Amino acid dipepetide frequency for Aggregatibacter phage S1249

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.474AlaAla: 5.474 ± 0.808
0.912AlaCys: 0.912 ± 0.238
6.843AlaAsp: 6.843 ± 0.927
5.246AlaGlu: 5.246 ± 0.649
4.106AlaPhe: 4.106 ± 0.717
4.714AlaGly: 4.714 ± 0.629
1.064AlaHis: 1.064 ± 0.285
6.311AlaIle: 6.311 ± 0.728
6.615AlaLys: 6.615 ± 0.801
7.984AlaLeu: 7.984 ± 0.678
2.053AlaMet: 2.053 ± 0.411
5.246AlaAsn: 5.246 ± 0.699
2.433AlaPro: 2.433 ± 0.314
5.094AlaGln: 5.094 ± 0.538
3.345AlaArg: 3.345 ± 0.615
2.965AlaSer: 2.965 ± 0.339
4.866AlaThr: 4.866 ± 0.599
5.322AlaVal: 5.322 ± 0.633
1.445AlaTrp: 1.445 ± 0.316
2.433AlaTyr: 2.433 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.684CysAla: 0.684 ± 0.267
0.076CysCys: 0.076 ± 0.081
0.228CysAsp: 0.228 ± 0.115
0.76CysGlu: 0.76 ± 0.212
0.456CysPhe: 0.456 ± 0.202
0.76CysGly: 0.76 ± 0.274
0.304CysHis: 0.304 ± 0.126
0.608CysIle: 0.608 ± 0.21
0.836CysLys: 0.836 ± 0.242
1.293CysLeu: 1.293 ± 0.299
0.076CysMet: 0.076 ± 0.075
0.38CysAsn: 0.38 ± 0.151
0.304CysPro: 0.304 ± 0.157
0.228CysGln: 0.228 ± 0.116
0.836CysArg: 0.836 ± 0.277
0.76CysSer: 0.76 ± 0.244
0.456CysThr: 0.456 ± 0.209
0.76CysVal: 0.76 ± 0.247
0.228CysTrp: 0.228 ± 0.137
0.38CysTyr: 0.38 ± 0.182
0.0CysXaa: 0.0 ± 0.0
Asp
4.486AspAla: 4.486 ± 0.571
0.38AspCys: 0.38 ± 0.154
3.345AspAsp: 3.345 ± 0.589
5.094AspGlu: 5.094 ± 0.684
3.498AspPhe: 3.498 ± 0.455
4.714AspGly: 4.714 ± 0.518
0.76AspHis: 0.76 ± 0.317
4.03AspIle: 4.03 ± 0.607
5.246AspLys: 5.246 ± 0.626
5.703AspLeu: 5.703 ± 0.686
0.988AspMet: 0.988 ± 0.238
2.813AspAsn: 2.813 ± 0.429
1.673AspPro: 1.673 ± 0.444
2.129AspGln: 2.129 ± 0.346
1.825AspArg: 1.825 ± 0.323
3.498AspSer: 3.498 ± 0.551
2.281AspThr: 2.281 ± 0.467
4.638AspVal: 4.638 ± 0.463
0.988AspTrp: 0.988 ± 0.282
1.825AspTyr: 1.825 ± 0.329
0.0AspXaa: 0.0 ± 0.0
Glu
4.41GluAla: 4.41 ± 0.77
0.608GluCys: 0.608 ± 0.21
3.269GluAsp: 3.269 ± 0.512
3.041GluGlu: 3.041 ± 0.501
2.433GluPhe: 2.433 ± 0.374
2.661GluGly: 2.661 ± 0.377
1.369GluHis: 1.369 ± 0.302
5.018GluIle: 5.018 ± 0.489
6.159GluLys: 6.159 ± 0.786
6.767GluLeu: 6.767 ± 0.776
2.357GluMet: 2.357 ± 0.43
4.258GluAsn: 4.258 ± 0.557
1.749GluPro: 1.749 ± 0.33
3.954GluGln: 3.954 ± 0.687
3.345GluArg: 3.345 ± 0.494
3.498GluSer: 3.498 ± 0.567
2.889GluThr: 2.889 ± 0.424
2.205GluVal: 2.205 ± 0.391
1.141GluTrp: 1.141 ± 0.308
2.281GluTyr: 2.281 ± 0.427
0.0GluXaa: 0.0 ± 0.0
Phe
3.117PheAla: 3.117 ± 0.605
0.532PheCys: 0.532 ± 0.212
3.726PheAsp: 3.726 ± 0.533
3.117PheGlu: 3.117 ± 0.529
1.673PhePhe: 1.673 ± 0.351
3.193PheGly: 3.193 ± 0.425
0.456PheHis: 0.456 ± 0.194
3.117PheIle: 3.117 ± 0.58
2.357PheLys: 2.357 ± 0.397
3.345PheLeu: 3.345 ± 0.499
0.456PheMet: 0.456 ± 0.19
2.965PheAsn: 2.965 ± 0.449
1.064PhePro: 1.064 ± 0.301
0.912PheGln: 0.912 ± 0.259
1.749PheArg: 1.749 ± 0.314
2.813PheSer: 2.813 ± 0.477
2.813PheThr: 2.813 ± 0.343
2.509PheVal: 2.509 ± 0.371
0.38PheTrp: 0.38 ± 0.181
1.217PheTyr: 1.217 ± 0.291
0.0PheXaa: 0.0 ± 0.0
Gly
5.246GlyAla: 5.246 ± 0.789
0.304GlyCys: 0.304 ± 0.172
4.41GlyAsp: 4.41 ± 0.539
4.486GlyGlu: 4.486 ± 0.617
3.878GlyPhe: 3.878 ± 0.471
4.79GlyGly: 4.79 ± 0.655
1.064GlyHis: 1.064 ± 0.253
4.106GlyIle: 4.106 ± 0.428
5.398GlyLys: 5.398 ± 0.633
5.779GlyLeu: 5.779 ± 0.768
1.977GlyMet: 1.977 ± 0.454
3.498GlyAsn: 3.498 ± 0.588
0.152GlyPro: 0.152 ± 0.102
2.889GlyGln: 2.889 ± 0.385
2.737GlyArg: 2.737 ± 0.451
3.269GlySer: 3.269 ± 0.469
3.041GlyThr: 3.041 ± 0.44
4.79GlyVal: 4.79 ± 0.57
0.76GlyTrp: 0.76 ± 0.213
2.129GlyTyr: 2.129 ± 0.41
0.0GlyXaa: 0.0 ± 0.0
His
1.064HisAla: 1.064 ± 0.277
0.152HisCys: 0.152 ± 0.101
1.217HisAsp: 1.217 ± 0.286
0.836HisGlu: 0.836 ± 0.247
0.456HisPhe: 0.456 ± 0.158
0.988HisGly: 0.988 ± 0.266
0.38HisHis: 0.38 ± 0.178
1.064HisIle: 1.064 ± 0.237
0.988HisLys: 0.988 ± 0.297
1.597HisLeu: 1.597 ± 0.377
0.152HisMet: 0.152 ± 0.106
0.912HisAsn: 0.912 ± 0.312
0.532HisPro: 0.532 ± 0.161
0.684HisGln: 0.684 ± 0.253
0.988HisArg: 0.988 ± 0.285
1.369HisSer: 1.369 ± 0.36
1.141HisThr: 1.141 ± 0.268
0.76HisVal: 0.76 ± 0.223
0.0HisTrp: 0.0 ± 0.0
0.608HisTyr: 0.608 ± 0.192
0.0HisXaa: 0.0 ± 0.0
Ile
6.235IleAla: 6.235 ± 0.648
0.684IleCys: 0.684 ± 0.218
4.486IleAsp: 4.486 ± 0.485
5.322IleGlu: 5.322 ± 0.723
2.053IlePhe: 2.053 ± 0.515
5.094IleGly: 5.094 ± 0.615
1.217IleHis: 1.217 ± 0.479
4.106IleIle: 4.106 ± 0.666
6.235IleLys: 6.235 ± 0.713
3.65IleLeu: 3.65 ± 0.48
0.988IleMet: 0.988 ± 0.231
4.562IleAsn: 4.562 ± 0.508
2.281IlePro: 2.281 ± 0.405
3.65IleGln: 3.65 ± 0.496
2.813IleArg: 2.813 ± 0.476
5.094IleSer: 5.094 ± 0.679
4.03IleThr: 4.03 ± 0.418
4.106IleVal: 4.106 ± 0.674
0.684IleTrp: 0.684 ± 0.19
2.281IleTyr: 2.281 ± 0.354
0.0IleXaa: 0.0 ± 0.0
Lys
7.299LysAla: 7.299 ± 0.702
1.217LysCys: 1.217 ± 0.361
4.182LysAsp: 4.182 ± 0.655
4.486LysGlu: 4.486 ± 0.479
3.117LysPhe: 3.117 ± 0.529
3.498LysGly: 3.498 ± 0.491
1.064LysHis: 1.064 ± 0.264
4.562LysIle: 4.562 ± 0.608
5.018LysLys: 5.018 ± 0.79
6.463LysLeu: 6.463 ± 0.766
1.825LysMet: 1.825 ± 0.375
4.106LysAsn: 4.106 ± 0.492
2.965LysPro: 2.965 ± 0.496
4.79LysGln: 4.79 ± 0.464
3.726LysArg: 3.726 ± 0.515
4.942LysSer: 4.942 ± 0.618
4.942LysThr: 4.942 ± 0.552
4.334LysVal: 4.334 ± 0.493
1.293LysTrp: 1.293 ± 0.296
2.205LysTyr: 2.205 ± 0.382
0.0LysXaa: 0.0 ± 0.0
Leu
7.071LeuAla: 7.071 ± 0.603
0.836LeuCys: 0.836 ± 0.287
4.942LeuAsp: 4.942 ± 0.603
5.855LeuGlu: 5.855 ± 0.733
3.117LeuPhe: 3.117 ± 0.46
4.942LeuGly: 4.942 ± 0.711
1.217LeuHis: 1.217 ± 0.318
5.627LeuIle: 5.627 ± 0.565
6.235LeuLys: 6.235 ± 0.817
7.527LeuLeu: 7.527 ± 0.705
1.673LeuMet: 1.673 ± 0.335
5.627LeuAsn: 5.627 ± 0.532
3.574LeuPro: 3.574 ± 0.55
3.345LeuGln: 3.345 ± 0.504
4.486LeuArg: 4.486 ± 0.604
7.375LeuSer: 7.375 ± 0.723
5.855LeuThr: 5.855 ± 0.646
4.562LeuVal: 4.562 ± 0.623
0.836LeuTrp: 0.836 ± 0.287
2.281LeuTyr: 2.281 ± 0.345
0.0LeuXaa: 0.0 ± 0.0
Met
2.053MetAla: 2.053 ± 0.384
0.152MetCys: 0.152 ± 0.095
0.836MetAsp: 0.836 ± 0.221
1.445MetGlu: 1.445 ± 0.359
0.912MetPhe: 0.912 ± 0.202
0.684MetGly: 0.684 ± 0.208
0.228MetHis: 0.228 ± 0.107
1.369MetIle: 1.369 ± 0.341
1.141MetLys: 1.141 ± 0.304
2.053MetLeu: 2.053 ± 0.357
0.152MetMet: 0.152 ± 0.102
1.064MetAsn: 1.064 ± 0.272
0.76MetPro: 0.76 ± 0.344
1.141MetGln: 1.141 ± 0.291
0.912MetArg: 0.912 ± 0.274
2.889MetSer: 2.889 ± 0.468
1.749MetThr: 1.749 ± 0.315
1.064MetVal: 1.064 ± 0.269
0.304MetTrp: 0.304 ± 0.141
0.38MetTyr: 0.38 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
5.17AsnAla: 5.17 ± 0.54
0.456AsnCys: 0.456 ± 0.2
2.737AsnAsp: 2.737 ± 0.449
2.357AsnGlu: 2.357 ± 0.444
1.369AsnPhe: 1.369 ± 0.337
5.474AsnGly: 5.474 ± 0.624
1.293AsnHis: 1.293 ± 0.328
4.334AsnIle: 4.334 ± 0.814
3.422AsnLys: 3.422 ± 0.421
4.562AsnLeu: 4.562 ± 0.466
1.369AsnMet: 1.369 ± 0.353
2.889AsnAsn: 2.889 ± 0.596
1.825AsnPro: 1.825 ± 0.384
2.813AsnGln: 2.813 ± 0.49
2.357AsnArg: 2.357 ± 0.546
3.117AsnSer: 3.117 ± 0.469
2.813AsnThr: 2.813 ± 0.451
3.117AsnVal: 3.117 ± 0.496
0.988AsnTrp: 0.988 ± 0.322
1.749AsnTyr: 1.749 ± 0.415
0.0AsnXaa: 0.0 ± 0.0
Pro
3.269ProAla: 3.269 ± 0.606
0.38ProCys: 0.38 ± 0.214
1.901ProAsp: 1.901 ± 0.44
2.965ProGlu: 2.965 ± 0.359
0.836ProPhe: 0.836 ± 0.335
0.456ProGly: 0.456 ± 0.18
0.608ProHis: 0.608 ± 0.199
2.053ProIle: 2.053 ± 0.379
2.661ProLys: 2.661 ± 0.346
2.813ProLeu: 2.813 ± 0.451
0.684ProMet: 0.684 ± 0.206
2.129ProAsn: 2.129 ± 0.476
0.76ProPro: 0.76 ± 0.257
1.141ProGln: 1.141 ± 0.295
0.988ProArg: 0.988 ± 0.238
1.597ProSer: 1.597 ± 0.366
1.369ProThr: 1.369 ± 0.337
1.673ProVal: 1.673 ± 0.282
0.38ProTrp: 0.38 ± 0.15
0.608ProTyr: 0.608 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
4.942GlnAla: 4.942 ± 0.59
0.304GlnCys: 0.304 ± 0.158
1.749GlnAsp: 1.749 ± 0.325
2.737GlnGlu: 2.737 ± 0.527
1.749GlnPhe: 1.749 ± 0.398
2.205GlnGly: 2.205 ± 0.361
0.76GlnHis: 0.76 ± 0.243
4.334GlnIle: 4.334 ± 0.573
3.193GlnLys: 3.193 ± 0.472
5.018GlnLeu: 5.018 ± 0.537
1.369GlnMet: 1.369 ± 0.308
2.813GlnAsn: 2.813 ± 0.432
1.749GlnPro: 1.749 ± 0.325
3.498GlnGln: 3.498 ± 0.565
1.977GlnArg: 1.977 ± 0.372
3.269GlnSer: 3.269 ± 0.476
3.802GlnThr: 3.802 ± 0.455
2.509GlnVal: 2.509 ± 0.546
1.217GlnTrp: 1.217 ± 0.237
1.749GlnTyr: 1.749 ± 0.428
0.0GlnXaa: 0.0 ± 0.0
Arg
2.737ArgAla: 2.737 ± 0.448
0.988ArgCys: 0.988 ± 0.281
2.737ArgAsp: 2.737 ± 0.423
1.749ArgGlu: 1.749 ± 0.452
2.281ArgPhe: 2.281 ± 0.404
3.345ArgGly: 3.345 ± 0.448
0.684ArgHis: 0.684 ± 0.259
3.422ArgIle: 3.422 ± 0.512
3.726ArgLys: 3.726 ± 0.473
4.182ArgLeu: 4.182 ± 0.628
1.064ArgMet: 1.064 ± 0.261
2.281ArgAsn: 2.281 ± 0.403
0.836ArgPro: 0.836 ± 0.221
2.205ArgGln: 2.205 ± 0.469
2.585ArgArg: 2.585 ± 0.428
2.129ArgSer: 2.129 ± 0.394
2.737ArgThr: 2.737 ± 0.427
3.498ArgVal: 3.498 ± 0.442
1.141ArgTrp: 1.141 ± 0.27
1.673ArgTyr: 1.673 ± 0.284
0.0ArgXaa: 0.0 ± 0.0
Ser
5.779SerAla: 5.779 ± 0.571
0.912SerCys: 0.912 ± 0.249
4.486SerAsp: 4.486 ± 0.483
3.878SerGlu: 3.878 ± 0.468
2.281SerPhe: 2.281 ± 0.398
5.55SerGly: 5.55 ± 0.675
0.912SerHis: 0.912 ± 0.212
3.878SerIle: 3.878 ± 0.409
4.866SerLys: 4.866 ± 0.566
5.094SerLeu: 5.094 ± 0.54
1.445SerMet: 1.445 ± 0.294
2.357SerAsn: 2.357 ± 0.402
1.597SerPro: 1.597 ± 0.314
2.737SerGln: 2.737 ± 0.363
3.193SerArg: 3.193 ± 0.328
3.65SerSer: 3.65 ± 0.567
3.269SerThr: 3.269 ± 0.477
4.182SerVal: 4.182 ± 0.408
0.988SerTrp: 0.988 ± 0.258
1.141SerTyr: 1.141 ± 0.271
0.0SerXaa: 0.0 ± 0.0
Thr
6.235ThrAla: 6.235 ± 0.604
0.228ThrCys: 0.228 ± 0.146
3.117ThrAsp: 3.117 ± 0.435
3.65ThrGlu: 3.65 ± 0.495
2.357ThrPhe: 2.357 ± 0.452
4.79ThrGly: 4.79 ± 0.522
0.608ThrHis: 0.608 ± 0.217
5.018ThrIle: 5.018 ± 0.735
4.562ThrLys: 4.562 ± 0.617
4.258ThrLeu: 4.258 ± 0.626
0.988ThrMet: 0.988 ± 0.269
2.129ThrAsn: 2.129 ± 0.396
2.433ThrPro: 2.433 ± 0.441
3.422ThrGln: 3.422 ± 0.561
2.205ThrArg: 2.205 ± 0.382
2.661ThrSer: 2.661 ± 0.364
3.574ThrThr: 3.574 ± 0.566
3.65ThrVal: 3.65 ± 0.377
0.836ThrTrp: 0.836 ± 0.223
1.521ThrTyr: 1.521 ± 0.346
0.0ThrXaa: 0.0 ± 0.0
Val
5.094ValAla: 5.094 ± 0.78
0.76ValCys: 0.76 ± 0.224
3.954ValAsp: 3.954 ± 0.588
3.726ValGlu: 3.726 ± 0.505
2.965ValPhe: 2.965 ± 0.501
3.65ValGly: 3.65 ± 0.414
0.684ValHis: 0.684 ± 0.249
4.334ValIle: 4.334 ± 0.551
4.714ValLys: 4.714 ± 0.423
4.334ValLeu: 4.334 ± 0.64
1.217ValMet: 1.217 ± 0.282
2.585ValAsn: 2.585 ± 0.45
1.597ValPro: 1.597 ± 0.3
3.422ValGln: 3.422 ± 0.493
2.813ValArg: 2.813 ± 0.543
4.41ValSer: 4.41 ± 0.54
3.878ValThr: 3.878 ± 0.581
3.65ValVal: 3.65 ± 0.527
0.684ValTrp: 0.684 ± 0.214
1.673ValTyr: 1.673 ± 0.368
0.0ValXaa: 0.0 ± 0.0
Trp
1.369TrpAla: 1.369 ± 0.264
0.228TrpCys: 0.228 ± 0.112
0.532TrpAsp: 0.532 ± 0.175
0.532TrpGlu: 0.532 ± 0.229
1.064TrpPhe: 1.064 ± 0.235
1.293TrpGly: 1.293 ± 0.336
0.304TrpHis: 0.304 ± 0.139
0.836TrpIle: 0.836 ± 0.189
0.684TrpLys: 0.684 ± 0.205
1.901TrpLeu: 1.901 ± 0.439
0.0TrpMet: 0.0 ± 0.0
0.38TrpAsn: 0.38 ± 0.231
0.0TrpPro: 0.0 ± 0.0
0.912TrpGln: 0.912 ± 0.239
0.988TrpArg: 0.988 ± 0.313
1.141TrpSer: 1.141 ± 0.256
0.532TrpThr: 0.532 ± 0.18
1.141TrpVal: 1.141 ± 0.233
0.228TrpTrp: 0.228 ± 0.119
0.684TrpTyr: 0.684 ± 0.177
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.737TyrAla: 2.737 ± 0.473
0.304TyrCys: 0.304 ± 0.133
1.217TyrAsp: 1.217 ± 0.305
2.129TyrGlu: 2.129 ± 0.374
0.912TyrPhe: 0.912 ± 0.27
1.901TyrGly: 1.901 ± 0.351
0.912TyrHis: 0.912 ± 0.233
1.445TyrIle: 1.445 ± 0.332
1.977TyrLys: 1.977 ± 0.345
2.661TyrLeu: 2.661 ± 0.419
0.38TyrMet: 0.38 ± 0.139
1.293TyrAsn: 1.293 ± 0.278
0.988TyrPro: 0.988 ± 0.303
1.977TyrGln: 1.977 ± 0.456
2.129TyrArg: 2.129 ± 0.427
1.749TyrSer: 1.749 ± 0.359
2.205TyrThr: 2.205 ± 0.393
1.673TyrVal: 1.673 ± 0.479
0.228TyrTrp: 0.228 ± 0.117
1.217TyrTyr: 1.217 ± 0.313
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (13153 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski