Amino acid dipepetide frequency for Hepatitis B virus genotype D subtype ayw (isolate France/Tiollais/1979) (HBV-D)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.195AlaAla: 3.195 ± 1.687
0.799AlaCys: 0.799 ± 0.594
2.396AlaAsp: 2.396 ± 1.267
2.796AlaGlu: 2.796 ± 1.412
4.393AlaPhe: 4.393 ± 0.979
4.393AlaGly: 4.393 ± 0.813
1.597AlaHis: 1.597 ± 1.168
1.198AlaIle: 1.198 ± 0.493
0.399AlaLys: 0.399 ± 0.297
4.792AlaLeu: 4.792 ± 1.43
1.997AlaMet: 1.997 ± 0.855
2.396AlaAsn: 2.396 ± 1.259
3.594AlaPro: 3.594 ± 1.213
2.796AlaGln: 2.796 ± 0.876
5.192AlaArg: 5.192 ± 1.872
6.39AlaSer: 6.39 ± 1.126
1.997AlaThr: 1.997 ± 1.018
1.997AlaVal: 1.997 ± 1.199
0.399AlaTrp: 0.399 ± 0.297
1.597AlaTyr: 1.597 ± 0.601
0.0AlaXaa: 0.0 ± 0.0
Cys
2.396CysAla: 2.396 ± 1.445
2.796CysCys: 2.796 ± 1.31
0.0CysAsp: 0.0 ± 0.0
0.399CysGlu: 0.399 ± 0.297
0.799CysPhe: 0.799 ± 0.594
1.198CysGly: 1.198 ± 0.634
0.0CysHis: 0.0 ± 0.0
1.997CysIle: 1.997 ± 0.652
0.799CysLys: 0.799 ± 0.515
8.387CysLeu: 8.387 ± 2.139
1.997CysMet: 1.997 ± 0.874
0.399CysAsn: 0.399 ± 0.486
3.994CysPro: 3.994 ± 1.929
1.198CysGln: 1.198 ± 0.696
1.597CysArg: 1.597 ± 0.765
2.396CysSer: 2.396 ± 0.936
2.396CysThr: 2.396 ± 1.251
0.399CysVal: 0.399 ± 0.522
1.198CysTrp: 1.198 ± 0.493
0.399CysTyr: 0.399 ± 0.297
0.0CysXaa: 0.0 ± 0.0
Asp
0.799AspAla: 0.799 ± 0.356
0.399AspCys: 0.399 ± 0.486
1.198AspAsp: 1.198 ± 0.89
1.597AspGlu: 1.597 ± 0.897
1.997AspPhe: 1.997 ± 0.621
1.597AspGly: 1.597 ± 0.801
0.799AspHis: 0.799 ± 0.544
1.597AspIle: 1.597 ± 0.596
0.799AspLys: 0.799 ± 0.594
3.195AspLeu: 3.195 ± 1.017
0.0AspMet: 0.0 ± 0.0
0.399AspAsn: 0.399 ± 0.297
4.792AspPro: 4.792 ± 1.581
0.399AspGln: 0.399 ± 0.522
0.799AspArg: 0.799 ± 0.515
1.997AspSer: 1.997 ± 0.604
1.198AspThr: 1.198 ± 0.661
1.597AspVal: 1.597 ± 0.774
1.597AspTrp: 1.597 ± 0.624
1.997AspTyr: 1.997 ± 0.378
0.0AspXaa: 0.0 ± 0.0
Glu
1.597GluAla: 1.597 ± 0.601
0.399GluCys: 0.399 ± 0.297
1.597GluAsp: 1.597 ± 0.586
1.597GluGlu: 1.597 ± 1.043
1.198GluPhe: 1.198 ± 0.493
0.799GluGly: 0.799 ± 0.448
2.396GluHis: 2.396 ± 1.036
0.399GluIle: 0.399 ± 0.486
1.597GluLys: 1.597 ± 0.897
2.796GluLeu: 2.796 ± 0.986
0.0GluMet: 0.0 ± 0.0
1.198GluAsn: 1.198 ± 0.626
0.399GluPro: 0.399 ± 0.297
0.799GluGln: 0.799 ± 0.594
1.198GluArg: 1.198 ± 0.817
3.994GluSer: 3.994 ± 1.165
2.796GluThr: 2.796 ± 1.159
0.399GluVal: 0.399 ± 0.421
1.198GluTrp: 1.198 ± 0.626
0.799GluTyr: 0.799 ± 0.565
0.0GluXaa: 0.0 ± 0.0
Phe
2.396PheAla: 2.396 ± 1.781
1.597PheCys: 1.597 ± 0.423
0.399PheAsp: 0.399 ± 0.522
0.399PheGlu: 0.399 ± 0.297
4.393PhePhe: 4.393 ± 1.712
4.792PheGly: 4.792 ± 1.561
3.195PheHis: 3.195 ± 0.751
2.396PheIle: 2.396 ± 1.251
0.799PheLys: 0.799 ± 0.971
11.581PheLeu: 11.581 ± 3.689
0.399PheMet: 0.399 ± 0.297
0.799PheAsn: 0.799 ± 0.356
3.994PhePro: 3.994 ± 0.664
0.399PheGln: 0.399 ± 0.297
3.195PheArg: 3.195 ± 1.197
5.192PheSer: 5.192 ± 1.053
3.594PheThr: 3.594 ± 1.447
3.594PheVal: 3.594 ± 0.873
0.0PheTrp: 0.0 ± 0.0
0.799PheTyr: 0.799 ± 0.594
0.0PheXaa: 0.0 ± 0.0
Gly
3.594GlyAla: 3.594 ± 0.948
1.597GlyCys: 1.597 ± 0.774
1.198GlyAsp: 1.198 ± 0.66
1.997GlyGlu: 1.997 ± 0.724
4.393GlyPhe: 4.393 ± 1.125
3.594GlyGly: 3.594 ± 1.263
1.597GlyHis: 1.597 ± 1.187
2.396GlyIle: 2.396 ± 1.049
1.198GlyLys: 1.198 ± 0.626
8.387GlyLeu: 8.387 ± 1.27
1.597GlyMet: 1.597 ± 0.753
2.796GlyAsn: 2.796 ± 0.58
5.99GlyPro: 5.99 ± 1.393
1.997GlyGln: 1.997 ± 0.948
4.792GlyArg: 4.792 ± 1.196
5.99GlySer: 5.99 ± 1.075
5.591GlyThr: 5.591 ± 0.981
3.195GlyVal: 3.195 ± 0.97
1.198GlyTrp: 1.198 ± 0.448
2.396GlyTyr: 2.396 ± 0.532
0.0GlyXaa: 0.0 ± 0.0
His
0.799HisAla: 0.799 ± 0.515
1.198HisCys: 1.198 ± 0.493
0.799HisAsp: 0.799 ± 0.515
0.0HisGlu: 0.0 ± 0.0
0.799HisPhe: 0.799 ± 0.594
2.396HisGly: 2.396 ± 0.779
1.198HisHis: 1.198 ± 0.493
1.597HisIle: 1.597 ± 0.586
1.597HisLys: 1.597 ± 1.082
4.792HisLeu: 4.792 ± 2.412
0.0HisMet: 0.0 ± 0.0
1.198HisAsn: 1.198 ± 0.658
1.597HisPro: 1.597 ± 0.822
3.594HisGln: 3.594 ± 0.896
0.399HisArg: 0.399 ± 0.297
2.396HisSer: 2.396 ± 0.515
1.997HisThr: 1.997 ± 0.788
0.399HisVal: 0.399 ± 0.297
0.399HisTrp: 0.399 ± 0.297
0.799HisTyr: 0.799 ± 0.594
0.0HisXaa: 0.0 ± 0.0
Ile
0.0IleAla: 0.0 ± 0.0
0.799IleCys: 0.799 ± 0.448
1.198IleAsp: 1.198 ± 0.493
0.799IleGlu: 0.799 ± 0.565
4.393IlePhe: 4.393 ± 2.315
1.997IleGly: 1.997 ± 0.49
1.198IleHis: 1.198 ± 0.89
3.195IleIle: 3.195 ± 0.703
1.198IleLys: 1.198 ± 0.89
7.987IleLeu: 7.987 ± 1.141
1.597IleMet: 1.597 ± 0.614
0.799IleAsn: 0.799 ± 0.515
5.99IlePro: 5.99 ± 1.858
1.198IleGln: 1.198 ± 0.658
1.997IleArg: 1.997 ± 0.64
1.198IleSer: 1.198 ± 0.886
2.396IleThr: 2.396 ± 1.747
0.799IleVal: 0.799 ± 0.594
1.198IleTrp: 1.198 ± 0.626
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
1.597LysAla: 1.597 ± 0.882
0.399LysCys: 0.399 ± 0.297
1.198LysAsp: 1.198 ± 0.973
1.597LysGlu: 1.597 ± 0.669
2.796LysPhe: 2.796 ± 0.776
1.597LysGly: 1.597 ± 1.035
1.198LysHis: 1.198 ± 0.658
1.198LysIle: 1.198 ± 0.658
0.399LysLys: 0.399 ± 0.297
1.597LysLeu: 1.597 ± 0.69
0.0LysMet: 0.0 ± 0.0
0.399LysAsn: 0.399 ± 0.297
1.997LysPro: 1.997 ± 0.378
1.198LysGln: 1.198 ± 0.634
2.396LysArg: 2.396 ± 0.906
1.198LysSer: 1.198 ± 0.89
1.997LysThr: 1.997 ± 1.493
2.796LysVal: 2.796 ± 1.113
0.0LysTrp: 0.0 ± 0.0
0.799LysTyr: 0.799 ± 0.594
0.0LysXaa: 0.0 ± 0.0
Leu
3.594LeuAla: 3.594 ± 1.169
4.792LeuCys: 4.792 ± 1.307
5.192LeuAsp: 5.192 ± 0.819
3.195LeuGlu: 3.195 ± 1.017
2.796LeuPhe: 2.796 ± 0.803
9.984LeuGly: 9.984 ± 1.761
3.195LeuHis: 3.195 ± 2.047
3.594LeuIle: 3.594 ± 0.873
1.198LeuLys: 1.198 ± 0.699
18.77LeuLeu: 18.77 ± 2.442
1.597LeuMet: 1.597 ± 0.596
5.591LeuAsn: 5.591 ± 1.538
10.383LeuPro: 10.383 ± 0.52
4.792LeuGln: 4.792 ± 1.174
4.792LeuArg: 4.792 ± 1.362
13.978LeuSer: 13.978 ± 1.374
5.192LeuThr: 5.192 ± 1.411
7.987LeuVal: 7.987 ± 0.998
4.393LeuTrp: 4.393 ± 1.422
6.39LeuTyr: 6.39 ± 1.19
0.0LeuXaa: 0.0 ± 0.0
Met
0.799MetAla: 0.799 ± 0.736
1.198MetCys: 1.198 ± 0.626
1.597MetAsp: 1.597 ± 0.596
1.997MetGlu: 1.997 ± 0.891
0.0MetPhe: 0.0 ± 0.0
2.396MetGly: 2.396 ± 0.711
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
0.0MetLys: 0.0 ± 0.0
1.198MetLeu: 1.198 ± 0.626
1.198MetMet: 1.198 ± 0.626
0.0MetAsn: 0.0 ± 0.0
1.997MetPro: 1.997 ± 1.484
1.198MetGln: 1.198 ± 0.679
0.799MetArg: 0.799 ± 0.448
0.399MetSer: 0.399 ± 0.486
1.997MetThr: 1.997 ± 0.893
0.0MetVal: 0.0 ± 0.0
1.198MetTrp: 1.198 ± 0.626
1.597MetTyr: 1.597 ± 0.801
0.0MetXaa: 0.0 ± 0.0
Asn
1.198AsnAla: 1.198 ± 0.699
1.198AsnCys: 1.198 ± 0.626
0.399AsnAsp: 0.399 ± 0.522
0.399AsnGlu: 0.399 ± 0.297
3.195AsnPhe: 3.195 ± 0.764
0.399AsnGly: 0.399 ± 0.522
1.597AsnHis: 1.597 ± 0.423
1.997AsnIle: 1.997 ± 0.378
1.198AsnLys: 1.198 ± 0.63
4.792AsnLeu: 4.792 ± 2.324
1.597AsnMet: 1.597 ± 0.8
0.399AsnAsn: 0.399 ± 0.297
3.994AsnPro: 3.994 ± 1.555
0.399AsnGln: 0.399 ± 0.297
1.997AsnArg: 1.997 ± 1.0
3.994AsnSer: 3.994 ± 0.748
2.396AsnThr: 2.396 ± 0.804
0.399AsnVal: 0.399 ± 0.297
0.399AsnTrp: 0.399 ± 0.297
0.399AsnTyr: 0.399 ± 0.297
0.0AsnXaa: 0.0 ± 0.0
Pro
7.987ProAla: 7.987 ± 1.254
3.195ProCys: 3.195 ± 0.91
1.997ProAsp: 1.997 ± 0.964
2.396ProGlu: 2.396 ± 1.154
4.393ProPhe: 4.393 ± 0.717
3.195ProGly: 3.195 ± 1.17
2.796ProHis: 2.796 ± 0.939
5.591ProIle: 5.591 ± 0.937
1.198ProLys: 1.198 ± 0.696
9.585ProLeu: 9.585 ± 1.834
0.799ProMet: 0.799 ± 0.578
2.796ProAsn: 2.796 ± 0.939
5.591ProPro: 5.591 ± 1.549
2.796ProGln: 2.796 ± 0.978
4.393ProArg: 4.393 ± 1.57
11.182ProSer: 11.182 ± 1.526
7.987ProThr: 7.987 ± 1.795
5.192ProVal: 5.192 ± 1.053
1.198ProTrp: 1.198 ± 0.634
1.597ProTyr: 1.597 ± 0.586
0.0ProXaa: 0.0 ± 0.0
Gln
3.994GlnAla: 3.994 ± 1.26
1.198GlnCys: 1.198 ± 0.493
1.997GlnAsp: 1.997 ± 0.49
0.399GlnGlu: 0.399 ± 0.297
1.597GlnPhe: 1.597 ± 1.187
3.994GlnGly: 3.994 ± 1.115
1.997GlnHis: 1.997 ± 1.154
0.399GlnIle: 0.399 ± 0.486
1.198GlnLys: 1.198 ± 0.993
2.396GlnLeu: 2.396 ± 0.829
0.0GlnMet: 0.0 ± 0.0
1.597GlnAsn: 1.597 ± 0.828
0.399GlnPro: 0.399 ± 0.34
1.597GlnGln: 1.597 ± 0.882
2.796GlnArg: 2.796 ± 1.525
7.987GlnSer: 7.987 ± 1.156
2.796GlnThr: 2.796 ± 0.696
0.799GlnVal: 0.799 ± 0.515
1.997GlnTrp: 1.997 ± 1.097
0.399GlnTyr: 0.399 ± 0.297
0.0GlnXaa: 0.0 ± 0.0
Arg
1.997ArgAla: 1.997 ± 0.832
0.399ArgCys: 0.399 ± 0.421
1.997ArgAsp: 1.997 ± 1.175
3.195ArgGlu: 3.195 ± 1.565
3.195ArgPhe: 3.195 ± 1.073
4.393ArgGly: 4.393 ± 0.911
1.198ArgHis: 1.198 ± 0.695
3.594ArgIle: 3.594 ± 0.741
3.994ArgLys: 3.994 ± 1.731
4.393ArgLeu: 4.393 ± 2.307
1.198ArgMet: 1.198 ± 0.565
1.198ArgAsn: 1.198 ± 0.56
5.591ArgPro: 5.591 ± 1.948
3.594ArgGln: 3.594 ± 1.032
12.78ArgArg: 12.78 ± 4.877
4.792ArgSer: 4.792 ± 1.48
4.393ArgThr: 4.393 ± 1.076
2.796ArgVal: 2.796 ± 0.866
1.597ArgTrp: 1.597 ± 0.423
0.399ArgTyr: 0.399 ± 0.297
0.0ArgXaa: 0.0 ± 0.0
Ser
7.588SerAla: 7.588 ± 2.263
4.393SerCys: 4.393 ± 1.596
2.796SerAsp: 2.796 ± 0.836
0.799SerGlu: 0.799 ± 0.515
3.594SerPhe: 3.594 ± 1.357
5.591SerGly: 5.591 ± 1.0
0.799SerHis: 0.799 ± 0.594
2.796SerIle: 2.796 ± 0.732
3.195SerLys: 3.195 ± 1.586
10.783SerLeu: 10.783 ± 1.482
1.198SerMet: 1.198 ± 0.626
2.796SerAsn: 2.796 ± 0.649
13.978SerPro: 13.978 ± 3.009
4.792SerGln: 4.792 ± 1.393
8.786SerArg: 8.786 ± 2.391
9.185SerSer: 9.185 ± 1.598
6.39SerThr: 6.39 ± 1.786
3.994SerVal: 3.994 ± 0.66
5.99SerTrp: 5.99 ± 1.245
1.997SerTyr: 1.997 ± 0.696
0.0SerXaa: 0.0 ± 0.0
Thr
5.99ThrAla: 5.99 ± 1.037
3.994ThrCys: 3.994 ± 2.001
1.198ThrAsp: 1.198 ± 0.963
0.0ThrGlu: 0.0 ± 0.0
3.594ThrPhe: 3.594 ± 0.64
3.594ThrGly: 3.594 ± 0.971
2.396ThrHis: 2.396 ± 1.47
1.198ThrIle: 1.198 ± 0.626
1.997ThrLys: 1.997 ± 0.378
4.393ThrLeu: 4.393 ± 1.414
0.799ThrMet: 0.799 ± 0.448
2.396ThrAsn: 2.396 ± 0.711
3.594ThrPro: 3.594 ± 1.045
1.198ThrGln: 1.198 ± 0.993
1.597ThrArg: 1.597 ± 0.423
10.783ThrSer: 10.783 ± 3.108
8.387ThrThr: 8.387 ± 2.273
7.188ThrVal: 7.188 ± 2.198
1.597ThrTrp: 1.597 ± 0.796
0.799ThrTyr: 0.799 ± 0.515
0.0ThrXaa: 0.0 ± 0.0
Val
1.597ValAla: 1.597 ± 1.187
3.594ValCys: 3.594 ± 1.312
0.799ValAsp: 0.799 ± 0.594
1.597ValGlu: 1.597 ± 0.586
2.396ValPhe: 2.396 ± 1.166
5.591ValGly: 5.591 ± 0.808
0.399ValHis: 0.399 ± 0.297
2.396ValIle: 2.396 ± 0.649
0.799ValLys: 0.799 ± 0.66
5.591ValLeu: 5.591 ± 1.86
0.399ValMet: 0.399 ± 0.297
4.393ValAsn: 4.393 ± 0.803
3.594ValPro: 3.594 ± 0.733
2.396ValGln: 2.396 ± 0.71
3.195ValArg: 3.195 ± 0.947
4.393ValSer: 4.393 ± 1.309
1.198ValThr: 1.198 ± 0.89
3.195ValVal: 3.195 ± 1.173
1.997ValTrp: 1.997 ± 0.893
1.597ValTyr: 1.597 ± 0.423
0.0ValXaa: 0.0 ± 0.0
Trp
2.396TrpAla: 2.396 ± 1.251
0.0TrpCys: 0.0 ± 0.0
0.399TrpAsp: 0.399 ± 0.34
1.997TrpGlu: 1.997 ± 0.566
1.997TrpPhe: 1.997 ± 0.893
3.594TrpGly: 3.594 ± 0.681
0.0TrpHis: 0.0 ± 0.0
1.198TrpIle: 1.198 ± 0.493
1.198TrpLys: 1.198 ± 0.89
3.994TrpLeu: 3.994 ± 0.729
2.396TrpMet: 2.396 ± 1.251
0.799TrpAsn: 0.799 ± 0.547
1.198TrpPro: 1.198 ± 0.541
0.799TrpGln: 0.799 ± 0.66
0.799TrpArg: 0.799 ± 0.515
1.198TrpSer: 1.198 ± 0.451
1.597TrpThr: 1.597 ± 0.423
1.997TrpVal: 1.997 ± 0.893
1.597TrpTrp: 1.597 ± 0.423
1.198TrpTyr: 1.198 ± 0.626
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.799TyrAla: 0.799 ± 0.594
0.799TyrCys: 0.799 ± 0.594
0.399TyrAsp: 0.399 ± 0.522
0.0TyrGlu: 0.0 ± 0.0
1.997TyrPhe: 1.997 ± 0.762
0.399TyrGly: 0.399 ± 0.297
0.399TyrHis: 0.399 ± 0.297
1.597TyrIle: 1.597 ± 0.801
1.597TyrLys: 1.597 ± 0.586
1.997TyrLeu: 1.997 ± 0.788
0.399TyrMet: 0.399 ± 0.297
0.0TyrAsn: 0.0 ± 0.0
3.195TyrPro: 3.195 ± 1.045
2.396TyrGln: 2.396 ± 0.515
3.195TyrArg: 3.195 ± 1.14
2.796TyrSer: 2.796 ± 0.774
0.399TyrThr: 0.399 ± 0.297
2.396TyrVal: 2.396 ± 1.036
1.198TyrTrp: 1.198 ± 0.626
0.399TyrTyr: 0.399 ± 0.297
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (2505 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski