Amino acid dipepetide frequency for Arthrobacter agilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.617AlaAla: 19.617 ± 0.238	0.74AlaCys: 0.74 ± 0.032	7.939AlaAsp: 7.939 ± 0.101	7.715AlaGlu: 7.715 ± 0.087	3.849AlaPhe: 3.849 ± 0.07	13.014AlaGly: 13.014 ± 0.152	2.347AlaHis: 2.347 ± 0.054	4.677AlaIle: 4.677 ± 0.079	2.491AlaLys: 2.491 ± 0.058	13.631AlaLeu: 13.631 ± 0.149	2.622AlaMet: 2.622 ± 0.059	2.137AlaAsn: 2.137 ± 0.052	6.46AlaPro: 6.46 ± 0.111	3.775AlaGln: 3.775 ± 0.069	8.796AlaArg: 8.796 ± 0.126	7.194AlaSer: 7.194 ± 0.096	6.984AlaThr: 6.984 ± 0.083	12.221AlaVal: 12.221 ± 0.118	1.65AlaTrp: 1.65 ± 0.043	2.248AlaTyr: 2.248 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.699CysAla: 0.699 ± 0.031	0.047CysCys: 0.047 ± 0.007	0.324CysAsp: 0.324 ± 0.019	0.276CysGlu: 0.276 ± 0.018	0.159CysPhe: 0.159 ± 0.012	0.677CysGly: 0.677 ± 0.028	0.115CysHis: 0.115 ± 0.01	0.245CysIle: 0.245 ± 0.018	0.075CysLys: 0.075 ± 0.009	0.527CysLeu: 0.527 ± 0.023	0.082CysMet: 0.082 ± 0.01	0.108CysAsn: 0.108 ± 0.01	0.355CysPro: 0.355 ± 0.022	0.145CysGln: 0.145 ± 0.013	0.412CysArg: 0.412 ± 0.021	0.402CysSer: 0.402 ± 0.019	0.377CysThr: 0.377 ± 0.023	0.469CysVal: 0.469 ± 0.022	0.081CysTrp: 0.081 ± 0.009	0.137CysTyr: 0.137 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.565AspAla: 8.565 ± 0.125	0.284AspCys: 0.284 ± 0.018	4.082AspAsp: 4.082 ± 0.076	3.673AspGlu: 3.673 ± 0.064	1.8AspPhe: 1.8 ± 0.052	6.517AspGly: 6.517 ± 0.104	1.332AspHis: 1.332 ± 0.037	2.416AspIle: 2.416 ± 0.056	0.945AspLys: 0.945 ± 0.034	6.648AspLeu: 6.648 ± 0.09	0.871AspMet: 0.871 ± 0.031	0.995AspAsn: 0.995 ± 0.042	3.945AspPro: 3.945 ± 0.07	1.731AspGln: 1.731 ± 0.051	4.316AspArg: 4.316 ± 0.072	2.891AspSer: 2.891 ± 0.053	3.193AspThr: 3.193 ± 0.062	5.481AspVal: 5.481 ± 0.085	0.83AspTrp: 0.83 ± 0.026	1.338AspTyr: 1.338 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.187GluAla: 7.187 ± 0.109	0.277GluCys: 0.277 ± 0.019	3.681GluAsp: 3.681 ± 0.074	3.563GluGlu: 3.563 ± 0.067	1.556GluPhe: 1.556 ± 0.042	4.519GluGly: 4.519 ± 0.073	1.422GluHis: 1.422 ± 0.041	2.409GluIle: 2.409 ± 0.057	1.456GluLys: 1.456 ± 0.038	6.174GluLeu: 6.174 ± 0.095	0.936GluMet: 0.936 ± 0.036	1.345GluAsn: 1.345 ± 0.045	2.967GluPro: 2.967 ± 0.059	2.355GluGln: 2.355 ± 0.055	4.517GluArg: 4.517 ± 0.064	2.837GluSer: 2.837 ± 0.054	2.94GluThr: 2.94 ± 0.061	4.474GluVal: 4.474 ± 0.083	0.68GluTrp: 0.68 ± 0.029	1.109GluTyr: 1.109 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.793PheAla: 3.793 ± 0.065	0.219PheCys: 0.219 ± 0.015	2.343PheAsp: 2.343 ± 0.051	1.715PheGlu: 1.715 ± 0.043	1.143PhePhe: 1.143 ± 0.043	3.223PheGly: 3.223 ± 0.069	0.556PheHis: 0.556 ± 0.024	1.271PheIle: 1.271 ± 0.043	0.521PheLys: 0.521 ± 0.026	3.05PheLeu: 3.05 ± 0.066	0.499PheMet: 0.499 ± 0.022	0.74PheAsn: 0.74 ± 0.03	1.332PhePro: 1.332 ± 0.039	0.743PheGln: 0.743 ± 0.026	1.864PheArg: 1.864 ± 0.047	1.967PheSer: 1.967 ± 0.056	2.117PheThr: 2.117 ± 0.049	2.7PheVal: 2.7 ± 0.059	0.449PheTrp: 0.449 ± 0.022	0.643PheTyr: 0.643 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.881GlyAla: 10.881 ± 0.125	0.583GlyCys: 0.583 ± 0.024	4.849GlyAsp: 4.849 ± 0.086	4.705GlyGlu: 4.705 ± 0.08	3.199GlyPhe: 3.199 ± 0.06	8.051GlyGly: 8.051 ± 0.123	1.888GlyHis: 1.888 ± 0.045	4.711GlyIle: 4.711 ± 0.08	2.312GlyLys: 2.312 ± 0.057	9.23GlyLeu: 9.23 ± 0.118	1.952GlyMet: 1.952 ± 0.042	1.977GlyAsn: 1.977 ± 0.051	4.311GlyPro: 4.311 ± 0.075	2.803GlyGln: 2.803 ± 0.054	6.913GlyArg: 6.913 ± 0.095	6.184GlySer: 6.184 ± 0.09	6.518GlyThr: 6.518 ± 0.108	7.695GlyVal: 7.695 ± 0.105	1.499GlyTrp: 1.499 ± 0.045	2.2GlyTyr: 2.2 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.44HisAla: 2.44 ± 0.063	0.137HisCys: 0.137 ± 0.012	1.256HisAsp: 1.256 ± 0.037	1.126HisGlu: 1.126 ± 0.037	0.589HisPhe: 0.589 ± 0.025	1.96HisGly: 1.96 ± 0.047	0.623HisHis: 0.623 ± 0.032	0.686HisIle: 0.686 ± 0.027	0.293HisLys: 0.293 ± 0.016	2.214HisLeu: 2.214 ± 0.053	0.316HisMet: 0.316 ± 0.019	0.381HisAsn: 0.381 ± 0.02	1.504HisPro: 1.504 ± 0.04	0.634HisGln: 0.634 ± 0.026	1.732HisArg: 1.732 ± 0.045	1.076HisSer: 1.076 ± 0.034	1.056HisThr: 1.056 ± 0.034	1.597HisVal: 1.597 ± 0.044	0.276HisTrp: 0.276 ± 0.018	0.463HisTyr: 0.463 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.685IleAla: 5.685 ± 0.093	0.291IleCys: 0.291 ± 0.019	3.134IleAsp: 3.134 ± 0.06	2.531IleGlu: 2.531 ± 0.058	1.268IlePhe: 1.268 ± 0.045	4.279IleGly: 4.279 ± 0.076	0.698IleHis: 0.698 ± 0.03	1.762IleIle: 1.762 ± 0.058	0.785IleLys: 0.785 ± 0.035	3.892IleLeu: 3.892 ± 0.078	0.657IleMet: 0.657 ± 0.027	1.05IleAsn: 1.05 ± 0.033	2.239IlePro: 2.239 ± 0.05	0.878IleGln: 0.878 ± 0.031	2.654IleArg: 2.654 ± 0.055	2.461IleSer: 2.461 ± 0.052	2.917IleThr: 2.917 ± 0.061	3.596IleVal: 3.596 ± 0.069	0.436IleTrp: 0.436 ± 0.021	0.717IleTyr: 0.717 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	2.594LysAla: 2.594 ± 0.061	0.064LysCys: 0.064 ± 0.008	1.37LysAsp: 1.37 ± 0.042	1.096LysGlu: 1.096 ± 0.039	0.501LysPhe: 0.501 ± 0.026	1.682LysGly: 1.682 ± 0.053	0.445LysHis: 0.445 ± 0.021	0.947LysIle: 0.947 ± 0.036	0.736LysLys: 0.736 ± 0.033	1.972LysLeu: 1.972 ± 0.055	0.398LysMet: 0.398 ± 0.021	0.562LysAsn: 0.562 ± 0.024	1.288LysPro: 1.288 ± 0.039	0.67LysGln: 0.67 ± 0.03	1.435LysArg: 1.435 ± 0.046	1.107LysSer: 1.107 ± 0.034	1.18LysThr: 1.18 ± 0.042	1.582LysVal: 1.582 ± 0.043	0.196LysTrp: 0.196 ± 0.014	0.495LysTyr: 0.495 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.313LeuAla: 14.313 ± 0.14	0.615LeuCys: 0.615 ± 0.024	6.604LeuAsp: 6.604 ± 0.09	5.515LeuGlu: 5.515 ± 0.09	2.897LeuPhe: 2.897 ± 0.063	9.454LeuGly: 9.454 ± 0.108	2.07LeuHis: 2.07 ± 0.049	4.202LeuIle: 4.202 ± 0.087	1.949LeuLys: 1.949 ± 0.054	10.847LeuLeu: 10.847 ± 0.154	1.842LeuMet: 1.842 ± 0.048	1.978LeuAsn: 1.978 ± 0.045	5.928LeuPro: 5.928 ± 0.077	2.982LeuGln: 2.982 ± 0.066	7.601LeuArg: 7.601 ± 0.09	5.847LeuSer: 5.847 ± 0.09	6.587LeuThr: 6.587 ± 0.079	9.11LeuVal: 9.11 ± 0.112	1.214LeuTrp: 1.214 ± 0.043	1.736LeuTyr: 1.736 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.341MetAla: 2.341 ± 0.053	0.093MetCys: 0.093 ± 0.011	0.992MetAsp: 0.992 ± 0.034	0.826MetGlu: 0.826 ± 0.03	0.518MetPhe: 0.518 ± 0.024	1.523MetGly: 1.523 ± 0.039	0.322MetHis: 0.322 ± 0.02	0.856MetIle: 0.856 ± 0.033	0.525MetLys: 0.525 ± 0.025	1.818MetLeu: 1.818 ± 0.046	0.351MetMet: 0.351 ± 0.018	0.497MetAsn: 0.497 ± 0.021	1.012MetPro: 1.012 ± 0.03	0.52MetGln: 0.52 ± 0.022	1.196MetArg: 1.196 ± 0.04	1.439MetSer: 1.439 ± 0.037	1.596MetThr: 1.596 ± 0.043	1.456MetVal: 1.456 ± 0.039	0.178MetTrp: 0.178 ± 0.015	0.299MetTyr: 0.299 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.488AsnAla: 2.488 ± 0.052	0.127AsnCys: 0.127 ± 0.011	1.192AsnAsp: 1.192 ± 0.041	1.09AsnGlu: 1.09 ± 0.033	0.656AsnPhe: 0.656 ± 0.027	2.036AsnGly: 2.036 ± 0.055	0.442AsnHis: 0.442 ± 0.021	0.91AsnIle: 0.91 ± 0.035	0.422AsnLys: 0.422 ± 0.023	2.054AsnLeu: 2.054 ± 0.045	0.328AsnMet: 0.328 ± 0.021	0.548AsnAsn: 0.548 ± 0.025	1.542AsnPro: 1.542 ± 0.044	0.661AsnGln: 0.661 ± 0.028	1.42AsnArg: 1.42 ± 0.042	1.096AsnSer: 1.096 ± 0.04	1.22AsnThr: 1.22 ± 0.041	1.629AsnVal: 1.629 ± 0.042	0.311AsnTrp: 0.311 ± 0.017	0.482AsnTyr: 0.482 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.674ProAla: 7.674 ± 0.122	0.242ProCys: 0.242 ± 0.015	3.985ProAsp: 3.985 ± 0.065	3.879ProGlu: 3.879 ± 0.064	1.657ProPhe: 1.657 ± 0.039	5.572ProGly: 5.572 ± 0.085	1.107ProHis: 1.107 ± 0.038	1.716ProIle: 1.716 ± 0.046	1.009ProLys: 1.009 ± 0.035	4.995ProLeu: 4.995 ± 0.079	0.936ProMet: 0.936 ± 0.033	0.941ProAsn: 0.941 ± 0.035	2.41ProPro: 2.41 ± 0.06	1.583ProGln: 1.583 ± 0.04	3.383ProArg: 3.383 ± 0.07	3.578ProSer: 3.578 ± 0.065	3.262ProThr: 3.262 ± 0.059	4.99ProVal: 4.99 ± 0.079	0.768ProTrp: 0.768 ± 0.028	1.035ProTyr: 1.035 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.655GlnAla: 3.655 ± 0.07	0.136GlnCys: 0.136 ± 0.013	1.767GlnAsp: 1.767 ± 0.045	1.646GlnGlu: 1.646 ± 0.045	0.861GlnPhe: 0.861 ± 0.037	2.413GlnGly: 2.413 ± 0.055	0.755GlnHis: 0.755 ± 0.026	1.271GlnIle: 1.271 ± 0.038	0.67GlnLys: 0.67 ± 0.03	3.227GlnLeu: 3.227 ± 0.067	0.536GlnMet: 0.536 ± 0.026	0.633GlnAsn: 0.633 ± 0.028	1.641GlnPro: 1.641 ± 0.043	1.333GlnGln: 1.333 ± 0.042	2.544GlnArg: 2.544 ± 0.056	1.528GlnSer: 1.528 ± 0.038	1.443GlnThr: 1.443 ± 0.04	2.46GlnVal: 2.46 ± 0.054	0.483GlnTrp: 0.483 ± 0.025	0.641GlnTyr: 0.641 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.284ArgAla: 8.284 ± 0.111	0.423ArgCys: 0.423 ± 0.022	3.986ArgAsp: 3.986 ± 0.062	4.056ArgGlu: 4.056 ± 0.071	2.399ArgPhe: 2.399 ± 0.046	5.482ArgGly: 5.482 ± 0.075	1.557ArgHis: 1.557 ± 0.038	3.379ArgIle: 3.379 ± 0.065	1.586ArgLys: 1.586 ± 0.048	7.237ArgLeu: 7.237 ± 0.099	1.587ArgMet: 1.587 ± 0.039	1.565ArgAsn: 1.565 ± 0.041	3.848ArgPro: 3.848 ± 0.07	2.23ArgGln: 2.23 ± 0.057	6.74ArgArg: 6.74 ± 0.104	4.825ArgSer: 4.825 ± 0.08	4.698ArgThr: 4.698 ± 0.074	5.453ArgVal: 5.453 ± 0.074	1.126ArgTrp: 1.126 ± 0.038	1.538ArgTyr: 1.538 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.496SerAla: 7.496 ± 0.106	0.35SerCys: 0.35 ± 0.018	3.304SerAsp: 3.304 ± 0.066	2.984SerGlu: 2.984 ± 0.054	2.005SerPhe: 2.005 ± 0.048	6.06SerGly: 6.06 ± 0.09	1.115SerHis: 1.115 ± 0.032	2.509SerIle: 2.509 ± 0.052	1.199SerLys: 1.199 ± 0.04	5.76SerLeu: 5.76 ± 0.076	1.334SerMet: 1.334 ± 0.038	1.241SerAsn: 1.241 ± 0.036	3.311SerPro: 3.311 ± 0.063	1.51SerGln: 1.51 ± 0.044	4.053SerArg: 4.053 ± 0.067	4.07SerSer: 4.07 ± 0.077	4.024SerThr: 4.024 ± 0.065	4.962SerVal: 4.962 ± 0.076	0.926SerTrp: 0.926 ± 0.028	1.293SerTyr: 1.293 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	8.279ThrAla: 8.279 ± 0.103	0.317ThrCys: 0.317 ± 0.021	3.561ThrAsp: 3.561 ± 0.065	3.222ThrGlu: 3.222 ± 0.061	1.854ThrPhe: 1.854 ± 0.046	6.159ThrGly: 6.159 ± 0.083	1.14ThrHis: 1.14 ± 0.038	2.606ThrIle: 2.606 ± 0.052	1.162ThrLys: 1.162 ± 0.036	6.139ThrLeu: 6.139 ± 0.08	1.066ThrMet: 1.066 ± 0.033	1.18ThrAsn: 1.18 ± 0.042	4.0ThrPro: 4.0 ± 0.07	1.506ThrGln: 1.506 ± 0.042	3.763ThrArg: 3.763 ± 0.057	3.831ThrSer: 3.831 ± 0.068	4.136ThrThr: 4.136 ± 0.07	5.623ThrVal: 5.623 ± 0.077	0.762ThrTrp: 0.762 ± 0.028	1.358ThrTyr: 1.358 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	10.39ValAla: 10.39 ± 0.118	0.515ValCys: 0.515 ± 0.023	5.474ValAsp: 5.474 ± 0.082	4.96ValGlu: 4.96 ± 0.076	2.724ValPhe: 2.724 ± 0.059	6.976ValGly: 6.976 ± 0.11	1.777ValHis: 1.777 ± 0.048	4.095ValIle: 4.095 ± 0.079	1.542ValLys: 1.542 ± 0.048	10.017ValLeu: 10.017 ± 0.132	1.509ValMet: 1.509 ± 0.041	1.882ValAsn: 1.882 ± 0.047	4.917ValPro: 4.917 ± 0.065	2.45ValGln: 2.45 ± 0.05	6.005ValArg: 6.005 ± 0.092	5.005ValSer: 5.005 ± 0.074	5.407ValThr: 5.407 ± 0.081	8.63ValVal: 8.63 ± 0.124	0.972ValTrp: 0.972 ± 0.033	1.483ValTyr: 1.483 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.376TrpAla: 1.376 ± 0.037	0.096TrpCys: 0.096 ± 0.01	0.781TrpAsp: 0.781 ± 0.026	0.622TrpGlu: 0.622 ± 0.024	0.488TrpPhe: 0.488 ± 0.022	0.933TrpGly: 0.933 ± 0.03	0.334TrpHis: 0.334 ± 0.017	0.608TrpIle: 0.608 ± 0.025	0.318TrpLys: 0.318 ± 0.019	1.677TrpLeu: 1.677 ± 0.047	0.27TrpMet: 0.27 ± 0.019	0.455TrpAsn: 0.455 ± 0.024	0.604TrpPro: 0.604 ± 0.024	0.525TrpGln: 0.525 ± 0.025	1.045TrpArg: 1.045 ± 0.04	0.882TrpSer: 0.882 ± 0.033	0.859TrpThr: 0.859 ± 0.028	1.023TrpVal: 1.023 ± 0.033	0.285TrpTrp: 0.285 ± 0.019	0.259TrpTyr: 0.259 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.349TyrAla: 2.349 ± 0.052	0.155TyrCys: 0.155 ± 0.014	1.231TyrAsp: 1.231 ± 0.043	1.201TyrGlu: 1.201 ± 0.04	0.768TyrPhe: 0.768 ± 0.031	1.935TyrGly: 1.935 ± 0.049	0.312TyrHis: 0.312 ± 0.019	0.651TyrIle: 0.651 ± 0.026	0.325TyrLys: 0.325 ± 0.018	2.181TyrLeu: 2.181 ± 0.046	0.265TyrMet: 0.265 ± 0.017	0.439TyrAsn: 0.439 ± 0.025	1.109TyrPro: 1.109 ± 0.042	0.611TyrGln: 0.611 ± 0.028	1.612TyrArg: 1.612 ± 0.046	1.287TyrSer: 1.287 ± 0.035	1.147TyrThr: 1.147 ± 0.043	1.579TyrVal: 1.579 ± 0.042	0.317TyrTrp: 0.317 ± 0.019	0.48TyrTyr: 0.48 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2887 proteins (945779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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