Amino acid dipepetide frequency for Streptomyces griseocarneus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.164AlaAla: 22.164 ± 0.174	1.236AlaCys: 1.236 ± 0.024	8.411AlaAsp: 8.411 ± 0.074	8.874AlaGlu: 8.874 ± 0.099	3.744AlaPhe: 3.744 ± 0.045	12.748AlaGly: 12.748 ± 0.091	3.079AlaHis: 3.079 ± 0.039	3.295AlaIle: 3.295 ± 0.048	2.808AlaLys: 2.808 ± 0.051	15.029AlaLeu: 15.029 ± 0.112	2.556AlaMet: 2.556 ± 0.036	1.855AlaAsn: 1.855 ± 0.032	7.523AlaPro: 7.523 ± 0.078	3.639AlaGln: 3.639 ± 0.046	10.741AlaArg: 10.741 ± 0.093	5.809AlaSer: 5.809 ± 0.058	6.975AlaThr: 6.975 ± 0.056	12.699AlaVal: 12.699 ± 0.087	1.94AlaTrp: 1.94 ± 0.032	2.751AlaTyr: 2.751 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.273CysAla: 1.273 ± 0.025	0.097CysCys: 0.097 ± 0.006	0.531CysAsp: 0.531 ± 0.015	0.441CysGlu: 0.441 ± 0.016	0.247CysPhe: 0.247 ± 0.01	1.059CysGly: 1.059 ± 0.021	0.242CysHis: 0.242 ± 0.011	0.174CysIle: 0.174 ± 0.007	0.127CysLys: 0.127 ± 0.009	0.817CysLeu: 0.817 ± 0.019	0.141CysMet: 0.141 ± 0.007	0.14CysAsn: 0.14 ± 0.007	0.586CysPro: 0.586 ± 0.017	0.179CysGln: 0.179 ± 0.008	0.703CysArg: 0.703 ± 0.017	0.493CysSer: 0.493 ± 0.014	0.54CysThr: 0.54 ± 0.014	0.729CysVal: 0.729 ± 0.018	0.136CysTrp: 0.136 ± 0.008	0.158CysTyr: 0.158 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.827AspAla: 7.827 ± 0.081	0.45AspCys: 0.45 ± 0.015	3.423AspAsp: 3.423 ± 0.047	3.796AspGlu: 3.796 ± 0.05	1.601AspPhe: 1.601 ± 0.029	6.519AspGly: 6.519 ± 0.07	1.467AspHis: 1.467 ± 0.027	1.823AspIle: 1.823 ± 0.028	1.212AspLys: 1.212 ± 0.026	5.97AspLeu: 5.97 ± 0.053	0.764AspMet: 0.764 ± 0.016	0.87AspAsn: 0.87 ± 0.021	4.429AspPro: 4.429 ± 0.044	1.397AspGln: 1.397 ± 0.023	5.061AspArg: 5.061 ± 0.048	2.457AspSer: 2.457 ± 0.036	3.119AspThr: 3.119 ± 0.041	4.551AspVal: 4.551 ± 0.052	0.995AspTrp: 0.995 ± 0.024	1.089AspTyr: 1.089 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	7.575GluAla: 7.575 ± 0.08	0.439GluCys: 0.439 ± 0.014	2.797GluAsp: 2.797 ± 0.037	3.631GluGlu: 3.631 ± 0.052	1.461GluPhe: 1.461 ± 0.026	4.322GluGly: 4.322 ± 0.048	1.64GluHis: 1.64 ± 0.031	2.178GluIle: 2.178 ± 0.034	1.44GluLys: 1.44 ± 0.03	6.931GluLeu: 6.931 ± 0.075	0.84GluMet: 0.84 ± 0.02	1.008GluAsn: 1.008 ± 0.021	3.327GluPro: 3.327 ± 0.046	2.16GluGln: 2.16 ± 0.036	5.66GluArg: 5.66 ± 0.061	2.409GluSer: 2.409 ± 0.033	2.838GluThr: 2.838 ± 0.033	4.137GluVal: 4.137 ± 0.051	0.777GluTrp: 0.777 ± 0.018	1.035GluTyr: 1.035 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.786PheAla: 3.786 ± 0.039	0.295PheCys: 0.295 ± 0.011	1.879PheAsp: 1.879 ± 0.03	1.366PheGlu: 1.366 ± 0.023	0.867PhePhe: 0.867 ± 0.021	2.957PheGly: 2.957 ± 0.041	0.69PheHis: 0.69 ± 0.018	0.672PheIle: 0.672 ± 0.015	0.475PheLys: 0.475 ± 0.013	2.668PheLeu: 2.668 ± 0.039	0.387PheMet: 0.387 ± 0.015	0.506PheAsn: 0.506 ± 0.014	1.461PhePro: 1.461 ± 0.021	0.66PheGln: 0.66 ± 0.015	1.932PheArg: 1.932 ± 0.029	1.468PheSer: 1.468 ± 0.027	2.095PheThr: 2.095 ± 0.033	2.148PheVal: 2.148 ± 0.033	0.424PheTrp: 0.424 ± 0.015	0.543PheTyr: 0.543 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.89GlyAla: 10.89 ± 0.082	0.886GlyCys: 0.886 ± 0.024	5.119GlyAsp: 5.119 ± 0.05	5.075GlyGlu: 5.075 ± 0.059	2.844GlyPhe: 2.844 ± 0.036	8.791GlyGly: 8.791 ± 0.072	2.559GlyHis: 2.559 ± 0.037	3.512GlyIle: 3.512 ± 0.044	2.513GlyLys: 2.513 ± 0.044	9.591GlyLeu: 9.591 ± 0.072	2.052GlyMet: 2.052 ± 0.036	1.729GlyAsn: 1.729 ± 0.034	5.488GlyPro: 5.488 ± 0.059	2.708GlyGln: 2.708 ± 0.034	7.978GlyArg: 7.978 ± 0.076	5.191GlySer: 5.191 ± 0.048	6.591GlyThr: 6.591 ± 0.06	7.381GlyVal: 7.381 ± 0.07	1.705GlyTrp: 1.705 ± 0.029	2.153GlyTyr: 2.153 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	2.931HisAla: 2.931 ± 0.035	0.262HisCys: 0.262 ± 0.01	1.416HisAsp: 1.416 ± 0.022	1.263HisGlu: 1.263 ± 0.024	0.676HisPhe: 0.676 ± 0.016	2.61HisGly: 2.61 ± 0.033	0.75HisHis: 0.75 ± 0.019	0.729HisIle: 0.729 ± 0.017	0.379HisLys: 0.379 ± 0.012	2.532HisLeu: 2.532 ± 0.031	0.354HisMet: 0.354 ± 0.011	0.375HisAsn: 0.375 ± 0.013	1.957HisPro: 1.957 ± 0.029	0.664HisGln: 0.664 ± 0.017	2.322HisArg: 2.322 ± 0.038	1.109HisSer: 1.109 ± 0.022	1.468HisThr: 1.468 ± 0.025	1.793HisVal: 1.793 ± 0.03	0.411HisTrp: 0.411 ± 0.015	0.537HisTyr: 0.537 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.602IleAla: 4.602 ± 0.046	0.297IleCys: 0.297 ± 0.011	2.051IleAsp: 2.051 ± 0.034	1.814IleGlu: 1.814 ± 0.029	0.636IlePhe: 0.636 ± 0.018	3.363IleGly: 3.363 ± 0.045	0.616IleHis: 0.616 ± 0.015	0.791IleIle: 0.791 ± 0.023	0.718IleLys: 0.718 ± 0.02	2.225IleLeu: 2.225 ± 0.032	0.403IleMet: 0.403 ± 0.015	0.63IleAsn: 0.63 ± 0.017	1.785IlePro: 1.785 ± 0.03	0.65IleGln: 0.65 ± 0.016	2.268IleArg: 2.268 ± 0.032	1.663IleSer: 1.663 ± 0.028	2.099IleThr: 2.099 ± 0.034	2.544IleVal: 2.544 ± 0.04	0.357IleTrp: 0.357 ± 0.011	0.482IleTyr: 0.482 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.927LysAla: 2.927 ± 0.051	0.135LysCys: 0.135 ± 0.007	1.32LysAsp: 1.32 ± 0.032	1.167LysGlu: 1.167 ± 0.027	0.436LysPhe: 0.436 ± 0.014	1.834LysGly: 1.834 ± 0.034	0.434LysHis: 0.434 ± 0.012	0.786LysIle: 0.786 ± 0.021	0.856LysLys: 0.856 ± 0.032	1.953LysLeu: 1.953 ± 0.032	0.384LysMet: 0.384 ± 0.014	0.539LysAsn: 0.539 ± 0.018	1.374LysPro: 1.374 ± 0.029	0.699LysGln: 0.699 ± 0.019	1.501LysArg: 1.501 ± 0.028	1.172LysSer: 1.172 ± 0.027	1.233LysThr: 1.233 ± 0.029	1.789LysVal: 1.789 ± 0.033	0.267LysTrp: 0.267 ± 0.011	0.435LysTyr: 0.435 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	15.433LeuAla: 15.433 ± 0.099	0.943LeuCys: 0.943 ± 0.021	6.649LeuAsp: 6.649 ± 0.06	4.692LeuGlu: 4.692 ± 0.051	2.654LeuPhe: 2.654 ± 0.041	9.216LeuGly: 9.216 ± 0.072	2.486LeuHis: 2.486 ± 0.035	3.03LeuIle: 3.03 ± 0.045	1.91LeuLys: 1.91 ± 0.03	11.375LeuLeu: 11.375 ± 0.094	1.642LeuMet: 1.642 ± 0.03	1.544LeuAsn: 1.544 ± 0.026	6.764LeuPro: 6.764 ± 0.058	2.119LeuGln: 2.119 ± 0.034	9.159LeuArg: 9.159 ± 0.073	5.315LeuSer: 5.315 ± 0.049	6.865LeuThr: 6.865 ± 0.061	8.629LeuVal: 8.629 ± 0.063	1.379LeuTrp: 1.379 ± 0.024	1.879LeuTyr: 1.879 ± 0.029	0.0LeuXaa: 0.0 ± 0.0
Met	2.341MetAla: 2.341 ± 0.034	0.156MetCys: 0.156 ± 0.008	0.912MetAsp: 0.912 ± 0.021	0.754MetGlu: 0.754 ± 0.017	0.429MetPhe: 0.429 ± 0.016	1.361MetGly: 1.361 ± 0.027	0.346MetHis: 0.346 ± 0.012	0.614MetIle: 0.614 ± 0.017	0.39MetLys: 0.39 ± 0.013	1.645MetLeu: 1.645 ± 0.028	0.293MetMet: 0.293 ± 0.013	0.416MetAsn: 0.416 ± 0.014	1.147MetPro: 1.147 ± 0.023	0.439MetGln: 0.439 ± 0.014	1.49MetArg: 1.49 ± 0.021	1.292MetSer: 1.292 ± 0.027	1.518MetThr: 1.518 ± 0.031	1.196MetVal: 1.196 ± 0.025	0.22MetTrp: 0.22 ± 0.01	0.318MetTyr: 0.318 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.174AsnAla: 2.174 ± 0.031	0.155AsnCys: 0.155 ± 0.008	0.918AsnAsp: 0.918 ± 0.022	0.746AsnGlu: 0.746 ± 0.019	0.457AsnPhe: 0.457 ± 0.014	1.911AsnGly: 1.911 ± 0.034	0.387AsnHis: 0.387 ± 0.012	0.618AsnIle: 0.618 ± 0.017	0.391AsnLys: 0.391 ± 0.014	1.555AsnLeu: 1.555 ± 0.026	0.278AsnMet: 0.278 ± 0.011	0.384AsnAsn: 0.384 ± 0.015	1.302AsnPro: 1.302 ± 0.026	0.433AsnGln: 0.433 ± 0.016	1.239AsnArg: 1.239 ± 0.025	0.888AsnSer: 0.888 ± 0.023	1.046AsnThr: 1.046 ± 0.023	1.268AsnVal: 1.268 ± 0.024	0.278AsnTrp: 0.278 ± 0.011	0.382AsnTyr: 0.382 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.812ProAla: 8.812 ± 0.089	0.411ProCys: 0.411 ± 0.012	4.572ProAsp: 4.572 ± 0.055	4.462ProGlu: 4.462 ± 0.053	1.601ProPhe: 1.601 ± 0.027	7.082ProGly: 7.082 ± 0.076	1.531ProHis: 1.531 ± 0.024	1.161ProIle: 1.161 ± 0.023	1.205ProLys: 1.205 ± 0.025	5.556ProLeu: 5.556 ± 0.053	1.036ProMet: 1.036 ± 0.021	0.874ProAsn: 0.874 ± 0.021	3.69ProPro: 3.69 ± 0.064	1.773ProGln: 1.773 ± 0.033	4.337ProArg: 4.337 ± 0.047	3.243ProSer: 3.243 ± 0.043	3.123ProThr: 3.123 ± 0.039	5.742ProVal: 5.742 ± 0.054	1.002ProTrp: 1.002 ± 0.022	1.461ProTyr: 1.461 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.659GlnAla: 3.659 ± 0.049	0.203GlnCys: 0.203 ± 0.01	1.432GlnAsp: 1.432 ± 0.025	1.46GlnGlu: 1.46 ± 0.028	0.644GlnPhe: 0.644 ± 0.017	2.32GlnGly: 2.32 ± 0.032	0.723GlnHis: 0.723 ± 0.017	0.982GlnIle: 0.982 ± 0.019	0.581GlnLys: 0.581 ± 0.017	2.852GlnLeu: 2.852 ± 0.039	0.494GlnMet: 0.494 ± 0.015	0.461GlnAsn: 0.461 ± 0.013	1.63GlnPro: 1.63 ± 0.036	1.237GlnGln: 1.237 ± 0.031	2.448GlnArg: 2.448 ± 0.035	1.19GlnSer: 1.19 ± 0.024	1.233GlnThr: 1.233 ± 0.027	2.146GlnVal: 2.146 ± 0.029	0.487GlnTrp: 0.487 ± 0.013	0.592GlnTyr: 0.592 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.411ArgAla: 10.411 ± 0.073	0.731ArgCys: 0.731 ± 0.017	4.329ArgAsp: 4.329 ± 0.049	4.938ArgGlu: 4.938 ± 0.054	2.385ArgPhe: 2.385 ± 0.029	5.967ArgGly: 5.967 ± 0.053	2.362ArgHis: 2.362 ± 0.034	3.129ArgIle: 3.129 ± 0.036	1.759ArgLys: 1.759 ± 0.029	9.084ArgLeu: 9.084 ± 0.079	1.8ArgMet: 1.8 ± 0.028	1.4ArgAsn: 1.4 ± 0.027	5.289ArgPro: 5.289 ± 0.058	2.389ArgGln: 2.389 ± 0.034	8.019ArgArg: 8.019 ± 0.079	4.073ArgSer: 4.073 ± 0.043	5.612ArgThr: 5.612 ± 0.052	6.063ArgVal: 6.063 ± 0.067	1.426ArgTrp: 1.426 ± 0.027	1.83ArgTyr: 1.83 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.67SerAla: 6.67 ± 0.059	0.451SerCys: 0.451 ± 0.013	2.515SerAsp: 2.515 ± 0.031	2.265SerGlu: 2.265 ± 0.033	1.53SerPhe: 1.53 ± 0.025	5.892SerGly: 5.892 ± 0.05	1.038SerHis: 1.038 ± 0.025	1.306SerIle: 1.306 ± 0.026	1.001SerLys: 1.001 ± 0.022	4.877SerLeu: 4.877 ± 0.053	1.029SerMet: 1.029 ± 0.02	0.825SerAsn: 0.825 ± 0.02	3.344SerPro: 3.344 ± 0.039	1.148SerGln: 1.148 ± 0.022	3.707SerArg: 3.707 ± 0.036	2.894SerSer: 2.894 ± 0.043	2.851SerThr: 2.851 ± 0.045	4.251SerVal: 4.251 ± 0.045	0.945SerTrp: 0.945 ± 0.022	1.184SerTyr: 1.184 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.167ThrAla: 9.167 ± 0.082	0.472ThrCys: 0.472 ± 0.016	3.566ThrAsp: 3.566 ± 0.043	3.189ThrGlu: 3.189 ± 0.037	1.57ThrPhe: 1.57 ± 0.027	7.046ThrGly: 7.046 ± 0.069	1.274ThrHis: 1.274 ± 0.026	1.556ThrIle: 1.556 ± 0.024	1.074ThrLys: 1.074 ± 0.027	5.633ThrLeu: 5.633 ± 0.048	0.906ThrMet: 0.906 ± 0.021	0.935ThrAsn: 0.935 ± 0.02	4.132ThrPro: 4.132 ± 0.042	1.266ThrGln: 1.266 ± 0.025	3.952ThrArg: 3.952 ± 0.039	3.001ThrSer: 3.001 ± 0.036	3.652ThrThr: 3.652 ± 0.048	6.015ThrVal: 6.015 ± 0.051	0.939ThrTrp: 0.939 ± 0.02	1.343ThrTyr: 1.343 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.656ValAla: 10.656 ± 0.082	0.802ValCys: 0.802 ± 0.019	4.783ValAsp: 4.783 ± 0.054	4.621ValGlu: 4.621 ± 0.049	2.388ValPhe: 2.388 ± 0.034	6.429ValGly: 6.429 ± 0.061	2.078ValHis: 2.078 ± 0.028	2.659ValIle: 2.659 ± 0.04	1.652ValLys: 1.652 ± 0.027	9.531ValLeu: 9.531 ± 0.075	1.388ValMet: 1.388 ± 0.026	1.547ValAsn: 1.547 ± 0.028	5.491ValPro: 5.491 ± 0.056	2.046ValGln: 2.046 ± 0.032	7.223ValArg: 7.223 ± 0.066	4.201ValSer: 4.201 ± 0.044	5.678ValThr: 5.678 ± 0.052	7.816ValVal: 7.816 ± 0.069	1.074ValTrp: 1.074 ± 0.021	1.463ValTyr: 1.463 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.733TrpAla: 1.733 ± 0.029	0.19TrpCys: 0.19 ± 0.009	0.834TrpAsp: 0.834 ± 0.023	0.778TrpGlu: 0.778 ± 0.02	0.504TrpPhe: 0.504 ± 0.014	1.101TrpGly: 1.101 ± 0.023	0.413TrpHis: 0.413 ± 0.015	0.523TrpIle: 0.523 ± 0.015	0.37TrpLys: 0.37 ± 0.014	1.825TrpLeu: 1.825 ± 0.028	0.28TrpMet: 0.28 ± 0.01	0.397TrpAsn: 0.397 ± 0.013	0.855TrpPro: 0.855 ± 0.023	0.619TrpGln: 0.619 ± 0.018	1.382TrpArg: 1.382 ± 0.027	0.923TrpSer: 0.923 ± 0.023	1.046TrpThr: 1.046 ± 0.024	0.998TrpVal: 0.998 ± 0.02	0.355TrpTrp: 0.355 ± 0.012	0.372TrpTyr: 0.372 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.844TyrAla: 2.844 ± 0.03	0.203TyrCys: 0.203 ± 0.009	1.364TyrAsp: 1.364 ± 0.024	1.272TyrGlu: 1.272 ± 0.026	0.604TyrPhe: 0.604 ± 0.014	2.229TyrGly: 2.229 ± 0.032	0.424TyrHis: 0.424 ± 0.013	0.457TyrIle: 0.457 ± 0.015	0.379TyrLys: 0.379 ± 0.014	2.033TyrLeu: 2.033 ± 0.032	0.248TyrMet: 0.248 ± 0.011	0.375TyrAsn: 0.375 ± 0.015	1.094TyrPro: 1.094 ± 0.02	0.554TyrGln: 0.554 ± 0.016	1.872TyrArg: 1.872 ± 0.032	0.934TyrSer: 0.934 ± 0.021	1.107TyrThr: 1.107 ± 0.022	1.632TyrVal: 1.632 ± 0.028	0.383TyrTrp: 0.383 ± 0.013	0.422TyrTyr: 0.422 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7467 proteins (2492201 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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