Amino acid dipepetide frequency for Rosellinia necatrix quadrivirus 1 (isolate Rosellinia necatrix/Japan/W1075/1997)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.449AlaAla: 11.449 ± 2.609
1.877AlaCys: 1.877 ± 0.232
6.757AlaAsp: 6.757 ± 0.551
5.631AlaGlu: 5.631 ± 0.232
1.877AlaPhe: 1.877 ± 0.952
9.197AlaGly: 9.197 ± 1.667
3.566AlaHis: 3.566 ± 0.501
4.88AlaIle: 4.88 ± 0.73
5.443AlaLys: 5.443 ± 0.764
10.323AlaLeu: 10.323 ± 1.757
4.88AlaMet: 4.88 ± 0.518
6.381AlaAsn: 6.381 ± 0.85
2.44AlaPro: 2.44 ± 0.49
4.505AlaGln: 4.505 ± 0.704
5.818AlaArg: 5.818 ± 1.111
5.631AlaSer: 5.631 ± 0.81
7.508AlaThr: 7.508 ± 1.195
6.569AlaVal: 6.569 ± 0.467
2.065AlaTrp: 2.065 ± 0.538
3.754AlaTyr: 3.754 ± 0.665
0.0AlaXaa: 0.0 ± 0.0
Cys
1.877CysAla: 1.877 ± 0.704
0.0CysCys: 0.0 ± 0.0
1.502CysAsp: 1.502 ± 0.402
1.877CysGlu: 1.877 ± 0.545
0.563CysPhe: 0.563 ± 0.19
0.751CysGly: 0.751 ± 0.227
0.188CysHis: 0.188 ± 0.176
0.188CysIle: 0.188 ± 0.156
0.751CysLys: 0.751 ± 0.368
0.751CysLeu: 0.751 ± 0.428
0.188CysMet: 0.188 ± 0.156
0.938CysAsn: 0.938 ± 0.331
0.375CysPro: 0.375 ± 0.186
0.563CysGln: 0.563 ± 0.29
0.563CysArg: 0.563 ± 0.337
0.938CysSer: 0.938 ± 0.476
1.314CysThr: 1.314 ± 0.66
1.126CysVal: 1.126 ± 0.164
0.0CysTrp: 0.0 ± 0.0
0.375CysTyr: 0.375 ± 0.184
0.0CysXaa: 0.0 ± 0.0
Asp
6.757AspAla: 6.757 ± 0.596
1.126AspCys: 1.126 ± 0.274
3.191AspAsp: 3.191 ± 0.647
4.129AspGlu: 4.129 ± 1.527
1.314AspPhe: 1.314 ± 0.422
5.631AspGly: 5.631 ± 1.113
0.751AspHis: 0.751 ± 0.319
3.378AspIle: 3.378 ± 0.472
2.252AspLys: 2.252 ± 0.723
5.818AspLeu: 5.818 ± 0.51
2.44AspMet: 2.44 ± 0.923
2.065AspAsn: 2.065 ± 0.749
1.314AspPro: 1.314 ± 0.37
2.065AspGln: 2.065 ± 0.642
3.191AspArg: 3.191 ± 0.282
2.815AspSer: 2.815 ± 0.722
3.941AspThr: 3.941 ± 1.139
4.129AspVal: 4.129 ± 0.833
1.502AspTrp: 1.502 ± 0.246
1.877AspTyr: 1.877 ± 0.381
0.0AspXaa: 0.0 ± 0.0
Glu
6.569GluAla: 6.569 ± 0.691
0.563GluCys: 0.563 ± 0.329
4.129GluAsp: 4.129 ± 1.391
3.191GluGlu: 3.191 ± 0.59
1.314GluPhe: 1.314 ± 0.219
4.129GluGly: 4.129 ± 1.538
2.815GluHis: 2.815 ± 0.33
3.003GluIle: 3.003 ± 0.494
1.689GluLys: 1.689 ± 1.001
5.255GluLeu: 5.255 ± 1.314
1.126GluMet: 1.126 ± 0.158
2.252GluAsn: 2.252 ± 0.343
3.191GluPro: 3.191 ± 0.9
2.252GluGln: 2.252 ± 0.725
5.255GluArg: 5.255 ± 0.777
2.252GluSer: 2.252 ± 0.492
2.628GluThr: 2.628 ± 0.41
3.003GluVal: 3.003 ± 0.527
1.877GluTrp: 1.877 ± 0.393
2.252GluTyr: 2.252 ± 0.707
0.0GluXaa: 0.0 ± 0.0
Phe
4.317PheAla: 4.317 ± 0.158
0.375PheCys: 0.375 ± 0.24
1.877PheAsp: 1.877 ± 0.526
0.938PheGlu: 0.938 ± 0.284
0.751PhePhe: 0.751 ± 0.372
2.815PheGly: 2.815 ± 0.834
0.188PheHis: 0.188 ± 0.18
0.375PheIle: 0.375 ± 0.186
0.375PheLys: 0.375 ± 0.36
1.689PheLeu: 1.689 ± 0.236
0.938PheMet: 0.938 ± 0.501
0.375PheAsn: 0.375 ± 0.36
0.188PhePro: 0.188 ± 0.156
0.938PheGln: 0.938 ± 0.494
1.502PheArg: 1.502 ± 0.585
1.877PheSer: 1.877 ± 0.651
2.628PheThr: 2.628 ± 0.522
1.314PheVal: 1.314 ± 0.459
0.375PheTrp: 0.375 ± 0.351
0.751PheTyr: 0.751 ± 0.319
0.0PheXaa: 0.0 ± 0.0
Gly
5.068GlyAla: 5.068 ± 1.841
1.314GlyCys: 1.314 ± 0.193
4.692GlyAsp: 4.692 ± 0.728
6.757GlyGlu: 6.757 ± 1.037
1.877GlyPhe: 1.877 ± 0.578
6.194GlyGly: 6.194 ± 1.366
2.628GlyHis: 2.628 ± 0.65
3.378GlyIle: 3.378 ± 0.849
3.003GlyLys: 3.003 ± 1.293
6.381GlyLeu: 6.381 ± 0.98
2.815GlyMet: 2.815 ± 0.383
2.065GlyAsn: 2.065 ± 0.802
0.938GlyPro: 0.938 ± 0.32
1.689GlyGln: 1.689 ± 0.542
6.381GlyArg: 6.381 ± 1.236
5.631GlySer: 5.631 ± 1.145
4.317GlyThr: 4.317 ± 1.323
6.194GlyVal: 6.194 ± 1.119
2.065GlyTrp: 2.065 ± 0.484
2.252GlyTyr: 2.252 ± 0.251
0.0GlyXaa: 0.0 ± 0.0
His
1.877HisAla: 1.877 ± 0.689
0.563HisCys: 0.563 ± 0.291
1.502HisAsp: 1.502 ± 0.476
1.502HisGlu: 1.502 ± 0.499
0.938HisPhe: 0.938 ± 0.237
1.689HisGly: 1.689 ± 0.707
1.314HisHis: 1.314 ± 0.374
2.065HisIle: 2.065 ± 0.094
0.938HisLys: 0.938 ± 0.201
2.252HisLeu: 2.252 ± 0.738
0.563HisMet: 0.563 ± 0.363
1.314HisAsn: 1.314 ± 0.468
0.563HisPro: 0.563 ± 0.177
0.375HisGln: 0.375 ± 0.184
1.689HisArg: 1.689 ± 0.491
2.815HisSer: 2.815 ± 0.905
1.126HisThr: 1.126 ± 0.377
1.689HisVal: 1.689 ± 0.518
0.563HisTrp: 0.563 ± 0.29
1.126HisTyr: 1.126 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
3.754IleAla: 3.754 ± 0.265
0.563IleCys: 0.563 ± 0.306
2.065IleAsp: 2.065 ± 0.491
2.252IleGlu: 2.252 ± 0.58
0.563IlePhe: 0.563 ± 0.291
4.129IleGly: 4.129 ± 0.736
1.314IleHis: 1.314 ± 0.504
2.44IleIle: 2.44 ± 0.324
2.44IleLys: 2.44 ± 0.417
2.628IleLeu: 2.628 ± 0.72
1.877IleMet: 1.877 ± 0.625
2.628IleAsn: 2.628 ± 0.723
1.502IlePro: 1.502 ± 0.665
1.689IleGln: 1.689 ± 0.876
3.566IleArg: 3.566 ± 0.668
3.003IleSer: 3.003 ± 0.789
5.443IleThr: 5.443 ± 0.73
2.628IleVal: 2.628 ± 0.41
0.188IleTrp: 0.188 ± 0.156
1.689IleTyr: 1.689 ± 0.503
0.0IleXaa: 0.0 ± 0.0
Lys
2.252LysAla: 2.252 ± 0.8
0.375LysCys: 0.375 ± 0.36
1.314LysAsp: 1.314 ± 0.416
2.815LysGlu: 2.815 ± 1.0
0.938LysPhe: 0.938 ± 0.331
3.003LysGly: 3.003 ± 1.052
0.751LysHis: 0.751 ± 0.299
1.877LysIle: 1.877 ± 0.382
1.314LysLys: 1.314 ± 0.416
4.317LysLeu: 4.317 ± 0.701
2.065LysMet: 2.065 ± 0.907
1.502LysAsn: 1.502 ± 0.499
1.126LysPro: 1.126 ± 0.379
2.252LysGln: 2.252 ± 0.349
2.252LysArg: 2.252 ± 0.347
2.815LysSer: 2.815 ± 1.121
1.689LysThr: 1.689 ± 0.932
3.378LysVal: 3.378 ± 0.577
0.938LysTrp: 0.938 ± 0.574
1.126LysTyr: 1.126 ± 0.579
0.0LysXaa: 0.0 ± 0.0
Leu
10.698LeuAla: 10.698 ± 1.002
1.877LeuCys: 1.877 ± 0.579
4.692LeuAsp: 4.692 ± 1.087
3.941LeuGlu: 3.941 ± 0.355
2.628LeuPhe: 2.628 ± 0.792
6.944LeuGly: 6.944 ± 0.376
2.252LeuHis: 2.252 ± 0.396
2.815LeuIle: 2.815 ± 0.364
2.44LeuLys: 2.44 ± 0.761
6.569LeuLeu: 6.569 ± 1.928
3.003LeuMet: 3.003 ± 0.909
3.378LeuAsn: 3.378 ± 0.631
2.628LeuPro: 2.628 ± 0.791
2.628LeuGln: 2.628 ± 0.964
5.443LeuArg: 5.443 ± 0.91
6.757LeuSer: 6.757 ± 1.012
4.505LeuThr: 4.505 ± 0.738
4.505LeuVal: 4.505 ± 1.091
0.751LeuTrp: 0.751 ± 0.059
2.815LeuTyr: 2.815 ± 0.264
0.0LeuXaa: 0.0 ± 0.0
Met
4.88MetAla: 4.88 ± 1.135
0.0MetCys: 0.0 ± 0.0
1.877MetAsp: 1.877 ± 0.596
1.502MetGlu: 1.502 ± 0.344
0.563MetPhe: 0.563 ± 0.321
2.065MetGly: 2.065 ± 0.531
0.188MetHis: 0.188 ± 0.176
1.126MetIle: 1.126 ± 0.164
1.502MetLys: 1.502 ± 0.235
2.815MetLeu: 2.815 ± 0.727
1.126MetMet: 1.126 ± 0.456
1.502MetAsn: 1.502 ± 0.778
2.252MetPro: 2.252 ± 0.772
1.502MetGln: 1.502 ± 0.246
2.44MetArg: 2.44 ± 0.427
3.754MetSer: 3.754 ± 1.418
2.628MetThr: 2.628 ± 0.453
1.877MetVal: 1.877 ± 0.567
0.375MetTrp: 0.375 ± 0.312
0.938MetTyr: 0.938 ± 0.32
0.0MetXaa: 0.0 ± 0.0
Asn
3.754AsnAla: 3.754 ± 0.746
0.0AsnCys: 0.0 ± 0.0
1.689AsnAsp: 1.689 ± 0.384
1.502AsnGlu: 1.502 ± 0.481
1.502AsnPhe: 1.502 ± 0.746
3.566AsnGly: 3.566 ± 0.649
0.188AsnHis: 0.188 ± 0.184
2.44AsnIle: 2.44 ± 0.627
1.877AsnLys: 1.877 ± 0.232
2.44AsnLeu: 2.44 ± 0.53
0.938AsnMet: 0.938 ± 0.365
1.502AsnAsn: 1.502 ± 0.402
1.314AsnPro: 1.314 ± 0.422
0.751AsnGln: 0.751 ± 0.39
2.065AsnArg: 2.065 ± 0.517
3.378AsnSer: 3.378 ± 0.337
2.628AsnThr: 2.628 ± 0.272
5.818AsnVal: 5.818 ± 0.443
0.938AsnTrp: 0.938 ± 0.323
0.375AsnTyr: 0.375 ± 0.184
0.0AsnXaa: 0.0 ± 0.0
Pro
4.317ProAla: 4.317 ± 0.351
0.0ProCys: 0.0 ± 0.0
1.502ProAsp: 1.502 ± 0.39
1.314ProGlu: 1.314 ± 0.341
0.751ProPhe: 0.751 ± 0.703
2.065ProGly: 2.065 ± 0.697
0.751ProHis: 0.751 ± 0.326
1.314ProIle: 1.314 ± 0.325
1.314ProLys: 1.314 ± 0.673
2.628ProLeu: 2.628 ± 0.514
1.689ProMet: 1.689 ± 0.997
0.563ProAsn: 0.563 ± 0.314
1.689ProPro: 1.689 ± 0.542
0.751ProGln: 0.751 ± 0.251
2.628ProArg: 2.628 ± 1.088
1.877ProSer: 1.877 ± 0.544
3.378ProThr: 3.378 ± 0.871
1.877ProVal: 1.877 ± 0.649
0.375ProTrp: 0.375 ± 0.187
1.314ProTyr: 1.314 ± 0.25
0.0ProXaa: 0.0 ± 0.0
Gln
4.505GlnAla: 4.505 ± 0.782
0.751GlnCys: 0.751 ± 0.375
1.126GlnAsp: 1.126 ± 0.485
3.003GlnGlu: 3.003 ± 0.559
1.502GlnPhe: 1.502 ± 0.246
1.877GlnGly: 1.877 ± 1.096
1.314GlnHis: 1.314 ± 0.555
1.126GlnIle: 1.126 ± 0.398
0.938GlnLys: 0.938 ± 0.411
3.191GlnLeu: 3.191 ± 0.399
0.938GlnMet: 0.938 ± 0.57
1.502GlnAsn: 1.502 ± 0.169
0.563GlnPro: 0.563 ± 0.29
2.065GlnGln: 2.065 ± 0.332
2.252GlnArg: 2.252 ± 0.577
1.689GlnSer: 1.689 ± 0.506
1.877GlnThr: 1.877 ± 0.776
3.754GlnVal: 3.754 ± 1.002
0.375GlnTrp: 0.375 ± 0.312
1.314GlnTyr: 1.314 ± 0.25
0.0GlnXaa: 0.0 ± 0.0
Arg
7.695ArgAla: 7.695 ± 0.658
0.938ArgCys: 0.938 ± 0.331
4.129ArgAsp: 4.129 ± 0.442
4.129ArgGlu: 4.129 ± 0.553
1.314ArgPhe: 1.314 ± 0.314
3.378ArgGly: 3.378 ± 0.432
2.065ArgHis: 2.065 ± 0.754
4.692ArgIle: 4.692 ± 0.528
1.314ArgLys: 1.314 ± 0.259
4.692ArgLeu: 4.692 ± 0.832
2.815ArgMet: 2.815 ± 0.561
1.314ArgAsn: 1.314 ± 0.459
3.191ArgPro: 3.191 ± 0.962
1.877ArgGln: 1.877 ± 0.65
3.941ArgArg: 3.941 ± 0.891
4.317ArgSer: 4.317 ± 0.941
3.378ArgThr: 3.378 ± 0.971
4.317ArgVal: 4.317 ± 0.833
1.126ArgTrp: 1.126 ± 0.642
1.689ArgTyr: 1.689 ± 0.489
0.0ArgXaa: 0.0 ± 0.0
Ser
6.757SerAla: 6.757 ± 0.988
1.126SerCys: 1.126 ± 0.402
4.505SerAsp: 4.505 ± 0.488
3.754SerGlu: 3.754 ± 0.651
1.502SerPhe: 1.502 ± 0.734
6.944SerGly: 6.944 ± 1.159
1.314SerHis: 1.314 ± 0.422
3.191SerIle: 3.191 ± 0.581
3.191SerLys: 3.191 ± 0.662
5.068SerLeu: 5.068 ± 0.566
1.314SerMet: 1.314 ± 0.193
1.314SerAsn: 1.314 ± 0.341
1.502SerPro: 1.502 ± 0.511
2.628SerGln: 2.628 ± 0.706
2.815SerArg: 2.815 ± 0.743
4.317SerSer: 4.317 ± 0.56
7.883SerThr: 7.883 ± 1.105
5.255SerVal: 5.255 ± 0.559
1.314SerTrp: 1.314 ± 0.341
0.938SerTyr: 0.938 ± 0.201
0.0SerXaa: 0.0 ± 0.0
Thr
8.821ThrAla: 8.821 ± 1.336
1.126ThrCys: 1.126 ± 0.364
5.255ThrAsp: 5.255 ± 1.166
3.941ThrGlu: 3.941 ± 0.324
1.314ThrPhe: 1.314 ± 0.279
5.443ThrGly: 5.443 ± 0.969
0.938ThrHis: 0.938 ± 0.677
3.378ThrIle: 3.378 ± 1.104
3.003ThrLys: 3.003 ± 0.535
4.129ThrLeu: 4.129 ± 0.308
3.003ThrMet: 3.003 ± 0.309
1.877ThrAsn: 1.877 ± 0.509
2.44ThrPro: 2.44 ± 0.777
2.44ThrGln: 2.44 ± 0.549
4.505ThrArg: 4.505 ± 0.62
3.941ThrSer: 3.941 ± 0.899
4.88ThrThr: 4.88 ± 1.329
5.631ThrVal: 5.631 ± 0.95
1.877ThrTrp: 1.877 ± 0.384
2.628ThrTyr: 2.628 ± 0.36
0.0ThrXaa: 0.0 ± 0.0
Val
9.572ValAla: 9.572 ± 0.835
0.751ValCys: 0.751 ± 0.497
4.129ValAsp: 4.129 ± 0.604
3.378ValGlu: 3.378 ± 0.87
1.877ValPhe: 1.877 ± 0.873
3.191ValGly: 3.191 ± 0.542
2.252ValHis: 2.252 ± 0.487
2.065ValIle: 2.065 ± 0.531
2.44ValLys: 2.44 ± 0.333
5.818ValLeu: 5.818 ± 1.931
1.126ValMet: 1.126 ± 0.267
4.317ValAsn: 4.317 ± 1.068
3.378ValPro: 3.378 ± 0.709
3.191ValGln: 3.191 ± 0.473
3.378ValArg: 3.378 ± 0.219
6.006ValSer: 6.006 ± 1.579
6.006ValThr: 6.006 ± 1.02
6.381ValVal: 6.381 ± 0.371
0.938ValTrp: 0.938 ± 0.512
2.44ValTyr: 2.44 ± 0.277
0.0ValXaa: 0.0 ± 0.0
Trp
2.815TrpAla: 2.815 ± 1.232
0.751TrpCys: 0.751 ± 0.428
0.751TrpAsp: 0.751 ± 0.256
1.126TrpGlu: 1.126 ± 0.591
0.938TrpPhe: 0.938 ± 0.365
1.314TrpGly: 1.314 ± 0.504
0.563TrpHis: 0.563 ± 0.291
0.751TrpIle: 0.751 ± 0.368
0.563TrpLys: 0.563 ± 0.35
2.44TrpLeu: 2.44 ± 0.7
0.938TrpMet: 0.938 ± 0.437
0.751TrpAsn: 0.751 ± 0.298
0.751TrpPro: 0.751 ± 0.227
0.375TrpGln: 0.375 ± 0.195
0.938TrpArg: 0.938 ± 0.476
0.938TrpSer: 0.938 ± 0.492
0.375TrpThr: 0.375 ± 0.218
0.375TrpVal: 0.375 ± 0.195
0.0TrpTrp: 0.0 ± 0.0
0.563TrpTyr: 0.563 ± 0.306
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.815TyrAla: 2.815 ± 0.811
0.751TyrCys: 0.751 ± 0.253
3.191TyrAsp: 3.191 ± 0.574
2.065TyrGlu: 2.065 ± 0.614
0.563TyrPhe: 0.563 ± 0.337
1.314TyrGly: 1.314 ± 0.365
1.126TyrHis: 1.126 ± 0.352
1.877TyrIle: 1.877 ± 0.672
1.314TyrLys: 1.314 ± 0.513
2.065TyrLeu: 2.065 ± 0.77
0.938TyrMet: 0.938 ± 0.317
1.126TyrAsn: 1.126 ± 0.158
0.751TyrPro: 0.751 ± 0.624
1.126TyrGln: 1.126 ± 0.164
1.689TyrArg: 1.689 ± 1.167
1.877TyrSer: 1.877 ± 0.538
2.44TyrThr: 2.44 ± 0.34
2.815TyrVal: 2.815 ± 0.627
0.375TyrTrp: 0.375 ± 0.312
2.065TyrTyr: 2.065 ± 0.41
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (5329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski