Amino acid dipepetide frequency for Alicycliphilus denitrificans (strain DSM 14773 / CIP 107495 / K601)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.613AlaAla: 19.613 ± 0.176	1.484AlaCys: 1.484 ± 0.034	6.474AlaAsp: 6.474 ± 0.067	6.838AlaGlu: 6.838 ± 0.077	3.987AlaPhe: 3.987 ± 0.058	11.675AlaGly: 11.675 ± 0.095	2.972AlaHis: 2.972 ± 0.048	5.229AlaIle: 5.229 ± 0.06	3.584AlaLys: 3.584 ± 0.067	15.962AlaLeu: 15.962 ± 0.139	3.735AlaMet: 3.735 ± 0.049	2.657AlaAsn: 2.657 ± 0.045	7.134AlaPro: 7.134 ± 0.087	7.018AlaGln: 7.018 ± 0.083	10.619AlaArg: 10.619 ± 0.103	6.518AlaSer: 6.518 ± 0.078	6.075AlaThr: 6.075 ± 0.077	9.283AlaVal: 9.283 ± 0.094	2.102AlaTrp: 2.102 ± 0.045	2.512AlaTyr: 2.512 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.341CysAla: 1.341 ± 0.029	0.149CysCys: 0.149 ± 0.01	0.548CysAsp: 0.548 ± 0.02	0.514CysGlu: 0.514 ± 0.02	0.309CysPhe: 0.309 ± 0.014	1.057CysGly: 1.057 ± 0.031	0.267CysHis: 0.267 ± 0.014	0.427CysIle: 0.427 ± 0.018	0.228CysLys: 0.228 ± 0.01	0.9CysLeu: 0.9 ± 0.026	0.257CysMet: 0.257 ± 0.013	0.235CysAsn: 0.235 ± 0.012	0.536CysPro: 0.536 ± 0.023	0.313CysGln: 0.313 ± 0.015	0.63CysArg: 0.63 ± 0.021	0.518CysSer: 0.518 ± 0.021	0.53CysThr: 0.53 ± 0.02	0.779CysVal: 0.779 ± 0.024	0.125CysTrp: 0.125 ± 0.01	0.199CysTyr: 0.199 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.379AspAla: 7.379 ± 0.086	0.476AspCys: 0.476 ± 0.018	2.429AspAsp: 2.429 ± 0.047	3.039AspGlu: 3.039 ± 0.053	1.913AspPhe: 1.913 ± 0.036	4.543AspGly: 4.543 ± 0.058	1.05AspHis: 1.05 ± 0.027	2.273AspIle: 2.273 ± 0.045	1.712AspLys: 1.712 ± 0.041	5.2AspLeu: 5.2 ± 0.059	1.41AspMet: 1.41 ± 0.033	1.119AspAsn: 1.119 ± 0.027	2.742AspPro: 2.742 ± 0.042	1.45AspGln: 1.45 ± 0.029	3.112AspArg: 3.112 ± 0.045	1.974AspSer: 1.974 ± 0.038	2.337AspThr: 2.337 ± 0.038	3.929AspVal: 3.929 ± 0.057	0.949AspTrp: 0.949 ± 0.028	1.333AspTyr: 1.333 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	6.834GluAla: 6.834 ± 0.062	0.462GluCys: 0.462 ± 0.018	2.234GluAsp: 2.234 ± 0.04	2.516GluGlu: 2.516 ± 0.049	1.611GluPhe: 1.611 ± 0.04	3.902GluGly: 3.902 ± 0.06	1.388GluHis: 1.388 ± 0.028	2.485GluIle: 2.485 ± 0.04	1.794GluLys: 1.794 ± 0.041	5.857GluLeu: 5.857 ± 0.068	1.207GluMet: 1.207 ± 0.029	1.224GluAsn: 1.224 ± 0.026	2.584GluPro: 2.584 ± 0.042	2.773GluGln: 2.773 ± 0.049	5.071GluArg: 5.071 ± 0.06	2.43GluSer: 2.43 ± 0.048	2.288GluThr: 2.288 ± 0.035	3.993GluVal: 3.993 ± 0.059	0.649GluTrp: 0.649 ± 0.023	1.072GluTyr: 1.072 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.271PheAla: 4.271 ± 0.06	0.401PheCys: 0.401 ± 0.017	2.305PheAsp: 2.305 ± 0.04	1.919PheGlu: 1.919 ± 0.037	1.212PhePhe: 1.212 ± 0.029	3.25PheGly: 3.25 ± 0.058	0.713PheHis: 0.713 ± 0.021	1.409PheIle: 1.409 ± 0.035	1.075PheLys: 1.075 ± 0.029	2.842PheLeu: 2.842 ± 0.049	0.824PheMet: 0.824 ± 0.025	0.958PheAsn: 0.958 ± 0.027	1.432PhePro: 1.432 ± 0.034	1.041PheGln: 1.041 ± 0.028	1.719PheArg: 1.719 ± 0.032	1.89PheSer: 1.89 ± 0.035	1.815PheThr: 1.815 ± 0.037	2.673PheVal: 2.673 ± 0.042	0.474PheTrp: 0.474 ± 0.021	0.775PheTyr: 0.775 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	10.138GlyAla: 10.138 ± 0.091	0.935GlyCys: 0.935 ± 0.027	3.975GlyAsp: 3.975 ± 0.058	4.478GlyGlu: 4.478 ± 0.063	3.179GlyPhe: 3.179 ± 0.047	7.489GlyGly: 7.489 ± 0.099	2.058GlyHis: 2.058 ± 0.042	3.927GlyIle: 3.927 ± 0.052	3.107GlyLys: 3.107 ± 0.062	9.128GlyLeu: 9.128 ± 0.087	2.544GlyMet: 2.544 ± 0.042	2.047GlyAsn: 2.047 ± 0.044	3.181GlyPro: 3.181 ± 0.047	3.749GlyGln: 3.749 ± 0.054	5.933GlyArg: 5.933 ± 0.067	4.542GlySer: 4.542 ± 0.061	4.452GlyThr: 4.452 ± 0.056	6.691GlyVal: 6.691 ± 0.073	1.496GlyTrp: 1.496 ± 0.038	2.425GlyTyr: 2.425 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	3.267HisAla: 3.267 ± 0.047	0.332HisCys: 0.332 ± 0.015	1.159HisAsp: 1.159 ± 0.032	1.218HisGlu: 1.218 ± 0.028	0.836HisPhe: 0.836 ± 0.022	2.273HisGly: 2.273 ± 0.045	0.647HisHis: 0.647 ± 0.021	0.955HisIle: 0.955 ± 0.025	0.585HisLys: 0.585 ± 0.021	2.348HisLeu: 2.348 ± 0.044	0.602HisMet: 0.602 ± 0.02	0.478HisAsn: 0.478 ± 0.018	1.606HisPro: 1.606 ± 0.039	0.785HisGln: 0.785 ± 0.021	1.534HisArg: 1.534 ± 0.037	1.007HisSer: 1.007 ± 0.024	1.052HisThr: 1.052 ± 0.028	1.714HisVal: 1.714 ± 0.035	0.438HisTrp: 0.438 ± 0.018	0.651HisTyr: 0.651 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.227IleAla: 6.227 ± 0.065	0.377IleCys: 0.377 ± 0.017	2.82IleAsp: 2.82 ± 0.051	2.795IleGlu: 2.795 ± 0.049	1.175IlePhe: 1.175 ± 0.031	3.884IleGly: 3.884 ± 0.054	0.926IleHis: 0.926 ± 0.026	1.387IleIle: 1.387 ± 0.038	1.408IleLys: 1.408 ± 0.035	3.16IleLeu: 3.16 ± 0.048	0.73IleMet: 0.73 ± 0.021	1.257IleAsn: 1.257 ± 0.032	1.964IlePro: 1.964 ± 0.04	1.284IleGln: 1.284 ± 0.027	2.569IleArg: 2.569 ± 0.041	2.043IleSer: 2.043 ± 0.033	2.426IleThr: 2.426 ± 0.04	3.562IleVal: 3.562 ± 0.053	0.422IleTrp: 0.422 ± 0.018	0.901IleTyr: 0.901 ± 0.026	0.0IleXaa: 0.0 ± 0.0
Lys	4.025LysAla: 4.025 ± 0.063	0.144LysCys: 0.144 ± 0.01	1.601LysAsp: 1.601 ± 0.039	1.561LysGlu: 1.561 ± 0.04	0.799LysPhe: 0.799 ± 0.024	2.367LysGly: 2.367 ± 0.048	0.58LysHis: 0.58 ± 0.021	1.299LysIle: 1.299 ± 0.032	1.331LysLys: 1.331 ± 0.04	3.09LysLeu: 3.09 ± 0.054	0.76LysMet: 0.76 ± 0.024	0.902LysAsn: 0.902 ± 0.023	1.862LysPro: 1.862 ± 0.039	1.123LysGln: 1.123 ± 0.028	2.043LysArg: 2.043 ± 0.046	1.611LysSer: 1.611 ± 0.038	1.794LysThr: 1.794 ± 0.037	2.391LysVal: 2.391 ± 0.047	0.35LysTrp: 0.35 ± 0.017	0.653LysTyr: 0.653 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	16.24LeuAla: 16.24 ± 0.153	1.131LeuCys: 1.131 ± 0.026	5.623LeuAsp: 5.623 ± 0.07	5.14LeuGlu: 5.14 ± 0.067	3.238LeuPhe: 3.238 ± 0.051	8.872LeuGly: 8.872 ± 0.082	2.541LeuHis: 2.541 ± 0.041	3.965LeuIle: 3.965 ± 0.058	3.232LeuLys: 3.232 ± 0.055	11.649LeuLeu: 11.649 ± 0.131	2.473LeuMet: 2.473 ± 0.04	2.444LeuAsn: 2.444 ± 0.041	6.415LeuPro: 6.415 ± 0.071	4.745LeuGln: 4.745 ± 0.057	8.256LeuArg: 8.256 ± 0.081	5.709LeuSer: 5.709 ± 0.067	4.93LeuThr: 4.93 ± 0.054	7.876LeuVal: 7.876 ± 0.084	1.42LeuTrp: 1.42 ± 0.04	2.082LeuTyr: 2.082 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	3.414MetAla: 3.414 ± 0.051	0.186MetCys: 0.186 ± 0.012	1.174MetAsp: 1.174 ± 0.03	1.13MetGlu: 1.13 ± 0.031	0.723MetPhe: 0.723 ± 0.021	2.065MetGly: 2.065 ± 0.043	0.615MetHis: 0.615 ± 0.023	0.85MetIle: 0.85 ± 0.023	0.931MetLys: 0.931 ± 0.025	2.686MetLeu: 2.686 ± 0.04	0.578MetMet: 0.578 ± 0.023	0.824MetAsn: 0.824 ± 0.023	1.61MetPro: 1.61 ± 0.034	1.238MetGln: 1.238 ± 0.031	1.848MetArg: 1.848 ± 0.036	1.461MetSer: 1.461 ± 0.031	1.524MetThr: 1.524 ± 0.03	1.802MetVal: 1.802 ± 0.039	0.202MetTrp: 0.202 ± 0.012	0.401MetTyr: 0.401 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.075AsnAla: 3.075 ± 0.054	0.242AsnCys: 0.242 ± 0.014	1.17AsnAsp: 1.17 ± 0.031	1.064AsnGlu: 1.064 ± 0.026	0.832AsnPhe: 0.832 ± 0.024	2.054AsnGly: 2.054 ± 0.041	0.518AsnHis: 0.518 ± 0.019	1.06AsnIle: 1.06 ± 0.023	0.78AsnLys: 0.78 ± 0.022	2.365AsnLeu: 2.365 ± 0.04	0.561AsnMet: 0.561 ± 0.017	0.623AsnAsn: 0.623 ± 0.025	1.797AsnPro: 1.797 ± 0.035	0.84AsnGln: 0.84 ± 0.024	1.549AsnArg: 1.549 ± 0.037	0.979AsnSer: 0.979 ± 0.026	1.27AsnThr: 1.27 ± 0.03	1.808AsnVal: 1.808 ± 0.036	0.349AsnTrp: 0.349 ± 0.016	0.628AsnTyr: 0.628 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.756ProAla: 7.756 ± 0.093	0.408ProCys: 0.408 ± 0.017	3.124ProAsp: 3.124 ± 0.051	3.351ProGlu: 3.351 ± 0.046	1.748ProPhe: 1.748 ± 0.033	5.117ProGly: 5.117 ± 0.064	1.255ProHis: 1.255 ± 0.029	1.893ProIle: 1.893 ± 0.039	1.337ProLys: 1.337 ± 0.03	5.571ProLeu: 5.571 ± 0.072	1.364ProMet: 1.364 ± 0.027	1.088ProAsn: 1.088 ± 0.028	2.878ProPro: 2.878 ± 0.059	2.486ProGln: 2.486 ± 0.044	3.394ProArg: 3.394 ± 0.054	2.58ProSer: 2.58 ± 0.043	2.413ProThr: 2.413 ± 0.039	4.396ProVal: 4.396 ± 0.06	0.84ProTrp: 0.84 ± 0.025	1.329ProTyr: 1.329 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	6.769GlnAla: 6.769 ± 0.081	0.355GlnCys: 0.355 ± 0.016	1.947GlnAsp: 1.947 ± 0.043	2.058GlnGlu: 2.058 ± 0.04	1.302GlnPhe: 1.302 ± 0.029	3.612GlnGly: 3.612 ± 0.049	0.994GlnHis: 0.994 ± 0.024	1.747GlnIle: 1.747 ± 0.037	1.14GlnLys: 1.14 ± 0.029	4.438GlnLeu: 4.438 ± 0.058	1.029GlnMet: 1.029 ± 0.025	0.796GlnAsn: 0.796 ± 0.024	2.497GlnPro: 2.497 ± 0.044	2.14GlnGln: 2.14 ± 0.044	3.774GlnArg: 3.774 ± 0.061	1.984GlnSer: 1.984 ± 0.039	1.737GlnThr: 1.737 ± 0.036	3.252GlnVal: 3.252 ± 0.053	0.776GlnTrp: 0.776 ± 0.021	0.836GlnTyr: 0.836 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.883ArgAla: 8.883 ± 0.093	0.655ArgCys: 0.655 ± 0.024	3.436ArgAsp: 3.436 ± 0.048	4.329ArgGlu: 4.329 ± 0.063	2.75ArgPhe: 2.75 ± 0.039	4.964ArgGly: 4.964 ± 0.06	2.066ArgHis: 2.066 ± 0.038	3.554ArgIle: 3.554 ± 0.053	2.136ArgLys: 2.136 ± 0.042	8.694ArgLeu: 8.694 ± 0.082	2.064ArgMet: 2.064 ± 0.032	1.736ArgAsn: 1.736 ± 0.034	3.608ArgPro: 3.608 ± 0.048	3.382ArgGln: 3.382 ± 0.05	5.677ArgArg: 5.677 ± 0.077	3.44ArgSer: 3.44 ± 0.053	3.383ArgThr: 3.383 ± 0.043	5.187ArgVal: 5.187 ± 0.062	1.274ArgTrp: 1.274 ± 0.028	1.817ArgTyr: 1.817 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.043SerAla: 6.043 ± 0.07	0.476SerCys: 0.476 ± 0.019	2.306SerAsp: 2.306 ± 0.043	2.347SerGlu: 2.347 ± 0.042	1.868SerPhe: 1.868 ± 0.036	4.9SerGly: 4.9 ± 0.052	1.166SerHis: 1.166 ± 0.029	2.199SerIle: 2.199 ± 0.039	1.339SerLys: 1.339 ± 0.031	5.174SerLeu: 5.174 ± 0.055	1.335SerMet: 1.335 ± 0.032	1.184SerAsn: 1.184 ± 0.028	2.764SerPro: 2.764 ± 0.052	1.818SerGln: 1.818 ± 0.036	3.285SerArg: 3.285 ± 0.053	2.73SerSer: 2.73 ± 0.051	2.673SerThr: 2.673 ± 0.045	3.751SerVal: 3.751 ± 0.046	0.665SerTrp: 0.665 ± 0.022	1.208SerTyr: 1.208 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.979ThrAla: 5.979 ± 0.074	0.432ThrCys: 0.432 ± 0.017	2.296ThrAsp: 2.296 ± 0.043	2.271ThrGlu: 2.271 ± 0.047	1.548ThrPhe: 1.548 ± 0.031	4.642ThrGly: 4.642 ± 0.062	1.181ThrHis: 1.181 ± 0.031	1.993ThrIle: 1.993 ± 0.037	1.124ThrLys: 1.124 ± 0.031	5.914ThrLeu: 5.914 ± 0.07	1.087ThrMet: 1.087 ± 0.025	1.063ThrAsn: 1.063 ± 0.03	3.52ThrPro: 3.52 ± 0.055	1.985ThrGln: 1.985 ± 0.043	3.347ThrArg: 3.347 ± 0.042	2.363ThrSer: 2.363 ± 0.039	2.588ThrThr: 2.588 ± 0.047	4.021ThrVal: 4.021 ± 0.05	0.631ThrTrp: 0.631 ± 0.022	0.958ThrTyr: 0.958 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	9.994ValAla: 9.994 ± 0.086	0.768ValCys: 0.768 ± 0.024	3.908ValAsp: 3.908 ± 0.051	4.008ValGlu: 4.008 ± 0.056	2.574ValPhe: 2.574 ± 0.042	5.674ValGly: 5.674 ± 0.07	1.729ValHis: 1.729 ± 0.033	3.282ValIle: 3.282 ± 0.044	2.277ValLys: 2.277 ± 0.048	8.495ValLeu: 8.495 ± 0.084	1.808ValMet: 1.808 ± 0.037	1.984ValAsn: 1.984 ± 0.041	4.281ValPro: 4.281 ± 0.048	3.331ValGln: 3.331 ± 0.049	5.639ValArg: 5.639 ± 0.071	3.661ValSer: 3.661 ± 0.047	3.814ValThr: 3.814 ± 0.052	6.323ValVal: 6.323 ± 0.071	0.908ValTrp: 0.908 ± 0.027	1.506ValTyr: 1.506 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.523TrpAla: 1.523 ± 0.035	0.176TrpCys: 0.176 ± 0.011	0.604TrpAsp: 0.604 ± 0.02	0.577TrpGlu: 0.577 ± 0.019	0.535TrpPhe: 0.535 ± 0.018	1.048TrpGly: 1.048 ± 0.029	0.382TrpHis: 0.382 ± 0.016	0.651TrpIle: 0.651 ± 0.021	0.415TrpLys: 0.415 ± 0.018	2.128TrpLeu: 2.128 ± 0.049	0.434TrpMet: 0.434 ± 0.018	0.403TrpAsn: 0.403 ± 0.017	0.762TrpPro: 0.762 ± 0.025	0.782TrpGln: 0.782 ± 0.025	1.348TrpArg: 1.348 ± 0.028	0.762TrpSer: 0.762 ± 0.027	0.674TrpThr: 0.674 ± 0.021	0.943TrpVal: 0.943 ± 0.026	0.295TrpTrp: 0.295 ± 0.016	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.7TyrAla: 2.7 ± 0.049	0.275TyrCys: 0.275 ± 0.014	1.234TyrAsp: 1.234 ± 0.03	1.22TyrGlu: 1.22 ± 0.031	0.86TyrPhe: 0.86 ± 0.022	2.086TyrGly: 2.086 ± 0.041	0.441TyrHis: 0.441 ± 0.016	0.732TyrIle: 0.732 ± 0.021	0.748TyrLys: 0.748 ± 0.025	2.379TyrLeu: 2.379 ± 0.043	0.462TyrMet: 0.462 ± 0.017	0.543TyrAsn: 0.543 ± 0.022	1.153TyrPro: 1.153 ± 0.029	0.9TyrGln: 0.9 ± 0.024	1.689TyrArg: 1.689 ± 0.033	1.026TyrSer: 1.026 ± 0.025	1.172TyrThr: 1.172 ± 0.031	1.591TyrVal: 1.591 ± 0.034	0.357TyrTrp: 0.357 ± 0.014	0.569TyrTyr: 0.569 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4620 proteins (1503000 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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