Amino acid dipepetide frequency for Microviridae sp. ctD0m35

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.552AlaAla: 12.552 ± 6.175
1.395AlaCys: 1.395 ± 0.991
5.579AlaAsp: 5.579 ± 2.861
3.487AlaGlu: 3.487 ± 2.123
2.789AlaPhe: 2.789 ± 1.648
7.671AlaGly: 7.671 ± 3.97
2.092AlaHis: 2.092 ± 0.925
5.579AlaIle: 5.579 ± 2.07
5.579AlaLys: 5.579 ± 2.552
5.579AlaLeu: 5.579 ± 1.612
2.092AlaMet: 2.092 ± 1.626
2.092AlaAsn: 2.092 ± 1.324
3.487AlaPro: 3.487 ± 1.786
4.184AlaGln: 4.184 ± 2.453
5.579AlaArg: 5.579 ± 1.56
3.487AlaSer: 3.487 ± 1.535
6.276AlaThr: 6.276 ± 2.847
9.066AlaVal: 9.066 ± 0.95
0.697AlaTrp: 0.697 ± 0.659
2.092AlaTyr: 2.092 ± 0.618
0.0AlaXaa: 0.0 ± 0.0
Cys
1.395CysAla: 1.395 ± 0.747
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
1.395CysPhe: 1.395 ± 0.59
1.395CysGly: 1.395 ± 1.317
0.0CysHis: 0.0 ± 0.0
0.697CysIle: 0.697 ± 0.659
0.697CysLys: 0.697 ± 0.659
2.092CysLeu: 2.092 ± 1.164
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.697CysPro: 0.697 ± 0.945
0.0CysGln: 0.0 ± 0.0
0.697CysArg: 0.697 ± 0.659
0.697CysSer: 0.697 ± 0.727
0.697CysThr: 0.697 ± 0.659
0.697CysVal: 0.697 ± 0.727
0.0CysTrp: 0.0 ± 0.0
1.395CysTyr: 1.395 ± 0.991
0.0CysXaa: 0.0 ± 0.0
Asp
6.276AspAla: 6.276 ± 1.363
0.0AspCys: 0.0 ± 0.0
4.184AspAsp: 4.184 ± 1.159
4.881AspGlu: 4.881 ± 2.205
4.184AspPhe: 4.184 ± 1.096
2.789AspGly: 2.789 ± 1.456
2.789AspHis: 2.789 ± 1.255
3.487AspIle: 3.487 ± 1.554
2.092AspLys: 2.092 ± 0.737
4.881AspLeu: 4.881 ± 1.49
0.697AspMet: 0.697 ± 0.827
2.092AspAsn: 2.092 ± 0.84
6.276AspPro: 6.276 ± 1.887
1.395AspGln: 1.395 ± 0.971
2.092AspArg: 2.092 ± 1.164
1.395AspSer: 1.395 ± 0.918
1.395AspThr: 1.395 ± 0.918
1.395AspVal: 1.395 ± 1.317
0.697AspTrp: 0.697 ± 0.714
4.881AspTyr: 4.881 ± 2.197
0.0AspXaa: 0.0 ± 0.0
Glu
6.276GluAla: 6.276 ± 2.258
0.0GluCys: 0.0 ± 0.0
3.487GluAsp: 3.487 ± 1.409
0.697GluGlu: 0.697 ± 0.827
1.395GluPhe: 1.395 ± 0.687
0.697GluGly: 0.697 ± 0.714
1.395GluHis: 1.395 ± 0.687
4.881GluIle: 4.881 ± 1.718
3.487GluLys: 3.487 ± 2.035
2.092GluLeu: 2.092 ± 1.473
0.697GluMet: 0.697 ± 0.593
2.092GluAsn: 2.092 ± 0.618
2.092GluPro: 2.092 ± 1.377
2.789GluGln: 2.789 ± 0.975
4.881GluArg: 4.881 ± 1.339
2.789GluSer: 2.789 ± 0.759
2.092GluThr: 2.092 ± 0.84
1.395GluVal: 1.395 ± 0.687
0.697GluTrp: 0.697 ± 0.459
4.184GluTyr: 4.184 ± 1.771
0.0GluXaa: 0.0 ± 0.0
Phe
2.789PheAla: 2.789 ± 1.39
0.0PheCys: 0.0 ± 0.0
2.789PheAsp: 2.789 ± 1.39
0.697PheGlu: 0.697 ± 0.659
1.395PhePhe: 1.395 ± 0.846
5.579PheGly: 5.579 ± 1.419
0.697PheHis: 0.697 ± 0.659
1.395PheIle: 1.395 ± 0.59
2.092PheLys: 2.092 ± 1.324
3.487PheLeu: 3.487 ± 1.488
2.789PheMet: 2.789 ± 0.825
1.395PheAsn: 1.395 ± 0.59
0.697PhePro: 0.697 ± 0.945
2.789PheGln: 2.789 ± 0.814
0.697PheArg: 0.697 ± 0.459
4.184PheSer: 4.184 ± 1.472
3.487PheThr: 3.487 ± 1.288
2.092PheVal: 2.092 ± 0.925
0.0PheTrp: 0.0 ± 0.0
2.789PheTyr: 2.789 ± 0.814
0.0PheXaa: 0.0 ± 0.0
Gly
7.671GlyAla: 7.671 ± 2.381
2.092GlyCys: 2.092 ± 1.415
6.974GlyAsp: 6.974 ± 1.899
4.881GlyGlu: 4.881 ± 1.223
1.395GlyPhe: 1.395 ± 0.918
5.579GlyGly: 5.579 ± 3.25
1.395GlyHis: 1.395 ± 0.965
2.789GlyIle: 2.789 ± 2.082
3.487GlyLys: 3.487 ± 1.048
5.579GlyLeu: 5.579 ± 1.811
0.697GlyMet: 0.697 ± 0.841
3.487GlyAsn: 3.487 ± 1.851
0.697GlyPro: 0.697 ± 0.459
1.395GlyGln: 1.395 ± 0.687
4.184GlyArg: 4.184 ± 1.8
4.881GlySer: 4.881 ± 2.266
3.487GlyThr: 3.487 ± 1.771
6.276GlyVal: 6.276 ± 2.198
0.697GlyTrp: 0.697 ± 0.659
3.487GlyTyr: 3.487 ± 1.362
0.0GlyXaa: 0.0 ± 0.0
His
1.395HisAla: 1.395 ± 0.965
0.697HisCys: 0.697 ± 0.659
0.697HisAsp: 0.697 ± 0.459
1.395HisGlu: 1.395 ± 0.965
1.395HisPhe: 1.395 ± 0.918
1.395HisGly: 1.395 ± 0.971
1.395HisHis: 1.395 ± 1.317
0.697HisIle: 0.697 ± 0.659
0.0HisLys: 0.0 ± 0.0
2.092HisLeu: 2.092 ± 1.377
0.0HisMet: 0.0 ± 0.0
1.395HisAsn: 1.395 ± 0.687
2.789HisPro: 2.789 ± 1.564
0.697HisGln: 0.697 ± 0.714
0.0HisArg: 0.0 ± 0.0
1.395HisSer: 1.395 ± 0.59
0.0HisThr: 0.0 ± 0.0
1.395HisVal: 1.395 ± 0.965
0.0HisTrp: 0.0 ± 0.0
1.395HisTyr: 1.395 ± 0.59
0.0HisXaa: 0.0 ± 0.0
Ile
2.092IleAla: 2.092 ± 1.259
0.697IleCys: 0.697 ± 0.749
4.184IleAsp: 4.184 ± 0.692
0.0IleGlu: 0.0 ± 0.0
0.0IlePhe: 0.0 ± 0.0
4.184IleGly: 4.184 ± 1.594
1.395IleHis: 1.395 ± 0.59
4.184IleIle: 4.184 ± 1.426
5.579IleLys: 5.579 ± 1.464
4.881IleLeu: 4.881 ± 2.16
1.395IleMet: 1.395 ± 0.687
3.487IleAsn: 3.487 ± 1.351
2.789IlePro: 2.789 ± 1.021
2.092IleGln: 2.092 ± 1.046
3.487IleArg: 3.487 ± 1.811
4.184IleSer: 4.184 ± 1.233
5.579IleThr: 5.579 ± 1.445
3.487IleVal: 3.487 ± 2.068
0.697IleTrp: 0.697 ± 0.459
1.395IleTyr: 1.395 ± 0.747
0.0IleXaa: 0.0 ± 0.0
Lys
2.789LysAla: 2.789 ± 1.198
0.697LysCys: 0.697 ± 0.659
2.789LysAsp: 2.789 ± 1.796
0.697LysGlu: 0.697 ± 0.827
3.487LysPhe: 3.487 ± 1.409
1.395LysGly: 1.395 ± 0.824
1.395LysHis: 1.395 ± 0.59
4.881LysIle: 4.881 ± 2.636
5.579LysLys: 5.579 ± 3.333
4.881LysLeu: 4.881 ± 2.08
1.395LysMet: 1.395 ± 1.271
3.487LysAsn: 3.487 ± 1.785
3.487LysPro: 3.487 ± 1.129
2.789LysGln: 2.789 ± 1.845
4.881LysArg: 4.881 ± 1.596
4.881LysSer: 4.881 ± 1.32
3.487LysThr: 3.487 ± 0.935
1.395LysVal: 1.395 ± 0.991
0.697LysTrp: 0.697 ± 0.714
1.395LysTyr: 1.395 ± 0.59
0.0LysXaa: 0.0 ± 0.0
Leu
4.881LeuAla: 4.881 ± 1.775
0.0LeuCys: 0.0 ± 0.0
3.487LeuAsp: 3.487 ± 0.935
4.184LeuGlu: 4.184 ± 2.31
3.487LeuPhe: 3.487 ± 1.043
6.974LeuGly: 6.974 ± 2.239
0.697LeuHis: 0.697 ± 0.659
4.881LeuIle: 4.881 ± 1.702
3.487LeuLys: 3.487 ± 1.241
4.184LeuLeu: 4.184 ± 2.0
1.395LeuMet: 1.395 ± 0.824
4.881LeuAsn: 4.881 ± 0.702
6.974LeuPro: 6.974 ± 2.077
2.789LeuGln: 2.789 ± 1.17
3.487LeuArg: 3.487 ± 0.99
6.276LeuSer: 6.276 ± 1.889
6.276LeuThr: 6.276 ± 1.58
1.395LeuVal: 1.395 ± 0.918
1.395LeuTrp: 1.395 ± 1.317
4.881LeuTyr: 4.881 ± 1.693
0.0LeuXaa: 0.0 ± 0.0
Met
2.789MetAla: 2.789 ± 1.021
0.0MetCys: 0.0 ± 0.0
2.789MetAsp: 2.789 ± 1.17
2.092MetGlu: 2.092 ± 0.984
0.697MetPhe: 0.697 ± 0.459
1.395MetGly: 1.395 ± 0.687
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
2.092MetLys: 2.092 ± 0.827
1.395MetLeu: 1.395 ± 1.037
0.0MetMet: 0.0 ± 0.0
0.697MetAsn: 0.697 ± 0.749
4.184MetPro: 4.184 ± 1.933
0.697MetGln: 0.697 ± 0.459
0.0MetArg: 0.0 ± 0.0
3.487MetSer: 3.487 ± 0.539
0.697MetThr: 0.697 ± 0.714
0.697MetVal: 0.697 ± 0.727
0.697MetTrp: 0.697 ± 0.659
0.697MetTyr: 0.697 ± 0.727
0.0MetXaa: 0.0 ± 0.0
Asn
4.881AsnAla: 4.881 ± 1.952
0.697AsnCys: 0.697 ± 0.659
1.395AsnAsp: 1.395 ± 1.093
1.395AsnGlu: 1.395 ± 0.59
2.092AsnPhe: 2.092 ± 1.046
2.092AsnGly: 2.092 ± 0.737
0.697AsnHis: 0.697 ± 0.659
2.789AsnIle: 2.789 ± 1.569
1.395AsnLys: 1.395 ± 0.965
3.487AsnLeu: 3.487 ± 1.097
0.0AsnMet: 0.0 ± 0.0
2.789AsnAsn: 2.789 ± 0.759
4.881AsnPro: 4.881 ± 1.331
2.092AsnGln: 2.092 ± 0.925
4.184AsnArg: 4.184 ± 0.642
4.184AsnSer: 4.184 ± 2.309
2.092AsnThr: 2.092 ± 1.06
2.092AsnVal: 2.092 ± 1.604
0.0AsnTrp: 0.0 ± 0.0
2.092AsnTyr: 2.092 ± 0.921
0.0AsnXaa: 0.0 ± 0.0
Pro
4.184ProAla: 4.184 ± 0.764
1.395ProCys: 1.395 ± 1.317
5.579ProAsp: 5.579 ± 2.006
2.789ProGlu: 2.789 ± 1.181
2.789ProPhe: 2.789 ± 2.013
4.881ProGly: 4.881 ± 1.718
2.092ProHis: 2.092 ± 1.32
4.881ProIle: 4.881 ± 1.165
2.092ProLys: 2.092 ± 1.62
4.184ProLeu: 4.184 ± 1.743
2.092ProMet: 2.092 ± 1.134
1.395ProAsn: 1.395 ± 0.965
2.092ProPro: 2.092 ± 0.618
2.789ProGln: 2.789 ± 0.94
1.395ProArg: 1.395 ± 0.918
2.092ProSer: 2.092 ± 1.586
6.276ProThr: 6.276 ± 2.407
6.276ProVal: 6.276 ± 1.497
2.092ProTrp: 2.092 ± 1.19
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
3.487GlnAla: 3.487 ± 2.012
0.0GlnCys: 0.0 ± 0.0
0.697GlnAsp: 0.697 ± 0.459
5.579GlnGlu: 5.579 ± 2.407
0.697GlnPhe: 0.697 ± 0.749
3.487GlnGly: 3.487 ± 0.99
0.0GlnHis: 0.0 ± 0.0
3.487GlnIle: 3.487 ± 1.058
3.487GlnLys: 3.487 ± 1.351
4.184GlnLeu: 4.184 ± 0.947
1.395GlnMet: 1.395 ± 1.037
2.092GlnAsn: 2.092 ± 1.586
0.697GlnPro: 0.697 ± 0.749
0.697GlnGln: 0.697 ± 0.459
2.789GlnArg: 2.789 ± 1.374
4.184GlnSer: 4.184 ± 1.938
2.789GlnThr: 2.789 ± 1.129
1.395GlnVal: 1.395 ± 0.99
0.0GlnTrp: 0.0 ± 0.0
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
5.579ArgAla: 5.579 ± 1.444
1.395ArgCys: 1.395 ± 1.317
2.789ArgAsp: 2.789 ± 0.686
4.184ArgGlu: 4.184 ± 2.569
1.395ArgPhe: 1.395 ± 0.919
4.184ArgGly: 4.184 ± 1.361
2.092ArgHis: 2.092 ± 0.988
2.092ArgIle: 2.092 ± 1.423
2.789ArgLys: 2.789 ± 2.119
5.579ArgLeu: 5.579 ± 2.175
4.184ArgMet: 4.184 ± 1.196
1.395ArgAsn: 1.395 ± 1.018
3.487ArgPro: 3.487 ± 1.724
1.395ArgGln: 1.395 ± 0.99
0.697ArgArg: 0.697 ± 0.659
7.671ArgSer: 7.671 ± 1.617
2.092ArgThr: 2.092 ± 2.482
0.697ArgVal: 0.697 ± 0.827
0.697ArgTrp: 0.697 ± 0.459
2.092ArgTyr: 2.092 ± 0.827
0.0ArgXaa: 0.0 ± 0.0
Ser
8.368SerAla: 8.368 ± 3.606
0.697SerCys: 0.697 ± 0.459
2.092SerAsp: 2.092 ± 1.631
1.395SerGlu: 1.395 ± 0.846
3.487SerPhe: 3.487 ± 1.682
4.881SerGly: 4.881 ± 2.285
0.697SerHis: 0.697 ± 0.459
2.789SerIle: 2.789 ± 1.021
2.789SerLys: 2.789 ± 1.077
4.881SerLeu: 4.881 ± 1.248
0.697SerMet: 0.697 ± 0.749
2.789SerAsn: 2.789 ± 0.949
3.487SerPro: 3.487 ± 1.663
5.579SerGln: 5.579 ± 1.01
5.579SerArg: 5.579 ± 0.853
4.184SerSer: 4.184 ± 1.765
4.881SerThr: 4.881 ± 0.933
6.276SerVal: 6.276 ± 1.976
0.697SerTrp: 0.697 ± 0.945
2.092SerTyr: 2.092 ± 1.377
0.0SerXaa: 0.0 ± 0.0
Thr
4.184ThrAla: 4.184 ± 1.126
1.395ThrCys: 1.395 ± 0.918
1.395ThrAsp: 1.395 ± 0.965
3.487ThrGlu: 3.487 ± 2.295
4.184ThrPhe: 4.184 ± 1.655
5.579ThrGly: 5.579 ± 0.956
0.0ThrHis: 0.0 ± 0.0
2.092ThrIle: 2.092 ± 0.927
2.789ThrLys: 2.789 ± 1.451
5.579ThrLeu: 5.579 ± 2.923
1.395ThrMet: 1.395 ± 0.846
2.092ThrAsn: 2.092 ± 1.06
4.184ThrPro: 4.184 ± 1.563
1.395ThrGln: 1.395 ± 0.99
2.092ThrArg: 2.092 ± 0.885
5.579ThrSer: 5.579 ± 1.435
4.184ThrThr: 4.184 ± 1.976
6.974ThrVal: 6.974 ± 2.25
0.0ThrTrp: 0.0 ± 0.0
1.395ThrTyr: 1.395 ± 0.918
0.0ThrXaa: 0.0 ± 0.0
Val
6.276ValAla: 6.276 ± 1.719
0.697ValCys: 0.697 ± 0.727
2.789ValAsp: 2.789 ± 0.814
4.184ValGlu: 4.184 ± 0.865
2.092ValPhe: 2.092 ± 0.827
4.184ValGly: 4.184 ± 1.393
0.697ValHis: 0.697 ± 0.749
2.789ValIle: 2.789 ± 0.869
4.184ValLys: 4.184 ± 2.397
3.487ValLeu: 3.487 ± 1.325
1.395ValMet: 1.395 ± 0.753
3.487ValAsn: 3.487 ± 1.431
5.579ValPro: 5.579 ± 2.402
2.789ValGln: 2.789 ± 1.198
4.881ValArg: 4.881 ± 1.533
0.697ValSer: 0.697 ± 0.749
3.487ValThr: 3.487 ± 1.839
0.697ValVal: 0.697 ± 0.727
1.395ValTrp: 1.395 ± 0.741
2.789ValTyr: 2.789 ± 1.427
0.0ValXaa: 0.0 ± 0.0
Trp
1.395TrpAla: 1.395 ± 0.59
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.697TrpGlu: 0.697 ± 0.659
0.697TrpPhe: 0.697 ± 0.714
0.697TrpGly: 0.697 ± 0.945
0.697TrpHis: 0.697 ± 0.459
0.697TrpIle: 0.697 ± 0.659
0.0TrpLys: 0.0 ± 0.0
0.697TrpLeu: 0.697 ± 0.727
0.0TrpMet: 0.0 ± 0.0
1.395TrpAsn: 1.395 ± 0.918
1.395TrpPro: 1.395 ± 0.918
0.697TrpGln: 0.697 ± 0.714
0.697TrpArg: 0.697 ± 0.659
0.697TrpSer: 0.697 ± 0.659
0.697TrpThr: 0.697 ± 0.714
0.697TrpVal: 0.697 ± 0.945
0.0TrpTrp: 0.0 ± 0.0
0.697TrpTyr: 0.697 ± 0.459
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.092TyrAla: 2.092 ± 1.377
0.697TyrCys: 0.697 ± 0.659
4.184TyrAsp: 4.184 ± 2.041
1.395TyrGlu: 1.395 ± 1.454
2.789TyrPhe: 2.789 ± 1.348
2.789TyrGly: 2.789 ± 1.94
0.0TyrHis: 0.0 ± 0.0
0.697TyrIle: 0.697 ± 0.459
2.789TyrLys: 2.789 ± 0.869
2.789TyrLeu: 2.789 ± 1.348
2.092TyrMet: 2.092 ± 0.995
2.789TyrAsn: 2.789 ± 1.181
1.395TyrPro: 1.395 ± 1.317
2.092TyrGln: 2.092 ± 1.046
4.184TyrArg: 4.184 ± 1.284
1.395TyrSer: 1.395 ± 0.918
0.0TyrThr: 0.0 ± 0.0
4.184TyrVal: 4.184 ± 1.771
1.395TyrTrp: 1.395 ± 0.687
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (1435 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski