Amino acid dipepetide frequency for Firmicutes bacterium CAG:176

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.345AlaAla: 15.345 ± 0.298
1.746AlaCys: 1.746 ± 0.065
6.535AlaAsp: 6.535 ± 0.147
7.224AlaGlu: 7.224 ± 0.142
3.548AlaPhe: 3.548 ± 0.094
8.479AlaGly: 8.479 ± 0.174
1.779AlaHis: 1.779 ± 0.066
5.263AlaIle: 5.263 ± 0.122
4.246AlaLys: 4.246 ± 0.095
12.26AlaLeu: 12.26 ± 0.22
3.067AlaMet: 3.067 ± 0.077
2.404AlaAsn: 2.404 ± 0.082
3.623AlaPro: 3.623 ± 0.099
3.708AlaGln: 3.708 ± 0.104
5.14AlaArg: 5.14 ± 0.121
4.013AlaSer: 4.013 ± 0.1
3.761AlaThr: 3.761 ± 0.106
9.562AlaVal: 9.562 ± 0.159
0.863AlaTrp: 0.863 ± 0.048
3.165AlaTyr: 3.165 ± 0.083
0.002AlaXaa: 0.002 ± 0.002
Cys
2.091CysAla: 2.091 ± 0.074
0.351CysCys: 0.351 ± 0.03
1.099CysAsp: 1.099 ± 0.051
0.821CysGlu: 0.821 ± 0.041
0.645CysPhe: 0.645 ± 0.037
2.198CysGly: 2.198 ± 0.089
0.38CysHis: 0.38 ± 0.028
0.974CysIle: 0.974 ± 0.048
0.654CysLys: 0.654 ± 0.041
1.455CysLeu: 1.455 ± 0.061
0.418CysMet: 0.418 ± 0.033
0.425CysAsn: 0.425 ± 0.03
0.89CysPro: 0.89 ± 0.054
0.538CysGln: 0.538 ± 0.034
1.263CysArg: 1.263 ± 0.063
0.845CysSer: 0.845 ± 0.041
0.974CysThr: 0.974 ± 0.046
1.348CysVal: 1.348 ± 0.057
0.171CysTrp: 0.171 ± 0.021
0.498CysTyr: 0.498 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
6.081AspAla: 6.081 ± 0.107
0.912AspCys: 0.912 ± 0.046
2.945AspAsp: 2.945 ± 0.079
4.001AspGlu: 4.001 ± 0.11
2.266AspPhe: 2.266 ± 0.077
5.182AspGly: 5.182 ± 0.132
1.085AspHis: 1.085 ± 0.051
3.681AspIle: 3.681 ± 0.091
2.9AspLys: 2.9 ± 0.088
5.047AspLeu: 5.047 ± 0.113
1.964AspMet: 1.964 ± 0.072
1.646AspAsn: 1.646 ± 0.072
2.511AspPro: 2.511 ± 0.08
1.315AspGln: 1.315 ± 0.054
3.065AspArg: 3.065 ± 0.097
2.707AspSer: 2.707 ± 0.081
3.459AspThr: 3.459 ± 0.102
4.44AspVal: 4.44 ± 0.109
0.654AspTrp: 0.654 ± 0.039
2.295AspTyr: 2.295 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
5.977GluAla: 5.977 ± 0.131
0.716GluCys: 0.716 ± 0.043
3.572GluAsp: 3.572 ± 0.09
4.308GluGlu: 4.308 ± 0.12
1.844GluPhe: 1.844 ± 0.066
4.415GluGly: 4.415 ± 0.11
1.188GluHis: 1.188 ± 0.054
3.403GluIle: 3.403 ± 0.106
4.435GluLys: 4.435 ± 0.126
6.564GluLeu: 6.564 ± 0.15
2.06GluMet: 2.06 ± 0.067
2.791GluAsn: 2.791 ± 0.076
2.046GluPro: 2.046 ± 0.082
2.845GluGln: 2.845 ± 0.097
3.552GluArg: 3.552 ± 0.107
2.636GluSer: 2.636 ± 0.069
3.706GluThr: 3.706 ± 0.096
4.039GluVal: 4.039 ± 0.11
0.432GluTrp: 0.432 ± 0.033
1.933GluTyr: 1.933 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.694PheAla: 3.694 ± 0.082
0.825PheCys: 0.825 ± 0.045
2.62PheAsp: 2.62 ± 0.086
1.664PheGlu: 1.664 ± 0.061
1.515PhePhe: 1.515 ± 0.07
3.034PheGly: 3.034 ± 0.1
0.738PheHis: 0.738 ± 0.04
1.962PheIle: 1.962 ± 0.076
1.148PheLys: 1.148 ± 0.058
3.396PheLeu: 3.396 ± 0.113
0.894PheMet: 0.894 ± 0.049
1.023PheAsn: 1.023 ± 0.05
1.526PhePro: 1.526 ± 0.055
0.928PheGln: 0.928 ± 0.043
1.915PheArg: 1.915 ± 0.076
2.12PheSer: 2.12 ± 0.073
2.355PheThr: 2.355 ± 0.077
2.427PheVal: 2.427 ± 0.072
0.376PheTrp: 0.376 ± 0.028
1.154PheTyr: 1.154 ± 0.059
0.0PheXaa: 0.0 ± 0.0
Gly
7.816GlyAla: 7.816 ± 0.168
1.75GlyCys: 1.75 ± 0.068
4.631GlyAsp: 4.631 ± 0.102
4.996GlyGlu: 4.996 ± 0.106
3.101GlyPhe: 3.101 ± 0.095
7.284GlyGly: 7.284 ± 0.195
1.559GlyHis: 1.559 ± 0.067
4.898GlyIle: 4.898 ± 0.112
4.671GlyLys: 4.671 ± 0.105
7.389GlyLeu: 7.389 ± 0.131
2.789GlyMet: 2.789 ± 0.084
2.249GlyAsn: 2.249 ± 0.082
1.684GlyPro: 1.684 ± 0.063
2.702GlyGln: 2.702 ± 0.095
4.453GlyArg: 4.453 ± 0.112
4.384GlySer: 4.384 ± 0.114
4.936GlyThr: 4.936 ± 0.128
6.65GlyVal: 6.65 ± 0.142
0.945GlyTrp: 0.945 ± 0.049
3.016GlyTyr: 3.016 ± 0.091
0.0GlyXaa: 0.0 ± 0.0
His
1.544HisAla: 1.544 ± 0.063
0.436HisCys: 0.436 ± 0.034
1.121HisAsp: 1.121 ± 0.055
0.95HisGlu: 0.95 ± 0.048
0.661HisPhe: 0.661 ± 0.041
1.646HisGly: 1.646 ± 0.071
0.512HisHis: 0.512 ± 0.055
1.368HisIle: 1.368 ± 0.056
0.745HisLys: 0.745 ± 0.042
1.784HisLeu: 1.784 ± 0.064
0.54HisMet: 0.54 ± 0.034
0.585HisAsn: 0.585 ± 0.033
1.088HisPro: 1.088 ± 0.059
0.572HisGln: 0.572 ± 0.034
1.172HisArg: 1.172 ± 0.055
0.901HisSer: 0.901 ± 0.044
1.203HisThr: 1.203 ± 0.053
1.217HisVal: 1.217 ± 0.048
0.169HisTrp: 0.169 ± 0.02
0.723HisTyr: 0.723 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.876IleAla: 5.876 ± 0.121
1.045IleCys: 1.045 ± 0.049
3.276IleAsp: 3.276 ± 0.09
2.851IleGlu: 2.851 ± 0.09
1.826IlePhe: 1.826 ± 0.071
4.351IleGly: 4.351 ± 0.11
1.057IleHis: 1.057 ± 0.048
3.067IleIle: 3.067 ± 0.109
2.035IleLys: 2.035 ± 0.078
5.245IleLeu: 5.245 ± 0.111
1.35IleMet: 1.35 ± 0.057
1.621IleAsn: 1.621 ± 0.059
2.691IlePro: 2.691 ± 0.087
1.479IleGln: 1.479 ± 0.052
3.272IleArg: 3.272 ± 0.098
3.138IleSer: 3.138 ± 0.095
3.488IleThr: 3.488 ± 0.087
3.928IleVal: 3.928 ± 0.104
0.489IleTrp: 0.489 ± 0.033
1.684IleTyr: 1.684 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.544LysAla: 4.544 ± 0.114
0.652LysCys: 0.652 ± 0.04
2.38LysAsp: 2.38 ± 0.086
2.883LysGlu: 2.883 ± 0.086
1.243LysPhe: 1.243 ± 0.054
3.187LysGly: 3.187 ± 0.09
0.776LysHis: 0.776 ± 0.041
2.131LysIle: 2.131 ± 0.068
3.307LysLys: 3.307 ± 0.106
4.54LysLeu: 4.54 ± 0.11
1.535LysMet: 1.535 ± 0.06
1.864LysAsn: 1.864 ± 0.069
1.873LysPro: 1.873 ± 0.062
1.546LysGln: 1.546 ± 0.057
2.694LysArg: 2.694 ± 0.081
2.124LysSer: 2.124 ± 0.07
2.903LysThr: 2.903 ± 0.088
3.121LysVal: 3.121 ± 0.087
0.425LysTrp: 0.425 ± 0.033
1.61LysTyr: 1.61 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.122LeuAla: 10.122 ± 0.179
2.275LeuCys: 2.275 ± 0.074
5.61LeuAsp: 5.61 ± 0.105
5.743LeuGlu: 5.743 ± 0.148
3.514LeuPhe: 3.514 ± 0.098
7.262LeuGly: 7.262 ± 0.157
2.189LeuHis: 2.189 ± 0.083
4.569LeuIle: 4.569 ± 0.122
3.892LeuLys: 3.892 ± 0.107
11.615LeuLeu: 11.615 ± 0.237
2.771LeuMet: 2.771 ± 0.081
2.742LeuAsn: 2.742 ± 0.095
5.269LeuPro: 5.269 ± 0.099
2.923LeuGln: 2.923 ± 0.091
6.957LeuArg: 6.957 ± 0.132
6.141LeuSer: 6.141 ± 0.139
6.955LeuThr: 6.955 ± 0.141
6.706LeuVal: 6.706 ± 0.137
0.948LeuTrp: 0.948 ± 0.052
3.321LeuTyr: 3.321 ± 0.078
0.002LeuXaa: 0.002 ± 0.002
Met
3.374MetAla: 3.374 ± 0.084
0.365MetCys: 0.365 ± 0.032
1.96MetAsp: 1.96 ± 0.061
1.951MetGlu: 1.951 ± 0.078
0.841MetPhe: 0.841 ± 0.042
2.295MetGly: 2.295 ± 0.069
0.454MetHis: 0.454 ± 0.033
1.43MetIle: 1.43 ± 0.058
1.675MetLys: 1.675 ± 0.06
2.578MetLeu: 2.578 ± 0.091
0.872MetMet: 0.872 ± 0.047
1.054MetAsn: 1.054 ± 0.053
1.27MetPro: 1.27 ± 0.05
1.019MetGln: 1.019 ± 0.05
1.517MetArg: 1.517 ± 0.055
1.666MetSer: 1.666 ± 0.067
2.109MetThr: 2.109 ± 0.078
1.953MetVal: 1.953 ± 0.071
0.189MetTrp: 0.189 ± 0.02
0.714MetTyr: 0.714 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.154AsnAla: 3.154 ± 0.095
0.558AsnCys: 0.558 ± 0.037
1.544AsnAsp: 1.544 ± 0.064
1.699AsnGlu: 1.699 ± 0.065
0.985AsnPhe: 0.985 ± 0.05
3.063AsnGly: 3.063 ± 0.09
0.503AsnHis: 0.503 ± 0.038
1.879AsnIle: 1.879 ± 0.078
1.295AsnLys: 1.295 ± 0.06
2.362AsnLeu: 2.362 ± 0.08
0.996AsnMet: 0.996 ± 0.044
0.91AsnAsn: 0.91 ± 0.047
1.259AsnPro: 1.259 ± 0.047
0.674AsnGln: 0.674 ± 0.038
1.646AsnArg: 1.646 ± 0.059
1.35AsnSer: 1.35 ± 0.06
1.864AsnThr: 1.864 ± 0.071
2.349AsnVal: 2.349 ± 0.083
0.416AsnTrp: 0.416 ± 0.031
1.048AsnTyr: 1.048 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
4.615ProAla: 4.615 ± 0.113
0.636ProCys: 0.636 ± 0.04
2.729ProAsp: 2.729 ± 0.089
4.03ProGlu: 4.03 ± 0.095
1.441ProPhe: 1.441 ± 0.061
3.123ProGly: 3.123 ± 0.082
0.714ProHis: 0.714 ± 0.035
1.891ProIle: 1.891 ± 0.073
1.541ProLys: 1.541 ± 0.061
3.748ProLeu: 3.748 ± 0.097
1.079ProMet: 1.079 ± 0.05
1.021ProAsn: 1.021 ± 0.049
1.319ProPro: 1.319 ± 0.062
1.41ProGln: 1.41 ± 0.068
1.895ProArg: 1.895 ± 0.064
1.753ProSer: 1.753 ± 0.065
2.08ProThr: 2.08 ± 0.061
3.777ProVal: 3.777 ± 0.088
0.414ProTrp: 0.414 ± 0.033
1.417ProTyr: 1.417 ± 0.061
0.002ProXaa: 0.002 ± 0.002
Gln
3.481GlnAla: 3.481 ± 0.091
0.416GlnCys: 0.416 ± 0.031
1.506GlnAsp: 1.506 ± 0.064
2.178GlnGlu: 2.178 ± 0.068
1.03GlnPhe: 1.03 ± 0.048
2.331GlnGly: 2.331 ± 0.071
0.634GlnHis: 0.634 ± 0.039
1.673GlnIle: 1.673 ± 0.061
1.601GlnLys: 1.601 ± 0.061
3.543GlnLeu: 3.543 ± 0.102
1.079GlnMet: 1.079 ± 0.055
1.065GlnAsn: 1.065 ± 0.051
1.35GlnPro: 1.35 ± 0.048
1.63GlnGln: 1.63 ± 0.073
2.358GlnArg: 2.358 ± 0.09
1.519GlnSer: 1.519 ± 0.057
1.699GlnThr: 1.699 ± 0.057
2.487GlnVal: 2.487 ± 0.081
0.343GlnTrp: 0.343 ± 0.03
1.148GlnTyr: 1.148 ± 0.059
0.002GlnXaa: 0.002 ± 0.002
Arg
5.24ArgAla: 5.24 ± 0.115
1.163ArgCys: 1.163 ± 0.06
3.058ArgAsp: 3.058 ± 0.099
4.204ArgGlu: 4.204 ± 0.12
2.191ArgPhe: 2.191 ± 0.083
3.995ArgGly: 3.995 ± 0.097
1.19ArgHis: 1.19 ± 0.047
3.187ArgIle: 3.187 ± 0.082
2.509ArgLys: 2.509 ± 0.078
5.821ArgLeu: 5.821 ± 0.139
1.722ArgMet: 1.722 ± 0.072
1.468ArgAsn: 1.468 ± 0.062
2.155ArgPro: 2.155 ± 0.068
2.836ArgGln: 2.836 ± 0.104
4.873ArgArg: 4.873 ± 0.151
2.887ArgSer: 2.887 ± 0.084
2.965ArgThr: 2.965 ± 0.084
3.806ArgVal: 3.806 ± 0.099
0.629ArgTrp: 0.629 ± 0.04
2.062ArgTyr: 2.062 ± 0.068
0.002ArgXaa: 0.002 ± 0.002
Ser
5.343SerAla: 5.343 ± 0.133
0.863SerCys: 0.863 ± 0.045
2.827SerAsp: 2.827 ± 0.071
2.533SerGlu: 2.533 ± 0.088
2.031SerPhe: 2.031 ± 0.065
5.211SerGly: 5.211 ± 0.115
0.939SerHis: 0.939 ± 0.052
2.593SerIle: 2.593 ± 0.076
1.891SerLys: 1.891 ± 0.069
4.709SerLeu: 4.709 ± 0.106
1.355SerMet: 1.355 ± 0.062
1.346SerAsn: 1.346 ± 0.056
1.926SerPro: 1.926 ± 0.064
1.441SerGln: 1.441 ± 0.055
3.054SerArg: 3.054 ± 0.079
2.46SerSer: 2.46 ± 0.09
2.58SerThr: 2.58 ± 0.07
4.284SerVal: 4.284 ± 0.105
0.569SerTrp: 0.569 ± 0.037
1.784SerTyr: 1.784 ± 0.074
0.0SerXaa: 0.0 ± 0.0
Thr
6.759ThrAla: 6.759 ± 0.143
0.856ThrCys: 0.856 ± 0.039
3.405ThrAsp: 3.405 ± 0.099
3.528ThrGlu: 3.528 ± 0.097
1.935ThrPhe: 1.935 ± 0.063
5.334ThrGly: 5.334 ± 0.12
1.07ThrHis: 1.07 ± 0.05
2.98ThrIle: 2.98 ± 0.089
1.964ThrLys: 1.964 ± 0.075
6.35ThrLeu: 6.35 ± 0.127
1.532ThrMet: 1.532 ± 0.063
1.512ThrAsn: 1.512 ± 0.059
2.965ThrPro: 2.965 ± 0.09
1.444ThrGln: 1.444 ± 0.063
2.4ThrArg: 2.4 ± 0.063
2.349ThrSer: 2.349 ± 0.075
2.943ThrThr: 2.943 ± 0.091
6.252ThrVal: 6.252 ± 0.146
0.54ThrTrp: 0.54 ± 0.035
1.897ThrTyr: 1.897 ± 0.068
0.002ThrXaa: 0.002 ± 0.002
Val
6.848ValAla: 6.848 ± 0.138
1.69ValCys: 1.69 ± 0.072
4.335ValAsp: 4.335 ± 0.109
4.366ValGlu: 4.366 ± 0.104
2.865ValPhe: 2.865 ± 0.089
5.774ValGly: 5.774 ± 0.138
1.303ValHis: 1.303 ± 0.052
4.455ValIle: 4.455 ± 0.111
3.214ValLys: 3.214 ± 0.111
8.579ValLeu: 8.579 ± 0.142
2.117ValMet: 2.117 ± 0.065
2.327ValAsn: 2.327 ± 0.067
3.468ValPro: 3.468 ± 0.084
2.476ValGln: 2.476 ± 0.077
4.03ValArg: 4.03 ± 0.106
4.738ValSer: 4.738 ± 0.105
5.323ValThr: 5.323 ± 0.139
5.787ValVal: 5.787 ± 0.137
0.736ValTrp: 0.736 ± 0.041
2.556ValTyr: 2.556 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.796TrpAla: 0.796 ± 0.044
0.196TrpCys: 0.196 ± 0.023
0.567TrpAsp: 0.567 ± 0.036
0.598TrpGlu: 0.598 ± 0.043
0.396TrpPhe: 0.396 ± 0.03
0.77TrpGly: 0.77 ± 0.046
0.225TrpHis: 0.225 ± 0.025
0.398TrpIle: 0.398 ± 0.034
0.427TrpLys: 0.427 ± 0.034
1.201TrpLeu: 1.201 ± 0.057
0.294TrpMet: 0.294 ± 0.029
0.354TrpAsn: 0.354 ± 0.029
0.247TrpPro: 0.247 ± 0.025
0.5TrpGln: 0.5 ± 0.032
0.667TrpArg: 0.667 ± 0.044
0.505TrpSer: 0.505 ± 0.035
0.527TrpThr: 0.527 ± 0.04
0.594TrpVal: 0.594 ± 0.037
0.131TrpTrp: 0.131 ± 0.017
0.365TrpTyr: 0.365 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.027TyrAla: 3.027 ± 0.095
0.585TyrCys: 0.585 ± 0.042
2.438TyrAsp: 2.438 ± 0.081
1.933TyrGlu: 1.933 ± 0.067
1.437TyrPhe: 1.437 ± 0.062
2.965TyrGly: 2.965 ± 0.074
0.641TyrHis: 0.641 ± 0.034
1.966TyrIle: 1.966 ± 0.068
1.186TyrLys: 1.186 ± 0.05
3.345TyrLeu: 3.345 ± 0.099
0.847TyrMet: 0.847 ± 0.045
1.145TyrAsn: 1.145 ± 0.058
1.475TyrPro: 1.475 ± 0.067
1.085TyrGln: 1.085 ± 0.052
2.04TyrArg: 2.04 ± 0.075
1.504TyrSer: 1.504 ± 0.067
2.191TyrThr: 2.191 ± 0.08
2.262TyrVal: 2.262 ± 0.063
0.318TyrTrp: 0.318 ± 0.027
1.39TyrTyr: 1.39 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.004XaaAla: 0.004 ± 0.003
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.004XaaGly: 0.004 ± 0.003
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.002
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.002XaaGln: 0.002 ± 0.002
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.022XaaXaa: 0.022 ± 0.011
Statistics based on 1505 proteins (449595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski