Amino acid dipepetide frequency for Desulfamplus magnetovallimortis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.56AlaAla: 5.56 ± 0.077	0.932AlaCys: 0.932 ± 0.022	3.798AlaAsp: 3.798 ± 0.046	4.301AlaGlu: 4.301 ± 0.048	3.188AlaPhe: 3.188 ± 0.043	5.52AlaGly: 5.52 ± 0.08	1.326AlaHis: 1.326 ± 0.029	5.218AlaIle: 5.218 ± 0.054	3.749AlaLys: 3.749 ± 0.052	7.12AlaLeu: 7.12 ± 0.065	2.312AlaMet: 2.312 ± 0.038	2.501AlaAsn: 2.501 ± 0.042	2.132AlaPro: 2.132 ± 0.036	1.999AlaGln: 1.999 ± 0.036	3.126AlaArg: 3.126 ± 0.042	4.773AlaSer: 4.773 ± 0.049	3.528AlaThr: 3.528 ± 0.047	4.93AlaVal: 4.93 ± 0.056	0.694AlaTrp: 0.694 ± 0.021	1.973AlaTyr: 1.973 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.827CysAla: 0.827 ± 0.022	0.229CysCys: 0.229 ± 0.012	0.658CysAsp: 0.658 ± 0.019	0.65CysGlu: 0.65 ± 0.021	0.664CysPhe: 0.664 ± 0.02	1.085CysGly: 1.085 ± 0.028	0.415CysHis: 0.415 ± 0.02	0.876CysIle: 0.876 ± 0.02	0.687CysLys: 0.687 ± 0.018	1.035CysLeu: 1.035 ± 0.022	0.361CysMet: 0.361 ± 0.013	0.549CysAsn: 0.549 ± 0.019	0.625CysPro: 0.625 ± 0.02	0.401CysGln: 0.401 ± 0.017	0.792CysArg: 0.792 ± 0.023	0.923CysSer: 0.923 ± 0.023	0.596CysThr: 0.596 ± 0.019	0.692CysVal: 0.692 ± 0.021	0.132CysTrp: 0.132 ± 0.009	0.418CysTyr: 0.418 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.171AspAla: 4.171 ± 0.05	0.609AspCys: 0.609 ± 0.02	3.33AspAsp: 3.33 ± 0.055	3.981AspGlu: 3.981 ± 0.051	3.033AspPhe: 3.033 ± 0.039	3.844AspGly: 3.844 ± 0.073	1.156AspHis: 1.156 ± 0.025	5.608AspIle: 5.608 ± 0.058	3.521AspLys: 3.521 ± 0.05	5.4AspLeu: 5.4 ± 0.051	1.571AspMet: 1.571 ± 0.031	2.863AspAsn: 2.863 ± 0.053	2.283AspPro: 2.283 ± 0.042	1.648AspGln: 1.648 ± 0.029	2.496AspArg: 2.496 ± 0.041	3.909AspSer: 3.909 ± 0.054	2.878AspThr: 2.878 ± 0.042	3.398AspVal: 3.398 ± 0.047	0.587AspTrp: 0.587 ± 0.018	2.057AspTyr: 2.057 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	4.527GluAla: 4.527 ± 0.057	0.627GluCys: 0.627 ± 0.018	3.493GluAsp: 3.493 ± 0.054	4.66GluGlu: 4.66 ± 0.064	2.495GluPhe: 2.495 ± 0.038	3.493GluGly: 3.493 ± 0.045	1.301GluHis: 1.301 ± 0.029	5.975GluIle: 5.975 ± 0.059	6.877GluLys: 6.877 ± 0.072	6.299GluLeu: 6.299 ± 0.069	2.194GluMet: 2.194 ± 0.034	4.065GluAsn: 4.065 ± 0.056	2.232GluPro: 2.232 ± 0.084	2.377GluGln: 2.377 ± 0.043	3.051GluArg: 3.051 ± 0.044	4.495GluSer: 4.495 ± 0.053	3.749GluThr: 3.749 ± 0.045	3.474GluVal: 3.474 ± 0.047	0.725GluTrp: 0.725 ± 0.022	2.108GluTyr: 2.108 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	2.882PheAla: 2.882 ± 0.041	0.66PheCys: 0.66 ± 0.02	2.955PheAsp: 2.955 ± 0.04	2.756PheGlu: 2.756 ± 0.042	2.66PhePhe: 2.66 ± 0.051	2.778PheGly: 2.778 ± 0.045	1.051PheHis: 1.051 ± 0.022	3.408PheIle: 3.408 ± 0.044	2.756PheLys: 2.756 ± 0.043	4.223PheLeu: 4.223 ± 0.052	1.39PheMet: 1.39 ± 0.028	2.294PheAsn: 2.294 ± 0.038	1.814PhePro: 1.814 ± 0.031	1.469PheGln: 1.469 ± 0.03	1.974PheArg: 1.974 ± 0.033	3.894PheSer: 3.894 ± 0.06	2.608PheThr: 2.608 ± 0.037	2.552PheVal: 2.552 ± 0.039	0.471PheTrp: 0.471 ± 0.015	1.641PheTyr: 1.641 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.433GlyAla: 4.433 ± 0.062	0.986GlyCys: 0.986 ± 0.026	3.671GlyAsp: 3.671 ± 0.058	4.184GlyGlu: 4.184 ± 0.047	3.311GlyPhe: 3.311 ± 0.047	4.586GlyGly: 4.586 ± 0.098	1.333GlyHis: 1.333 ± 0.03	5.859GlyIle: 5.859 ± 0.056	5.026GlyLys: 5.026 ± 0.053	5.626GlyLeu: 5.626 ± 0.07	2.16GlyMet: 2.16 ± 0.044	3.3GlyAsn: 3.3 ± 0.061	1.363GlyPro: 1.363 ± 0.03	1.862GlyGln: 1.862 ± 0.035	2.916GlyArg: 2.916 ± 0.04	4.291GlySer: 4.291 ± 0.058	3.962GlyThr: 3.962 ± 0.072	4.286GlyVal: 4.286 ± 0.051	0.724GlyTrp: 0.724 ± 0.019	2.582GlyTyr: 2.582 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.331HisAla: 1.331 ± 0.029	0.305HisCys: 0.305 ± 0.013	1.198HisAsp: 1.198 ± 0.028	1.385HisGlu: 1.385 ± 0.035	1.073HisPhe: 1.073 ± 0.024	1.52HisGly: 1.52 ± 0.026	0.569HisHis: 0.569 ± 0.017	1.598HisIle: 1.598 ± 0.029	1.181HisLys: 1.181 ± 0.024	2.053HisLeu: 2.053 ± 0.035	0.52HisMet: 0.52 ± 0.017	0.948HisAsn: 0.948 ± 0.022	1.071HisPro: 1.071 ± 0.025	0.662HisGln: 0.662 ± 0.019	0.923HisArg: 0.923 ± 0.022	1.298HisSer: 1.298 ± 0.026	1.01HisThr: 1.01 ± 0.025	1.098HisVal: 1.098 ± 0.024	0.198HisTrp: 0.198 ± 0.009	0.754HisTyr: 0.754 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.465IleAla: 5.465 ± 0.062	1.061IleCys: 1.061 ± 0.024	4.781IleAsp: 4.781 ± 0.053	5.58IleGlu: 5.58 ± 0.058	3.626IlePhe: 3.626 ± 0.047	4.22IleGly: 4.22 ± 0.059	1.723IleHis: 1.723 ± 0.035	5.738IleIle: 5.738 ± 0.062	5.473IleLys: 5.473 ± 0.064	7.163IleLeu: 7.163 ± 0.078	2.041IleMet: 2.041 ± 0.033	4.127IleAsn: 4.127 ± 0.049	3.659IlePro: 3.659 ± 0.047	2.386IleGln: 2.386 ± 0.038	3.57IleArg: 3.57 ± 0.045	6.217IleSer: 6.217 ± 0.061	4.57IleThr: 4.57 ± 0.058	4.556IleVal: 4.556 ± 0.048	0.696IleTrp: 0.696 ± 0.023	2.438IleTyr: 2.438 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	4.665LysAla: 4.665 ± 0.053	0.703LysCys: 0.703 ± 0.022	3.748LysAsp: 3.748 ± 0.053	5.211LysGlu: 5.211 ± 0.067	2.165LysPhe: 2.165 ± 0.041	4.482LysGly: 4.482 ± 0.056	1.202LysHis: 1.202 ± 0.025	5.76LysIle: 5.76 ± 0.055	6.402LysLys: 6.402 ± 0.087	5.168LysLeu: 5.168 ± 0.057	1.999LysMet: 1.999 ± 0.035	4.259LysAsn: 4.259 ± 0.052	2.472LysPro: 2.472 ± 0.039	2.319LysGln: 2.319 ± 0.042	3.25LysArg: 3.25 ± 0.039	4.559LysSer: 4.559 ± 0.049	3.819LysThr: 3.819 ± 0.05	3.539LysVal: 3.539 ± 0.052	0.679LysTrp: 0.679 ± 0.021	2.186LysTyr: 2.186 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	6.274LeuAla: 6.274 ± 0.058	1.236LeuCys: 1.236 ± 0.029	5.15LeuAsp: 5.15 ± 0.049	6.307LeuGlu: 6.307 ± 0.069	4.815LeuPhe: 4.815 ± 0.059	5.418LeuGly: 5.418 ± 0.062	1.801LeuHis: 1.801 ± 0.032	6.278LeuIle: 6.278 ± 0.077	7.33LeuLys: 7.33 ± 0.066	8.669LeuLeu: 8.669 ± 0.096	2.665LeuMet: 2.665 ± 0.043	4.53LeuAsn: 4.53 ± 0.051	4.195LeuPro: 4.195 ± 0.055	2.891LeuGln: 2.891 ± 0.038	3.601LeuArg: 3.601 ± 0.046	7.303LeuSer: 7.303 ± 0.071	4.944LeuThr: 4.944 ± 0.065	5.169LeuVal: 5.169 ± 0.05	0.886LeuTrp: 0.886 ± 0.023	2.822LeuTyr: 2.822 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.431MetAla: 2.431 ± 0.037	0.264MetCys: 0.264 ± 0.012	1.916MetAsp: 1.916 ± 0.037	2.349MetGlu: 2.349 ± 0.044	0.94MetPhe: 0.94 ± 0.022	2.156MetGly: 2.156 ± 0.037	0.482MetHis: 0.482 ± 0.014	2.162MetIle: 2.162 ± 0.033	2.266MetLys: 2.266 ± 0.034	2.541MetLeu: 2.541 ± 0.039	0.807MetMet: 0.807 ± 0.023	1.398MetAsn: 1.398 ± 0.03	1.35MetPro: 1.35 ± 0.032	0.91MetGln: 0.91 ± 0.025	1.065MetArg: 1.065 ± 0.026	1.682MetSer: 1.682 ± 0.03	1.754MetThr: 1.754 ± 0.033	1.914MetVal: 1.914 ± 0.034	0.207MetTrp: 0.207 ± 0.011	0.504MetTyr: 0.504 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.2AsnAla: 3.2 ± 0.043	0.645AsnCys: 0.645 ± 0.022	2.605AsnAsp: 2.605 ± 0.044	2.859AsnGlu: 2.859 ± 0.047	2.0AsnPhe: 2.0 ± 0.036	3.31AsnGly: 3.31 ± 0.059	1.095AsnHis: 1.095 ± 0.03	4.466AsnIle: 4.466 ± 0.051	2.619AsnLys: 2.619 ± 0.04	4.518AsnLeu: 4.518 ± 0.053	1.353AsnMet: 1.353 ± 0.031	2.467AsnAsn: 2.467 ± 0.045	2.466AsnPro: 2.466 ± 0.039	1.61AsnGln: 1.61 ± 0.026	2.664AsnArg: 2.664 ± 0.043	3.494AsnSer: 3.494 ± 0.055	2.426AsnThr: 2.426 ± 0.044	2.491AsnVal: 2.491 ± 0.042	0.449AsnTrp: 0.449 ± 0.018	1.476AsnTyr: 1.476 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	2.618ProAla: 2.618 ± 0.043	0.507ProCys: 0.507 ± 0.017	3.261ProAsp: 3.261 ± 0.054	3.893ProGlu: 3.893 ± 0.075	2.125ProPhe: 2.125 ± 0.036	2.783ProGly: 2.783 ± 0.043	0.812ProHis: 0.812 ± 0.023	2.099ProIle: 2.099 ± 0.035	1.724ProLys: 1.724 ± 0.035	3.717ProLeu: 3.717 ± 0.05	1.041ProMet: 1.041 ± 0.023	1.287ProAsn: 1.287 ± 0.025	1.496ProPro: 1.496 ± 0.036	1.094ProGln: 1.094 ± 0.026	1.344ProArg: 1.344 ± 0.029	2.666ProSer: 2.666 ± 0.044	1.481ProThr: 1.481 ± 0.035	3.495ProVal: 3.495 ± 0.045	0.464ProTrp: 0.464 ± 0.018	1.294ProTyr: 1.294 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	2.172GlnAla: 2.172 ± 0.04	0.345GlnCys: 0.345 ± 0.012	1.632GlnAsp: 1.632 ± 0.032	2.218GlnGlu: 2.218 ± 0.037	1.274GlnPhe: 1.274 ± 0.025	2.11GlnGly: 2.11 ± 0.033	0.592GlnHis: 0.592 ± 0.019	2.545GlnIle: 2.545 ± 0.036	2.772GlnLys: 2.772 ± 0.044	2.681GlnLeu: 2.681 ± 0.045	0.993GlnMet: 0.993 ± 0.025	1.739GlnAsn: 1.739 ± 0.034	1.02GlnPro: 1.02 ± 0.026	1.269GlnGln: 1.269 ± 0.034	1.404GlnArg: 1.404 ± 0.026	2.064GlnSer: 2.064 ± 0.033	1.656GlnThr: 1.656 ± 0.034	1.682GlnVal: 1.682 ± 0.031	0.401GlnTrp: 0.401 ± 0.014	1.068GlnTyr: 1.068 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.693ArgAla: 2.693 ± 0.036	0.593ArgCys: 0.593 ± 0.018	2.524ArgAsp: 2.524 ± 0.04	3.442ArgGlu: 3.442 ± 0.046	2.259ArgPhe: 2.259 ± 0.038	2.429ArgGly: 2.429 ± 0.038	1.047ArgHis: 1.047 ± 0.026	3.746ArgIle: 3.746 ± 0.049	3.318ArgLys: 3.318 ± 0.052	4.39ArgLeu: 4.39 ± 0.061	1.304ArgMet: 1.304 ± 0.026	2.043ArgAsn: 2.043 ± 0.039	1.453ArgPro: 1.453 ± 0.029	1.701ArgGln: 1.701 ± 0.03	2.08ArgArg: 2.08 ± 0.037	2.619ArgSer: 2.619 ± 0.037	2.049ArgThr: 2.049 ± 0.037	2.749ArgVal: 2.749 ± 0.041	0.458ArgTrp: 0.458 ± 0.018	1.659ArgTyr: 1.659 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	4.527SerAla: 4.527 ± 0.052	0.903SerCys: 0.903 ± 0.022	4.411SerAsp: 4.411 ± 0.067	4.504SerGlu: 4.504 ± 0.057	3.365SerPhe: 3.365 ± 0.044	5.886SerGly: 5.886 ± 0.083	1.583SerHis: 1.583 ± 0.031	5.37SerIle: 5.37 ± 0.062	3.671SerLys: 3.671 ± 0.05	6.718SerLeu: 6.718 ± 0.068	2.046SerMet: 2.046 ± 0.035	2.824SerAsn: 2.824 ± 0.042	2.761SerPro: 2.761 ± 0.042	2.276SerGln: 2.276 ± 0.042	3.438SerArg: 3.438 ± 0.043	5.684SerSer: 5.684 ± 0.075	3.382SerThr: 3.382 ± 0.055	4.482SerVal: 4.482 ± 0.05	0.744SerTrp: 0.744 ± 0.024	2.051SerTyr: 2.051 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	3.826ThrAla: 3.826 ± 0.055	0.631ThrCys: 0.631 ± 0.019	3.02ThrAsp: 3.02 ± 0.046	3.137ThrGlu: 3.137 ± 0.044	2.349ThrPhe: 2.349 ± 0.037	4.703ThrGly: 4.703 ± 0.067	1.055ThrHis: 1.055 ± 0.023	4.44ThrIle: 4.44 ± 0.062	2.568ThrLys: 2.568 ± 0.042	5.503ThrLeu: 5.503 ± 0.058	1.346ThrMet: 1.346 ± 0.027	1.97ThrAsn: 1.97 ± 0.036	2.672ThrPro: 2.672 ± 0.044	1.433ThrGln: 1.433 ± 0.03	2.211ThrArg: 2.211 ± 0.037	3.542ThrSer: 3.542 ± 0.053	2.926ThrThr: 2.926 ± 0.054	3.52ThrVal: 3.52 ± 0.059	0.567ThrTrp: 0.567 ± 0.022	1.463ThrTyr: 1.463 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	4.483ValAla: 4.483 ± 0.057	0.776ValCys: 0.776 ± 0.019	3.753ValAsp: 3.753 ± 0.054	4.211ValGlu: 4.211 ± 0.051	2.784ValPhe: 2.784 ± 0.042	3.338ValGly: 3.338 ± 0.046	1.106ValHis: 1.106 ± 0.023	4.828ValIle: 4.828 ± 0.047	4.049ValLys: 4.049 ± 0.046	5.362ValLeu: 5.362 ± 0.053	1.904ValMet: 1.904 ± 0.032	2.989ValAsn: 2.989 ± 0.043	2.329ValPro: 2.329 ± 0.04	1.707ValGln: 1.707 ± 0.031	2.538ValArg: 2.538 ± 0.044	4.368ValSer: 4.368 ± 0.052	3.55ValThr: 3.55 ± 0.062	4.353ValVal: 4.353 ± 0.059	0.563ValTrp: 0.563 ± 0.017	1.674ValTyr: 1.674 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	0.599TrpAla: 0.599 ± 0.017	0.151TrpCys: 0.151 ± 0.01	0.576TrpAsp: 0.576 ± 0.018	0.683TrpGlu: 0.683 ± 0.022	0.475TrpPhe: 0.475 ± 0.016	0.666TrpGly: 0.666 ± 0.021	0.259TrpHis: 0.259 ± 0.012	0.79TrpIle: 0.79 ± 0.026	0.755TrpLys: 0.755 ± 0.02	1.025TrpLeu: 1.025 ± 0.027	0.301TrpMet: 0.301 ± 0.011	0.522TrpAsn: 0.522 ± 0.016	0.356TrpPro: 0.356 ± 0.016	0.467TrpGln: 0.467 ± 0.016	0.463TrpArg: 0.463 ± 0.017	0.596TrpSer: 0.596 ± 0.019	0.388TrpThr: 0.388 ± 0.016	0.624TrpVal: 0.624 ± 0.024	0.126TrpTrp: 0.126 ± 0.007	0.349TrpTyr: 0.349 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.997TyrAla: 1.997 ± 0.037	0.451TyrCys: 0.451 ± 0.015	1.863TyrAsp: 1.863 ± 0.034	1.909TyrGlu: 1.909 ± 0.037	1.637TyrPhe: 1.637 ± 0.035	2.131TyrGly: 2.131 ± 0.036	0.79TyrHis: 0.79 ± 0.021	2.329TyrIle: 2.329 ± 0.035	1.842TyrLys: 1.842 ± 0.037	3.069TyrLeu: 3.069 ± 0.043	0.786TyrMet: 0.786 ± 0.022	1.536TyrAsn: 1.536 ± 0.032	1.453TyrPro: 1.453 ± 0.029	1.158TyrGln: 1.158 ± 0.027	1.644TyrArg: 1.644 ± 0.029	2.25TyrSer: 2.25 ± 0.04	1.607TyrThr: 1.607 ± 0.03	1.664TyrVal: 1.664 ± 0.031	0.4TyrTrp: 0.4 ± 0.014	1.231TyrTyr: 1.231 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5913 proteins (1866641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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