlnArg: 2.154 ± 0.047
1.313GlnSer: 1.313 ± 0.036
1.485GlnThr: 1.485 ± 0.036
1.978GlnVal: 1.978 ± 0.04
0.337GlnTrp: 0.337 ± 0.017
0.473GlnTyr: 0.473 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
9.84ArgAla: 9.84 ± 0.101
0.674ArgCys: 0.674 ± 0.028
4.49ArgAsp: 4.49 ± 0.068
4.671ArgGlu: 4.671 ± 0.065
2.994ArgPhe: 2.994 ± 0.051
5.702ArgGly: 5.702 ± 0.083
1.963ArgHis: 1.963 ± 0.038
3.977ArgIle: 3.977 ± 0.058
2.389ArgLys: 2.389 ± 0.042
8.79ArgLeu: 8.79 ± 0.103
1.993ArgMet: 1.993 ± 0.039
1.649ArgAsn: 1.649 ± 0.037
4.892ArgPro: 4.892 ± 0.083
2.168ArgGln: 2.168 ± 0.045
7.765ArgArg: 7.765 ± 0.103
3.903ArgSer: 3.903 ± 0.064
4.343ArgThr: 4.343 ± 0.063
5.57ArgVal: 5.57 ± 0.069
1.154ArgTrp: 1.154 ± 0.033
1.596ArgTyr: 1.596 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.2SerAla: 6.2 ± 0.102
0.433SerCys: 0.433 ± 0.02
2.58SerAsp: 2.58 ± 0.049
2.501SerGlu: 2.501 ± 0.047
1.881SerPhe: 1.881 ± 0.044
5.029SerGly: 5.029 ± 0.066
0.968SerHis: 0.968 ± 0.031
2.227SerIle: 2.227 ± 0.049
1.266SerLys: 1.266 ± 0.038
4.714SerLeu: 4.714 ± 0.067
1.067SerMet: 1.067 ± 0.029
1.013SerAsn: 1.013 ± 0.029
3.089SerPro: 3.089 ± 0.054
1.195SerGln: 1.195 ± 0.034
3.975SerArg: 3.975 ± 0.059
2.509SerSer: 2.509 ± 0.05
2.49SerThr: 2.49 ± 0.043
3.721SerVal: 3.721 ± 0.055
0.627SerTrp: 0.627 ± 0.023
1.006SerTyr: 1.006 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
7.123ThrAla: 7.123 ± 0.094
0.443ThrCys: 0.443 ± 0.019
2.869ThrAsp: 2.869 ± 0.048
2.709ThrGlu: 2.709 ± 0.054
2.006ThrPhe: 2.006 ± 0.038
5.256ThrGly: 5.256 ± 0.07
1.007ThrHis: 1.007 ± 0.03
2.786ThrIle: 2.786 ± 0.047
1.445ThrLys: 1.445 ± 0.036
6.05ThrLeu: 6.05 ± 0.065
1.15ThrMet: 1.15 ± 0.027
1.014ThrAsn: 1.014 ± 0.026
3.701ThrPro: 3.701 ± 0.056
1.111ThrGln: 1.111 ± 0.036
3.782ThrArg: 3.782 ± 0.056
2.599ThrSer: 2.599 ± 0.046
3.31ThrThr: 3.31 ± 0.055
5.078ThrVal: 5.078 ± 0.069
0.655ThrTrp: 0.655 ± 0.025
1.054ThrTyr: 1.054 ± 0.027
0.0ThrXaa: 0.0 ± 0.0
Val
11.0ValAla: 11.0 ± 0.112
0.763ValCys: 0.763 ± 0.029
4.358ValAsp: 4.358 ± 0.059
4.786ValGlu: 4.786 ± 0.069
2.931ValPhe: 2.931 ± 0.044
6.127ValGly: 6.127 ± 0.077
1.637ValHis: 1.637 ± 0.037
3.82ValIle: 3.82 ± 0.062
2.281ValLys: 2.281 ± 0.045
8.491ValLeu: 8.491 ± 0.093
1.832ValMet: 1.832 ± 0.042
1.596ValAsn: 1.596 ± 0.034
4.778ValPro: 4.778 ± 0.067
1.982ValGln: 1.982 ± 0.041
6.124ValArg: 6.124 ± 0.077
4.304ValSer: 4.304 ± 0.06
4.825ValThr: 4.825 ± 0.06
7.591ValVal: 7.591 ± 0.095
0.976ValTrp: 0.976 ± 0.03
1.456ValTyr: 1.456 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.195TrpAla: 1.195 ± 0.034
0.136TrpCys: 0.136 ± 0.011
0.597TrpAsp: 0.597 ± 0.021
0.495TrpGlu: 0.495 ± 0.02
0.518TrpPhe: 0.518 ± 0.019
0.869TrpGly: 0.869 ± 0.031
0.32TrpHis: 0.32 ± 0.016
0.56TrpIle: 0.56 ± 0.022
0.35TrpLys: 0.35 ± 0.017
1.565TrpLeu: 1.565 ± 0.038
0.335TrpMet: 0.335 ± 0.016
0.345TrpAsn: 0.345 ± 0.018
0.722TrpPro: 0.722 ± 0.023
0.485TrpGln: 0.485 ± 0.019
1.281TrpArg: 1.281 ± 0.036
0.773TrpSer: 0.773 ± 0.022
0.768TrpThr: 0.768 ± 0.028
0.859TrpVal: 0.859 ± 0.025
0.251TrpTrp: 0.251 ± 0.015
0.257TrpTyr: 0.257 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.324TyrAla: 2.324 ± 0.05
0.221TyrCys: 0.221 ± 0.013
1.332TyrAsp: 1.332 ± 0.031
1.061TyrGlu: 1.061 ± 0.029
0.753TyrPhe: 0.753 ± 0.02
1.935TyrGly: 1.935 ± 0.042
0.414TyrHis: 0.414 ± 0.018
0.615TyrIle: 0.615 ± 0.025
0.501TyrLys: 0.501 ± 0.019
1.977TyrLeu: 1.977 ± 0.045
0.356TyrMet: 0.356 ± 0.019
0.415TyrAsn: 0.415 ± 0.019
0.947TyrPro: 0.947 ± 0.029
0.538TyrGln: 0.538 ± 0.02
1.75TyrArg: 1.75 ± 0.035
0.877TyrSer: 0.877 ± 0.027
0.953TyrThr: 0.953 ± 0.027
1.583TyrVal: 1.583 ± 0.037
0.305TyrTrp: 0.305 ± 0.016
0.489TyrTyr: 0.489 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4490 proteins (1324287 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski