Amino acid dipepetide frequency for Curtobacterium sp. MR_MD2014

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.945AlaAla: 20.945 ± 0.235
0.604AlaCys: 0.604 ± 0.032
8.634AlaAsp: 8.634 ± 0.117
7.453AlaGlu: 7.453 ± 0.119
3.99AlaPhe: 3.99 ± 0.072
12.144AlaGly: 12.144 ± 0.136
2.394AlaHis: 2.394 ± 0.051
4.782AlaIle: 4.782 ± 0.084
2.714AlaLys: 2.714 ± 0.072
13.756AlaLeu: 13.756 ± 0.16
2.611AlaMet: 2.611 ± 0.056
2.192AlaAsn: 2.192 ± 0.052
6.617AlaPro: 6.617 ± 0.135
3.676AlaGln: 3.676 ± 0.06
9.201AlaArg: 9.201 ± 0.144
7.248AlaSer: 7.248 ± 0.098
8.252AlaThr: 8.252 ± 0.136
13.767AlaVal: 13.767 ± 0.186
1.908AlaTrp: 1.908 ± 0.052
2.241AlaTyr: 2.241 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.583CysAla: 0.583 ± 0.03
0.046CysCys: 0.046 ± 0.007
0.286CysAsp: 0.286 ± 0.017
0.194CysGlu: 0.194 ± 0.015
0.126CysPhe: 0.126 ± 0.012
0.503CysGly: 0.503 ± 0.026
0.104CysHis: 0.104 ± 0.011
0.175CysIle: 0.175 ± 0.014
0.045CysLys: 0.045 ± 0.007
0.381CysLeu: 0.381 ± 0.023
0.081CysMet: 0.081 ± 0.011
0.101CysAsn: 0.101 ± 0.012
0.244CysPro: 0.244 ± 0.02
0.098CysGln: 0.098 ± 0.011
0.281CysArg: 0.281 ± 0.017
0.366CysSer: 0.366 ± 0.023
0.375CysThr: 0.375 ± 0.024
0.403CysVal: 0.403 ± 0.022
0.07CysTrp: 0.07 ± 0.01
0.088CysTyr: 0.088 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
9.38AspAla: 9.38 ± 0.126
0.206AspCys: 0.206 ± 0.016
5.109AspAsp: 5.109 ± 0.094
4.591AspGlu: 4.591 ± 0.079
1.613AspPhe: 1.613 ± 0.043
6.973AspGly: 6.973 ± 0.119
1.436AspHis: 1.436 ± 0.051
1.793AspIle: 1.793 ± 0.051
0.973AspLys: 0.973 ± 0.043
6.476AspLeu: 6.476 ± 0.093
0.819AspMet: 0.819 ± 0.031
0.8AspAsn: 0.8 ± 0.036
4.277AspPro: 4.277 ± 0.072
1.902AspGln: 1.902 ± 0.055
5.517AspArg: 5.517 ± 0.1
2.374AspSer: 2.374 ± 0.058
3.547AspThr: 3.547 ± 0.085
6.801AspVal: 6.801 ± 0.105
0.973AspTrp: 0.973 ± 0.037
1.012AspTyr: 1.012 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.332GluAla: 6.332 ± 0.108
0.186GluCys: 0.186 ± 0.017
3.193GluAsp: 3.193 ± 0.07
2.422GluGlu: 2.422 ± 0.059
1.411GluPhe: 1.411 ± 0.043
3.695GluGly: 3.695 ± 0.071
1.852GluHis: 1.852 ± 0.048
2.04GluIle: 2.04 ± 0.054
1.07GluLys: 1.07 ± 0.046
5.691GluLeu: 5.691 ± 0.086
0.764GluMet: 0.764 ± 0.032
0.87GluAsn: 0.87 ± 0.035
2.986GluPro: 2.986 ± 0.084
2.691GluGln: 2.691 ± 0.059
5.416GluArg: 5.416 ± 0.103
2.551GluSer: 2.551 ± 0.066
2.972GluThr: 2.972 ± 0.059
4.845GluVal: 4.845 ± 0.087
0.706GluTrp: 0.706 ± 0.033
1.121GluTyr: 1.121 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
3.971PheAla: 3.971 ± 0.077
0.164PheCys: 0.164 ± 0.014
2.249PheAsp: 2.249 ± 0.055
1.511PheGlu: 1.511 ± 0.042
0.966PhePhe: 0.966 ± 0.046
3.269PheGly: 3.269 ± 0.074
0.529PheHis: 0.529 ± 0.024
0.873PheIle: 0.873 ± 0.041
0.41PheLys: 0.41 ± 0.022
2.764PheLeu: 2.764 ± 0.071
0.389PheMet: 0.389 ± 0.022
0.518PheAsn: 0.518 ± 0.028
1.442PhePro: 1.442 ± 0.036
0.735PheGln: 0.735 ± 0.034
2.038PheArg: 2.038 ± 0.058
1.639PheSer: 1.639 ± 0.046
2.096PheThr: 2.096 ± 0.052
3.169PheVal: 3.169 ± 0.077
0.439PheTrp: 0.439 ± 0.023
0.519PheTyr: 0.519 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
11.294GlyAla: 11.294 ± 0.15
0.535GlyCys: 0.535 ± 0.025
5.437GlyAsp: 5.437 ± 0.092
4.29GlyGlu: 4.29 ± 0.077
3.187GlyPhe: 3.187 ± 0.062
7.947GlyGly: 7.947 ± 0.141
1.945GlyHis: 1.945 ± 0.05
4.434GlyIle: 4.434 ± 0.097
2.24GlyLys: 2.24 ± 0.06
8.589GlyLeu: 8.589 ± 0.112
1.724GlyMet: 1.724 ± 0.047
1.743GlyAsn: 1.743 ± 0.051
4.062GlyPro: 4.062 ± 0.071
2.638GlyGln: 2.638 ± 0.061
6.828GlyArg: 6.828 ± 0.119
6.051GlySer: 6.051 ± 0.11
6.86GlyThr: 6.86 ± 0.162
8.521GlyVal: 8.521 ± 0.117
1.606GlyTrp: 1.606 ± 0.048
2.107GlyTyr: 2.107 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
2.532HisAla: 2.532 ± 0.055
0.13HisCys: 0.13 ± 0.011
1.55HisAsp: 1.55 ± 0.047
1.309HisGlu: 1.309 ± 0.045
0.538HisPhe: 0.538 ± 0.027
2.261HisGly: 2.261 ± 0.062
0.575HisHis: 0.575 ± 0.03
0.546HisIle: 0.546 ± 0.027
0.242HisLys: 0.242 ± 0.017
1.873HisLeu: 1.873 ± 0.054
0.33HisMet: 0.33 ± 0.02
0.297HisAsn: 0.297 ± 0.018
1.436HisPro: 1.436 ± 0.046
0.513HisGln: 0.513 ± 0.024
1.741HisArg: 1.741 ± 0.049
0.765HisSer: 0.765 ± 0.032
1.052HisThr: 1.052 ± 0.035
2.025HisVal: 2.025 ± 0.053
0.318HisTrp: 0.318 ± 0.022
0.356HisTyr: 0.356 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
6.051IleAla: 6.051 ± 0.096
0.184IleCys: 0.184 ± 0.016
2.891IleAsp: 2.891 ± 0.06
2.207IleGlu: 2.207 ± 0.051
0.697IlePhe: 0.697 ± 0.034
4.226IleGly: 4.226 ± 0.085
0.495IleHis: 0.495 ± 0.025
1.272IleIle: 1.272 ± 0.057
0.707IleLys: 0.707 ± 0.039
2.46IleLeu: 2.46 ± 0.064
0.464IleMet: 0.464 ± 0.027
0.715IleAsn: 0.715 ± 0.029
1.864IlePro: 1.864 ± 0.046
0.786IleGln: 0.786 ± 0.033
2.415IleArg: 2.415 ± 0.058
1.67IleSer: 1.67 ± 0.05
2.551IleThr: 2.551 ± 0.065
4.145IleVal: 4.145 ± 0.075
0.412IleTrp: 0.412 ± 0.022
0.51IleTyr: 0.51 ± 0.027
0.0IleXaa: 0.0 ± 0.0
Lys
2.287LysAla: 2.287 ± 0.072
0.057LysCys: 0.057 ± 0.009
1.248LysAsp: 1.248 ± 0.049
0.866LysGlu: 0.866 ± 0.041
0.434LysPhe: 0.434 ± 0.022
1.57LysGly: 1.57 ± 0.053
0.46LysHis: 0.46 ± 0.021
0.772LysIle: 0.772 ± 0.037
0.735LysLys: 0.735 ± 0.042
1.703LysLeu: 1.703 ± 0.057
0.35LysMet: 0.35 ± 0.021
0.45LysAsn: 0.45 ± 0.028
1.135LysPro: 1.135 ± 0.033
0.77LysGln: 0.77 ± 0.03
1.418LysArg: 1.418 ± 0.045
1.003LysSer: 1.003 ± 0.036
1.259LysThr: 1.259 ± 0.049
1.745LysVal: 1.745 ± 0.056
0.234LysTrp: 0.234 ± 0.016
0.419LysTyr: 0.419 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
13.589LeuAla: 13.589 ± 0.146
0.393LeuCys: 0.393 ± 0.022
6.849LeuAsp: 6.849 ± 0.107
4.843LeuGlu: 4.843 ± 0.087
2.7LeuPhe: 2.7 ± 0.072
9.292LeuGly: 9.292 ± 0.13
1.92LeuHis: 1.92 ± 0.043
2.745LeuIle: 2.745 ± 0.069
1.422LeuLys: 1.422 ± 0.057
9.594LeuLeu: 9.594 ± 0.141
1.296LeuMet: 1.296 ± 0.043
1.43LeuAsn: 1.43 ± 0.042
5.5LeuPro: 5.5 ± 0.089
2.653LeuGln: 2.653 ± 0.055
7.331LeuArg: 7.331 ± 0.111
4.827LeuSer: 4.827 ± 0.079
5.927LeuThr: 5.927 ± 0.084
10.947LeuVal: 10.947 ± 0.169
1.139LeuTrp: 1.139 ± 0.038
1.476LeuTyr: 1.476 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.076MetAla: 2.076 ± 0.054
0.076MetCys: 0.076 ± 0.009
0.822MetAsp: 0.822 ± 0.036
0.554MetGlu: 0.554 ± 0.028
0.452MetPhe: 0.452 ± 0.023
1.165MetGly: 1.165 ± 0.038
0.39MetHis: 0.39 ± 0.02
0.675MetIle: 0.675 ± 0.029
0.286MetLys: 0.286 ± 0.018
1.585MetLeu: 1.585 ± 0.043
0.238MetMet: 0.238 ± 0.017
0.387MetAsn: 0.387 ± 0.021
1.064MetPro: 1.064 ± 0.034
0.522MetGln: 0.522 ± 0.027
1.344MetArg: 1.344 ± 0.042
1.28MetSer: 1.28 ± 0.037
1.623MetThr: 1.623 ± 0.046
1.36MetVal: 1.36 ± 0.034
0.18MetTrp: 0.18 ± 0.014
0.267MetTyr: 0.267 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.222AsnAla: 2.222 ± 0.055
0.099AsnCys: 0.099 ± 0.01
1.156AsnAsp: 1.156 ± 0.041
0.874AsnGlu: 0.874 ± 0.034
0.51AsnPhe: 0.51 ± 0.031
1.82AsnGly: 1.82 ± 0.058
0.332AsnHis: 0.332 ± 0.022
0.682AsnIle: 0.682 ± 0.027
0.349AsnLys: 0.349 ± 0.023
1.534AsnLeu: 1.534 ± 0.045
0.283AsnMet: 0.283 ± 0.019
0.383AsnAsn: 0.383 ± 0.024
1.296AsnPro: 1.296 ± 0.042
0.51AsnGln: 0.51 ± 0.024
1.217AsnArg: 1.217 ± 0.039
0.824AsnSer: 0.824 ± 0.036
1.128AsnThr: 1.128 ± 0.045
1.642AsnVal: 1.642 ± 0.047
0.27AsnTrp: 0.27 ± 0.018
0.415AsnTyr: 0.415 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
7.154ProAla: 7.154 ± 0.104
0.192ProCys: 0.192 ± 0.016
4.225ProAsp: 4.225 ± 0.076
3.706ProGlu: 3.706 ± 0.085
1.713ProPhe: 1.713 ± 0.045
5.216ProGly: 5.216 ± 0.127
1.048ProHis: 1.048 ± 0.035
1.825ProIle: 1.825 ± 0.053
1.017ProLys: 1.017 ± 0.04
4.428ProLeu: 4.428 ± 0.083
0.849ProMet: 0.849 ± 0.033
0.966ProAsn: 0.966 ± 0.035
1.862ProPro: 1.862 ± 0.062
1.469ProGln: 1.469 ± 0.042
3.146ProArg: 3.146 ± 0.081
3.268ProSer: 3.268 ± 0.068
3.849ProThr: 3.849 ± 0.083
5.687ProVal: 5.687 ± 0.102
0.865ProTrp: 0.865 ± 0.033
1.029ProTyr: 1.029 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
3.745GlnAla: 3.745 ± 0.066
0.105GlnCys: 0.105 ± 0.01
1.801GlnAsp: 1.801 ± 0.044
1.374GlnGlu: 1.374 ± 0.042
0.845GlnPhe: 0.845 ± 0.032
2.346GlnGly: 2.346 ± 0.056
0.752GlnHis: 0.752 ± 0.034
1.136GlnIle: 1.136 ± 0.038
0.587GlnLys: 0.587 ± 0.031
2.992GlnLeu: 2.992 ± 0.065
0.46GlnMet: 0.46 ± 0.023
0.569GlnAsn: 0.569 ± 0.031
1.616GlnPro: 1.616 ± 0.06
1.582GlnGln: 1.582 ± 0.067
2.569GlnArg: 2.569 ± 0.068
1.403GlnSer: 1.403 ± 0.041
1.576GlnThr: 1.576 ± 0.049
2.832GlnVal: 2.832 ± 0.055
0.45GlnTrp: 0.45 ± 0.027
0.728GlnTyr: 0.728 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
9.551ArgAla: 9.551 ± 0.152
0.293ArgCys: 0.293 ± 0.021
4.435ArgAsp: 4.435 ± 0.083
3.825ArgGlu: 3.825 ± 0.097
2.488ArgPhe: 2.488 ± 0.059
5.66ArgGly: 5.66 ± 0.081
1.511ArgHis: 1.511 ± 0.049
3.374ArgIle: 3.374 ± 0.054
1.386ArgLys: 1.386 ± 0.045
6.941ArgLeu: 6.941 ± 0.126
1.662ArgMet: 1.662 ± 0.044
1.321ArgAsn: 1.321 ± 0.041
4.017ArgPro: 4.017 ± 0.081
2.206ArgGln: 2.206 ± 0.052
6.735ArgArg: 6.735 ± 0.134
4.421ArgSer: 4.421 ± 0.085
5.075ArgThr: 5.075 ± 0.097
6.598ArgVal: 6.598 ± 0.111
1.373ArgTrp: 1.373 ± 0.043
1.605ArgTyr: 1.605 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
7.163SerAla: 7.163 ± 0.111
0.271SerCys: 0.271 ± 0.015
3.253SerAsp: 3.253 ± 0.072
2.416SerGlu: 2.416 ± 0.055
1.787SerPhe: 1.787 ± 0.052
6.053SerGly: 6.053 ± 0.109
0.91SerHis: 0.91 ± 0.032
2.246SerIle: 2.246 ± 0.055
1.161SerLys: 1.161 ± 0.042
4.72SerLeu: 4.72 ± 0.078
1.064SerMet: 1.064 ± 0.033
1.039SerAsn: 1.039 ± 0.04
2.73SerPro: 2.73 ± 0.057
1.319SerGln: 1.319 ± 0.04
3.541SerArg: 3.541 ± 0.068
3.556SerSer: 3.556 ± 0.077
4.064SerThr: 4.064 ± 0.074
5.055SerVal: 5.055 ± 0.08
0.926SerTrp: 0.926 ± 0.041
1.087SerTyr: 1.087 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
9.047ThrAla: 9.047 ± 0.149
0.29ThrCys: 0.29 ± 0.02
4.222ThrAsp: 4.222 ± 0.086
3.217ThrGlu: 3.217 ± 0.069
1.906ThrPhe: 1.906 ± 0.05
6.627ThrGly: 6.627 ± 0.109
1.103ThrHis: 1.103 ± 0.036
2.773ThrIle: 2.773 ± 0.056
1.38ThrLys: 1.38 ± 0.043
5.879ThrLeu: 5.879 ± 0.099
1.037ThrMet: 1.037 ± 0.034
1.333ThrAsn: 1.333 ± 0.042
4.138ThrPro: 4.138 ± 0.085
1.468ThrGln: 1.468 ± 0.043
3.799ThrArg: 3.799 ± 0.069
3.657ThrSer: 3.657 ± 0.073
5.1ThrThr: 5.1 ± 0.127
7.254ThrVal: 7.254 ± 0.161
1.011ThrTrp: 1.011 ± 0.039
1.197ThrTyr: 1.197 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
13.341ValAla: 13.341 ± 0.167
0.506ValCys: 0.506 ± 0.024
7.01ValAsp: 7.01 ± 0.106
5.456ValGlu: 5.456 ± 0.078
3.144ValPhe: 3.144 ± 0.07
8.345ValGly: 8.345 ± 0.134
2.069ValHis: 2.069 ± 0.05
3.486ValIle: 3.486 ± 0.076
1.545ValLys: 1.545 ± 0.051
11.031ValLeu: 11.031 ± 0.158
1.412ValMet: 1.412 ± 0.04
1.66ValAsn: 1.66 ± 0.048
5.622ValPro: 5.622 ± 0.095
2.772ValGln: 2.772 ± 0.058
7.225ValArg: 7.225 ± 0.106
5.316ValSer: 5.316 ± 0.077
6.887ValThr: 6.887 ± 0.126
12.219ValVal: 12.219 ± 0.181
1.24ValTrp: 1.24 ± 0.047
1.587ValTyr: 1.587 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
1.607TrpAla: 1.607 ± 0.049
0.107TrpCys: 0.107 ± 0.011
0.853TrpAsp: 0.853 ± 0.028
0.619TrpGlu: 0.619 ± 0.028
0.587TrpPhe: 0.587 ± 0.029
1.03TrpGly: 1.03 ± 0.038
0.305TrpHis: 0.305 ± 0.018
0.579TrpIle: 0.579 ± 0.029
0.309TrpLys: 0.309 ± 0.02
1.598TrpLeu: 1.598 ± 0.05
0.284TrpMet: 0.284 ± 0.018
0.385TrpAsn: 0.385 ± 0.021
0.698TrpPro: 0.698 ± 0.029
0.563TrpGln: 0.563 ± 0.025
1.153TrpArg: 1.153 ± 0.039
1.11TrpSer: 1.11 ± 0.035
1.104TrpThr: 1.104 ± 0.038
1.222TrpVal: 1.222 ± 0.044
0.365TrpTrp: 0.365 ± 0.023
0.312TrpTyr: 0.312 ± 0.022
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.258TyrAla: 2.258 ± 0.05
0.106TyrCys: 0.106 ± 0.012
1.347TyrAsp: 1.347 ± 0.049
1.084TyrGlu: 1.084 ± 0.04
0.597TyrPhe: 0.597 ± 0.029
1.896TyrGly: 1.896 ± 0.053
0.255TyrHis: 0.255 ± 0.016
0.515TyrIle: 0.515 ± 0.028
0.338TyrLys: 0.338 ± 0.021
1.881TyrLeu: 1.881 ± 0.049
0.226TyrMet: 0.226 ± 0.017
0.391TyrAsn: 0.391 ± 0.024
0.909TyrPro: 0.909 ± 0.032
0.592TyrGln: 0.592 ± 0.028
1.562TyrArg: 1.562 ± 0.046
1.034TyrSer: 1.034 ± 0.037
1.141TyrThr: 1.141 ± 0.048
1.637TyrVal: 1.637 ± 0.04
0.307TyrTrp: 0.307 ± 0.018
0.414TyrTyr: 0.414 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2675 proteins (840519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski