Amino acid dipepetide frequency for Spirosoma montaniterrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.302AlaAla: 7.302 ± 0.088
0.721AlaCys: 0.721 ± 0.022
5.777AlaAsp: 5.777 ± 0.076
4.918AlaGlu: 4.918 ± 0.061
3.866AlaPhe: 3.866 ± 0.051
6.924AlaGly: 6.924 ± 0.065
1.449AlaHis: 1.449 ± 0.033
4.801AlaIle: 4.801 ± 0.062
3.578AlaLys: 3.578 ± 0.052
8.507AlaLeu: 8.507 ± 0.087
1.864AlaMet: 1.864 ± 0.037
4.077AlaAsn: 4.077 ± 0.047
3.344AlaPro: 3.344 ± 0.057
4.049AlaGln: 4.049 ± 0.05
4.702AlaArg: 4.702 ± 0.056
4.906AlaSer: 4.906 ± 0.065
5.708AlaThr: 5.708 ± 0.083
6.187AlaVal: 6.187 ± 0.062
0.986AlaTrp: 0.986 ± 0.027
3.137AlaTyr: 3.137 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.019
0.107CysCys: 0.107 ± 0.008
0.358CysAsp: 0.358 ± 0.014
0.365CysGlu: 0.365 ± 0.017
0.367CysPhe: 0.367 ± 0.016
0.587CysGly: 0.587 ± 0.019
0.21CysHis: 0.21 ± 0.013
0.422CysIle: 0.422 ± 0.016
0.222CysLys: 0.222 ± 0.012
0.821CysLeu: 0.821 ± 0.026
0.131CysMet: 0.131 ± 0.009
0.289CysAsn: 0.289 ± 0.014
0.365CysPro: 0.365 ± 0.019
0.349CysGln: 0.349 ± 0.02
0.494CysArg: 0.494 ± 0.019
0.458CysSer: 0.458 ± 0.017
0.444CysThr: 0.444 ± 0.019
0.538CysVal: 0.538 ± 0.018
0.116CysTrp: 0.116 ± 0.009
0.286CysTyr: 0.286 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
5.079AspAla: 5.079 ± 0.057
0.377AspCys: 0.377 ± 0.016
2.813AspAsp: 2.813 ± 0.051
3.453AspGlu: 3.453 ± 0.051
2.611AspPhe: 2.611 ± 0.044
4.16AspGly: 4.16 ± 0.066
0.861AspHis: 0.861 ± 0.021
2.908AspIle: 2.908 ± 0.043
2.454AspLys: 2.454 ± 0.04
5.302AspLeu: 5.302 ± 0.064
1.086AspMet: 1.086 ± 0.028
2.299AspAsn: 2.299 ± 0.043
2.523AspPro: 2.523 ± 0.041
1.999AspGln: 1.999 ± 0.035
3.372AspArg: 3.372 ± 0.053
2.752AspSer: 2.752 ± 0.048
2.835AspThr: 2.835 ± 0.044
4.033AspVal: 4.033 ± 0.054
0.924AspTrp: 0.924 ± 0.024
2.303AspTyr: 2.303 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.408GluAla: 4.408 ± 0.059
0.271GluCys: 0.271 ± 0.014
1.952GluAsp: 1.952 ± 0.038
2.576GluGlu: 2.576 ± 0.052
2.036GluPhe: 2.036 ± 0.04
3.217GluGly: 3.217 ± 0.036
0.968GluHis: 0.968 ± 0.026
2.866GluIle: 2.866 ± 0.051
2.875GluLys: 2.875 ± 0.047
5.314GluLeu: 5.314 ± 0.065
1.173GluMet: 1.173 ± 0.026
2.228GluAsn: 2.228 ± 0.041
2.248GluPro: 2.248 ± 0.038
2.887GluGln: 2.887 ± 0.044
3.611GluArg: 3.611 ± 0.045
2.594GluSer: 2.594 ± 0.04
3.42GluThr: 3.42 ± 0.051
3.421GluVal: 3.421 ± 0.046
0.647GluTrp: 0.647 ± 0.022
1.669GluTyr: 1.669 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
3.814PheAla: 3.814 ± 0.052
0.413PheCys: 0.413 ± 0.015
2.954PheAsp: 2.954 ± 0.04
2.077PheGlu: 2.077 ± 0.038
2.202PhePhe: 2.202 ± 0.041
3.726PheGly: 3.726 ± 0.047
0.667PheHis: 0.667 ± 0.022
2.319PheIle: 2.319 ± 0.04
1.58PheLys: 1.58 ± 0.028
4.079PheLeu: 4.079 ± 0.062
0.993PheMet: 0.993 ± 0.02
2.054PheAsn: 2.054 ± 0.041
1.859PhePro: 1.859 ± 0.033
1.622PheGln: 1.622 ± 0.032
2.844PheArg: 2.844 ± 0.041
3.071PheSer: 3.071 ± 0.045
2.965PheThr: 2.965 ± 0.045
3.334PheVal: 3.334 ± 0.046
0.681PheTrp: 0.681 ± 0.022
1.715PheTyr: 1.715 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.234GlyAla: 5.234 ± 0.066
0.733GlyCys: 0.733 ± 0.021
3.438GlyAsp: 3.438 ± 0.047
3.373GlyGlu: 3.373 ± 0.044
3.558GlyPhe: 3.558 ± 0.045
5.549GlyGly: 5.549 ± 0.076
1.282GlyHis: 1.282 ± 0.027
4.533GlyIle: 4.533 ± 0.056
3.697GlyLys: 3.697 ± 0.053
7.5GlyLeu: 7.5 ± 0.082
1.7GlyMet: 1.7 ± 0.03
3.538GlyAsn: 3.538 ± 0.064
2.511GlyPro: 2.511 ± 0.043
3.596GlyGln: 3.596 ± 0.05
4.473GlyArg: 4.473 ± 0.052
4.533GlySer: 4.533 ± 0.059
4.763GlyThr: 4.763 ± 0.069
5.309GlyVal: 5.309 ± 0.062
1.293GlyTrp: 1.293 ± 0.031
3.044GlyTyr: 3.044 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
1.275HisAla: 1.275 ± 0.033
0.181HisCys: 0.181 ± 0.01
0.971HisAsp: 0.971 ± 0.026
0.964HisGlu: 0.964 ± 0.024
0.906HisPhe: 0.906 ± 0.023
1.145HisGly: 1.145 ± 0.026
0.482HisHis: 0.482 ± 0.019
1.077HisIle: 1.077 ± 0.026
0.647HisLys: 0.647 ± 0.02
1.852HisLeu: 1.852 ± 0.04
0.289HisMet: 0.289 ± 0.014
0.733HisAsn: 0.733 ± 0.022
1.112HisPro: 1.112 ± 0.026
0.793HisGln: 0.793 ± 0.024
1.183HisArg: 1.183 ± 0.026
0.91HisSer: 0.91 ± 0.023
1.129HisThr: 1.129 ± 0.027
1.149HisVal: 1.149 ± 0.03
0.307HisTrp: 0.307 ± 0.012
0.807HisTyr: 0.807 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
4.864IleAla: 4.864 ± 0.059
0.499IleCys: 0.499 ± 0.018
3.67IleAsp: 3.67 ± 0.048
3.145IleGlu: 3.145 ± 0.047
1.992IlePhe: 1.992 ± 0.039
4.53IleGly: 4.53 ± 0.066
0.963IleHis: 0.963 ± 0.024
2.834IleIle: 2.834 ± 0.045
2.211IleLys: 2.211 ± 0.045
4.512IleLeu: 4.512 ± 0.066
0.973IleMet: 0.973 ± 0.027
2.682IleAsn: 2.682 ± 0.044
2.624IlePro: 2.624 ± 0.038
2.095IleGln: 2.095 ± 0.038
3.745IleArg: 3.745 ± 0.052
3.343IleSer: 3.343 ± 0.039
3.616IleThr: 3.616 ± 0.049
3.746IleVal: 3.746 ± 0.049
0.664IleTrp: 0.664 ± 0.024
1.812IleTyr: 1.812 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.001LysAla: 4.001 ± 0.051
0.193LysCys: 0.193 ± 0.011
2.082LysAsp: 2.082 ± 0.038
2.263LysGlu: 2.263 ± 0.042
1.454LysPhe: 1.454 ± 0.03
2.907LysGly: 2.907 ± 0.052
0.802LysHis: 0.802 ± 0.025
2.418LysIle: 2.418 ± 0.039
2.332LysLys: 2.332 ± 0.048
4.363LysLeu: 4.363 ± 0.054
1.039LysMet: 1.039 ± 0.026
2.063LysAsn: 2.063 ± 0.036
2.645LysPro: 2.645 ± 0.045
2.132LysGln: 2.132 ± 0.039
2.662LysArg: 2.662 ± 0.042
2.228LysSer: 2.228 ± 0.039
3.116LysThr: 3.116 ± 0.052
2.629LysVal: 2.629 ± 0.042
0.481LysTrp: 0.481 ± 0.018
1.442LysTyr: 1.442 ± 0.03
0.0LysXaa: 0.0 ± 0.0
Leu
8.924LeuAla: 8.924 ± 0.089
0.793LeuCys: 0.793 ± 0.023
4.933LeuAsp: 4.933 ± 0.057
4.265LeuGlu: 4.265 ± 0.05
4.694LeuPhe: 4.694 ± 0.06
6.447LeuGly: 6.447 ± 0.079
1.835LeuHis: 1.835 ± 0.038
5.598LeuIle: 5.598 ± 0.07
4.467LeuLys: 4.467 ± 0.055
11.364LeuLeu: 11.364 ± 0.131
2.255LeuMet: 2.255 ± 0.04
4.986LeuAsn: 4.986 ± 0.059
5.408LeuPro: 5.408 ± 0.061
3.707LeuGln: 3.707 ± 0.063
6.061LeuArg: 6.061 ± 0.071
6.713LeuSer: 6.713 ± 0.068
8.017LeuThr: 8.017 ± 0.088
6.337LeuVal: 6.337 ± 0.065
1.134LeuTrp: 1.134 ± 0.028
3.354LeuTyr: 3.354 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.063MetAla: 2.063 ± 0.037
0.118MetCys: 0.118 ± 0.009
0.914MetAsp: 0.914 ± 0.022
0.938MetGlu: 0.938 ± 0.023
0.62MetPhe: 0.62 ± 0.019
1.456MetGly: 1.456 ± 0.035
0.445MetHis: 0.445 ± 0.015
1.017MetIle: 1.017 ± 0.026
1.336MetLys: 1.336 ± 0.03
2.253MetLeu: 2.253 ± 0.039
0.471MetMet: 0.471 ± 0.017
1.174MetAsn: 1.174 ± 0.024
1.243MetPro: 1.243 ± 0.027
1.011MetGln: 1.011 ± 0.026
1.251MetArg: 1.251 ± 0.026
1.135MetSer: 1.135 ± 0.029
1.353MetThr: 1.353 ± 0.033
1.284MetVal: 1.284 ± 0.03
0.171MetTrp: 0.171 ± 0.011
0.525MetTyr: 0.525 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
4.09AsnAla: 4.09 ± 0.062
0.334AsnCys: 0.334 ± 0.017
2.461AsnAsp: 2.461 ± 0.043
2.402AsnGlu: 2.402 ± 0.033
1.925AsnPhe: 1.925 ± 0.043
3.934AsnGly: 3.934 ± 0.06
0.794AsnHis: 0.794 ± 0.026
2.316AsnIle: 2.316 ± 0.043
1.693AsnLys: 1.693 ± 0.037
4.423AsnLeu: 4.423 ± 0.059
0.815AsnMet: 0.815 ± 0.02
2.325AsnAsn: 2.325 ± 0.054
2.9AsnPro: 2.9 ± 0.042
2.293AsnGln: 2.293 ± 0.048
3.244AsnArg: 3.244 ± 0.053
2.466AsnSer: 2.466 ± 0.043
2.911AsnThr: 2.911 ± 0.055
3.253AsnVal: 3.253 ± 0.053
0.76AsnTrp: 0.76 ± 0.019
1.836AsnTyr: 1.836 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
5.094ProAla: 5.094 ± 0.065
0.233ProCys: 0.233 ± 0.013
3.664ProAsp: 3.664 ± 0.049
2.719ProGlu: 2.719 ± 0.047
2.193ProPhe: 2.193 ± 0.038
3.66ProGly: 3.66 ± 0.055
0.829ProHis: 0.829 ± 0.023
2.466ProIle: 2.466 ± 0.04
1.981ProLys: 1.981 ± 0.039
4.22ProLeu: 4.22 ± 0.051
0.946ProMet: 0.946 ± 0.028
2.586ProAsn: 2.586 ± 0.043
1.7ProPro: 1.7 ± 0.04
1.732ProGln: 1.732 ± 0.03
1.947ProArg: 1.947 ± 0.038
2.331ProSer: 2.331 ± 0.035
3.434ProThr: 3.434 ± 0.051
4.042ProVal: 4.042 ± 0.056
0.461ProTrp: 0.461 ± 0.019
1.637ProTyr: 1.637 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.813GlnAla: 3.813 ± 0.052
0.233GlnCys: 0.233 ± 0.012
1.533GlnAsp: 1.533 ± 0.028
1.882GlnGlu: 1.882 ± 0.04
2.016GlnPhe: 2.016 ± 0.037
2.436GlnGly: 2.436 ± 0.04
0.926GlnHis: 0.926 ± 0.026
2.445GlnIle: 2.445 ± 0.04
2.109GlnLys: 2.109 ± 0.039
4.803GlnLeu: 4.803 ± 0.064
0.987GlnMet: 0.987 ± 0.026
2.183GlnAsn: 2.183 ± 0.04
2.772GlnPro: 2.772 ± 0.043
2.837GlnGln: 2.837 ± 0.056
2.835GlnArg: 2.835 ± 0.043
2.491GlnSer: 2.491 ± 0.036
3.542GlnThr: 3.542 ± 0.056
2.726GlnVal: 2.726 ± 0.04
0.536GlnTrp: 0.536 ± 0.02
1.773GlnTyr: 1.773 ± 0.028
0.0GlnXaa: 0.0 ± 0.0
Arg
4.723ArgAla: 4.723 ± 0.061
0.342ArgCys: 0.342 ± 0.014
3.021ArgAsp: 3.021 ± 0.057
3.165ArgGlu: 3.165 ± 0.052
3.025ArgPhe: 3.025 ± 0.045
3.414ArgGly: 3.414 ± 0.05
1.154ArgHis: 1.154 ± 0.025
3.633ArgIle: 3.633 ± 0.045
2.524ArgLys: 2.524 ± 0.043
6.423ArgLeu: 6.423 ± 0.07
1.423ArgMet: 1.423 ± 0.03
2.844ArgAsn: 2.844 ± 0.049
2.838ArgPro: 2.838 ± 0.042
3.516ArgGln: 3.516 ± 0.05
3.471ArgArg: 3.471 ± 0.051
3.22ArgSer: 3.22 ± 0.049
3.538ArgThr: 3.538 ± 0.047
4.207ArgVal: 4.207 ± 0.059
0.985ArgTrp: 0.985 ± 0.029
2.594ArgTyr: 2.594 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.054SerAla: 5.054 ± 0.06
0.453SerCys: 0.453 ± 0.019
3.013SerAsp: 3.013 ± 0.047
2.667SerGlu: 2.667 ± 0.043
2.956SerPhe: 2.956 ± 0.044
4.891SerGly: 4.891 ± 0.064
0.95SerHis: 0.95 ± 0.024
3.131SerIle: 3.131 ± 0.048
2.123SerLys: 2.123 ± 0.042
6.29SerLeu: 6.29 ± 0.076
1.15SerMet: 1.15 ± 0.024
2.339SerAsn: 2.339 ± 0.05
2.788SerPro: 2.788 ± 0.038
2.288SerGln: 2.288 ± 0.032
3.277SerArg: 3.277 ± 0.046
3.348SerSer: 3.348 ± 0.046
3.447SerThr: 3.447 ± 0.053
4.62SerVal: 4.62 ± 0.058
0.697SerTrp: 0.697 ± 0.02
2.184SerTyr: 2.184 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
5.931ThrAla: 5.931 ± 0.085
0.398ThrCys: 0.398 ± 0.018
4.177ThrAsp: 4.177 ± 0.052
3.09ThrGlu: 3.09 ± 0.048
2.988ThrPhe: 2.988 ± 0.04
5.592ThrGly: 5.592 ± 0.07
1.118ThrHis: 1.118 ± 0.026
3.723ThrIle: 3.723 ± 0.052
2.398ThrLys: 2.398 ± 0.042
6.91ThrLeu: 6.91 ± 0.069
1.037ThrMet: 1.037 ± 0.026
3.176ThrAsn: 3.176 ± 0.049
3.645ThrPro: 3.645 ± 0.051
2.426ThrGln: 2.426 ± 0.045
3.047ThrArg: 3.047 ± 0.041
3.483ThrSer: 3.483 ± 0.055
4.38ThrThr: 4.38 ± 0.07
5.068ThrVal: 5.068 ± 0.076
0.687ThrTrp: 0.687 ± 0.021
2.546ThrTyr: 2.546 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
6.45ValAla: 6.45 ± 0.066
0.664ValCys: 0.664 ± 0.024
3.648ValAsp: 3.648 ± 0.042
3.59ValGlu: 3.59 ± 0.051
3.072ValPhe: 3.072 ± 0.048
5.364ValGly: 5.364 ± 0.069
1.131ValHis: 1.131 ± 0.029
3.675ValIle: 3.675 ± 0.058
2.884ValLys: 2.884 ± 0.04
7.135ValLeu: 7.135 ± 0.076
1.506ValMet: 1.506 ± 0.032
3.212ValAsn: 3.212 ± 0.049
3.205ValPro: 3.205 ± 0.042
2.839ValGln: 2.839 ± 0.042
4.413ValArg: 4.413 ± 0.058
4.932ValSer: 4.932 ± 0.06
4.216ValThr: 4.216 ± 0.063
5.639ValVal: 5.639 ± 0.061
0.991ValTrp: 0.991 ± 0.027
2.417ValTyr: 2.417 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.008TrpAla: 1.008 ± 0.029
0.098TrpCys: 0.098 ± 0.007
0.599TrpAsp: 0.599 ± 0.019
0.618TrpGlu: 0.618 ± 0.016
0.644TrpPhe: 0.644 ± 0.02
0.928TrpGly: 0.928 ± 0.028
0.337TrpHis: 0.337 ± 0.015
0.6TrpIle: 0.6 ± 0.017
0.55TrpLys: 0.55 ± 0.02
1.699TrpLeu: 1.699 ± 0.037
0.303TrpMet: 0.303 ± 0.014
0.633TrpAsn: 0.633 ± 0.022
0.495TrpPro: 0.495 ± 0.022
0.903TrpGln: 0.903 ± 0.025
0.824TrpArg: 0.824 ± 0.023
0.72TrpSer: 0.72 ± 0.02
0.741TrpThr: 0.741 ± 0.021
0.883TrpVal: 0.883 ± 0.026
0.215TrpTrp: 0.215 ± 0.01
0.474TrpTyr: 0.474 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.118TyrAla: 3.118 ± 0.043
0.327TyrCys: 0.327 ± 0.016
2.166TyrAsp: 2.166 ± 0.038
1.91TyrGlu: 1.91 ± 0.035
1.845TyrPhe: 1.845 ± 0.033
2.789TyrGly: 2.789 ± 0.044
0.71TyrHis: 0.71 ± 0.022
1.735TyrIle: 1.735 ± 0.034
1.59TyrLys: 1.59 ± 0.034
3.524TyrLeu: 3.524 ± 0.051
0.636TyrMet: 0.636 ± 0.016
1.753TyrAsn: 1.753 ± 0.037
1.651TyrPro: 1.651 ± 0.026
1.805TyrGln: 1.805 ± 0.033
2.605TyrArg: 2.605 ± 0.048
2.036TyrSer: 2.036 ± 0.04
2.245TyrThr: 2.245 ± 0.042
2.579TyrVal: 2.579 ± 0.033
0.532TyrTrp: 0.532 ± 0.018
1.509TyrTyr: 1.509 ± 0.039
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4811 proteins (1699614 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski