Amino acid dipepetide frequency for Streptomyces colonosanans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.264AlaAla: 20.264 ± 0.172	1.119AlaCys: 1.119 ± 0.026	7.965AlaAsp: 7.965 ± 0.065	8.568AlaGlu: 8.568 ± 0.106	3.486AlaPhe: 3.486 ± 0.047	11.998AlaGly: 11.998 ± 0.093	2.938AlaHis: 2.938 ± 0.041	3.813AlaIle: 3.813 ± 0.05	3.183AlaLys: 3.183 ± 0.052	14.272AlaLeu: 14.272 ± 0.115	2.591AlaMet: 2.591 ± 0.036	1.943AlaAsn: 1.943 ± 0.038	6.583AlaPro: 6.583 ± 0.081	4.004AlaGln: 4.004 ± 0.05	10.088AlaArg: 10.088 ± 0.093	6.118AlaSer: 6.118 ± 0.066	6.929AlaThr: 6.929 ± 0.07	11.909AlaVal: 11.909 ± 0.106	1.849AlaTrp: 1.849 ± 0.034	2.836AlaTyr: 2.836 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.072CysAla: 1.072 ± 0.025	0.094CysCys: 0.094 ± 0.007	0.491CysAsp: 0.491 ± 0.017	0.423CysGlu: 0.423 ± 0.015	0.223CysPhe: 0.223 ± 0.011	0.973CysGly: 0.973 ± 0.024	0.211CysHis: 0.211 ± 0.01	0.198CysIle: 0.198 ± 0.011	0.131CysLys: 0.131 ± 0.009	0.787CysLeu: 0.787 ± 0.023	0.13CysMet: 0.13 ± 0.008	0.137CysAsn: 0.137 ± 0.008	0.487CysPro: 0.487 ± 0.016	0.174CysGln: 0.174 ± 0.01	0.629CysArg: 0.629 ± 0.02	0.444CysSer: 0.444 ± 0.017	0.555CysThr: 0.555 ± 0.017	0.675CysVal: 0.675 ± 0.018	0.117CysTrp: 0.117 ± 0.007	0.161CysTyr: 0.161 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.362AspAla: 7.362 ± 0.063	0.455AspCys: 0.455 ± 0.017	3.497AspAsp: 3.497 ± 0.043	3.855AspGlu: 3.855 ± 0.054	1.635AspPhe: 1.635 ± 0.032	5.988AspGly: 5.988 ± 0.067	1.437AspHis: 1.437 ± 0.029	2.0AspIle: 2.0 ± 0.033	1.363AspLys: 1.363 ± 0.031	6.223AspLeu: 6.223 ± 0.062	0.894AspMet: 0.894 ± 0.022	1.006AspAsn: 1.006 ± 0.027	4.309AspPro: 4.309 ± 0.05	1.601AspGln: 1.601 ± 0.035	4.796AspArg: 4.796 ± 0.057	2.601AspSer: 2.601 ± 0.04	3.192AspThr: 3.192 ± 0.044	4.691AspVal: 4.691 ± 0.055	0.992AspTrp: 0.992 ± 0.025	1.139AspTyr: 1.139 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.439GluAla: 7.439 ± 0.095	0.377GluCys: 0.377 ± 0.014	2.852GluAsp: 2.852 ± 0.038	3.726GluGlu: 3.726 ± 0.06	1.458GluPhe: 1.458 ± 0.028	4.334GluGly: 4.334 ± 0.044	1.589GluHis: 1.589 ± 0.03	2.315GluIle: 2.315 ± 0.035	1.597GluLys: 1.597 ± 0.033	6.708GluLeu: 6.708 ± 0.07	0.966GluMet: 0.966 ± 0.023	1.103GluAsn: 1.103 ± 0.026	3.326GluPro: 3.326 ± 0.043	2.34GluGln: 2.34 ± 0.037	5.458GluArg: 5.458 ± 0.065	2.57GluSer: 2.57 ± 0.037	2.937GluThr: 2.937 ± 0.044	4.441GluVal: 4.441 ± 0.054	0.773GluTrp: 0.773 ± 0.023	1.147GluTyr: 1.147 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	3.651PheAla: 3.651 ± 0.052	0.268PheCys: 0.268 ± 0.012	1.932PheAsp: 1.932 ± 0.034	1.421PheGlu: 1.421 ± 0.026	0.894PhePhe: 0.894 ± 0.026	2.973PheGly: 2.973 ± 0.044	0.649PheHis: 0.649 ± 0.018	0.782PheIle: 0.782 ± 0.021	0.57PheLys: 0.57 ± 0.018	2.626PheLeu: 2.626 ± 0.043	0.428PheMet: 0.428 ± 0.016	0.553PheAsn: 0.553 ± 0.016	1.419PhePro: 1.419 ± 0.029	0.684PheGln: 0.684 ± 0.019	1.816PheArg: 1.816 ± 0.034	1.496PheSer: 1.496 ± 0.034	2.023PheThr: 2.023 ± 0.035	2.265PheVal: 2.265 ± 0.037	0.426PheTrp: 0.426 ± 0.016	0.602PheTyr: 0.602 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.465GlyAla: 10.465 ± 0.091	0.842GlyCys: 0.842 ± 0.023	4.942GlyAsp: 4.942 ± 0.053	4.948GlyGlu: 4.948 ± 0.057	2.873GlyPhe: 2.873 ± 0.042	8.319GlyGly: 8.319 ± 0.091	2.326GlyHis: 2.326 ± 0.035	3.571GlyIle: 3.571 ± 0.051	2.714GlyLys: 2.714 ± 0.046	9.237GlyLeu: 9.237 ± 0.076	2.013GlyMet: 2.013 ± 0.033	1.792GlyAsn: 1.792 ± 0.037	4.805GlyPro: 4.805 ± 0.053	2.725GlyGln: 2.725 ± 0.044	7.432GlyArg: 7.432 ± 0.063	5.281GlySer: 5.281 ± 0.055	6.075GlyThr: 6.075 ± 0.073	7.306GlyVal: 7.306 ± 0.079	1.714GlyTrp: 1.714 ± 0.035	2.271GlyTyr: 2.271 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.747HisAla: 2.747 ± 0.043	0.217HisCys: 0.217 ± 0.01	1.385HisAsp: 1.385 ± 0.027	1.295HisGlu: 1.295 ± 0.026	0.687HisPhe: 0.687 ± 0.021	2.502HisGly: 2.502 ± 0.041	0.704HisHis: 0.704 ± 0.021	0.767HisIle: 0.767 ± 0.023	0.446HisLys: 0.446 ± 0.014	2.462HisLeu: 2.462 ± 0.042	0.367HisMet: 0.367 ± 0.013	0.414HisAsn: 0.414 ± 0.013	1.825HisPro: 1.825 ± 0.036	0.68HisGln: 0.68 ± 0.019	2.087HisArg: 2.087 ± 0.036	1.052HisSer: 1.052 ± 0.023	1.409HisThr: 1.409 ± 0.028	1.767HisVal: 1.767 ± 0.03	0.417HisTrp: 0.417 ± 0.015	0.514HisTyr: 0.514 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.092IleAla: 5.092 ± 0.047	0.305IleCys: 0.305 ± 0.012	2.362IleAsp: 2.362 ± 0.04	2.126IleGlu: 2.126 ± 0.037	0.741IlePhe: 0.741 ± 0.021	3.675IleGly: 3.675 ± 0.059	0.67IleHis: 0.67 ± 0.019	0.948IleIle: 0.948 ± 0.026	0.88IleLys: 0.88 ± 0.027	2.569IleLeu: 2.569 ± 0.039	0.494IleMet: 0.494 ± 0.017	0.732IleAsn: 0.732 ± 0.021	1.906IlePro: 1.906 ± 0.031	0.814IleGln: 0.814 ± 0.023	2.458IleArg: 2.458 ± 0.043	1.738IleSer: 1.738 ± 0.032	2.393IleThr: 2.393 ± 0.036	2.961IleVal: 2.961 ± 0.044	0.392IleTrp: 0.392 ± 0.016	0.59IleTyr: 0.59 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	3.326LysAla: 3.326 ± 0.051	0.135LysCys: 0.135 ± 0.009	1.521LysAsp: 1.521 ± 0.037	1.37LysGlu: 1.37 ± 0.029	0.513LysPhe: 0.513 ± 0.017	2.114LysGly: 2.114 ± 0.041	0.5LysHis: 0.5 ± 0.016	1.008LysIle: 1.008 ± 0.026	1.022LysLys: 1.022 ± 0.03	2.24LysLeu: 2.24 ± 0.039	0.431LysMet: 0.431 ± 0.014	0.624LysAsn: 0.624 ± 0.019	1.468LysPro: 1.468 ± 0.03	0.836LysGln: 0.836 ± 0.023	1.65LysArg: 1.65 ± 0.03	1.29LysSer: 1.29 ± 0.031	1.464LysThr: 1.464 ± 0.03	2.154LysVal: 2.154 ± 0.038	0.313LysTrp: 0.313 ± 0.013	0.508LysTyr: 0.508 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	14.747LeuAla: 14.747 ± 0.109	0.854LeuCys: 0.854 ± 0.024	6.582LeuAsp: 6.582 ± 0.068	4.943LeuGlu: 4.943 ± 0.065	2.603LeuPhe: 2.603 ± 0.043	9.171LeuGly: 9.171 ± 0.076	2.379LeuHis: 2.379 ± 0.035	3.481LeuIle: 3.481 ± 0.047	2.302LeuLys: 2.302 ± 0.04	11.13LeuLeu: 11.13 ± 0.114	1.723LeuMet: 1.723 ± 0.038	1.751LeuAsn: 1.751 ± 0.034	6.387LeuPro: 6.387 ± 0.074	2.474LeuGln: 2.474 ± 0.036	8.536LeuArg: 8.536 ± 0.083	5.381LeuSer: 5.381 ± 0.054	6.809LeuThr: 6.809 ± 0.061	8.745LeuVal: 8.745 ± 0.082	1.3LeuTrp: 1.3 ± 0.029	1.861LeuTyr: 1.861 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	2.399MetAla: 2.399 ± 0.038	0.142MetCys: 0.142 ± 0.01	0.927MetAsp: 0.927 ± 0.023	0.815MetGlu: 0.815 ± 0.022	0.466MetPhe: 0.466 ± 0.017	1.371MetGly: 1.371 ± 0.033	0.39MetHis: 0.39 ± 0.016	0.688MetIle: 0.688 ± 0.019	0.454MetLys: 0.454 ± 0.017	1.783MetLeu: 1.783 ± 0.034	0.318MetMet: 0.318 ± 0.013	0.449MetAsn: 0.449 ± 0.015	1.187MetPro: 1.187 ± 0.025	0.498MetGln: 0.498 ± 0.017	1.464MetArg: 1.464 ± 0.03	1.346MetSer: 1.346 ± 0.027	1.581MetThr: 1.581 ± 0.029	1.364MetVal: 1.364 ± 0.027	0.214MetTrp: 0.214 ± 0.011	0.334MetTyr: 0.334 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.274AsnAla: 2.274 ± 0.034	0.166AsnCys: 0.166 ± 0.009	0.996AsnAsp: 0.996 ± 0.027	0.865AsnGlu: 0.865 ± 0.023	0.489AsnPhe: 0.489 ± 0.017	1.916AsnGly: 1.916 ± 0.041	0.418AsnHis: 0.418 ± 0.015	0.693AsnIle: 0.693 ± 0.019	0.479AsnLys: 0.479 ± 0.018	1.721AsnLeu: 1.721 ± 0.03	0.324AsnMet: 0.324 ± 0.015	0.395AsnAsn: 0.395 ± 0.014	1.445AsnPro: 1.445 ± 0.032	0.534AsnGln: 0.534 ± 0.016	1.297AsnArg: 1.297 ± 0.026	0.99AsnSer: 0.99 ± 0.026	1.16AsnThr: 1.16 ± 0.03	1.431AsnVal: 1.431 ± 0.031	0.308AsnTrp: 0.308 ± 0.015	0.403AsnTyr: 0.403 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.891ProAla: 7.891 ± 0.092	0.337ProCys: 0.337 ± 0.016	4.296ProAsp: 4.296 ± 0.058	4.256ProGlu: 4.256 ± 0.049	1.526ProPhe: 1.526 ± 0.032	6.225ProGly: 6.225 ± 0.067	1.433ProHis: 1.433 ± 0.033	1.375ProIle: 1.375 ± 0.031	1.334ProLys: 1.334 ± 0.028	5.283ProLeu: 5.283 ± 0.066	1.013ProMet: 1.013 ± 0.025	0.966ProAsn: 0.966 ± 0.023	3.326ProPro: 3.326 ± 0.07	1.894ProGln: 1.894 ± 0.045	3.904ProArg: 3.904 ± 0.046	3.314ProSer: 3.314 ± 0.051	3.171ProThr: 3.171 ± 0.045	5.302ProVal: 5.302 ± 0.056	0.892ProTrp: 0.892 ± 0.024	1.478ProTyr: 1.478 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.968GlnAla: 3.968 ± 0.051	0.186GlnCys: 0.186 ± 0.01	1.49GlnAsp: 1.49 ± 0.026	1.619GlnGlu: 1.619 ± 0.032	0.704GlnPhe: 0.704 ± 0.021	2.467GlnGly: 2.467 ± 0.048	0.731GlnHis: 0.731 ± 0.02	1.195GlnIle: 1.195 ± 0.026	0.729GlnLys: 0.729 ± 0.02	3.185GlnLeu: 3.185 ± 0.041	0.552GlnMet: 0.552 ± 0.018	0.543GlnAsn: 0.543 ± 0.017	1.817GlnPro: 1.817 ± 0.044	1.373GlnGln: 1.373 ± 0.041	2.509GlnArg: 2.509 ± 0.039	1.362GlnSer: 1.362 ± 0.028	1.452GlnThr: 1.452 ± 0.029	2.519GlnVal: 2.519 ± 0.033	0.495GlnTrp: 0.495 ± 0.018	0.624GlnTyr: 0.624 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	9.463ArgAla: 9.463 ± 0.086	0.624ArgCys: 0.624 ± 0.019	4.239ArgAsp: 4.239 ± 0.05	4.731ArgGlu: 4.731 ± 0.065	2.314ArgPhe: 2.314 ± 0.039	5.649ArgGly: 5.649 ± 0.057	2.161ArgHis: 2.161 ± 0.037	3.388ArgIle: 3.388 ± 0.037	1.881ArgLys: 1.881 ± 0.032	8.844ArgLeu: 8.844 ± 0.074	1.767ArgMet: 1.767 ± 0.037	1.416ArgAsn: 1.416 ± 0.03	4.775ArgPro: 4.775 ± 0.054	2.463ArgGln: 2.463 ± 0.042	7.713ArgArg: 7.713 ± 0.073	4.021ArgSer: 4.021 ± 0.046	5.343ArgThr: 5.343 ± 0.05	5.756ArgVal: 5.756 ± 0.058	1.381ArgTrp: 1.381 ± 0.028	1.808ArgTyr: 1.808 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	6.651SerAla: 6.651 ± 0.068	0.426SerCys: 0.426 ± 0.015	2.772SerAsp: 2.772 ± 0.042	2.506SerGlu: 2.506 ± 0.038	1.561SerPhe: 1.561 ± 0.029	5.792SerGly: 5.792 ± 0.064	1.088SerHis: 1.088 ± 0.024	1.561SerIle: 1.561 ± 0.032	1.224SerLys: 1.224 ± 0.027	4.917SerLeu: 4.917 ± 0.059	1.15SerMet: 1.15 ± 0.026	0.933SerAsn: 0.933 ± 0.023	3.152SerPro: 3.152 ± 0.049	1.341SerGln: 1.341 ± 0.029	3.783SerArg: 3.783 ± 0.047	3.024SerSer: 3.024 ± 0.045	3.206SerThr: 3.206 ± 0.042	4.269SerVal: 4.269 ± 0.051	0.905SerTrp: 0.905 ± 0.022	1.265SerTyr: 1.265 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	8.732ThrAla: 8.732 ± 0.075	0.458ThrCys: 0.458 ± 0.016	3.61ThrAsp: 3.61 ± 0.051	3.219ThrGlu: 3.219 ± 0.049	1.635ThrPhe: 1.635 ± 0.036	6.443ThrGly: 6.443 ± 0.059	1.297ThrHis: 1.297 ± 0.027	1.812ThrIle: 1.812 ± 0.037	1.329ThrLys: 1.329 ± 0.03	5.825ThrLeu: 5.825 ± 0.066	0.957ThrMet: 0.957 ± 0.025	1.047ThrAsn: 1.047 ± 0.024	4.084ThrPro: 4.084 ± 0.048	1.515ThrGln: 1.515 ± 0.028	3.933ThrArg: 3.933 ± 0.052	3.306ThrSer: 3.306 ± 0.045	3.823ThrThr: 3.823 ± 0.058	6.021ThrVal: 6.021 ± 0.059	0.922ThrTrp: 0.922 ± 0.025	1.4ThrTyr: 1.4 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.418ValAla: 10.418 ± 0.089	0.768ValCys: 0.768 ± 0.02	4.826ValAsp: 4.826 ± 0.058	4.732ValGlu: 4.732 ± 0.06	2.494ValPhe: 2.494 ± 0.046	6.343ValGly: 6.343 ± 0.061	2.036ValHis: 2.036 ± 0.033	3.128ValIle: 3.128 ± 0.041	1.972ValLys: 1.972 ± 0.036	9.425ValLeu: 9.425 ± 0.085	1.488ValMet: 1.488 ± 0.033	1.682ValAsn: 1.682 ± 0.034	5.062ValPro: 5.062 ± 0.047	2.24ValGln: 2.24 ± 0.033	6.999ValArg: 6.999 ± 0.074	4.277ValSer: 4.277 ± 0.051	5.573ValThr: 5.573 ± 0.062	7.776ValVal: 7.776 ± 0.089	1.151ValTrp: 1.151 ± 0.024	1.64ValTyr: 1.64 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.672TrpAla: 1.672 ± 0.031	0.163TrpCys: 0.163 ± 0.008	0.778TrpAsp: 0.778 ± 0.02	0.738TrpGlu: 0.738 ± 0.022	0.507TrpPhe: 0.507 ± 0.018	1.106TrpGly: 1.106 ± 0.026	0.403TrpHis: 0.403 ± 0.017	0.572TrpIle: 0.572 ± 0.019	0.404TrpLys: 0.404 ± 0.015	1.803TrpLeu: 1.803 ± 0.035	0.295TrpMet: 0.295 ± 0.011	0.412TrpAsn: 0.412 ± 0.016	0.771TrpPro: 0.771 ± 0.022	0.648TrpGln: 0.648 ± 0.018	1.34TrpArg: 1.34 ± 0.026	0.892TrpSer: 0.892 ± 0.02	1.038TrpThr: 1.038 ± 0.026	0.986TrpVal: 0.986 ± 0.024	0.334TrpTrp: 0.334 ± 0.014	0.387TrpTyr: 0.387 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.825TyrAla: 2.825 ± 0.037	0.172TyrCys: 0.172 ± 0.009	1.572TyrAsp: 1.572 ± 0.032	1.301TyrGlu: 1.301 ± 0.025	0.669TyrPhe: 0.669 ± 0.02	2.292TyrGly: 2.292 ± 0.042	0.385TyrHis: 0.385 ± 0.016	0.55TyrIle: 0.55 ± 0.018	0.472TyrLys: 0.472 ± 0.018	2.12TyrLeu: 2.12 ± 0.038	0.288TyrMet: 0.288 ± 0.014	0.407TyrAsn: 0.407 ± 0.015	1.084TyrPro: 1.084 ± 0.025	0.68TyrGln: 0.68 ± 0.019	1.844TyrArg: 1.844 ± 0.033	1.023TyrSer: 1.023 ± 0.021	1.237TyrThr: 1.237 ± 0.029	1.691TyrVal: 1.691 ± 0.028	0.355TyrTrp: 0.355 ± 0.014	0.468TyrTyr: 0.468 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5856 proteins (1867334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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