Amino acid dipepetide frequency for secondary endosymbiont of Heteropsylla cubana

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.916AlaAla: 4.916 ± 0.195
1.001AlaCys: 1.001 ± 0.073
2.865AlaAsp: 2.865 ± 0.13
3.434AlaGlu: 3.434 ± 0.152
2.455AlaPhe: 2.455 ± 0.122
4.123AlaGly: 4.123 ± 0.152
1.52AlaHis: 1.52 ± 0.086
5.938AlaIle: 5.938 ± 0.184
3.893AlaLys: 3.893 ± 0.151
7.737AlaLeu: 7.737 ± 0.234
1.722AlaMet: 1.722 ± 0.091
3.078AlaAsn: 3.078 ± 0.144
1.826AlaPro: 1.826 ± 0.1
2.242AlaGln: 2.242 ± 0.104
3.817AlaArg: 3.817 ± 0.179
3.751AlaSer: 3.751 ± 0.132
3.412AlaThr: 3.412 ± 0.142
3.981AlaVal: 3.981 ± 0.194
0.694AlaTrp: 0.694 ± 0.067
1.892AlaTyr: 1.892 ± 0.096
0.0AlaXaa: 0.0 ± 0.0
Cys
0.787CysAla: 0.787 ± 0.073
0.191CysCys: 0.191 ± 0.03
0.749CysAsp: 0.749 ± 0.055
0.509CysGlu: 0.509 ± 0.063
0.651CysPhe: 0.651 ± 0.058
1.033CysGly: 1.033 ± 0.09
0.421CysHis: 0.421 ± 0.048
1.099CysIle: 1.099 ± 0.08
0.727CysLys: 0.727 ± 0.069
1.367CysLeu: 1.367 ± 0.079
0.257CysMet: 0.257 ± 0.037
0.673CysAsn: 0.673 ± 0.061
0.536CysPro: 0.536 ± 0.058
0.629CysGln: 0.629 ± 0.057
0.7CysArg: 0.7 ± 0.063
0.919CysSer: 0.919 ± 0.075
0.612CysThr: 0.612 ± 0.051
0.607CysVal: 0.607 ± 0.055
0.219CysTrp: 0.219 ± 0.034
0.503CysTyr: 0.503 ± 0.04
0.0CysXaa: 0.0 ± 0.0
Asp
3.013AspAla: 3.013 ± 0.134
0.607AspCys: 0.607 ± 0.056
1.865AspAsp: 1.865 ± 0.094
2.559AspGlu: 2.559 ± 0.136
2.368AspPhe: 2.368 ± 0.116
2.652AspGly: 2.652 ± 0.135
1.197AspHis: 1.197 ± 0.075
5.118AspIle: 5.118 ± 0.174
3.013AspLys: 3.013 ± 0.122
4.768AspLeu: 4.768 ± 0.157
1.187AspMet: 1.187 ± 0.095
2.417AspAsn: 2.417 ± 0.123
1.706AspPro: 1.706 ± 0.095
1.613AspGln: 1.613 ± 0.098
2.286AspArg: 2.286 ± 0.128
2.75AspSer: 2.75 ± 0.108
2.433AspThr: 2.433 ± 0.133
3.199AspVal: 3.199 ± 0.16
0.585AspTrp: 0.585 ± 0.058
1.947AspTyr: 1.947 ± 0.111
0.0AspXaa: 0.0 ± 0.0
Glu
3.877GluAla: 3.877 ± 0.146
0.514GluCys: 0.514 ± 0.056
2.537GluAsp: 2.537 ± 0.138
3.773GluGlu: 3.773 ± 0.193
1.881GluPhe: 1.881 ± 0.12
3.106GluGly: 3.106 ± 0.133
1.29GluHis: 1.29 ± 0.095
5.184GluIle: 5.184 ± 0.17
4.856GluLys: 4.856 ± 0.157
5.561GluLeu: 5.561 ± 0.194
1.465GluMet: 1.465 ± 0.094
2.838GluAsn: 2.838 ± 0.122
1.356GluPro: 1.356 ± 0.077
2.515GluGln: 2.515 ± 0.138
3.281GluArg: 3.281 ± 0.151
2.838GluSer: 2.838 ± 0.125
2.641GluThr: 2.641 ± 0.131
3.456GluVal: 3.456 ± 0.141
0.487GluTrp: 0.487 ± 0.052
1.526GluTyr: 1.526 ± 0.086
0.0GluXaa: 0.0 ± 0.0
Phe
1.81PheAla: 1.81 ± 0.108
0.716PheCys: 0.716 ± 0.061
1.919PheAsp: 1.919 ± 0.103
1.793PheGlu: 1.793 ± 0.108
2.28PhePhe: 2.28 ± 0.127
2.811PheGly: 2.811 ± 0.12
0.957PheHis: 0.957 ± 0.07
4.041PheIle: 4.041 ± 0.164
2.018PheLys: 2.018 ± 0.11
4.199PheLeu: 4.199 ± 0.166
0.908PheMet: 0.908 ± 0.071
2.4PheAsn: 2.4 ± 0.108
1.684PhePro: 1.684 ± 0.098
1.536PheGln: 1.536 ± 0.097
1.897PheArg: 1.897 ± 0.11
4.238PheSer: 4.238 ± 0.149
1.832PheThr: 1.832 ± 0.094
2.018PheVal: 2.018 ± 0.121
0.492PheTrp: 0.492 ± 0.063
1.586PheTyr: 1.586 ± 0.103
0.0PheXaa: 0.0 ± 0.0
Gly
3.735GlyAla: 3.735 ± 0.155
1.012GlyCys: 1.012 ± 0.074
3.068GlyAsp: 3.068 ± 0.135
3.27GlyGlu: 3.27 ± 0.146
2.756GlyPhe: 2.756 ± 0.115
4.27GlyGly: 4.27 ± 0.176
1.651GlyHis: 1.651 ± 0.104
5.955GlyIle: 5.955 ± 0.19
5.047GlyLys: 5.047 ± 0.141
6.026GlyLeu: 6.026 ± 0.221
1.711GlyMet: 1.711 ± 0.105
2.893GlyAsn: 2.893 ± 0.146
1.526GlyPro: 1.526 ± 0.08
2.236GlyGln: 2.236 ± 0.133
3.385GlyArg: 3.385 ± 0.157
3.8GlySer: 3.8 ± 0.173
2.996GlyThr: 2.996 ± 0.133
4.249GlyVal: 4.249 ± 0.182
0.705GlyTrp: 0.705 ± 0.071
2.444GlyTyr: 2.444 ± 0.107
0.0GlyXaa: 0.0 ± 0.0
His
1.706HisAla: 1.706 ± 0.095
0.383HisCys: 0.383 ± 0.05
0.99HisAsp: 0.99 ± 0.073
1.028HisGlu: 1.028 ± 0.067
1.312HisPhe: 1.312 ± 0.092
1.509HisGly: 1.509 ± 0.101
0.815HisHis: 0.815 ± 0.078
2.171HisIle: 2.171 ± 0.116
1.23HisLys: 1.23 ± 0.075
2.745HisLeu: 2.745 ± 0.135
0.519HisMet: 0.519 ± 0.053
1.323HisAsn: 1.323 ± 0.089
1.34HisPro: 1.34 ± 0.099
1.187HisGln: 1.187 ± 0.084
1.34HisArg: 1.34 ± 0.084
1.405HisSer: 1.405 ± 0.075
1.345HisThr: 1.345 ± 0.095
1.411HisVal: 1.411 ± 0.096
0.317HisTrp: 0.317 ± 0.041
1.121HisTyr: 1.121 ± 0.071
0.0HisXaa: 0.0 ± 0.0
Ile
6.551IleAla: 6.551 ± 0.2
1.219IleCys: 1.219 ± 0.082
4.97IleAsp: 4.97 ± 0.155
4.954IleGlu: 4.954 ± 0.19
3.505IlePhe: 3.505 ± 0.166
5.823IleGly: 5.823 ± 0.183
2.056IleHis: 2.056 ± 0.114
7.464IleIle: 7.464 ± 0.222
5.801IleLys: 5.801 ± 0.178
8.672IleLeu: 8.672 ± 0.234
1.876IleMet: 1.876 ± 0.125
5.32IleAsn: 5.32 ± 0.183
3.647IlePro: 3.647 ± 0.125
3.106IleGln: 3.106 ± 0.134
4.752IleArg: 4.752 ± 0.168
6.277IleSer: 6.277 ± 0.192
5.495IleThr: 5.495 ± 0.192
4.987IleVal: 4.987 ± 0.166
0.798IleTrp: 0.798 ± 0.067
2.69IleTyr: 2.69 ± 0.128
0.0IleXaa: 0.0 ± 0.0
Lys
3.696LysAla: 3.696 ± 0.143
0.629LysCys: 0.629 ± 0.054
2.668LysAsp: 2.668 ± 0.136
4.178LysGlu: 4.178 ± 0.155
1.914LysPhe: 1.914 ± 0.109
3.439LysGly: 3.439 ± 0.15
1.438LysHis: 1.438 ± 0.083
6.168LysIle: 6.168 ± 0.183
6.638LysLys: 6.638 ± 0.207
6.392LysLeu: 6.392 ± 0.179
1.706LysMet: 1.706 ± 0.108
4.44LysAsn: 4.44 ± 0.178
2.149LysPro: 2.149 ± 0.108
2.953LysGln: 2.953 ± 0.123
3.718LysArg: 3.718 ± 0.143
3.844LysSer: 3.844 ± 0.14
3.784LysThr: 3.784 ± 0.141
4.013LysVal: 4.013 ± 0.146
0.591LysTrp: 0.591 ± 0.053
1.865LysTyr: 1.865 ± 0.11
0.0LysXaa: 0.0 ± 0.0
Leu
7.086LeuAla: 7.086 ± 0.199
1.367LeuCys: 1.367 ± 0.086
5.462LeuAsp: 5.462 ± 0.168
6.408LeuGlu: 6.408 ± 0.189
4.046LeuPhe: 4.046 ± 0.171
6.359LeuGly: 6.359 ± 0.173
2.86LeuHis: 2.86 ± 0.121
8.847LeuIle: 8.847 ± 0.249
6.737LeuLys: 6.737 ± 0.209
11.428LeuLeu: 11.428 ± 0.361
2.712LeuMet: 2.712 ± 0.146
5.413LeuAsn: 5.413 ± 0.173
4.604LeuPro: 4.604 ± 0.158
4.046LeuGln: 4.046 ± 0.156
5.916LeuArg: 5.916 ± 0.21
7.939LeuSer: 7.939 ± 0.215
5.807LeuThr: 5.807 ± 0.163
6.157LeuVal: 6.157 ± 0.173
1.143LeuTrp: 1.143 ± 0.077
3.21LeuTyr: 3.21 ± 0.125
0.0LeuXaa: 0.0 ± 0.0
Met
1.908MetAla: 1.908 ± 0.096
0.202MetCys: 0.202 ± 0.034
0.957MetAsp: 0.957 ± 0.086
1.214MetGlu: 1.214 ± 0.082
0.891MetPhe: 0.891 ± 0.07
1.52MetGly: 1.52 ± 0.096
0.596MetHis: 0.596 ± 0.051
1.766MetIle: 1.766 ± 0.103
1.64MetLys: 1.64 ± 0.085
2.964MetLeu: 2.964 ± 0.141
0.705MetMet: 0.705 ± 0.064
1.258MetAsn: 1.258 ± 0.079
0.973MetPro: 0.973 ± 0.068
1.137MetGln: 1.137 ± 0.076
1.597MetArg: 1.597 ± 0.099
1.427MetSer: 1.427 ± 0.091
1.356MetThr: 1.356 ± 0.092
1.547MetVal: 1.547 ± 0.088
0.202MetTrp: 0.202 ± 0.039
0.591MetTyr: 0.591 ± 0.052
0.0MetXaa: 0.0 ± 0.0
Asn
2.953AsnAla: 2.953 ± 0.134
0.656AsnCys: 0.656 ± 0.056
2.395AsnAsp: 2.395 ± 0.122
2.789AsnGlu: 2.789 ± 0.113
2.056AsnPhe: 2.056 ± 0.116
2.909AsnGly: 2.909 ± 0.138
1.482AsnHis: 1.482 ± 0.085
5.014AsnIle: 5.014 ± 0.177
3.778AsnLys: 3.778 ± 0.154
5.424AsnLeu: 5.424 ± 0.203
1.203AsnMet: 1.203 ± 0.082
3.297AsnAsn: 3.297 ± 0.154
2.373AsnPro: 2.373 ± 0.113
2.28AsnGln: 2.28 ± 0.109
2.876AsnArg: 2.876 ± 0.123
2.909AsnSer: 2.909 ± 0.135
2.761AsnThr: 2.761 ± 0.129
2.756AsnVal: 2.756 ± 0.125
0.738AsnTrp: 0.738 ± 0.07
1.744AsnTyr: 1.744 ± 0.09
0.0AsnXaa: 0.0 ± 0.0
Pro
1.897ProAla: 1.897 ± 0.095
0.394ProCys: 0.394 ± 0.044
1.87ProAsp: 1.87 ± 0.113
2.422ProGlu: 2.422 ± 0.104
1.657ProPhe: 1.657 ± 0.102
2.433ProGly: 2.433 ± 0.12
0.886ProHis: 0.886 ± 0.073
3.39ProIle: 3.39 ± 0.134
2.242ProLys: 2.242 ± 0.111
4.095ProLeu: 4.095 ± 0.124
0.962ProMet: 0.962 ± 0.063
1.744ProAsn: 1.744 ± 0.09
1.197ProPro: 1.197 ± 0.09
1.225ProGln: 1.225 ± 0.084
1.515ProArg: 1.515 ± 0.103
2.253ProSer: 2.253 ± 0.108
2.198ProThr: 2.198 ± 0.12
2.291ProVal: 2.291 ± 0.098
0.443ProTrp: 0.443 ± 0.055
1.362ProTyr: 1.362 ± 0.075
0.0ProXaa: 0.0 ± 0.0
Gln
2.789GlnAla: 2.789 ± 0.113
0.405GlnCys: 0.405 ± 0.048
1.657GlnAsp: 1.657 ± 0.096
2.132GlnGlu: 2.132 ± 0.115
1.619GlnPhe: 1.619 ± 0.093
2.291GlnGly: 2.291 ± 0.118
1.159GlnHis: 1.159 ± 0.08
3.226GlnIle: 3.226 ± 0.124
2.532GlnLys: 2.532 ± 0.139
4.467GlnLeu: 4.467 ± 0.172
0.815GlnMet: 0.815 ± 0.061
1.509GlnAsn: 1.509 ± 0.09
1.482GlnPro: 1.482 ± 0.089
1.711GlnGln: 1.711 ± 0.121
2.253GlnArg: 2.253 ± 0.11
2.143GlnSer: 2.143 ± 0.115
1.799GlnThr: 1.799 ± 0.091
2.619GlnVal: 2.619 ± 0.123
0.525GlnTrp: 0.525 ± 0.055
1.444GlnTyr: 1.444 ± 0.105
0.0GlnXaa: 0.0 ± 0.0
Arg
3.407ArgAla: 3.407 ± 0.147
0.727ArgCys: 0.727 ± 0.06
2.537ArgAsp: 2.537 ± 0.128
3.204ArgGlu: 3.204 ± 0.149
2.646ArgPhe: 2.646 ± 0.121
3.396ArgGly: 3.396 ± 0.161
1.345ArgHis: 1.345 ± 0.088
5.052ArgIle: 5.052 ± 0.176
3.417ArgLys: 3.417 ± 0.12
5.922ArgLeu: 5.922 ± 0.175
1.378ArgMet: 1.378 ± 0.085
2.86ArgAsn: 2.86 ± 0.125
1.761ArgPro: 1.761 ± 0.108
2.291ArgGln: 2.291 ± 0.11
3.281ArgArg: 3.281 ± 0.156
2.964ArgSer: 2.964 ± 0.12
2.444ArgThr: 2.444 ± 0.121
3.412ArgVal: 3.412 ± 0.132
0.683ArgTrp: 0.683 ± 0.068
2.045ArgTyr: 2.045 ± 0.116
0.0ArgXaa: 0.0 ± 0.0
Ser
4.26SerAla: 4.26 ± 0.143
0.99SerCys: 0.99 ± 0.076
3.286SerAsp: 3.286 ± 0.133
3.144SerGlu: 3.144 ± 0.132
2.657SerPhe: 2.657 ± 0.106
4.719SerGly: 4.719 ± 0.141
1.476SerHis: 1.476 ± 0.088
5.441SerIle: 5.441 ± 0.166
3.642SerLys: 3.642 ± 0.145
7.13SerLeu: 7.13 ± 0.234
1.619SerMet: 1.619 ± 0.088
3.16SerAsn: 3.16 ± 0.123
2.127SerPro: 2.127 ± 0.103
2.105SerGln: 2.105 ± 0.107
3.505SerArg: 3.505 ± 0.135
4.451SerSer: 4.451 ± 0.152
3.45SerThr: 3.45 ± 0.139
3.866SerVal: 3.866 ± 0.174
0.787SerTrp: 0.787 ± 0.067
2.209SerTyr: 2.209 ± 0.125
0.0SerXaa: 0.0 ± 0.0
Thr
3.275ThrAla: 3.275 ± 0.143
0.749ThrCys: 0.749 ± 0.076
2.269ThrAsp: 2.269 ± 0.101
2.614ThrGlu: 2.614 ± 0.11
2.236ThrPhe: 2.236 ± 0.114
3.625ThrGly: 3.625 ± 0.146
1.219ThrHis: 1.219 ± 0.088
4.484ThrIle: 4.484 ± 0.17
2.8ThrLys: 2.8 ± 0.13
7.147ThrLeu: 7.147 ± 0.18
1.055ThrMet: 1.055 ± 0.073
2.417ThrAsn: 2.417 ± 0.116
2.417ThrPro: 2.417 ± 0.106
1.799ThrGln: 1.799 ± 0.096
2.772ThrArg: 2.772 ± 0.122
3.242ThrSer: 3.242 ± 0.131
2.98ThrThr: 2.98 ± 0.115
3.21ThrVal: 3.21 ± 0.147
0.541ThrTrp: 0.541 ± 0.056
1.536ThrTyr: 1.536 ± 0.096
0.0ThrXaa: 0.0 ± 0.0
Val
4.041ValAla: 4.041 ± 0.172
0.683ValCys: 0.683 ± 0.062
3.281ValAsp: 3.281 ± 0.156
3.494ValGlu: 3.494 ± 0.147
2.258ValPhe: 2.258 ± 0.118
4.035ValGly: 4.035 ± 0.176
1.356ValHis: 1.356 ± 0.09
5.736ValIle: 5.736 ± 0.183
3.587ValLys: 3.587 ± 0.159
6.239ValLeu: 6.239 ± 0.202
1.673ValMet: 1.673 ± 0.107
3.013ValAsn: 3.013 ± 0.128
2.154ValPro: 2.154 ± 0.093
1.793ValGln: 1.793 ± 0.103
3.177ValArg: 3.177 ± 0.142
4.243ValSer: 4.243 ± 0.159
3.111ValThr: 3.111 ± 0.124
4.254ValVal: 4.254 ± 0.189
0.465ValTrp: 0.465 ± 0.05
1.657ValTyr: 1.657 ± 0.093
0.0ValXaa: 0.0 ± 0.0
Trp
0.476TrpAla: 0.476 ± 0.052
0.202TrpCys: 0.202 ± 0.032
0.35TrpAsp: 0.35 ± 0.051
0.481TrpGlu: 0.481 ± 0.047
0.525TrpPhe: 0.525 ± 0.06
0.47TrpGly: 0.47 ± 0.047
0.295TrpHis: 0.295 ± 0.037
1.143TrpIle: 1.143 ± 0.088
0.864TrpLys: 0.864 ± 0.067
1.46TrpLeu: 1.46 ± 0.099
0.29TrpMet: 0.29 ± 0.042
0.541TrpAsn: 0.541 ± 0.055
0.394TrpPro: 0.394 ± 0.052
0.536TrpGln: 0.536 ± 0.053
0.673TrpArg: 0.673 ± 0.061
0.629TrpSer: 0.629 ± 0.055
0.377TrpThr: 0.377 ± 0.045
0.601TrpVal: 0.601 ± 0.054
0.12TrpTrp: 0.12 ± 0.032
0.498TrpTyr: 0.498 ± 0.056
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.116TyrAla: 2.116 ± 0.102
0.541TyrCys: 0.541 ± 0.049
1.586TyrAsp: 1.586 ± 0.087
1.58TyrGlu: 1.58 ± 0.103
1.422TyrPhe: 1.422 ± 0.078
2.209TyrGly: 2.209 ± 0.096
1.176TyrHis: 1.176 ± 0.09
2.729TyrIle: 2.729 ± 0.116
1.761TyrLys: 1.761 ± 0.106
3.806TyrLeu: 3.806 ± 0.154
0.683TyrMet: 0.683 ± 0.064
1.804TyrAsn: 1.804 ± 0.098
1.225TyrPro: 1.225 ± 0.085
1.635TyrGln: 1.635 ± 0.091
2.034TyrArg: 2.034 ± 0.089
2.001TyrSer: 2.001 ± 0.098
1.553TyrThr: 1.553 ± 0.095
1.619TyrVal: 1.619 ± 0.099
0.388TyrTrp: 0.388 ± 0.049
1.323TyrTyr: 1.323 ± 0.083
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 576 proteins (182885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski