Amino acid dipepetide frequency for Roseofilum reptotaenium AO1-A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.835AlaAla: 5.835 ± 0.077	0.828AlaCys: 0.828 ± 0.022	3.661AlaAsp: 3.661 ± 0.048	4.988AlaGlu: 4.988 ± 0.07	2.629AlaPhe: 2.629 ± 0.048	4.712AlaGly: 4.712 ± 0.075	1.385AlaHis: 1.385 ± 0.029	7.039AlaIle: 7.039 ± 0.08	3.449AlaLys: 3.449 ± 0.053	8.516AlaLeu: 8.516 ± 0.095	1.564AlaMet: 1.564 ± 0.032	2.99AlaAsn: 2.99 ± 0.069	2.914AlaPro: 2.914 ± 0.057	4.653AlaGln: 4.653 ± 0.066	3.227AlaArg: 3.227 ± 0.043	4.367AlaSer: 4.367 ± 0.063	4.066AlaThr: 4.066 ± 0.061	4.544AlaVal: 4.544 ± 0.064	0.969AlaTrp: 0.969 ± 0.027	2.253AlaTyr: 2.253 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.609CysAla: 0.609 ± 0.022	0.177CysCys: 0.177 ± 0.011	0.644CysAsp: 0.644 ± 0.022	0.602CysGlu: 0.602 ± 0.023	0.436CysPhe: 0.436 ± 0.015	0.784CysGly: 0.784 ± 0.023	0.323CysHis: 0.323 ± 0.016	0.593CysIle: 0.593 ± 0.019	0.328CysLys: 0.328 ± 0.014	1.16CysLeu: 1.16 ± 0.028	0.163CysMet: 0.163 ± 0.01	0.373CysAsn: 0.373 ± 0.015	0.562CysPro: 0.562 ± 0.024	0.653CysGln: 0.653 ± 0.022	0.533CysArg: 0.533 ± 0.02	0.681CysSer: 0.681 ± 0.022	0.475CysThr: 0.475 ± 0.016	0.53CysVal: 0.53 ± 0.022	0.146CysTrp: 0.146 ± 0.01	0.401CysTyr: 0.401 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.218AspAla: 3.218 ± 0.053	0.531AspCys: 0.531 ± 0.017	2.291AspAsp: 2.291 ± 0.043	3.077AspGlu: 3.077 ± 0.056	2.377AspPhe: 2.377 ± 0.043	3.226AspGly: 3.226 ± 0.064	0.908AspHis: 0.908 ± 0.024	3.344AspIle: 3.344 ± 0.047	1.858AspLys: 1.858 ± 0.035	6.556AspLeu: 6.556 ± 0.064	0.862AspMet: 0.862 ± 0.023	1.92AspAsn: 1.92 ± 0.04	2.923AspPro: 2.923 ± 0.046	2.17AspGln: 2.17 ± 0.042	5.048AspArg: 5.048 ± 0.061	2.921AspSer: 2.921 ± 0.052	2.442AspThr: 2.442 ± 0.049	2.74AspVal: 2.74 ± 0.043	1.013AspTrp: 1.013 ± 0.026	2.052AspTyr: 2.052 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.683GluAla: 5.683 ± 0.067	0.56GluCys: 0.56 ± 0.018	3.335GluAsp: 3.335 ± 0.051	5.21GluGlu: 5.21 ± 0.07	2.568GluPhe: 2.568 ± 0.043	4.026GluGly: 4.026 ± 0.052	1.128GluHis: 1.128 ± 0.029	4.987GluIle: 4.987 ± 0.057	3.493GluLys: 3.493 ± 0.053	7.464GluLeu: 7.464 ± 0.073	1.465GluMet: 1.465 ± 0.032	2.829GluAsn: 2.829 ± 0.044	2.659GluPro: 2.659 ± 0.049	4.212GluGln: 4.212 ± 0.057	3.65GluArg: 3.65 ± 0.051	4.047GluSer: 4.047 ± 0.049	4.027GluThr: 4.027 ± 0.053	4.567GluVal: 4.567 ± 0.066	0.933GluTrp: 0.933 ± 0.027	2.027GluTyr: 2.027 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.677PheAla: 2.677 ± 0.049	0.521PheCys: 0.521 ± 0.022	2.228PheAsp: 2.228 ± 0.032	2.392PheGlu: 2.392 ± 0.04	1.598PhePhe: 1.598 ± 0.036	2.611PheGly: 2.611 ± 0.045	0.78PheHis: 0.78 ± 0.023	2.233PheIle: 2.233 ± 0.038	1.48PheLys: 1.48 ± 0.037	4.035PheLeu: 4.035 ± 0.061	0.762PheMet: 0.762 ± 0.022	1.698PheAsn: 1.698 ± 0.035	1.951PhePro: 1.951 ± 0.039	1.858PheGln: 1.858 ± 0.035	1.773PheArg: 1.773 ± 0.032	2.981PheSer: 2.981 ± 0.052	2.214PheThr: 2.214 ± 0.034	2.156PheVal: 2.156 ± 0.034	0.749PheTrp: 0.749 ± 0.021	1.395PheTyr: 1.395 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.567GlyAla: 4.567 ± 0.075	0.832GlyCys: 0.832 ± 0.024	3.75GlyAsp: 3.75 ± 0.056	4.414GlyGlu: 4.414 ± 0.061	3.018GlyPhe: 3.018 ± 0.053	4.627GlyGly: 4.627 ± 0.086	1.292GlyHis: 1.292 ± 0.031	4.969GlyIle: 4.969 ± 0.057	3.652GlyLys: 3.652 ± 0.052	7.372GlyLeu: 7.372 ± 0.074	1.653GlyMet: 1.653 ± 0.032	3.036GlyAsn: 3.036 ± 0.068	1.455GlyPro: 1.455 ± 0.037	3.416GlyGln: 3.416 ± 0.049	3.073GlyArg: 3.073 ± 0.046	4.001GlySer: 4.001 ± 0.06	3.827GlyThr: 3.827 ± 0.068	4.574GlyVal: 4.574 ± 0.062	1.221GlyTrp: 1.221 ± 0.027	2.482GlyTyr: 2.482 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.104HisAla: 1.104 ± 0.026	0.292HisCys: 0.292 ± 0.015	0.839HisAsp: 0.839 ± 0.023	1.073HisGlu: 1.073 ± 0.026	0.875HisPhe: 0.875 ± 0.023	1.138HisGly: 1.138 ± 0.028	0.743HisHis: 0.743 ± 0.025	1.125HisIle: 1.125 ± 0.03	0.769HisLys: 0.769 ± 0.023	2.732HisLeu: 2.732 ± 0.045	0.267HisMet: 0.267 ± 0.011	0.712HisAsn: 0.712 ± 0.023	1.525HisPro: 1.525 ± 0.033	1.57HisGln: 1.57 ± 0.036	1.162HisArg: 1.162 ± 0.029	1.298HisSer: 1.298 ± 0.031	0.938HisThr: 0.938 ± 0.025	0.841HisVal: 0.841 ± 0.021	0.426HisTrp: 0.426 ± 0.017	0.855HisTyr: 0.855 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.806IleAla: 6.806 ± 0.073	0.703IleCys: 0.703 ± 0.019	3.859IleAsp: 3.859 ± 0.053	4.642IleGlu: 4.642 ± 0.057	2.314IlePhe: 2.314 ± 0.045	4.392IleGly: 4.392 ± 0.06	1.394IleHis: 1.394 ± 0.03	3.577IleIle: 3.577 ± 0.055	2.647IleLys: 2.647 ± 0.045	7.047IleLeu: 7.047 ± 0.077	0.867IleMet: 0.867 ± 0.023	2.713IleAsn: 2.713 ± 0.05	3.744IlePro: 3.744 ± 0.051	3.383IleGln: 3.383 ± 0.05	3.17IleArg: 3.17 ± 0.049	4.404IleSer: 4.404 ± 0.062	3.558IleThr: 3.558 ± 0.055	3.914IleVal: 3.914 ± 0.055	0.913IleTrp: 0.913 ± 0.026	1.923IleTyr: 1.923 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	3.557LysAla: 3.557 ± 0.049	0.294LysCys: 0.294 ± 0.014	1.968LysAsp: 1.968 ± 0.042	2.799LysGlu: 2.799 ± 0.051	1.476LysPhe: 1.476 ± 0.026	2.628LysGly: 2.628 ± 0.044	0.818LysHis: 0.818 ± 0.023	3.261LysIle: 3.261 ± 0.059	2.157LysLys: 2.157 ± 0.048	4.738LysLeu: 4.738 ± 0.063	0.901LysMet: 0.901 ± 0.025	1.725LysAsn: 1.725 ± 0.033	2.345LysPro: 2.345 ± 0.042	2.47LysGln: 2.47 ± 0.041	2.431LysArg: 2.431 ± 0.04	2.762LysSer: 2.762 ± 0.048	2.913LysThr: 2.913 ± 0.05	2.808LysVal: 2.808 ± 0.043	0.456LysTrp: 0.456 ± 0.019	1.202LysTyr: 1.202 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	8.973LeuAla: 8.973 ± 0.08	1.144LeuCys: 1.144 ± 0.027	6.108LeuAsp: 6.108 ± 0.066	8.67LeuGlu: 8.67 ± 0.083	3.856LeuPhe: 3.856 ± 0.058	8.011LeuGly: 8.011 ± 0.088	2.12LeuHis: 2.12 ± 0.039	6.838LeuIle: 6.838 ± 0.069	5.689LeuLys: 5.689 ± 0.067	11.057LeuLeu: 11.057 ± 0.106	2.413LeuMet: 2.413 ± 0.04	4.815LeuAsn: 4.815 ± 0.051	5.759LeuPro: 5.759 ± 0.075	5.736LeuGln: 5.736 ± 0.064	5.475LeuArg: 5.475 ± 0.061	8.134LeuSer: 8.134 ± 0.075	6.308LeuThr: 6.308 ± 0.066	7.019LeuVal: 7.019 ± 0.08	1.6LeuTrp: 1.6 ± 0.038	2.981LeuTyr: 2.981 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.883MetAla: 1.883 ± 0.029	0.123MetCys: 0.123 ± 0.009	0.931MetAsp: 0.931 ± 0.025	1.238MetGlu: 1.238 ± 0.03	0.55MetPhe: 0.55 ± 0.018	1.667MetGly: 1.667 ± 0.027	0.317MetHis: 0.317 ± 0.015	1.247MetIle: 1.247 ± 0.032	0.988MetLys: 0.988 ± 0.022	1.745MetLeu: 1.745 ± 0.035	0.506MetMet: 0.506 ± 0.018	0.917MetAsn: 0.917 ± 0.025	0.941MetPro: 0.941 ± 0.026	0.836MetGln: 0.836 ± 0.023	0.927MetArg: 0.927 ± 0.026	1.428MetSer: 1.428 ± 0.033	1.356MetThr: 1.356 ± 0.026	1.478MetVal: 1.478 ± 0.032	0.134MetTrp: 0.134 ± 0.01	0.349MetTyr: 0.349 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.631AsnAla: 2.631 ± 0.042	0.441AsnCys: 0.441 ± 0.019	1.717AsnAsp: 1.717 ± 0.052	1.827AsnGlu: 1.827 ± 0.038	1.634AsnPhe: 1.634 ± 0.035	2.605AsnGly: 2.605 ± 0.051	0.951AsnHis: 0.951 ± 0.023	2.405AsnIle: 2.405 ± 0.05	1.246AsnLys: 1.246 ± 0.028	5.42AsnLeu: 5.42 ± 0.093	0.662AsnMet: 0.662 ± 0.018	1.477AsnAsn: 1.477 ± 0.038	3.162AsnPro: 3.162 ± 0.05	2.782AsnGln: 2.782 ± 0.04	2.544AsnArg: 2.544 ± 0.042	2.494AsnSer: 2.494 ± 0.044	2.02AsnThr: 2.02 ± 0.039	1.838AsnVal: 1.838 ± 0.032	0.757AsnTrp: 0.757 ± 0.021	1.336AsnTyr: 1.336 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	2.799ProAla: 2.799 ± 0.047	0.35ProCys: 0.35 ± 0.018	3.161ProAsp: 3.161 ± 0.051	4.78ProGlu: 4.78 ± 0.062	1.808ProPhe: 1.808 ± 0.031	3.152ProGly: 3.152 ± 0.05	1.088ProHis: 1.088 ± 0.026	3.234ProIle: 3.234 ± 0.043	2.206ProLys: 2.206 ± 0.042	5.141ProLeu: 5.141 ± 0.063	0.875ProMet: 0.875 ± 0.023	2.147ProAsn: 2.147 ± 0.039	2.594ProPro: 2.594 ± 0.064	2.918ProGln: 2.918 ± 0.044	1.783ProArg: 1.783 ± 0.037	3.311ProSer: 3.311 ± 0.057	2.825ProThr: 2.825 ± 0.055	3.374ProVal: 3.374 ± 0.049	0.676ProTrp: 0.676 ± 0.021	1.427ProTyr: 1.427 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.721GlnAla: 4.721 ± 0.056	0.422GlnCys: 0.422 ± 0.017	2.545GlnAsp: 2.545 ± 0.042	4.361GlnGlu: 4.361 ± 0.053	2.066GlnPhe: 2.066 ± 0.04	3.973GlnGly: 3.973 ± 0.054	0.994GlnHis: 0.994 ± 0.027	3.663GlnIle: 3.663 ± 0.049	2.695GlnLys: 2.695 ± 0.049	6.506GlnLeu: 6.506 ± 0.072	1.21GlnMet: 1.21 ± 0.025	2.146GlnAsn: 2.146 ± 0.035	2.599GlnPro: 2.599 ± 0.041	3.61GlnGln: 3.61 ± 0.052	2.84GlnArg: 2.84 ± 0.045	3.158GlnSer: 3.158 ± 0.044	3.253GlnThr: 3.253 ± 0.05	4.166GlnVal: 4.166 ± 0.052	0.959GlnTrp: 0.959 ± 0.026	1.4GlnTyr: 1.4 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.265ArgAla: 3.265 ± 0.048	0.531ArgCys: 0.531 ± 0.018	2.657ArgAsp: 2.657 ± 0.044	3.461ArgGlu: 3.461 ± 0.05	2.166ArgPhe: 2.166 ± 0.031	3.018ArgGly: 3.018 ± 0.047	1.103ArgHis: 1.103 ± 0.028	3.414ArgIle: 3.414 ± 0.05	2.312ArgLys: 2.312 ± 0.041	6.264ArgLeu: 6.264 ± 0.068	1.099ArgMet: 1.099 ± 0.027	1.901ArgAsn: 1.901 ± 0.036	2.167ArgPro: 2.167 ± 0.038	3.49ArgGln: 3.49 ± 0.046	2.836ArgArg: 2.836 ± 0.047	3.54ArgSer: 3.54 ± 0.049	2.573ArgThr: 2.573 ± 0.04	3.332ArgVal: 3.332 ± 0.046	0.902ArgTrp: 0.902 ± 0.025	1.986ArgTyr: 1.986 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.372SerAla: 4.372 ± 0.055	0.678SerCys: 0.678 ± 0.023	3.385SerAsp: 3.385 ± 0.049	4.238SerGlu: 4.238 ± 0.057	2.437SerPhe: 2.437 ± 0.037	4.684SerGly: 4.684 ± 0.065	1.472SerHis: 1.472 ± 0.029	3.863SerIle: 3.863 ± 0.05	2.277SerLys: 2.277 ± 0.042	7.775SerLeu: 7.775 ± 0.07	1.285SerMet: 1.285 ± 0.026	2.31SerAsn: 2.31 ± 0.045	3.843SerPro: 3.843 ± 0.054	3.856SerGln: 3.856 ± 0.045	3.18SerArg: 3.18 ± 0.045	4.648SerSer: 4.648 ± 0.069	3.347SerThr: 3.347 ± 0.048	3.919SerVal: 3.919 ± 0.046	1.001SerTrp: 1.001 ± 0.025	1.966SerTyr: 1.966 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	4.011ThrAla: 4.011 ± 0.058	0.493ThrCys: 0.493 ± 0.017	2.677ThrAsp: 2.677 ± 0.052	3.632ThrGlu: 3.632 ± 0.051	1.973ThrPhe: 1.973 ± 0.036	4.264ThrGly: 4.264 ± 0.062	1.21ThrHis: 1.21 ± 0.029	3.502ThrIle: 3.502 ± 0.05	1.71ThrLys: 1.71 ± 0.035	7.325ThrLeu: 7.325 ± 0.082	0.752ThrMet: 0.752 ± 0.021	1.736ThrAsn: 1.736 ± 0.038	3.61ThrPro: 3.61 ± 0.066	3.256ThrGln: 3.256 ± 0.05	2.357ThrArg: 2.357 ± 0.043	3.218ThrSer: 3.218 ± 0.046	3.0ThrThr: 3.0 ± 0.053	3.73ThrVal: 3.73 ± 0.055	0.817ThrTrp: 0.817 ± 0.024	1.659ThrTyr: 1.659 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	5.025ValAla: 5.025 ± 0.068	0.67ValCys: 0.67 ± 0.024	3.377ValAsp: 3.377 ± 0.049	4.494ValGlu: 4.494 ± 0.054	2.399ValPhe: 2.399 ± 0.041	4.411ValGly: 4.411 ± 0.057	1.059ValHis: 1.059 ± 0.026	3.992ValIle: 3.992 ± 0.053	2.984ValLys: 2.984 ± 0.046	6.43ValLeu: 6.43 ± 0.066	1.431ValMet: 1.431 ± 0.03	2.78ValAsn: 2.78 ± 0.049	2.707ValPro: 2.707 ± 0.046	2.937ValGln: 2.937 ± 0.045	3.03ValArg: 3.03 ± 0.048	4.137ValSer: 4.137 ± 0.052	3.554ValThr: 3.554 ± 0.05	4.295ValVal: 4.295 ± 0.06	0.873ValTrp: 0.873 ± 0.026	1.886ValTyr: 1.886 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.86TrpAla: 0.86 ± 0.026	0.171TrpCys: 0.171 ± 0.01	0.699TrpAsp: 0.699 ± 0.022	1.064TrpGlu: 1.064 ± 0.025	0.623TrpPhe: 0.623 ± 0.023	1.117TrpGly: 1.117 ± 0.027	0.373TrpHis: 0.373 ± 0.017	1.063TrpIle: 1.063 ± 0.027	0.711TrpLys: 0.711 ± 0.022	1.797TrpLeu: 1.797 ± 0.042	0.378TrpMet: 0.378 ± 0.017	0.623TrpAsn: 0.623 ± 0.019	0.407TrpPro: 0.407 ± 0.017	1.162TrpGln: 1.162 ± 0.027	0.863TrpArg: 0.863 ± 0.023	0.999TrpSer: 0.999 ± 0.024	0.648TrpThr: 0.648 ± 0.023	1.096TrpVal: 1.096 ± 0.03	0.262TrpTrp: 0.262 ± 0.014	0.448TrpTyr: 0.448 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.994TyrAla: 1.994 ± 0.034	0.412TyrCys: 0.412 ± 0.014	1.647TyrAsp: 1.647 ± 0.034	1.91TyrGlu: 1.91 ± 0.036	1.286TyrPhe: 1.286 ± 0.032	2.187TyrGly: 2.187 ± 0.038	0.821TyrHis: 0.821 ± 0.024	1.623TyrIle: 1.623 ± 0.035	1.059TyrLys: 1.059 ± 0.025	3.626TyrLeu: 3.626 ± 0.05	0.447TyrMet: 0.447 ± 0.015	1.098TyrAsn: 1.098 ± 0.026	1.782TyrPro: 1.782 ± 0.036	2.319TyrGln: 2.319 ± 0.037	2.114TyrArg: 2.114 ± 0.037	2.007TyrSer: 2.007 ± 0.045	1.589TyrThr: 1.589 ± 0.038	1.547TyrVal: 1.547 ± 0.032	0.56TyrTrp: 0.56 ± 0.019	1.104TyrTyr: 1.104 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4956 proteins (1620154 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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