Amino acid dipepetide frequency for Kitasatospora viridis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.903AlaAla: 24.903 ± 0.159	1.109AlaCys: 1.109 ± 0.019	8.821AlaAsp: 8.821 ± 0.065	9.664AlaGlu: 9.664 ± 0.084	3.618AlaPhe: 3.618 ± 0.036	14.829AlaGly: 14.829 ± 0.108	2.878AlaHis: 2.878 ± 0.035	3.364AlaIle: 3.364 ± 0.042	2.422AlaLys: 2.422 ± 0.041	15.955AlaLeu: 15.955 ± 0.1	2.282AlaMet: 2.282 ± 0.029	2.22AlaAsn: 2.22 ± 0.034	8.153AlaPro: 8.153 ± 0.07	4.379AlaGln: 4.379 ± 0.047	10.219AlaArg: 10.219 ± 0.075	5.438AlaSer: 5.438 ± 0.055	7.428AlaThr: 7.428 ± 0.065	12.795AlaVal: 12.795 ± 0.095	1.904AlaTrp: 1.904 ± 0.031	2.475AlaTyr: 2.475 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	1.146CysAla: 1.146 ± 0.021	0.1CysCys: 0.1 ± 0.007	0.443CysAsp: 0.443 ± 0.013	0.384CysGlu: 0.384 ± 0.012	0.218CysPhe: 0.218 ± 0.009	0.943CysGly: 0.943 ± 0.02	0.192CysHis: 0.192 ± 0.008	0.146CysIle: 0.146 ± 0.008	0.089CysLys: 0.089 ± 0.006	0.809CysLeu: 0.809 ± 0.018	0.125CysMet: 0.125 ± 0.007	0.148CysAsn: 0.148 ± 0.008	0.523CysPro: 0.523 ± 0.016	0.211CysGln: 0.211 ± 0.009	0.589CysArg: 0.589 ± 0.014	0.462CysSer: 0.462 ± 0.015	0.544CysThr: 0.544 ± 0.015	0.605CysVal: 0.605 ± 0.014	0.153CysTrp: 0.153 ± 0.007	0.189CysTyr: 0.189 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	6.847AspAla: 6.847 ± 0.059	0.466AspCys: 0.466 ± 0.014	2.824AspAsp: 2.824 ± 0.038	3.177AspGlu: 3.177 ± 0.035	1.535AspPhe: 1.535 ± 0.025	6.352AspGly: 6.352 ± 0.057	1.406AspHis: 1.406 ± 0.025	1.327AspIle: 1.327 ± 0.025	0.752AspLys: 0.752 ± 0.018	6.407AspLeu: 6.407 ± 0.06	0.628AspMet: 0.628 ± 0.014	0.888AspAsn: 0.888 ± 0.021	4.993AspPro: 4.993 ± 0.049	2.056AspGln: 2.056 ± 0.029	5.019AspArg: 5.019 ± 0.055	2.464AspSer: 2.464 ± 0.034	2.85AspThr: 2.85 ± 0.036	3.718AspVal: 3.718 ± 0.042	1.091AspTrp: 1.091 ± 0.021	1.216AspTyr: 1.216 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.798GluAla: 6.798 ± 0.063	0.351GluCys: 0.351 ± 0.011	2.239GluAsp: 2.239 ± 0.032	2.999GluGlu: 2.999 ± 0.041	1.489GluPhe: 1.489 ± 0.023	3.399GluGly: 3.399 ± 0.037	1.603GluHis: 1.603 ± 0.025	1.755GluIle: 1.755 ± 0.027	0.86GluLys: 0.86 ± 0.021	8.226GluLeu: 8.226 ± 0.084	0.682GluMet: 0.682 ± 0.016	0.826GluAsn: 0.826 ± 0.019	3.602GluPro: 3.602 ± 0.042	2.77GluGln: 2.77 ± 0.038	5.311GluArg: 5.311 ± 0.061	2.21GluSer: 2.21 ± 0.027	2.299GluThr: 2.299 ± 0.03	4.38GluVal: 4.38 ± 0.041	0.722GluTrp: 0.722 ± 0.015	1.08GluTyr: 1.08 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.876PheAla: 3.876 ± 0.038	0.268PheCys: 0.268 ± 0.011	1.948PheAsp: 1.948 ± 0.029	1.429PheGlu: 1.429 ± 0.025	0.828PhePhe: 0.828 ± 0.017	3.0PheGly: 3.0 ± 0.036	0.616PheHis: 0.616 ± 0.014	0.615PheIle: 0.615 ± 0.015	0.426PheLys: 0.426 ± 0.014	2.508PheLeu: 2.508 ± 0.029	0.335PheMet: 0.335 ± 0.012	0.534PheAsn: 0.534 ± 0.016	1.391PhePro: 1.391 ± 0.024	0.786PheGln: 0.786 ± 0.018	1.738PheArg: 1.738 ± 0.022	1.387PheSer: 1.387 ± 0.022	2.004PheThr: 2.004 ± 0.028	1.986PheVal: 1.986 ± 0.027	0.43PheTrp: 0.43 ± 0.012	0.56PheTyr: 0.56 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	11.801GlyAla: 11.801 ± 0.085	0.88GlyCys: 0.88 ± 0.017	4.709GlyAsp: 4.709 ± 0.047	5.05GlyGlu: 5.05 ± 0.045	2.885GlyPhe: 2.885 ± 0.032	9.166GlyGly: 9.166 ± 0.094	2.314GlyHis: 2.314 ± 0.03	3.109GlyIle: 3.109 ± 0.037	1.924GlyLys: 1.924 ± 0.031	10.21GlyLeu: 10.21 ± 0.072	1.82GlyMet: 1.82 ± 0.028	1.827GlyAsn: 1.827 ± 0.033	5.713GlyPro: 5.713 ± 0.05	3.081GlyGln: 3.081 ± 0.037	7.811GlyArg: 7.811 ± 0.064	5.714GlySer: 5.714 ± 0.064	6.516GlyThr: 6.516 ± 0.068	7.139GlyVal: 7.139 ± 0.066	1.897GlyTrp: 1.897 ± 0.025	2.48GlyTyr: 2.48 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.628HisAla: 2.628 ± 0.039	0.226HisCys: 0.226 ± 0.011	1.259HisAsp: 1.259 ± 0.025	1.113HisGlu: 1.113 ± 0.021	0.615HisPhe: 0.615 ± 0.013	2.446HisGly: 2.446 ± 0.03	0.738HisHis: 0.738 ± 0.019	0.512HisIle: 0.512 ± 0.014	0.265HisLys: 0.265 ± 0.01	2.662HisLeu: 2.662 ± 0.029	0.289HisMet: 0.289 ± 0.01	0.345HisAsn: 0.345 ± 0.012	2.011HisPro: 2.011 ± 0.029	0.852HisGln: 0.852 ± 0.019	2.288HisArg: 2.288 ± 0.03	1.01HisSer: 1.01 ± 0.021	1.267HisThr: 1.267 ± 0.02	1.413HisVal: 1.413 ± 0.021	0.454HisTrp: 0.454 ± 0.012	0.501HisTyr: 0.501 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.48IleAla: 4.48 ± 0.041	0.271IleCys: 0.271 ± 0.009	1.987IleAsp: 1.987 ± 0.029	1.809IleGlu: 1.809 ± 0.025	0.579IlePhe: 0.579 ± 0.014	3.496IleGly: 3.496 ± 0.037	0.573IleHis: 0.573 ± 0.014	0.713IleIle: 0.713 ± 0.018	0.547IleLys: 0.547 ± 0.013	2.0IleLeu: 2.0 ± 0.032	0.366IleMet: 0.366 ± 0.011	0.658IleAsn: 0.658 ± 0.017	1.535IlePro: 1.535 ± 0.025	0.687IleGln: 0.687 ± 0.015	2.03IleArg: 2.03 ± 0.028	1.567IleSer: 1.567 ± 0.023	2.158IleThr: 2.158 ± 0.029	2.122IleVal: 2.122 ± 0.032	0.371IleTrp: 0.371 ± 0.012	0.458IleTyr: 0.458 ± 0.012	0.0IleXaa: 0.0 ± 0.0
Lys	2.288LysAla: 2.288 ± 0.039	0.088LysCys: 0.088 ± 0.006	0.901LysAsp: 0.901 ± 0.021	0.775LysGlu: 0.775 ± 0.021	0.382LysPhe: 0.382 ± 0.012	1.29LysGly: 1.29 ± 0.023	0.366LysHis: 0.366 ± 0.012	0.591LysIle: 0.591 ± 0.017	0.449LysLys: 0.449 ± 0.019	1.704LysLeu: 1.704 ± 0.023	0.277LysMet: 0.277 ± 0.011	0.358LysAsn: 0.358 ± 0.012	1.069LysPro: 1.069 ± 0.025	0.601LysGln: 0.601 ± 0.017	1.027LysArg: 1.027 ± 0.022	0.904LysSer: 0.904 ± 0.02	0.968LysThr: 0.968 ± 0.023	1.531LysVal: 1.531 ± 0.028	0.19LysTrp: 0.19 ± 0.008	0.356LysTyr: 0.356 ± 0.01	0.0LysXaa: 0.0 ± 0.0
Leu	18.475LeuAla: 18.475 ± 0.14	0.879LeuCys: 0.879 ± 0.019	7.044LeuAsp: 7.044 ± 0.063	4.467LeuGlu: 4.467 ± 0.054	2.627LeuPhe: 2.627 ± 0.031	10.184LeuGly: 10.184 ± 0.066	2.497LeuHis: 2.497 ± 0.034	3.091LeuIle: 3.091 ± 0.036	1.551LeuLys: 1.551 ± 0.027	13.203LeuLeu: 13.203 ± 0.108	1.426LeuMet: 1.426 ± 0.026	1.746LeuAsn: 1.746 ± 0.027	7.527LeuPro: 7.527 ± 0.057	2.32LeuGln: 2.32 ± 0.026	9.238LeuArg: 9.238 ± 0.08	5.172LeuSer: 5.172 ± 0.047	7.469LeuThr: 7.469 ± 0.058	9.377LeuVal: 9.377 ± 0.068	1.38LeuTrp: 1.38 ± 0.024	1.757LeuTyr: 1.757 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	2.036MetAla: 2.036 ± 0.026	0.106MetCys: 0.106 ± 0.006	0.741MetAsp: 0.741 ± 0.016	0.546MetGlu: 0.546 ± 0.016	0.397MetPhe: 0.397 ± 0.013	1.121MetGly: 1.121 ± 0.022	0.303MetHis: 0.303 ± 0.01	0.579MetIle: 0.579 ± 0.014	0.295MetLys: 0.295 ± 0.01	1.519MetLeu: 1.519 ± 0.026	0.247MetMet: 0.247 ± 0.009	0.378MetAsn: 0.378 ± 0.01	0.97MetPro: 0.97 ± 0.018	0.411MetGln: 0.411 ± 0.013	1.151MetArg: 1.151 ± 0.018	1.118MetSer: 1.118 ± 0.018	1.452MetThr: 1.452 ± 0.024	1.174MetVal: 1.174 ± 0.02	0.163MetTrp: 0.163 ± 0.008	0.264MetTyr: 0.264 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.198AsnAla: 2.198 ± 0.036	0.173AsnCys: 0.173 ± 0.009	0.894AsnAsp: 0.894 ± 0.019	0.705AsnGlu: 0.705 ± 0.017	0.466AsnPhe: 0.466 ± 0.013	2.107AsnGly: 2.107 ± 0.039	0.415AsnHis: 0.415 ± 0.013	0.544AsnIle: 0.544 ± 0.014	0.32AsnLys: 0.32 ± 0.015	1.778AsnLeu: 1.778 ± 0.026	0.269AsnMet: 0.269 ± 0.009	0.453AsnAsn: 0.453 ± 0.019	1.441AsnPro: 1.441 ± 0.025	0.636AsnGln: 0.636 ± 0.016	1.243AsnArg: 1.243 ± 0.022	1.056AsnSer: 1.056 ± 0.025	1.18AsnThr: 1.18 ± 0.031	1.234AsnVal: 1.234 ± 0.023	0.307AsnTrp: 0.307 ± 0.01	0.41AsnTyr: 0.41 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	10.727ProAla: 10.727 ± 0.082	0.364ProCys: 0.364 ± 0.013	4.469ProAsp: 4.469 ± 0.047	4.233ProGlu: 4.233 ± 0.044	1.619ProPhe: 1.619 ± 0.026	7.378ProGly: 7.378 ± 0.059	1.337ProHis: 1.337 ± 0.026	1.425ProIle: 1.425 ± 0.023	0.956ProLys: 0.956 ± 0.02	5.84ProLeu: 5.84 ± 0.05	0.878ProMet: 0.878 ± 0.017	1.09ProAsn: 1.09 ± 0.023	3.728ProPro: 3.728 ± 0.05	2.173ProGln: 2.173 ± 0.03	3.699ProArg: 3.699 ± 0.04	3.266ProSer: 3.266 ± 0.046	3.739ProThr: 3.739 ± 0.044	5.917ProVal: 5.917 ± 0.048	0.894ProTrp: 0.894 ± 0.019	1.219ProTyr: 1.219 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	4.561GlnAla: 4.561 ± 0.057	0.193GlnCys: 0.193 ± 0.007	1.599GlnAsp: 1.599 ± 0.025	1.441GlnGlu: 1.441 ± 0.023	0.747GlnPhe: 0.747 ± 0.017	2.507GlnGly: 2.507 ± 0.033	0.8GlnHis: 0.8 ± 0.017	1.002GlnIle: 1.002 ± 0.019	0.453GlnLys: 0.453 ± 0.014	4.093GlnLeu: 4.093 ± 0.043	0.424GlnMet: 0.424 ± 0.014	0.57GlnAsn: 0.57 ± 0.018	2.235GlnPro: 2.235 ± 0.038	1.738GlnGln: 1.738 ± 0.041	2.596GlnArg: 2.596 ± 0.036	1.467GlnSer: 1.467 ± 0.026	1.452GlnThr: 1.452 ± 0.027	2.957GlnVal: 2.957 ± 0.033	0.552GlnTrp: 0.552 ± 0.015	0.678GlnTyr: 0.678 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.211ArgAla: 10.211 ± 0.077	0.614ArgCys: 0.614 ± 0.014	3.614ArgAsp: 3.614 ± 0.039	4.579ArgGlu: 4.579 ± 0.048	2.24ArgPhe: 2.24 ± 0.028	5.347ArgGly: 5.347 ± 0.05	2.058ArgHis: 2.058 ± 0.034	3.159ArgIle: 3.159 ± 0.035	1.183ArgLys: 1.183 ± 0.024	9.541ArgLeu: 9.541 ± 0.087	1.49ArgMet: 1.49 ± 0.022	1.202ArgAsn: 1.202 ± 0.021	5.264ArgPro: 5.264 ± 0.063	2.615ArgGln: 2.615 ± 0.032	7.479ArgArg: 7.479 ± 0.066	3.941ArgSer: 3.941 ± 0.036	5.134ArgThr: 5.134 ± 0.057	5.418ArgVal: 5.418 ± 0.047	1.387ArgTrp: 1.387 ± 0.027	1.706ArgTyr: 1.706 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.985SerAla: 6.985 ± 0.057	0.483SerCys: 0.483 ± 0.013	2.326SerAsp: 2.326 ± 0.034	1.978SerGlu: 1.978 ± 0.029	1.527SerPhe: 1.527 ± 0.022	5.712SerGly: 5.712 ± 0.057	0.961SerHis: 0.961 ± 0.019	1.476SerIle: 1.476 ± 0.024	0.804SerLys: 0.804 ± 0.019	4.653SerLeu: 4.653 ± 0.042	0.988SerMet: 0.988 ± 0.019	0.976SerAsn: 0.976 ± 0.023	3.206SerPro: 3.206 ± 0.035	1.347SerGln: 1.347 ± 0.025	3.256SerArg: 3.256 ± 0.036	2.952SerSer: 2.952 ± 0.047	3.333SerThr: 3.333 ± 0.046	3.929SerVal: 3.929 ± 0.04	1.037SerTrp: 1.037 ± 0.016	1.302SerTyr: 1.302 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	9.83ThrAla: 9.83 ± 0.068	0.42ThrCys: 0.42 ± 0.012	3.623ThrAsp: 3.623 ± 0.04	3.194ThrGlu: 3.194 ± 0.035	1.494ThrPhe: 1.494 ± 0.025	7.199ThrGly: 7.199 ± 0.061	1.077ThrHis: 1.077 ± 0.021	1.569ThrIle: 1.569 ± 0.026	0.897ThrLys: 0.897 ± 0.021	5.652ThrLeu: 5.652 ± 0.05	0.842ThrMet: 0.842 ± 0.02	1.11ThrAsn: 1.11 ± 0.032	4.157ThrPro: 4.157 ± 0.05	1.43ThrGln: 1.43 ± 0.025	3.551ThrArg: 3.551 ± 0.036	3.042ThrSer: 3.042 ± 0.048	3.979ThrThr: 3.979 ± 0.062	6.374ThrVal: 6.374 ± 0.053	0.83ThrTrp: 0.83 ± 0.02	1.107ThrTyr: 1.107 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	10.831ValAla: 10.831 ± 0.079	0.676ValCys: 0.676 ± 0.017	4.52ValAsp: 4.52 ± 0.041	4.475ValGlu: 4.475 ± 0.037	2.302ValPhe: 2.302 ± 0.027	6.403ValGly: 6.403 ± 0.056	1.901ValHis: 1.901 ± 0.024	2.562ValIle: 2.562 ± 0.034	1.392ValLys: 1.392 ± 0.028	10.362ValLeu: 10.362 ± 0.078	1.164ValMet: 1.164 ± 0.022	1.655ValAsn: 1.655 ± 0.027	5.383ValPro: 5.383 ± 0.047	2.288ValGln: 2.288 ± 0.029	6.683ValArg: 6.683 ± 0.053	4.021ValSer: 4.021 ± 0.039	5.272ValThr: 5.272 ± 0.053	7.34ValVal: 7.34 ± 0.063	1.052ValTrp: 1.052 ± 0.018	1.465ValTyr: 1.465 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.732TrpAla: 1.732 ± 0.026	0.169TrpCys: 0.169 ± 0.008	0.759TrpAsp: 0.759 ± 0.017	0.688TrpGlu: 0.688 ± 0.015	0.488TrpPhe: 0.488 ± 0.013	1.079TrpGly: 1.079 ± 0.022	0.425TrpHis: 0.425 ± 0.012	0.491TrpIle: 0.491 ± 0.012	0.259TrpLys: 0.259 ± 0.01	1.906TrpLeu: 1.906 ± 0.031	0.246TrpMet: 0.246 ± 0.008	0.425TrpAsn: 0.425 ± 0.013	0.844TrpPro: 0.844 ± 0.017	0.791TrpGln: 0.791 ± 0.017	1.339TrpArg: 1.339 ± 0.023	1.057TrpSer: 1.057 ± 0.02	1.123TrpThr: 1.123 ± 0.022	1.001TrpVal: 1.001 ± 0.022	0.351TrpTrp: 0.351 ± 0.01	0.367TrpTyr: 0.367 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.502TyrAla: 2.502 ± 0.029	0.185TyrCys: 0.185 ± 0.009	1.294TyrAsp: 1.294 ± 0.03	0.896TyrGlu: 0.896 ± 0.021	0.61TyrPhe: 0.61 ± 0.014	2.091TyrGly: 2.091 ± 0.029	0.436TyrHis: 0.436 ± 0.012	0.378TyrIle: 0.378 ± 0.014	0.272TyrLys: 0.272 ± 0.011	2.403TyrLeu: 2.403 ± 0.033	0.195TyrMet: 0.195 ± 0.009	0.42TyrAsn: 0.42 ± 0.014	1.205TyrPro: 1.205 ± 0.019	0.891TyrGln: 0.891 ± 0.018	1.913TyrArg: 1.913 ± 0.026	0.981TyrSer: 0.981 ± 0.022	1.209TyrThr: 1.209 ± 0.025	1.337TyrVal: 1.337 ± 0.024	0.373TyrTrp: 0.373 ± 0.015	0.47TyrTyr: 0.47 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8776 proteins (2985417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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