Amino acid dipepetide frequency for Acholeplasma sp. CAG:878

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.626AlaAla: 1.626 ± 0.105
0.532AlaCys: 0.532 ± 0.044
1.895AlaAsp: 1.895 ± 0.079
1.868AlaGlu: 1.868 ± 0.084
1.775AlaPhe: 1.775 ± 0.087
2.376AlaGly: 2.376 ± 0.098
0.608AlaHis: 0.608 ± 0.045
4.761AlaIle: 4.761 ± 0.138
4.048AlaLys: 4.048 ± 0.111
4.169AlaLeu: 4.169 ± 0.127
0.916AlaMet: 0.916 ± 0.059
2.778AlaAsn: 2.778 ± 0.09
0.961AlaPro: 0.961 ± 0.053
0.877AlaGln: 0.877 ± 0.052
1.593AlaArg: 1.593 ± 0.07
2.993AlaSer: 2.993 ± 0.092
2.385AlaThr: 2.385 ± 0.101
2.6AlaVal: 2.6 ± 0.098
0.248AlaTrp: 0.248 ± 0.03
2.016AlaTyr: 2.016 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.463CysAla: 0.463 ± 0.044
0.142CysCys: 0.142 ± 0.024
0.804CysAsp: 0.804 ± 0.053
0.798CysGlu: 0.798 ± 0.052
0.52CysPhe: 0.52 ± 0.037
0.865CysGly: 0.865 ± 0.055
0.157CysHis: 0.157 ± 0.022
0.877CysIle: 0.877 ± 0.045
0.976CysLys: 0.976 ± 0.057
0.989CysLeu: 0.989 ± 0.051
0.281CysMet: 0.281 ± 0.027
0.804CysAsn: 0.804 ± 0.047
0.426CysPro: 0.426 ± 0.038
0.2CysGln: 0.2 ± 0.026
0.284CysArg: 0.284 ± 0.029
0.774CysSer: 0.774 ± 0.056
0.577CysThr: 0.577 ± 0.044
0.644CysVal: 0.644 ± 0.044
0.073CysTrp: 0.073 ± 0.015
0.614CysTyr: 0.614 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
2.361AspAla: 2.361 ± 0.092
0.62AspCys: 0.62 ± 0.048
3.359AspAsp: 3.359 ± 0.12
5.091AspGlu: 5.091 ± 0.127
3.065AspPhe: 3.065 ± 0.1
3.247AspGly: 3.247 ± 0.103
0.423AspHis: 0.423 ± 0.04
6.013AspIle: 6.013 ± 0.148
5.318AspLys: 5.318 ± 0.141
5.502AspLeu: 5.502 ± 0.13
1.382AspMet: 1.382 ± 0.069
4.477AspAsn: 4.477 ± 0.116
0.88AspPro: 0.88 ± 0.064
0.535AspGln: 0.535 ± 0.035
1.421AspArg: 1.421 ± 0.072
3.513AspSer: 3.513 ± 0.111
2.833AspThr: 2.833 ± 0.097
3.721AspVal: 3.721 ± 0.099
0.33AspTrp: 0.33 ± 0.035
3.957AspTyr: 3.957 ± 0.128
0.0AspXaa: 0.0 ± 0.0
Glu
3.35GluAla: 3.35 ± 0.121
0.71GluCys: 0.71 ± 0.049
3.851GluAsp: 3.851 ± 0.126
6.506GluGlu: 6.506 ± 0.171
2.805GluPhe: 2.805 ± 0.105
2.842GluGly: 2.842 ± 0.104
0.813GluHis: 0.813 ± 0.049
7.162GluIle: 7.162 ± 0.152
7.591GluLys: 7.591 ± 0.173
7.533GluLeu: 7.533 ± 0.192
1.802GluMet: 1.802 ± 0.076
5.741GluAsn: 5.741 ± 0.135
1.651GluPro: 1.651 ± 0.073
2.328GluGln: 2.328 ± 0.087
2.385GluArg: 2.385 ± 0.103
3.005GluSer: 3.005 ± 0.099
3.108GluThr: 3.108 ± 0.102
4.734GluVal: 4.734 ± 0.138
0.432GluTrp: 0.432 ± 0.038
3.643GluTyr: 3.643 ± 0.107
0.0GluXaa: 0.0 ± 0.0
Phe
1.841PheAla: 1.841 ± 0.087
0.526PheCys: 0.526 ± 0.041
2.947PheAsp: 2.947 ± 0.1
3.262PheGlu: 3.262 ± 0.098
1.623PhePhe: 1.623 ± 0.086
2.452PheGly: 2.452 ± 0.101
0.423PheHis: 0.423 ± 0.035
4.77PheIle: 4.77 ± 0.135
4.308PheLys: 4.308 ± 0.111
3.885PheLeu: 3.885 ± 0.128
0.967PheMet: 0.967 ± 0.052
3.495PheAsn: 3.495 ± 0.118
1.052PhePro: 1.052 ± 0.061
0.849PheGln: 0.849 ± 0.059
1.221PheArg: 1.221 ± 0.064
2.908PheSer: 2.908 ± 0.104
2.276PheThr: 2.276 ± 0.08
2.557PheVal: 2.557 ± 0.074
0.248PheTrp: 0.248 ± 0.03
2.044PheTyr: 2.044 ± 0.085
0.0PheXaa: 0.0 ± 0.0
Gly
2.31GlyAla: 2.31 ± 0.104
0.807GlyCys: 0.807 ± 0.052
2.588GlyAsp: 2.588 ± 0.099
3.253GlyGlu: 3.253 ± 0.101
2.781GlyPhe: 2.781 ± 0.101
2.987GlyGly: 2.987 ± 0.113
0.955GlyHis: 0.955 ± 0.059
5.762GlyIle: 5.762 ± 0.148
4.891GlyLys: 4.891 ± 0.132
4.643GlyLeu: 4.643 ± 0.128
1.264GlyMet: 1.264 ± 0.068
3.585GlyAsn: 3.585 ± 0.127
0.907GlyPro: 0.907 ± 0.065
1.058GlyGln: 1.058 ± 0.067
1.708GlyArg: 1.708 ± 0.09
3.495GlySer: 3.495 ± 0.114
3.259GlyThr: 3.259 ± 0.119
3.467GlyVal: 3.467 ± 0.103
0.399GlyTrp: 0.399 ± 0.042
3.114GlyTyr: 3.114 ± 0.104
0.0GlyXaa: 0.0 ± 0.0
His
0.535HisAla: 0.535 ± 0.04
0.148HisCys: 0.148 ± 0.021
0.692HisAsp: 0.692 ± 0.045
0.801HisGlu: 0.801 ± 0.059
0.586HisPhe: 0.586 ± 0.04
0.741HisGly: 0.741 ± 0.05
0.254HisHis: 0.254 ± 0.031
1.233HisIle: 1.233 ± 0.058
0.862HisLys: 0.862 ± 0.055
1.182HisLeu: 1.182 ± 0.058
0.305HisMet: 0.305 ± 0.029
0.834HisAsn: 0.834 ± 0.055
0.541HisPro: 0.541 ± 0.042
0.317HisGln: 0.317 ± 0.031
0.405HisArg: 0.405 ± 0.034
0.768HisSer: 0.768 ± 0.052
0.744HisThr: 0.744 ± 0.055
0.65HisVal: 0.65 ± 0.046
0.06HisTrp: 0.06 ± 0.013
0.707HisTyr: 0.707 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
4.45IleAla: 4.45 ± 0.091
1.103IleCys: 1.103 ± 0.059
6.787IleAsp: 6.787 ± 0.145
7.059IleGlu: 7.059 ± 0.155
4.199IlePhe: 4.199 ± 0.142
5.399IleGly: 5.399 ± 0.152
1.116IleHis: 1.116 ± 0.057
11.158IleIle: 11.158 ± 0.244
10.832IleLys: 10.832 ± 0.199
9.565IleLeu: 9.565 ± 0.203
2.095IleMet: 2.095 ± 0.084
8.289IleAsn: 8.289 ± 0.163
3.093IlePro: 3.093 ± 0.092
1.575IleGln: 1.575 ± 0.073
2.805IleArg: 2.805 ± 0.104
6.778IleSer: 6.778 ± 0.151
5.726IleThr: 5.726 ± 0.155
6.309IleVal: 6.309 ± 0.152
0.438IleTrp: 0.438 ± 0.037
4.417IleTyr: 4.417 ± 0.116
0.0IleXaa: 0.0 ± 0.0
Lys
3.788LysAla: 3.788 ± 0.127
0.958LysCys: 0.958 ± 0.056
5.792LysAsp: 5.792 ± 0.129
9.365LysGlu: 9.365 ± 0.204
3.189LysPhe: 3.189 ± 0.1
4.692LysGly: 4.692 ± 0.115
1.209LysHis: 1.209 ± 0.063
10.145LysIle: 10.145 ± 0.169
10.206LysLys: 10.206 ± 0.228
8.362LysLeu: 8.362 ± 0.162
2.666LysMet: 2.666 ± 0.085
8.338LysAsn: 8.338 ± 0.162
2.361LysPro: 2.361 ± 0.092
3.002LysGln: 3.002 ± 0.098
3.283LysArg: 3.283 ± 0.1
4.519LysSer: 4.519 ± 0.113
6.01LysThr: 6.01 ± 0.147
6.055LysVal: 6.055 ± 0.139
0.511LysTrp: 0.511 ± 0.045
5.925LysTyr: 5.925 ± 0.151
0.0LysXaa: 0.0 ± 0.0
Leu
3.764LeuAla: 3.764 ± 0.105
0.913LeuCys: 0.913 ± 0.044
5.571LeuAsp: 5.571 ± 0.153
6.877LeuGlu: 6.877 ± 0.197
4.447LeuPhe: 4.447 ± 0.135
5.266LeuGly: 5.266 ± 0.129
0.992LeuHis: 0.992 ± 0.06
9.456LeuIle: 9.456 ± 0.194
10.206LeuLys: 10.206 ± 0.218
9.105LeuLeu: 9.105 ± 0.222
1.811LeuMet: 1.811 ± 0.074
7.283LeuAsn: 7.283 ± 0.156
2.488LeuPro: 2.488 ± 0.092
1.883LeuGln: 1.883 ± 0.084
2.545LeuArg: 2.545 ± 0.088
6.614LeuSer: 6.614 ± 0.141
5.203LeuThr: 5.203 ± 0.14
5.574LeuVal: 5.574 ± 0.148
0.46LeuTrp: 0.46 ± 0.042
4.036LeuTyr: 4.036 ± 0.126
0.0LeuXaa: 0.0 ± 0.0
Met
1.134MetAla: 1.134 ± 0.054
0.257MetCys: 0.257 ± 0.026
1.303MetAsp: 1.303 ± 0.066
1.657MetGlu: 1.657 ± 0.069
1.028MetPhe: 1.028 ± 0.061
1.203MetGly: 1.203 ± 0.066
0.272MetHis: 0.272 ± 0.031
1.886MetIle: 1.886 ± 0.073
2.373MetLys: 2.373 ± 0.082
2.31MetLeu: 2.31 ± 0.085
0.583MetMet: 0.583 ± 0.053
1.717MetAsn: 1.717 ± 0.075
0.686MetPro: 0.686 ± 0.05
0.547MetGln: 0.547 ± 0.043
0.726MetArg: 0.726 ± 0.047
1.372MetSer: 1.372 ± 0.059
1.125MetThr: 1.125 ± 0.047
1.215MetVal: 1.215 ± 0.057
0.157MetTrp: 0.157 ± 0.025
1.079MetTyr: 1.079 ± 0.061
0.0MetXaa: 0.0 ± 0.0
Asn
2.833AsnAla: 2.833 ± 0.094
0.786AsnCys: 0.786 ± 0.052
4.598AsnAsp: 4.598 ± 0.131
5.605AsnGlu: 5.605 ± 0.154
2.954AsnPhe: 2.954 ± 0.101
4.09AsnGly: 4.09 ± 0.114
0.895AsnHis: 0.895 ± 0.049
8.214AsnIle: 8.214 ± 0.192
8.613AsnLys: 8.613 ± 0.193
7.11AsnLeu: 7.11 ± 0.174
1.844AsnMet: 1.844 ± 0.07
7.053AsnAsn: 7.053 ± 0.223
1.95AsnPro: 1.95 ± 0.088
1.796AsnGln: 1.796 ± 0.08
2.022AsnArg: 2.022 ± 0.086
4.504AsnSer: 4.504 ± 0.119
3.534AsnThr: 3.534 ± 0.137
4.507AsnVal: 4.507 ± 0.113
0.502AsnTrp: 0.502 ± 0.042
4.444AsnTyr: 4.444 ± 0.145
0.0AsnXaa: 0.0 ± 0.0
Pro
0.958ProAla: 0.958 ± 0.057
0.26ProCys: 0.26 ± 0.031
1.273ProAsp: 1.273 ± 0.061
1.418ProGlu: 1.418 ± 0.073
1.279ProPhe: 1.279 ± 0.067
1.176ProGly: 1.176 ± 0.069
0.411ProHis: 0.411 ± 0.035
2.724ProIle: 2.724 ± 0.092
2.4ProLys: 2.4 ± 0.089
2.222ProLeu: 2.222 ± 0.086
0.487ProMet: 0.487 ± 0.039
1.917ProAsn: 1.917 ± 0.071
0.375ProPro: 0.375 ± 0.033
0.562ProGln: 0.562 ± 0.044
0.762ProArg: 0.762 ± 0.053
1.687ProSer: 1.687 ± 0.081
1.569ProThr: 1.569 ± 0.089
1.611ProVal: 1.611 ± 0.072
0.172ProTrp: 0.172 ± 0.021
1.391ProTyr: 1.391 ± 0.066
0.0ProXaa: 0.0 ± 0.0
Gln
1.176GlnAla: 1.176 ± 0.056
0.169GlnCys: 0.169 ± 0.023
1.04GlnAsp: 1.04 ± 0.051
1.802GlnGlu: 1.802 ± 0.081
0.934GlnPhe: 0.934 ± 0.053
1.128GlnGly: 1.128 ± 0.06
0.181GlnHis: 0.181 ± 0.023
2.458GlnIle: 2.458 ± 0.089
1.935GlnLys: 1.935 ± 0.083
2.028GlnLeu: 2.028 ± 0.07
0.577GlnMet: 0.577 ± 0.045
1.651GlnAsn: 1.651 ± 0.069
0.511GlnPro: 0.511 ± 0.049
0.605GlnGln: 0.605 ± 0.046
0.732GlnArg: 0.732 ± 0.05
1.106GlnSer: 1.106 ± 0.057
1.23GlnThr: 1.23 ± 0.064
1.239GlnVal: 1.239 ± 0.064
0.139GlnTrp: 0.139 ± 0.021
0.913GlnTyr: 0.913 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
1.309ArgAla: 1.309 ± 0.062
0.39ArgCys: 0.39 ± 0.035
1.557ArgAsp: 1.557 ± 0.085
2.288ArgGlu: 2.288 ± 0.1
1.267ArgPhe: 1.267 ± 0.064
1.557ArgGly: 1.557 ± 0.073
0.444ArgHis: 0.444 ± 0.039
2.908ArgIle: 2.908 ± 0.096
3.044ArgLys: 3.044 ± 0.098
2.872ArgLeu: 2.872 ± 0.091
0.868ArgMet: 0.868 ± 0.055
2.122ArgAsn: 2.122 ± 0.081
0.846ArgPro: 0.846 ± 0.055
0.747ArgGln: 0.747 ± 0.048
1.176ArgArg: 1.176 ± 0.064
1.394ArgSer: 1.394 ± 0.062
1.645ArgThr: 1.645 ± 0.075
1.865ArgVal: 1.865 ± 0.085
0.187ArgTrp: 0.187 ± 0.024
1.702ArgTyr: 1.702 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
2.077SerAla: 2.077 ± 0.074
0.777SerCys: 0.777 ± 0.048
3.437SerAsp: 3.437 ± 0.107
3.888SerGlu: 3.888 ± 0.121
3.029SerPhe: 3.029 ± 0.094
3.7SerGly: 3.7 ± 0.13
0.904SerHis: 0.904 ± 0.053
6.085SerIle: 6.085 ± 0.17
6.285SerLys: 6.285 ± 0.145
6.028SerLeu: 6.028 ± 0.13
1.312SerMet: 1.312 ± 0.059
4.973SerAsn: 4.973 ± 0.147
1.285SerPro: 1.285 ± 0.057
1.375SerGln: 1.375 ± 0.065
1.793SerArg: 1.793 ± 0.077
4.169SerSer: 4.169 ± 0.142
2.914SerThr: 2.914 ± 0.107
3.353SerVal: 3.353 ± 0.097
0.366SerTrp: 0.366 ± 0.035
3.213SerTyr: 3.213 ± 0.112
0.0SerXaa: 0.0 ± 0.0
Thr
2.044ThrAla: 2.044 ± 0.092
0.629ThrCys: 0.629 ± 0.045
2.811ThrAsp: 2.811 ± 0.117
2.548ThrGlu: 2.548 ± 0.092
2.633ThrPhe: 2.633 ± 0.084
3.316ThrGly: 3.316 ± 0.123
0.792ThrHis: 0.792 ± 0.045
5.931ThrIle: 5.931 ± 0.136
5.499ThrLys: 5.499 ± 0.147
5.308ThrLeu: 5.308 ± 0.133
0.934ThrMet: 0.934 ± 0.059
3.927ThrAsn: 3.927 ± 0.129
1.756ThrPro: 1.756 ± 0.077
0.986ThrGln: 0.986 ± 0.06
1.669ThrArg: 1.669 ± 0.074
3.594ThrSer: 3.594 ± 0.117
3.347ThrThr: 3.347 ± 0.161
3.014ThrVal: 3.014 ± 0.092
0.33ThrTrp: 0.33 ± 0.033
2.911ThrTyr: 2.911 ± 0.105
0.0ThrXaa: 0.0 ± 0.0
Val
2.736ValAla: 2.736 ± 0.099
0.801ValCys: 0.801 ± 0.049
3.691ValAsp: 3.691 ± 0.1
3.706ValGlu: 3.706 ± 0.14
2.684ValPhe: 2.684 ± 0.102
3.22ValGly: 3.22 ± 0.103
0.677ValHis: 0.677 ± 0.042
6.155ValIle: 6.155 ± 0.153
5.52ValLys: 5.52 ± 0.148
6.031ValLeu: 6.031 ± 0.173
1.379ValMet: 1.379 ± 0.058
4.139ValAsn: 4.139 ± 0.102
1.502ValPro: 1.502 ± 0.067
0.934ValGln: 0.934 ± 0.047
1.895ValArg: 1.895 ± 0.078
4.392ValSer: 4.392 ± 0.119
3.519ValThr: 3.519 ± 0.113
4.269ValVal: 4.269 ± 0.139
0.36ValTrp: 0.36 ± 0.03
2.917ValTyr: 2.917 ± 0.094
0.0ValXaa: 0.0 ± 0.0
Trp
0.269TrpAla: 0.269 ± 0.024
0.1TrpCys: 0.1 ± 0.02
0.336TrpAsp: 0.336 ± 0.038
0.287TrpGlu: 0.287 ± 0.03
0.378TrpPhe: 0.378 ± 0.038
0.308TrpGly: 0.308 ± 0.03
0.106TrpHis: 0.106 ± 0.017
0.435TrpIle: 0.435 ± 0.042
0.463TrpLys: 0.463 ± 0.041
0.68TrpLeu: 0.68 ± 0.046
0.124TrpMet: 0.124 ± 0.019
0.408TrpAsn: 0.408 ± 0.032
0.097TrpPro: 0.097 ± 0.018
0.16TrpGln: 0.16 ± 0.022
0.163TrpArg: 0.163 ± 0.023
0.314TrpSer: 0.314 ± 0.035
0.287TrpThr: 0.287 ± 0.034
0.272TrpVal: 0.272 ± 0.033
0.067TrpTrp: 0.067 ± 0.016
0.472TrpTyr: 0.472 ± 0.054
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.004TyrAla: 2.004 ± 0.072
0.638TyrCys: 0.638 ± 0.047
3.712TyrAsp: 3.712 ± 0.12
3.912TyrGlu: 3.912 ± 0.115
2.479TyrPhe: 2.479 ± 0.086
2.669TyrGly: 2.669 ± 0.099
0.735TyrHis: 0.735 ± 0.045
5.058TyrIle: 5.058 ± 0.136
5.009TyrLys: 5.009 ± 0.128
4.97TyrLeu: 4.97 ± 0.143
1.031TyrMet: 1.031 ± 0.061
4.326TyrAsn: 4.326 ± 0.13
1.285TyrPro: 1.285 ± 0.064
1.218TyrGln: 1.218 ± 0.07
1.599TyrArg: 1.599 ± 0.069
3.062TyrSer: 3.062 ± 0.11
2.691TyrThr: 2.691 ± 0.099
2.869TyrVal: 2.869 ± 0.092
0.248TyrTrp: 0.248 ± 0.024
2.763TyrTyr: 2.763 ± 0.117
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1145 proteins (330793 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski