Amino acid dipepetide frequency for Rickenella mellea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.557AlaAla: 7.557 ± 0.055
1.173AlaCys: 1.173 ± 0.015
3.986AlaAsp: 3.986 ± 0.024
4.402AlaGlu: 4.402 ± 0.033
3.286AlaPhe: 3.286 ± 0.021
5.05AlaGly: 5.05 ± 0.04
2.013AlaHis: 2.013 ± 0.018
4.223AlaIle: 4.223 ± 0.027
3.829AlaLys: 3.829 ± 0.032
7.893AlaLeu: 7.893 ± 0.043
1.861AlaMet: 1.861 ± 0.016
2.959AlaAsn: 2.959 ± 0.022
4.565AlaPro: 4.565 ± 0.038
3.091AlaGln: 3.091 ± 0.025
4.831AlaArg: 4.831 ± 0.031
7.08AlaSer: 7.08 ± 0.043
5.138AlaThr: 5.138 ± 0.032
5.249AlaVal: 5.249 ± 0.026
1.091AlaTrp: 1.091 ± 0.014
1.981AlaTyr: 1.981 ± 0.019
0.0AlaXaa: 0.0 ± 0.0
Cys
1.083CysAla: 1.083 ± 0.017
0.274CysCys: 0.274 ± 0.008
0.756CysAsp: 0.756 ± 0.011
0.675CysGlu: 0.675 ± 0.01
0.556CysPhe: 0.556 ± 0.009
1.01CysGly: 1.01 ± 0.017
0.388CysHis: 0.388 ± 0.008
0.793CysIle: 0.793 ± 0.01
0.58CysLys: 0.58 ± 0.01
1.519CysLeu: 1.519 ± 0.02
0.321CysMet: 0.321 ± 0.007
0.512CysAsn: 0.512 ± 0.011
0.852CysPro: 0.852 ± 0.015
0.491CysGln: 0.491 ± 0.01
0.881CysArg: 0.881 ± 0.013
1.106CysSer: 1.106 ± 0.015
0.853CysThr: 0.853 ± 0.013
0.942CysVal: 0.942 ± 0.013
0.238CysTrp: 0.238 ± 0.005
0.351CysTyr: 0.351 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
4.748AspAla: 4.748 ± 0.029
0.699AspCys: 0.699 ± 0.009
4.273AspAsp: 4.273 ± 0.039
4.151AspGlu: 4.151 ± 0.033
2.139AspPhe: 2.139 ± 0.019
4.288AspGly: 4.288 ± 0.027
1.335AspHis: 1.335 ± 0.014
3.25AspIle: 3.25 ± 0.025
2.122AspLys: 2.122 ± 0.019
4.852AspLeu: 4.852 ± 0.029
1.257AspMet: 1.257 ± 0.016
1.823AspAsn: 1.823 ± 0.019
3.187AspPro: 3.187 ± 0.023
1.547AspGln: 1.547 ± 0.014
2.909AspArg: 2.909 ± 0.022
4.026AspSer: 4.026 ± 0.031
2.938AspThr: 2.938 ± 0.023
4.126AspVal: 4.126 ± 0.027
0.835AspTrp: 0.835 ± 0.013
1.343AspTyr: 1.343 ± 0.015
0.0AspXaa: 0.0 ± 0.0
Glu
4.291GluAla: 4.291 ± 0.029
0.77GluCys: 0.77 ± 0.011
3.745GluAsp: 3.745 ± 0.03
4.523GluGlu: 4.523 ± 0.039
2.008GluPhe: 2.008 ± 0.018
3.393GluGly: 3.393 ± 0.024
1.444GluHis: 1.444 ± 0.017
2.949GluIle: 2.949 ± 0.022
3.064GluLys: 3.064 ± 0.026
5.09GluLeu: 5.09 ± 0.032
1.373GluMet: 1.373 ± 0.015
2.05GluAsn: 2.05 ± 0.019
2.536GluPro: 2.536 ± 0.023
1.935GluGln: 1.935 ± 0.017
3.978GluArg: 3.978 ± 0.029
3.975GluSer: 3.975 ± 0.029
3.039GluThr: 3.039 ± 0.022
3.481GluVal: 3.481 ± 0.026
0.928GluTrp: 0.928 ± 0.013
1.454GluTyr: 1.454 ± 0.015
0.0GluXaa: 0.0 ± 0.0
Phe
3.199PheAla: 3.199 ± 0.024
0.602PheCys: 0.602 ± 0.011
2.326PheAsp: 2.326 ± 0.019
2.093PheGlu: 2.093 ± 0.019
1.634PhePhe: 1.634 ± 0.019
2.844PheGly: 2.844 ± 0.029
1.052PheHis: 1.052 ± 0.013
1.975PheIle: 1.975 ± 0.02
1.555PheLys: 1.555 ± 0.017
3.704PheLeu: 3.704 ± 0.027
0.799PheMet: 0.799 ± 0.011
1.42PheAsn: 1.42 ± 0.016
2.185PhePro: 2.185 ± 0.02
1.347PheGln: 1.347 ± 0.014
2.166PheArg: 2.166 ± 0.019
3.359PheSer: 3.359 ± 0.021
2.334PheThr: 2.334 ± 0.019
2.6PheVal: 2.6 ± 0.022
0.594PheTrp: 0.594 ± 0.01
1.064PheTyr: 1.064 ± 0.011
0.0PheXaa: 0.0 ± 0.0
Gly
4.736GlyAla: 4.736 ± 0.039
0.939GlyCys: 0.939 ± 0.014
3.621GlyAsp: 3.621 ± 0.025
3.415GlyGlu: 3.415 ± 0.025
2.525GlyPhe: 2.525 ± 0.023
5.871GlyGly: 5.871 ± 0.063
1.743GlyHis: 1.743 ± 0.018
3.307GlyIle: 3.307 ± 0.025
3.312GlyLys: 3.312 ± 0.029
5.431GlyLeu: 5.431 ± 0.032
1.513GlyMet: 1.513 ± 0.017
2.491GlyAsn: 2.491 ± 0.022
3.091GlyPro: 3.091 ± 0.027
2.203GlyGln: 2.203 ± 0.02
3.975GlyArg: 3.975 ± 0.03
5.495GlySer: 5.495 ± 0.036
3.953GlyThr: 3.953 ± 0.027
4.356GlyVal: 4.356 ± 0.032
1.059GlyTrp: 1.059 ± 0.014
1.753GlyTyr: 1.753 ± 0.019
0.0GlyXaa: 0.0 ± 0.0
His
2.143HisAla: 2.143 ± 0.018
0.437HisCys: 0.437 ± 0.011
1.443HisAsp: 1.443 ± 0.015
1.322HisGlu: 1.322 ± 0.016
1.099HisPhe: 1.099 ± 0.015
1.76HisGly: 1.76 ± 0.017
1.003HisHis: 1.003 ± 0.014
1.482HisIle: 1.482 ± 0.016
0.91HisLys: 0.91 ± 0.014
2.696HisLeu: 2.696 ± 0.025
0.506HisMet: 0.506 ± 0.008
0.922HisAsn: 0.922 ± 0.012
1.998HisPro: 1.998 ± 0.022
0.978HisGln: 0.978 ± 0.015
1.781HisArg: 1.781 ± 0.018
2.288HisSer: 2.288 ± 0.024
1.573HisThr: 1.573 ± 0.017
1.744HisVal: 1.744 ± 0.017
0.395HisTrp: 0.395 ± 0.008
0.68HisTyr: 0.68 ± 0.009
0.0HisXaa: 0.0 ± 0.0
Ile
4.209IleAla: 4.209 ± 0.03
0.826IleCys: 0.826 ± 0.013
2.867IleAsp: 2.867 ± 0.023
2.659IleGlu: 2.659 ± 0.02
2.179IlePhe: 2.179 ± 0.02
3.044IleGly: 3.044 ± 0.025
1.409IleHis: 1.409 ± 0.016
2.629IleIle: 2.629 ± 0.026
2.029IleLys: 2.029 ± 0.018
4.96IleLeu: 4.96 ± 0.031
1.013IleMet: 1.013 ± 0.014
1.741IleAsn: 1.741 ± 0.017
3.393IlePro: 3.393 ± 0.026
1.852IleGln: 1.852 ± 0.02
2.973IleArg: 2.973 ± 0.022
4.307IleSer: 4.307 ± 0.03
2.92IleThr: 2.92 ± 0.023
3.418IleVal: 3.418 ± 0.026
0.778IleTrp: 0.778 ± 0.012
1.366IleTyr: 1.366 ± 0.013
0.0IleXaa: 0.0 ± 0.0
Lys
3.844LysAla: 3.844 ± 0.029
0.599LysCys: 0.599 ± 0.011
2.511LysAsp: 2.511 ± 0.021
2.899LysGlu: 2.899 ± 0.025
1.581LysPhe: 1.581 ± 0.015
2.753LysGly: 2.753 ± 0.023
1.147LysHis: 1.147 ± 0.014
2.195LysIle: 2.195 ± 0.02
2.758LysLys: 2.758 ± 0.033
4.068LysLeu: 4.068 ± 0.031
0.966LysMet: 0.966 ± 0.012
1.606LysAsn: 1.606 ± 0.016
2.484LysPro: 2.484 ± 0.022
1.489LysGln: 1.489 ± 0.017
3.367LysArg: 3.367 ± 0.029
3.404LysSer: 3.404 ± 0.028
2.597LysThr: 2.597 ± 0.022
2.681LysVal: 2.681 ± 0.023
0.679LysTrp: 0.679 ± 0.012
1.277LysTyr: 1.277 ± 0.015
0.0LysXaa: 0.0 ± 0.0
Leu
7.746LeuAla: 7.746 ± 0.036
1.431LeuCys: 1.431 ± 0.018
5.051LeuAsp: 5.051 ± 0.034
5.182LeuGlu: 5.182 ± 0.03
3.471LeuPhe: 3.471 ± 0.025
5.5LeuGly: 5.5 ± 0.029
2.634LeuHis: 2.634 ± 0.022
4.001LeuIle: 4.001 ± 0.031
4.256LeuLys: 4.256 ± 0.028
8.637LeuLeu: 8.637 ± 0.056
1.783LeuMet: 1.783 ± 0.016
3.321LeuAsn: 3.321 ± 0.02
6.092LeuPro: 6.092 ± 0.035
3.718LeuGln: 3.718 ± 0.025
6.458LeuArg: 6.458 ± 0.039
8.244LeuSer: 8.244 ± 0.039
5.529LeuThr: 5.529 ± 0.034
5.716LeuVal: 5.716 ± 0.034
1.343LeuTrp: 1.343 ± 0.015
2.262LeuTyr: 2.262 ± 0.019
0.0LeuXaa: 0.0 ± 0.0
Met
1.864MetAla: 1.864 ± 0.016
0.287MetCys: 0.287 ± 0.007
1.322MetAsp: 1.322 ± 0.015
1.249MetGlu: 1.249 ± 0.014
0.79MetPhe: 0.79 ± 0.011
1.252MetGly: 1.252 ± 0.012
0.578MetHis: 0.578 ± 0.009
0.945MetIle: 0.945 ± 0.012
1.05MetLys: 1.05 ± 0.015
1.824MetLeu: 1.824 ± 0.017
0.508MetMet: 0.508 ± 0.01
0.784MetAsn: 0.784 ± 0.011
1.263MetPro: 1.263 ± 0.014
0.805MetGln: 0.805 ± 0.012
1.325MetArg: 1.325 ± 0.015
2.005MetSer: 2.005 ± 0.017
1.385MetThr: 1.385 ± 0.014
1.257MetVal: 1.257 ± 0.014
0.308MetTrp: 0.308 ± 0.007
0.506MetTyr: 0.506 ± 0.009
0.0MetXaa: 0.0 ± 0.0
Asn
3.265AsnAla: 3.265 ± 0.026
0.524AsnCys: 0.524 ± 0.01
1.966AsnAsp: 1.966 ± 0.019
1.867AsnGlu: 1.867 ± 0.019
1.462AsnPhe: 1.462 ± 0.014
2.878AsnGly: 2.878 ± 0.027
0.935AsnHis: 0.935 ± 0.013
2.206AsnIle: 2.206 ± 0.019
1.342AsnLys: 1.342 ± 0.017
3.47AsnLeu: 3.47 ± 0.026
0.767AsnMet: 0.767 ± 0.01
1.428AsnAsn: 1.428 ± 0.017
2.448AsnPro: 2.448 ± 0.02
1.142AsnGln: 1.142 ± 0.013
1.838AsnArg: 1.838 ± 0.016
2.851AsnSer: 2.851 ± 0.02
2.219AsnThr: 2.219 ± 0.019
2.605AsnVal: 2.605 ± 0.023
0.521AsnTrp: 0.521 ± 0.008
0.907AsnTyr: 0.907 ± 0.011
0.0AsnXaa: 0.0 ± 0.0
Pro
4.949ProAla: 4.949 ± 0.04
0.635ProCys: 0.635 ± 0.012
3.182ProAsp: 3.182 ± 0.025
3.289ProGlu: 3.289 ± 0.022
2.308ProPhe: 2.308 ± 0.018
3.565ProGly: 3.565 ± 0.027
1.746ProHis: 1.746 ± 0.017
2.765ProIle: 2.765 ± 0.025
2.416ProLys: 2.416 ± 0.019
5.301ProLeu: 5.301 ± 0.03
1.105ProMet: 1.105 ± 0.013
2.404ProAsn: 2.404 ± 0.018
6.38ProPro: 6.38 ± 0.071
2.419ProGln: 2.419 ± 0.025
3.591ProArg: 3.591 ± 0.032
6.97ProSer: 6.97 ± 0.052
4.507ProThr: 4.507 ± 0.033
3.642ProVal: 3.642 ± 0.03
0.724ProTrp: 0.724 ± 0.011
1.491ProTyr: 1.491 ± 0.015
0.0ProXaa: 0.0 ± 0.0
Gln
2.963GlnAla: 2.963 ± 0.024
0.532GlnCys: 0.532 ± 0.008
1.743GlnAsp: 1.743 ± 0.019
1.842GlnGlu: 1.842 ± 0.017
1.35GlnPhe: 1.35 ± 0.016
1.896GlnGly: 1.896 ± 0.016
1.116GlnHis: 1.116 ± 0.017
1.854GlnIle: 1.854 ± 0.018
1.586GlnLys: 1.586 ± 0.017
3.366GlnLeu: 3.366 ± 0.023
0.82GlnMet: 0.82 ± 0.013
1.468GlnAsn: 1.468 ± 0.017
2.366GlnPro: 2.366 ± 0.024
1.869GlnGln: 1.869 ± 0.043
2.451GlnArg: 2.451 ± 0.019
3.114GlnSer: 3.114 ± 0.026
2.329GlnThr: 2.329 ± 0.02
2.048GlnVal: 2.048 ± 0.018
0.569GlnTrp: 0.569 ± 0.009
0.987GlnTyr: 0.987 ± 0.014
0.0GlnXaa: 0.0 ± 0.0
Arg
4.658ArgAla: 4.658 ± 0.031
0.913ArgCys: 0.913 ± 0.014
3.379ArgAsp: 3.379 ± 0.026
3.669ArgGlu: 3.669 ± 0.029
2.275ArgPhe: 2.275 ± 0.017
3.689ArgGly: 3.689 ± 0.025
1.817ArgHis: 1.817 ± 0.017
3.136ArgIle: 3.136 ± 0.025
3.286ArgLys: 3.286 ± 0.029
5.757ArgLeu: 5.757 ± 0.036
1.408ArgMet: 1.408 ± 0.016
2.341ArgAsn: 2.341 ± 0.02
3.484ArgPro: 3.484 ± 0.029
2.364ArgGln: 2.364 ± 0.02
5.462ArgArg: 5.462 ± 0.039
5.267ArgSer: 5.267 ± 0.041
3.774ArgThr: 3.774 ± 0.026
3.718ArgVal: 3.718 ± 0.027
1.096ArgTrp: 1.096 ± 0.012
1.559ArgTyr: 1.559 ± 0.014
0.0ArgXaa: 0.0 ± 0.0
Ser
6.764SerAla: 6.764 ± 0.047
1.067SerCys: 1.067 ± 0.015
4.464SerAsp: 4.464 ± 0.028
4.013SerGlu: 4.013 ± 0.027
3.371SerPhe: 3.371 ± 0.023
5.619SerGly: 5.619 ± 0.035
2.331SerHis: 2.331 ± 0.02
4.167SerIle: 4.167 ± 0.029
3.565SerLys: 3.565 ± 0.026
8.019SerLeu: 8.019 ± 0.042
1.754SerMet: 1.754 ± 0.018
3.174SerAsn: 3.174 ± 0.022
6.382SerPro: 6.382 ± 0.051
3.156SerGln: 3.156 ± 0.023
5.279SerArg: 5.279 ± 0.041
9.758SerSer: 9.758 ± 0.078
6.152SerThr: 6.152 ± 0.037
5.146SerVal: 5.146 ± 0.033
1.116SerTrp: 1.116 ± 0.015
1.96SerTyr: 1.96 ± 0.02
0.0SerXaa: 0.0 ± 0.0
Thr
4.934ThrAla: 4.934 ± 0.03
0.864ThrCys: 0.864 ± 0.013
2.875ThrAsp: 2.875 ± 0.024
2.834ThrGlu: 2.834 ± 0.023
2.557ThrPhe: 2.557 ± 0.019
3.86ThrGly: 3.86 ± 0.03
1.642ThrHis: 1.642 ± 0.017
3.338ThrIle: 3.338 ± 0.022
2.466ThrLys: 2.466 ± 0.02
5.962ThrLeu: 5.962 ± 0.031
1.226ThrMet: 1.226 ± 0.014
2.236ThrAsn: 2.236 ± 0.02
4.826ThrPro: 4.826 ± 0.036
2.056ThrGln: 2.056 ± 0.015
3.528ThrArg: 3.528 ± 0.026
5.986ThrSer: 5.986 ± 0.038
4.688ThrThr: 4.688 ± 0.042
3.929ThrVal: 3.929 ± 0.026
0.832ThrTrp: 0.832 ± 0.011
1.571ThrTyr: 1.571 ± 0.015
0.0ThrXaa: 0.0 ± 0.0
Val
5.197ValAla: 5.197 ± 0.032
0.928ValCys: 0.928 ± 0.013
3.856ValAsp: 3.856 ± 0.025
3.791ValGlu: 3.791 ± 0.024
2.568ValPhe: 2.568 ± 0.019
3.936ValGly: 3.936 ± 0.026
1.725ValHis: 1.725 ± 0.015
3.235ValIle: 3.235 ± 0.024
2.974ValLys: 2.974 ± 0.024
6.049ValLeu: 6.049 ± 0.032
1.372ValMet: 1.372 ± 0.012
2.344ValAsn: 2.344 ± 0.02
3.716ValPro: 3.716 ± 0.026
2.418ValGln: 2.418 ± 0.021
3.691ValArg: 3.691 ± 0.024
4.865ValSer: 4.865 ± 0.032
3.791ValThr: 3.791 ± 0.025
4.651ValVal: 4.651 ± 0.029
0.994ValTrp: 0.994 ± 0.015
1.66ValTyr: 1.66 ± 0.017
0.0ValXaa: 0.0 ± 0.0
Trp
1.063TrpAla: 1.063 ± 0.013
0.24TrpCys: 0.24 ± 0.006
0.926TrpAsp: 0.926 ± 0.016
0.821TrpGlu: 0.821 ± 0.012
0.539TrpPhe: 0.539 ± 0.01
0.842TrpGly: 0.842 ± 0.012
0.362TrpHis: 0.362 ± 0.007
0.791TrpIle: 0.791 ± 0.012
0.825TrpLys: 0.825 ± 0.011
1.301TrpLeu: 1.301 ± 0.014
0.409TrpMet: 0.409 ± 0.007
0.679TrpAsn: 0.679 ± 0.011
0.633TrpPro: 0.633 ± 0.01
0.502TrpGln: 0.502 ± 0.01
1.116TrpArg: 1.116 ± 0.014
1.206TrpSer: 1.206 ± 0.015
0.987TrpThr: 0.987 ± 0.012
0.874TrpVal: 0.874 ± 0.012
0.311TrpTrp: 0.311 ± 0.008
0.373TrpTyr: 0.373 ± 0.007
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.047TyrAla: 2.047 ± 0.019
0.441TyrCys: 0.441 ± 0.009
1.559TyrAsp: 1.559 ± 0.016
1.332TyrGlu: 1.332 ± 0.015
1.154TyrPhe: 1.154 ± 0.015
1.739TyrGly: 1.739 ± 0.02
0.74TyrHis: 0.74 ± 0.01
1.331TyrIle: 1.331 ± 0.013
0.976TyrLys: 0.976 ± 0.013
2.478TyrLeu: 2.478 ± 0.019
0.545TyrMet: 0.545 ± 0.009
0.938TyrAsn: 0.938 ± 0.012
1.507TyrPro: 1.507 ± 0.016
0.887TyrGln: 0.887 ± 0.011
1.451TyrArg: 1.451 ± 0.016
1.953TyrSer: 1.953 ± 0.016
1.504TyrThr: 1.504 ± 0.019
1.576TyrVal: 1.576 ± 0.015
0.39TyrTrp: 0.39 ± 0.008
0.801TyrTyr: 0.801 ± 0.012
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.003XaaXaa: 0.003 ± 0.002
Statistics based on 17053 proteins (6715176 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski