Amino acid dipepetide frequency for Enterococcus sp. 10A9_DIV0425

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.434AlaAla: 4.434 ± 0.107
0.446AlaCys: 0.446 ± 0.022
3.17AlaAsp: 3.17 ± 0.065
4.592AlaGlu: 4.592 ± 0.077
3.082AlaPhe: 3.082 ± 0.063
4.236AlaGly: 4.236 ± 0.094
1.218AlaHis: 1.218 ± 0.045
5.603AlaIle: 5.603 ± 0.099
4.813AlaLys: 4.813 ± 0.084
6.48AlaLeu: 6.48 ± 0.084
1.857AlaMet: 1.857 ± 0.058
2.796AlaAsn: 2.796 ± 0.055
2.038AlaPro: 2.038 ± 0.055
2.803AlaGln: 2.803 ± 0.061
2.418AlaArg: 2.418 ± 0.052
3.939AlaSer: 3.939 ± 0.069
4.044AlaThr: 4.044 ± 0.071
4.548AlaVal: 4.548 ± 0.078
0.513AlaTrp: 0.513 ± 0.026
2.5AlaTyr: 2.5 ± 0.057
0.0AlaXaa: 0.0 ± 0.0
Cys
0.335CysAla: 0.335 ± 0.019
0.079CysCys: 0.079 ± 0.008
0.303CysAsp: 0.303 ± 0.02
0.39CysGlu: 0.39 ± 0.024
0.317CysPhe: 0.317 ± 0.02
0.555CysGly: 0.555 ± 0.029
0.17CysHis: 0.17 ± 0.014
0.391CysIle: 0.391 ± 0.022
0.283CysLys: 0.283 ± 0.017
0.674CysLeu: 0.674 ± 0.034
0.166CysMet: 0.166 ± 0.014
0.211CysAsn: 0.211 ± 0.016
0.277CysPro: 0.277 ± 0.018
0.336CysGln: 0.336 ± 0.02
0.295CysArg: 0.295 ± 0.02
0.421CysSer: 0.421 ± 0.021
0.324CysThr: 0.324 ± 0.022
0.418CysVal: 0.418 ± 0.022
0.047CysTrp: 0.047 ± 0.008
0.258CysTyr: 0.258 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.096AspAla: 3.096 ± 0.068
0.326AspCys: 0.326 ± 0.018
2.104AspAsp: 2.104 ± 0.06
3.898AspGlu: 3.898 ± 0.086
2.651AspPhe: 2.651 ± 0.061
3.15AspGly: 3.15 ± 0.067
1.102AspHis: 1.102 ± 0.036
3.544AspIle: 3.544 ± 0.067
3.138AspLys: 3.138 ± 0.061
5.096AspLeu: 5.096 ± 0.08
1.173AspMet: 1.173 ± 0.039
1.791AspAsn: 1.791 ± 0.049
2.31AspPro: 2.31 ± 0.056
2.672AspGln: 2.672 ± 0.061
2.151AspArg: 2.151 ± 0.055
2.802AspSer: 2.802 ± 0.056
2.749AspThr: 2.749 ± 0.058
3.304AspVal: 3.304 ± 0.058
0.639AspTrp: 0.639 ± 0.029
2.397AspTyr: 2.397 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
5.442GluAla: 5.442 ± 0.086
0.337GluCys: 0.337 ± 0.02
3.514GluAsp: 3.514 ± 0.071
7.183GluGlu: 7.183 ± 0.116
2.582GluPhe: 2.582 ± 0.052
4.143GluGly: 4.143 ± 0.091
1.236GluHis: 1.236 ± 0.039
5.824GluIle: 5.824 ± 0.086
7.256GluLys: 7.256 ± 0.091
7.275GluLeu: 7.275 ± 0.103
2.367GluMet: 2.367 ± 0.051
4.23GluAsn: 4.23 ± 0.08
1.982GluPro: 1.982 ± 0.051
3.761GluGln: 3.761 ± 0.068
3.181GluArg: 3.181 ± 0.068
3.739GluSer: 3.739 ± 0.066
4.992GluThr: 4.992 ± 0.094
5.053GluVal: 5.053 ± 0.086
0.862GluTrp: 0.862 ± 0.032
2.215GluTyr: 2.215 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
2.848PheAla: 2.848 ± 0.059
0.319PheCys: 0.319 ± 0.02
2.697PheAsp: 2.697 ± 0.055
3.021PheGlu: 3.021 ± 0.063
2.565PhePhe: 2.565 ± 0.069
2.901PheGly: 2.901 ± 0.069
0.888PheHis: 0.888 ± 0.031
3.497PheIle: 3.497 ± 0.073
2.475PheLys: 2.475 ± 0.057
4.925PheLeu: 4.925 ± 0.086
1.123PheMet: 1.123 ± 0.041
1.87PheAsn: 1.87 ± 0.046
1.582PhePro: 1.582 ± 0.044
1.776PheGln: 1.776 ± 0.052
1.617PheArg: 1.617 ± 0.046
3.574PheSer: 3.574 ± 0.066
2.646PheThr: 2.646 ± 0.063
3.097PheVal: 3.097 ± 0.064
0.588PheTrp: 0.588 ± 0.03
1.958PheTyr: 1.958 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.016GlyAla: 4.016 ± 0.077
0.375GlyCys: 0.375 ± 0.022
2.728GlyAsp: 2.728 ± 0.063
4.171GlyGlu: 4.171 ± 0.082
2.968GlyPhe: 2.968 ± 0.066
4.115GlyGly: 4.115 ± 0.091
1.095GlyHis: 1.095 ± 0.042
5.518GlyIle: 5.518 ± 0.095
4.652GlyLys: 4.652 ± 0.078
6.133GlyLeu: 6.133 ± 0.104
1.817GlyMet: 1.817 ± 0.056
2.873GlyAsn: 2.873 ± 0.057
1.328GlyPro: 1.328 ± 0.045
2.345GlyGln: 2.345 ± 0.057
2.426GlyArg: 2.426 ± 0.052
3.53GlySer: 3.53 ± 0.069
4.017GlyThr: 4.017 ± 0.089
4.272GlyVal: 4.272 ± 0.086
0.655GlyTrp: 0.655 ± 0.032
2.734GlyTyr: 2.734 ± 0.065
0.0GlyXaa: 0.0 ± 0.0
His
1.103HisAla: 1.103 ± 0.033
0.166HisCys: 0.166 ± 0.015
0.842HisAsp: 0.842 ± 0.033
1.401HisGlu: 1.401 ± 0.044
1.169HisPhe: 1.169 ± 0.036
1.269HisGly: 1.269 ± 0.042
0.512HisHis: 0.512 ± 0.024
1.193HisIle: 1.193 ± 0.038
0.848HisLys: 0.848 ± 0.029
2.114HisLeu: 2.114 ± 0.048
0.416HisMet: 0.416 ± 0.023
0.629HisAsn: 0.629 ± 0.029
0.994HisPro: 0.994 ± 0.036
1.058HisGln: 1.058 ± 0.035
0.767HisArg: 0.767 ± 0.033
1.166HisSer: 1.166 ± 0.04
1.136HisThr: 1.136 ± 0.042
1.053HisVal: 1.053 ± 0.034
0.225HisTrp: 0.225 ± 0.017
0.904HisTyr: 0.904 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.375IleAla: 5.375 ± 0.084
0.646IleCys: 0.646 ± 0.029
4.536IleAsp: 4.536 ± 0.074
5.566IleGlu: 5.566 ± 0.092
3.497IlePhe: 3.497 ± 0.077
5.051IleGly: 5.051 ± 0.1
1.678IleHis: 1.678 ± 0.038
5.297IleIle: 5.297 ± 0.107
4.692IleLys: 4.692 ± 0.084
7.192IleLeu: 7.192 ± 0.112
1.607IleMet: 1.607 ± 0.048
3.43IleAsn: 3.43 ± 0.062
3.362IlePro: 3.362 ± 0.062
3.256IleGln: 3.256 ± 0.066
3.212IleArg: 3.212 ± 0.071
4.905IleSer: 4.905 ± 0.073
4.328IleThr: 4.328 ± 0.072
4.901IleVal: 4.901 ± 0.094
0.637IleTrp: 0.637 ± 0.031
2.632IleTyr: 2.632 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
4.535LysAla: 4.535 ± 0.082
0.297LysCys: 0.297 ± 0.019
3.727LysAsp: 3.727 ± 0.06
7.998LysGlu: 7.998 ± 0.111
1.991LysPhe: 1.991 ± 0.047
3.895LysGly: 3.895 ± 0.073
1.224LysHis: 1.224 ± 0.041
5.438LysIle: 5.438 ± 0.089
7.271LysLys: 7.271 ± 0.119
5.778LysLeu: 5.778 ± 0.09
2.255LysMet: 2.255 ± 0.051
4.322LysAsn: 4.322 ± 0.079
1.791LysPro: 1.791 ± 0.044
3.684LysGln: 3.684 ± 0.072
3.447LysArg: 3.447 ± 0.068
3.419LysSer: 3.419 ± 0.069
3.913LysThr: 3.913 ± 0.067
4.266LysVal: 4.266 ± 0.071
0.749LysTrp: 0.749 ± 0.03
2.141LysTyr: 2.141 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
7.453LeuAla: 7.453 ± 0.098
0.693LeuCys: 0.693 ± 0.029
4.931LeuAsp: 4.931 ± 0.081
6.759LeuGlu: 6.759 ± 0.097
4.925LeuPhe: 4.925 ± 0.099
5.81LeuGly: 5.81 ± 0.111
1.557LeuHis: 1.557 ± 0.043
7.139LeuIle: 7.139 ± 0.099
6.753LeuLys: 6.753 ± 0.096
10.168LeuLeu: 10.168 ± 0.166
2.5LeuMet: 2.5 ± 0.057
4.522LeuAsn: 4.522 ± 0.081
4.368LeuPro: 4.368 ± 0.085
3.629LeuGln: 3.629 ± 0.077
3.623LeuArg: 3.623 ± 0.076
7.117LeuSer: 7.117 ± 0.101
6.031LeuThr: 6.031 ± 0.091
6.266LeuVal: 6.266 ± 0.088
0.806LeuTrp: 0.806 ± 0.031
3.141LeuTyr: 3.141 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.049
0.132MetCys: 0.132 ± 0.013
1.446MetAsp: 1.446 ± 0.041
1.823MetGlu: 1.823 ± 0.049
0.957MetPhe: 0.957 ± 0.037
1.546MetGly: 1.546 ± 0.044
0.337MetHis: 0.337 ± 0.02
2.389MetIle: 2.389 ± 0.061
2.325MetLys: 2.325 ± 0.054
2.154MetLeu: 2.154 ± 0.054
0.832MetMet: 0.832 ± 0.034
1.549MetAsn: 1.549 ± 0.043
0.96MetPro: 0.96 ± 0.034
0.932MetGln: 0.932 ± 0.032
1.005MetArg: 1.005 ± 0.037
1.5MetSer: 1.5 ± 0.046
1.827MetThr: 1.827 ± 0.048
1.64MetVal: 1.64 ± 0.045
0.178MetTrp: 0.178 ± 0.013
0.716MetTyr: 0.716 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.704AsnAla: 2.704 ± 0.058
0.362AsnCys: 0.362 ± 0.022
2.421AsnAsp: 2.421 ± 0.054
3.892AsnGlu: 3.892 ± 0.069
1.867AsnPhe: 1.867 ± 0.044
3.204AsnGly: 3.204 ± 0.068
1.201AsnHis: 1.201 ± 0.037
3.229AsnIle: 3.229 ± 0.067
3.043AsnLys: 3.043 ± 0.073
4.069AsnLeu: 4.069 ± 0.068
1.083AsnMet: 1.083 ± 0.044
2.298AsnAsn: 2.298 ± 0.08
1.918AsnPro: 1.918 ± 0.05
2.964AsnGln: 2.964 ± 0.075
2.105AsnArg: 2.105 ± 0.051
2.386AsnSer: 2.386 ± 0.064
2.428AsnThr: 2.428 ± 0.07
2.894AsnVal: 2.894 ± 0.054
0.549AsnTrp: 0.549 ± 0.028
1.986AsnTyr: 1.986 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
2.153ProAla: 2.153 ± 0.046
0.204ProCys: 0.204 ± 0.018
1.922ProAsp: 1.922 ± 0.049
3.318ProGlu: 3.318 ± 0.063
1.983ProPhe: 1.983 ± 0.054
1.896ProGly: 1.896 ± 0.055
0.618ProHis: 0.618 ± 0.022
2.632ProIle: 2.632 ± 0.054
2.443ProLys: 2.443 ± 0.051
3.302ProLeu: 3.302 ± 0.056
0.882ProMet: 0.882 ± 0.03
1.726ProAsn: 1.726 ± 0.047
0.928ProPro: 0.928 ± 0.044
1.443ProGln: 1.443 ± 0.033
0.986ProArg: 0.986 ± 0.032
2.324ProSer: 2.324 ± 0.05
2.585ProThr: 2.585 ± 0.059
2.644ProVal: 2.644 ± 0.053
0.303ProTrp: 0.303 ± 0.02
1.348ProTyr: 1.348 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
3.321GlnAla: 3.321 ± 0.058
0.157GlnCys: 0.157 ± 0.014
1.658GlnAsp: 1.658 ± 0.042
3.896GlnGlu: 3.896 ± 0.068
1.787GlnPhe: 1.787 ± 0.045
2.307GlnGly: 2.307 ± 0.046
0.781GlnHis: 0.781 ± 0.033
3.017GlnIle: 3.017 ± 0.059
3.677GlnLys: 3.677 ± 0.073
5.258GlnLeu: 5.258 ± 0.092
1.165GlnMet: 1.165 ± 0.035
1.777GlnAsn: 1.777 ± 0.048
1.49GlnPro: 1.49 ± 0.042
2.55GlnGln: 2.55 ± 0.08
1.815GlnArg: 1.815 ± 0.052
2.487GlnSer: 2.487 ± 0.057
3.044GlnThr: 3.044 ± 0.071
2.852GlnVal: 2.852 ± 0.063
0.627GlnTrp: 0.627 ± 0.038
1.304GlnTyr: 1.304 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
2.079ArgAla: 2.079 ± 0.048
0.23ArgCys: 0.23 ± 0.019
1.779ArgAsp: 1.779 ± 0.046
3.122ArgGlu: 3.122 ± 0.073
2.079ArgPhe: 2.079 ± 0.049
2.103ArgGly: 2.103 ± 0.056
0.733ArgHis: 0.733 ± 0.028
3.107ArgIle: 3.107 ± 0.068
3.463ArgLys: 3.463 ± 0.068
4.138ArgLeu: 4.138 ± 0.077
1.127ArgMet: 1.127 ± 0.036
1.997ArgAsn: 1.997 ± 0.058
1.347ArgPro: 1.347 ± 0.042
1.817ArgGln: 1.817 ± 0.053
1.914ArgArg: 1.914 ± 0.05
2.296ArgSer: 2.296 ± 0.044
2.185ArgThr: 2.185 ± 0.047
2.498ArgVal: 2.498 ± 0.052
0.401ArgTrp: 0.401 ± 0.022
1.717ArgTyr: 1.717 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.665SerAla: 3.665 ± 0.065
0.391SerCys: 0.391 ± 0.021
2.949SerAsp: 2.949 ± 0.063
4.291SerGlu: 4.291 ± 0.062
3.152SerPhe: 3.152 ± 0.068
4.324SerGly: 4.324 ± 0.074
1.158SerHis: 1.158 ± 0.034
4.666SerIle: 4.666 ± 0.088
3.939SerLys: 3.939 ± 0.09
6.317SerLeu: 6.317 ± 0.09
1.533SerMet: 1.533 ± 0.05
2.689SerAsn: 2.689 ± 0.067
1.984SerPro: 1.984 ± 0.053
2.514SerGln: 2.514 ± 0.054
2.316SerArg: 2.316 ± 0.049
4.2SerSer: 4.2 ± 0.092
3.902SerThr: 3.902 ± 0.106
4.025SerVal: 4.025 ± 0.068
0.627SerTrp: 0.627 ± 0.026
2.47SerTyr: 2.47 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
3.875ThrAla: 3.875 ± 0.063
0.342ThrCys: 0.342 ± 0.02
3.303ThrAsp: 3.303 ± 0.066
4.077ThrGlu: 4.077 ± 0.073
2.795ThrPhe: 2.795 ± 0.063
3.931ThrGly: 3.931 ± 0.083
1.204ThrHis: 1.204 ± 0.035
5.24ThrIle: 5.24 ± 0.077
4.125ThrLys: 4.125 ± 0.067
5.468ThrLeu: 5.468 ± 0.083
1.419ThrMet: 1.419 ± 0.045
2.889ThrAsn: 2.889 ± 0.061
2.692ThrPro: 2.692 ± 0.067
2.268ThrGln: 2.268 ± 0.055
2.162ThrArg: 2.162 ± 0.051
4.127ThrSer: 4.127 ± 0.111
4.343ThrThr: 4.343 ± 0.11
4.383ThrVal: 4.383 ± 0.073
0.521ThrTrp: 0.521 ± 0.025
2.236ThrTyr: 2.236 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
4.817ValAla: 4.817 ± 0.094
0.432ValCys: 0.432 ± 0.022
3.514ValAsp: 3.514 ± 0.082
4.526ValGlu: 4.526 ± 0.084
2.932ValPhe: 2.932 ± 0.062
4.16ValGly: 4.16 ± 0.09
1.123ValHis: 1.123 ± 0.038
5.108ValIle: 5.108 ± 0.097
4.36ValLys: 4.36 ± 0.075
6.228ValLeu: 6.228 ± 0.093
1.663ValMet: 1.663 ± 0.046
3.001ValAsn: 3.001 ± 0.072
2.643ValPro: 2.643 ± 0.056
2.146ValGln: 2.146 ± 0.049
2.475ValArg: 2.475 ± 0.059
4.523ValSer: 4.523 ± 0.068
4.385ValThr: 4.385 ± 0.082
4.45ValVal: 4.45 ± 0.102
0.516ValTrp: 0.516 ± 0.023
2.237ValTyr: 2.237 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.47TrpAla: 0.47 ± 0.026
0.058TrpCys: 0.058 ± 0.008
0.487TrpAsp: 0.487 ± 0.023
0.675TrpGlu: 0.675 ± 0.028
0.516TrpPhe: 0.516 ± 0.028
0.639TrpGly: 0.639 ± 0.029
0.214TrpHis: 0.214 ± 0.013
0.718TrpIle: 0.718 ± 0.031
0.645TrpLys: 0.645 ± 0.026
1.171TrpLeu: 1.171 ± 0.042
0.237TrpMet: 0.237 ± 0.017
0.594TrpAsn: 0.594 ± 0.027
0.214TrpPro: 0.214 ± 0.016
0.597TrpGln: 0.597 ± 0.028
0.524TrpArg: 0.524 ± 0.025
0.54TrpSer: 0.54 ± 0.024
0.498TrpThr: 0.498 ± 0.026
0.596TrpVal: 0.596 ± 0.023
0.125TrpTrp: 0.125 ± 0.014
0.484TrpTyr: 0.484 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.047TyrAla: 2.047 ± 0.047
0.254TyrCys: 0.254 ± 0.017
2.062TyrAsp: 2.062 ± 0.049
2.576TyrGlu: 2.576 ± 0.052
2.151TyrPhe: 2.151 ± 0.053
2.534TyrGly: 2.534 ± 0.063
0.918TyrHis: 0.918 ± 0.033
2.25TyrIle: 2.25 ± 0.061
1.941TyrLys: 1.941 ± 0.055
4.25TyrLeu: 4.25 ± 0.081
0.788TyrMet: 0.788 ± 0.027
1.41TyrAsn: 1.41 ± 0.039
1.43TyrPro: 1.43 ± 0.042
2.419TyrGln: 2.419 ± 0.058
1.693TyrArg: 1.693 ± 0.046
2.118TyrSer: 2.118 ± 0.049
2.024TyrThr: 2.024 ± 0.047
2.078TyrVal: 2.078 ± 0.054
0.435TyrTrp: 0.435 ± 0.025
1.629TyrTyr: 1.629 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2644 proteins (877332 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski