Amino acid dipepetide frequency for Gulosibacter sp. 10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.471AlaAla: 19.471 ± 0.209	0.782AlaCys: 0.782 ± 0.033	7.674AlaAsp: 7.674 ± 0.106	10.67AlaGlu: 10.67 ± 0.153	3.899AlaPhe: 3.899 ± 0.058	12.199AlaGly: 12.199 ± 0.114	2.286AlaHis: 2.286 ± 0.055	5.896AlaIle: 5.896 ± 0.079	2.581AlaLys: 2.581 ± 0.066	14.055AlaLeu: 14.055 ± 0.17	2.785AlaMet: 2.785 ± 0.053	2.355AlaAsn: 2.355 ± 0.052	6.665AlaPro: 6.665 ± 0.103	3.698AlaGln: 3.698 ± 0.071	9.315AlaArg: 9.315 ± 0.114	6.888AlaSer: 6.888 ± 0.113	6.053AlaThr: 6.053 ± 0.078	10.745AlaVal: 10.745 ± 0.122	1.672AlaTrp: 1.672 ± 0.039	2.299AlaTyr: 2.299 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	0.758CysAla: 0.758 ± 0.026	0.065CysCys: 0.065 ± 0.008	0.317CysAsp: 0.317 ± 0.017	0.364CysGlu: 0.364 ± 0.019	0.212CysPhe: 0.212 ± 0.014	0.681CysGly: 0.681 ± 0.027	0.132CysHis: 0.132 ± 0.011	0.25CysIle: 0.25 ± 0.016	0.071CysLys: 0.071 ± 0.009	0.467CysLeu: 0.467 ± 0.021	0.096CysMet: 0.096 ± 0.009	0.098CysAsn: 0.098 ± 0.01	0.288CysPro: 0.288 ± 0.018	0.109CysGln: 0.109 ± 0.01	0.397CysArg: 0.397 ± 0.02	0.406CysSer: 0.406 ± 0.02	0.316CysThr: 0.316 ± 0.016	0.427CysVal: 0.427 ± 0.021	0.086CysTrp: 0.086 ± 0.01	0.123CysTyr: 0.123 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.597AspAla: 8.597 ± 0.106	0.257AspCys: 0.257 ± 0.018	3.206AspAsp: 3.206 ± 0.069	5.044AspGlu: 5.044 ± 0.085	1.724AspPhe: 1.724 ± 0.039	5.84AspGly: 5.84 ± 0.102	1.078AspHis: 1.078 ± 0.035	2.213AspIle: 2.213 ± 0.051	0.771AspLys: 0.771 ± 0.03	5.632AspLeu: 5.632 ± 0.082	0.842AspMet: 0.842 ± 0.03	0.764AspAsn: 0.764 ± 0.03	3.975AspPro: 3.975 ± 0.075	1.351AspGln: 1.351 ± 0.04	5.064AspArg: 5.064 ± 0.081	2.672AspSer: 2.672 ± 0.056	2.532AspThr: 2.532 ± 0.057	4.409AspVal: 4.409 ± 0.074	0.887AspTrp: 0.887 ± 0.032	1.325AspTyr: 1.325 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	9.115GluAla: 9.115 ± 0.124	0.322GluCys: 0.322 ± 0.02	3.967GluAsp: 3.967 ± 0.063	5.074GluGlu: 5.074 ± 0.085	2.378GluPhe: 2.378 ± 0.047	5.43GluGly: 5.43 ± 0.08	2.094GluHis: 2.094 ± 0.049	3.254GluIle: 3.254 ± 0.067	1.148GluLys: 1.148 ± 0.035	7.667GluLeu: 7.667 ± 0.097	1.15GluMet: 1.15 ± 0.036	1.285GluAsn: 1.285 ± 0.04	4.039GluPro: 4.039 ± 0.074	3.021GluGln: 3.021 ± 0.061	6.875GluArg: 6.875 ± 0.114	3.547GluSer: 3.547 ± 0.063	3.514GluThr: 3.514 ± 0.062	4.947GluVal: 4.947 ± 0.078	1.017GluTrp: 1.017 ± 0.03	1.491GluTyr: 1.491 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.573PheAla: 4.573 ± 0.072	0.177PheCys: 0.177 ± 0.013	2.404PheAsp: 2.404 ± 0.048	2.205PheGlu: 2.205 ± 0.049	1.094PhePhe: 1.094 ± 0.039	3.639PheGly: 3.639 ± 0.065	0.522PheHis: 0.522 ± 0.023	1.332PheIle: 1.332 ± 0.041	0.484PheLys: 0.484 ± 0.021	2.871PheLeu: 2.871 ± 0.057	0.54PheMet: 0.54 ± 0.025	0.644PheAsn: 0.644 ± 0.024	1.422PhePro: 1.422 ± 0.04	0.747PheGln: 0.747 ± 0.025	1.831PheArg: 1.831 ± 0.042	1.774PheSer: 1.774 ± 0.045	1.886PheThr: 1.886 ± 0.041	2.724PheVal: 2.724 ± 0.054	0.446PheTrp: 0.446 ± 0.022	0.609PheTyr: 0.609 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.787GlyAla: 11.787 ± 0.131	0.63GlyCys: 0.63 ± 0.025	4.811GlyAsp: 4.811 ± 0.09	6.344GlyGlu: 6.344 ± 0.09	3.368GlyPhe: 3.368 ± 0.064	8.344GlyGly: 8.344 ± 0.116	1.717GlyHis: 1.717 ± 0.046	4.953GlyIle: 4.953 ± 0.084	1.98GlyLys: 1.98 ± 0.052	9.184GlyLeu: 9.184 ± 0.105	2.215GlyMet: 2.215 ± 0.046	1.678GlyAsn: 1.678 ± 0.045	3.983GlyPro: 3.983 ± 0.067	2.568GlyGln: 2.568 ± 0.089	7.262GlyArg: 7.262 ± 0.094	5.334GlySer: 5.334 ± 0.077	5.121GlyThr: 5.121 ± 0.078	7.385GlyVal: 7.385 ± 0.104	1.581GlyTrp: 1.581 ± 0.041	2.347GlyTyr: 2.347 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.263HisAla: 2.263 ± 0.05	0.146HisCys: 0.146 ± 0.012	1.301HisAsp: 1.301 ± 0.037	1.451HisGlu: 1.451 ± 0.037	0.588HisPhe: 0.588 ± 0.024	2.043HisGly: 2.043 ± 0.045	0.517HisHis: 0.517 ± 0.026	0.698HisIle: 0.698 ± 0.026	0.233HisLys: 0.233 ± 0.016	2.036HisLeu: 2.036 ± 0.048	0.31HisMet: 0.31 ± 0.017	0.351HisAsn: 0.351 ± 0.019	1.519HisPro: 1.519 ± 0.042	0.484HisGln: 0.484 ± 0.022	1.784HisArg: 1.784 ± 0.046	1.027HisSer: 1.027 ± 0.032	0.869HisThr: 0.869 ± 0.036	1.585HisVal: 1.585 ± 0.039	0.299HisTrp: 0.299 ± 0.017	0.419HisTyr: 0.419 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.225IleAla: 7.225 ± 0.093	0.26IleCys: 0.26 ± 0.018	3.265IleAsp: 3.265 ± 0.062	3.306IleGlu: 3.306 ± 0.065	1.109IlePhe: 1.109 ± 0.035	5.28IleGly: 5.28 ± 0.092	0.692IleHis: 0.692 ± 0.028	1.895IleIle: 1.895 ± 0.056	0.681IleLys: 0.681 ± 0.027	3.79IleLeu: 3.79 ± 0.073	0.732IleMet: 0.732 ± 0.027	0.947IleAsn: 0.947 ± 0.036	2.426IlePro: 2.426 ± 0.049	0.865IleGln: 0.865 ± 0.031	3.377IleArg: 3.377 ± 0.059	2.249IleSer: 2.249 ± 0.054	2.559IleThr: 2.559 ± 0.058	4.161IleVal: 4.161 ± 0.075	0.491IleTrp: 0.491 ± 0.021	0.725IleTyr: 0.725 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	2.108LysAla: 2.108 ± 0.055	0.08LysCys: 0.08 ± 0.009	0.908LysAsp: 0.908 ± 0.033	0.937LysGlu: 0.937 ± 0.038	0.475LysPhe: 0.475 ± 0.025	1.379LysGly: 1.379 ± 0.041	0.481LysHis: 0.481 ± 0.022	0.862LysIle: 0.862 ± 0.031	0.645LysLys: 0.645 ± 0.037	1.655LysLeu: 1.655 ± 0.044	0.315LysMet: 0.315 ± 0.019	0.486LysAsn: 0.486 ± 0.021	1.173LysPro: 1.173 ± 0.041	0.714LysGln: 0.714 ± 0.031	1.679LysArg: 1.679 ± 0.047	1.091LysSer: 1.091 ± 0.04	1.187LysThr: 1.187 ± 0.038	1.384LysVal: 1.384 ± 0.043	0.2LysTrp: 0.2 ± 0.013	0.432LysTyr: 0.432 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.385LeuAla: 14.385 ± 0.151	0.58LeuCys: 0.58 ± 0.024	6.699LeuAsp: 6.699 ± 0.103	6.932LeuGlu: 6.932 ± 0.09	3.009LeuPhe: 3.009 ± 0.055	9.778LeuGly: 9.778 ± 0.119	1.927LeuHis: 1.927 ± 0.052	4.396LeuIle: 4.396 ± 0.073	1.551LeuLys: 1.551 ± 0.048	11.085LeuLeu: 11.085 ± 0.164	1.711LeuMet: 1.711 ± 0.046	1.728LeuAsn: 1.728 ± 0.038	5.491LeuPro: 5.491 ± 0.082	2.569LeuGln: 2.569 ± 0.054	8.158LeuArg: 8.158 ± 0.108	5.309LeuSer: 5.309 ± 0.073	5.069LeuThr: 5.069 ± 0.067	9.102LeuVal: 9.102 ± 0.111	1.213LeuTrp: 1.213 ± 0.04	1.585LeuTyr: 1.585 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.12MetAla: 2.12 ± 0.043	0.123MetCys: 0.123 ± 0.01	0.826MetAsp: 0.826 ± 0.026	0.724MetGlu: 0.724 ± 0.023	0.575MetPhe: 0.575 ± 0.024	1.316MetGly: 1.316 ± 0.037	0.428MetHis: 0.428 ± 0.022	1.016MetIle: 1.016 ± 0.036	0.37MetLys: 0.37 ± 0.018	2.24MetLeu: 2.24 ± 0.05	0.37MetMet: 0.37 ± 0.019	0.527MetAsn: 0.527 ± 0.025	1.224MetPro: 1.224 ± 0.035	0.6MetGln: 0.6 ± 0.023	1.778MetArg: 1.778 ± 0.039	1.407MetSer: 1.407 ± 0.04	1.674MetThr: 1.674 ± 0.041	1.276MetVal: 1.276 ± 0.035	0.214MetTrp: 0.214 ± 0.014	0.294MetTyr: 0.294 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.383AsnAla: 2.383 ± 0.045	0.121AsnCys: 0.121 ± 0.009	1.038AsnAsp: 1.038 ± 0.032	1.182AsnGlu: 1.182 ± 0.034	0.597AsnPhe: 0.597 ± 0.024	1.842AsnGly: 1.842 ± 0.043	0.368AsnHis: 0.368 ± 0.019	0.884AsnIle: 0.884 ± 0.033	0.32AsnLys: 0.32 ± 0.018	1.824AsnLeu: 1.824 ± 0.041	0.338AsnMet: 0.338 ± 0.02	0.418AsnAsn: 0.418 ± 0.019	1.495AsnPro: 1.495 ± 0.034	0.52AsnGln: 0.52 ± 0.024	1.494AsnArg: 1.494 ± 0.041	0.99AsnSer: 0.99 ± 0.03	1.107AsnThr: 1.107 ± 0.033	1.48AsnVal: 1.48 ± 0.042	0.321AsnTrp: 0.321 ± 0.017	0.425AsnTyr: 0.425 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.992ProAla: 6.992 ± 0.093	0.217ProCys: 0.217 ± 0.019	3.532ProAsp: 3.532 ± 0.053	5.403ProGlu: 5.403 ± 0.081	1.705ProPhe: 1.705 ± 0.038	5.506ProGly: 5.506 ± 0.092	1.076ProHis: 1.076 ± 0.035	2.154ProIle: 2.154 ± 0.04	1.119ProLys: 1.119 ± 0.037	4.865ProLeu: 4.865 ± 0.073	0.944ProMet: 0.944 ± 0.031	1.143ProAsn: 1.143 ± 0.034	2.206ProPro: 2.206 ± 0.058	1.604ProGln: 1.604 ± 0.059	3.647ProArg: 3.647 ± 0.065	2.887ProSer: 2.887 ± 0.054	2.729ProThr: 2.729 ± 0.065	4.557ProVal: 4.557 ± 0.059	0.756ProTrp: 0.756 ± 0.031	1.056ProTyr: 1.056 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.438GlnAla: 3.438 ± 0.074	0.141GlnCys: 0.141 ± 0.011	1.405GlnAsp: 1.405 ± 0.035	1.711GlnGlu: 1.711 ± 0.046	0.874GlnPhe: 0.874 ± 0.026	2.208GlnGly: 2.208 ± 0.06	0.733GlnHis: 0.733 ± 0.028	1.265GlnIle: 1.265 ± 0.033	0.534GlnLys: 0.534 ± 0.023	3.067GlnLeu: 3.067 ± 0.062	0.504GlnMet: 0.504 ± 0.022	0.599GlnAsn: 0.599 ± 0.025	1.674GlnPro: 1.674 ± 0.066	1.437GlnGln: 1.437 ± 0.065	2.565GlnArg: 2.565 ± 0.053	1.488GlnSer: 1.488 ± 0.038	1.362GlnThr: 1.362 ± 0.036	2.234GlnVal: 2.234 ± 0.052	0.376GlnTrp: 0.376 ± 0.018	0.613GlnTyr: 0.613 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	9.411ArgAla: 9.411 ± 0.131	0.448ArgCys: 0.448 ± 0.021	4.254ArgAsp: 4.254 ± 0.085	5.861ArgGlu: 5.861 ± 0.09	2.664ArgPhe: 2.664 ± 0.058	6.23ArgGly: 6.23 ± 0.081	1.709ArgHis: 1.709 ± 0.049	4.461ArgIle: 4.461 ± 0.063	1.597ArgLys: 1.597 ± 0.039	8.164ArgLeu: 8.164 ± 0.107	1.932ArgMet: 1.932 ± 0.041	1.465ArgAsn: 1.465 ± 0.038	4.136ArgPro: 4.136 ± 0.072	2.068ArgGln: 2.068 ± 0.044	7.862ArgArg: 7.862 ± 0.123	4.292ArgSer: 4.292 ± 0.075	4.24ArgThr: 4.24 ± 0.065	5.941ArgVal: 5.941 ± 0.087	1.166ArgTrp: 1.166 ± 0.037	1.58ArgTyr: 1.58 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.874SerAla: 6.874 ± 0.096	0.284SerCys: 0.284 ± 0.016	2.653SerAsp: 2.653 ± 0.053	3.161SerGlu: 3.161 ± 0.066	1.823SerPhe: 1.823 ± 0.042	5.913SerGly: 5.913 ± 0.087	0.926SerHis: 0.926 ± 0.028	2.711SerIle: 2.711 ± 0.059	1.145SerLys: 1.145 ± 0.037	5.33SerLeu: 5.33 ± 0.066	1.237SerMet: 1.237 ± 0.035	1.084SerAsn: 1.084 ± 0.035	3.079SerPro: 3.079 ± 0.052	1.422SerGln: 1.422 ± 0.031	3.926SerArg: 3.926 ± 0.059	3.202SerSer: 3.202 ± 0.065	3.24SerThr: 3.24 ± 0.059	4.058SerVal: 4.058 ± 0.072	0.85SerTrp: 0.85 ± 0.031	1.092SerTyr: 1.092 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.917ThrAla: 6.917 ± 0.089	0.294ThrCys: 0.294 ± 0.017	2.853ThrAsp: 2.853 ± 0.063	3.062ThrGlu: 3.062 ± 0.065	1.639ThrPhe: 1.639 ± 0.039	5.51ThrGly: 5.51 ± 0.08	0.998ThrHis: 0.998 ± 0.032	2.62ThrIle: 2.62 ± 0.056	1.027ThrLys: 1.027 ± 0.036	5.12ThrLeu: 5.12 ± 0.07	1.003ThrMet: 1.003 ± 0.029	1.117ThrAsn: 1.117 ± 0.033	3.295ThrPro: 3.295 ± 0.069	1.225ThrGln: 1.225 ± 0.039	3.405ThrArg: 3.405 ± 0.059	2.9ThrSer: 2.9 ± 0.053	3.246ThrThr: 3.246 ± 0.077	4.735ThrVal: 4.735 ± 0.083	0.731ThrTrp: 0.731 ± 0.029	1.13ThrTyr: 1.13 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.7ValAla: 9.7 ± 0.1	0.498ValCys: 0.498 ± 0.025	5.145ValAsp: 5.145 ± 0.076	5.769ValGlu: 5.769 ± 0.097	2.886ValPhe: 2.886 ± 0.062	6.365ValGly: 6.365 ± 0.093	1.624ValHis: 1.624 ± 0.044	3.873ValIle: 3.873 ± 0.064	1.399ValLys: 1.399 ± 0.038	9.43ValLeu: 9.43 ± 0.129	1.466ValMet: 1.466 ± 0.041	1.644ValAsn: 1.644 ± 0.037	4.25ValPro: 4.25 ± 0.067	2.112ValGln: 2.112 ± 0.044	6.01ValArg: 6.01 ± 0.094	4.575ValSer: 4.575 ± 0.069	4.348ValThr: 4.348 ± 0.065	7.627ValVal: 7.627 ± 0.092	1.015ValTrp: 1.015 ± 0.034	1.508ValTyr: 1.508 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.476TrpAla: 1.476 ± 0.039	0.095TrpCys: 0.095 ± 0.01	0.672TrpAsp: 0.672 ± 0.028	0.687TrpGlu: 0.687 ± 0.027	0.556TrpPhe: 0.556 ± 0.027	1.005TrpGly: 1.005 ± 0.035	0.299TrpHis: 0.299 ± 0.017	0.705TrpIle: 0.705 ± 0.029	0.262TrpLys: 0.262 ± 0.018	1.728TrpLeu: 1.728 ± 0.049	0.334TrpMet: 0.334 ± 0.018	0.385TrpAsn: 0.385 ± 0.02	0.697TrpPro: 0.697 ± 0.031	0.553TrpGln: 0.553 ± 0.022	1.287TrpArg: 1.287 ± 0.036	0.857TrpSer: 0.857 ± 0.028	0.731TrpThr: 0.731 ± 0.025	0.979TrpVal: 0.979 ± 0.032	0.346TrpTrp: 0.346 ± 0.018	0.29TrpTyr: 0.29 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.395TyrAla: 2.395 ± 0.051	0.142TyrCys: 0.142 ± 0.01	1.253TyrAsp: 1.253 ± 0.039	1.45TyrGlu: 1.45 ± 0.032	0.748TyrPhe: 0.748 ± 0.03	2.08TyrGly: 2.08 ± 0.06	0.32TyrHis: 0.32 ± 0.018	0.6TyrIle: 0.6 ± 0.025	0.272TyrLys: 0.272 ± 0.017	2.069TyrLeu: 2.069 ± 0.047	0.277TyrMet: 0.277 ± 0.016	0.429TyrAsn: 0.429 ± 0.021	1.06TyrPro: 1.06 ± 0.033	0.557TyrGln: 0.557 ± 0.022	1.762TyrArg: 1.762 ± 0.048	1.114TyrSer: 1.114 ± 0.035	1.046TyrThr: 1.046 ± 0.036	1.491TyrVal: 1.491 ± 0.04	0.278TyrTrp: 0.278 ± 0.015	0.459TyrTyr: 0.459 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3335 proteins (1064179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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