Amino acid dipepetide frequency for Oscillibacter sp. CAG:155

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.063AlaAla: 13.063 ± 0.183
1.69AlaCys: 1.69 ± 0.055
5.753AlaAsp: 5.753 ± 0.107
6.935AlaGlu: 6.935 ± 0.131
3.473AlaPhe: 3.473 ± 0.082
8.424AlaGly: 8.424 ± 0.136
1.556AlaHis: 1.556 ± 0.056
5.0AlaIle: 5.0 ± 0.108
4.084AlaLys: 4.084 ± 0.097
10.413AlaLeu: 10.413 ± 0.15
3.002AlaMet: 3.002 ± 0.065
2.234AlaAsn: 2.234 ± 0.056
3.456AlaPro: 3.456 ± 0.087
3.883AlaGln: 3.883 ± 0.083
4.833AlaArg: 4.833 ± 0.106
4.568AlaSer: 4.568 ± 0.077
3.861AlaThr: 3.861 ± 0.085
9.111AlaVal: 9.111 ± 0.141
0.95AlaTrp: 0.95 ± 0.041
2.864AlaTyr: 2.864 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
1.657CysAla: 1.657 ± 0.051
0.372CysCys: 0.372 ± 0.029
0.926CysAsp: 0.926 ± 0.036
0.854CysGlu: 0.854 ± 0.036
0.617CysPhe: 0.617 ± 0.032
1.982CysGly: 1.982 ± 0.067
0.358CysHis: 0.358 ± 0.023
0.912CysIle: 0.912 ± 0.041
0.651CysLys: 0.651 ± 0.032
1.492CysLeu: 1.492 ± 0.049
0.405CysMet: 0.405 ± 0.027
0.495CysAsn: 0.495 ± 0.027
0.904CysPro: 0.904 ± 0.041
0.548CysGln: 0.548 ± 0.031
1.169CysArg: 1.169 ± 0.045
0.898CysSer: 0.898 ± 0.042
0.879CysThr: 0.879 ± 0.037
1.295CysVal: 1.295 ± 0.044
0.18CysTrp: 0.18 ± 0.019
0.521CysTyr: 0.521 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
5.667AspAla: 5.667 ± 0.094
0.887AspCys: 0.887 ± 0.039
2.618AspAsp: 2.618 ± 0.098
3.639AspGlu: 3.639 ± 0.08
2.369AspPhe: 2.369 ± 0.063
5.236AspGly: 5.236 ± 0.111
1.144AspHis: 1.144 ± 0.047
3.114AspIle: 3.114 ± 0.078
2.115AspLys: 2.115 ± 0.068
5.886AspLeu: 5.886 ± 0.112
1.413AspMet: 1.413 ± 0.051
1.459AspAsn: 1.459 ± 0.049
2.705AspPro: 2.705 ± 0.067
1.923AspGln: 1.923 ± 0.045
2.987AspArg: 2.987 ± 0.072
2.657AspSer: 2.657 ± 0.074
3.402AspThr: 3.402 ± 0.087
3.892AspVal: 3.892 ± 0.089
0.655AspTrp: 0.655 ± 0.04
2.152AspTyr: 2.152 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
6.589GluAla: 6.589 ± 0.13
0.723GluCys: 0.723 ± 0.035
3.817GluAsp: 3.817 ± 0.09
5.729GluGlu: 5.729 ± 0.106
1.961GluPhe: 1.961 ± 0.059
4.554GluGly: 4.554 ± 0.093
1.377GluHis: 1.377 ± 0.049
3.888GluIle: 3.888 ± 0.085
4.002GluLys: 4.002 ± 0.103
6.647GluLeu: 6.647 ± 0.114
2.03GluMet: 2.03 ± 0.05
2.719GluAsn: 2.719 ± 0.066
2.281GluPro: 2.281 ± 0.066
2.813GluGln: 2.813 ± 0.071
3.919GluArg: 3.919 ± 0.095
3.076GluSer: 3.076 ± 0.077
4.28GluThr: 4.28 ± 0.091
4.143GluVal: 4.143 ± 0.089
0.52GluTrp: 0.52 ± 0.03
1.827GluTyr: 1.827 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.492PheAla: 3.492 ± 0.082
0.841PheCys: 0.841 ± 0.035
2.256PheAsp: 2.256 ± 0.055
1.769PheGlu: 1.769 ± 0.048
1.586PhePhe: 1.586 ± 0.068
3.108PheGly: 3.108 ± 0.081
0.814PheHis: 0.814 ± 0.034
1.73PheIle: 1.73 ± 0.064
1.024PheLys: 1.024 ± 0.045
4.021PheLeu: 4.021 ± 0.095
0.748PheMet: 0.748 ± 0.035
1.01PheAsn: 1.01 ± 0.039
1.604PhePro: 1.604 ± 0.057
1.309PheGln: 1.309 ± 0.049
2.112PheArg: 2.112 ± 0.064
2.607PheSer: 2.607 ± 0.074
2.408PheThr: 2.408 ± 0.067
2.434PheVal: 2.434 ± 0.079
0.422PheTrp: 0.422 ± 0.025
1.288PheTyr: 1.288 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
7.213GlyAla: 7.213 ± 0.116
1.564GlyCys: 1.564 ± 0.056
4.376GlyAsp: 4.376 ± 0.092
5.02GlyGlu: 5.02 ± 0.095
2.953GlyPhe: 2.953 ± 0.074
7.047GlyGly: 7.047 ± 0.138
1.611GlyHis: 1.611 ± 0.061
5.064GlyIle: 5.064 ± 0.085
4.433GlyLys: 4.433 ± 0.086
7.402GlyLeu: 7.402 ± 0.118
2.519GlyMet: 2.519 ± 0.065
2.435GlyAsn: 2.435 ± 0.052
2.166GlyPro: 2.166 ± 0.055
2.747GlyGln: 2.747 ± 0.078
4.54GlyArg: 4.54 ± 0.093
4.566GlySer: 4.566 ± 0.102
5.529GlyThr: 5.529 ± 0.101
6.534GlyVal: 6.534 ± 0.111
0.925GlyTrp: 0.925 ± 0.042
2.917GlyTyr: 2.917 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
1.533HisAla: 1.533 ± 0.054
0.432HisCys: 0.432 ± 0.026
0.969HisAsp: 0.969 ± 0.044
0.955HisGlu: 0.955 ± 0.042
0.799HisPhe: 0.799 ± 0.035
1.698HisGly: 1.698 ± 0.056
0.545HisHis: 0.545 ± 0.032
1.197HisIle: 1.197 ± 0.052
0.666HisLys: 0.666 ± 0.038
2.106HisLeu: 2.106 ± 0.059
0.496HisMet: 0.496 ± 0.031
0.603HisAsn: 0.603 ± 0.034
1.156HisPro: 1.156 ± 0.05
0.679HisGln: 0.679 ± 0.039
1.139HisArg: 1.139 ± 0.051
0.923HisSer: 0.923 ± 0.035
1.114HisThr: 1.114 ± 0.038
1.396HisVal: 1.396 ± 0.052
0.244HisTrp: 0.244 ± 0.021
0.638HisTyr: 0.638 ± 0.03
0.002HisXaa: 0.002 ± 0.002
Ile
5.337IleAla: 5.337 ± 0.098
1.052IleCys: 1.052 ± 0.044
2.868IleAsp: 2.868 ± 0.057
2.621IleGlu: 2.621 ± 0.073
1.941IlePhe: 1.941 ± 0.061
4.217IleGly: 4.217 ± 0.102
1.158IleHis: 1.158 ± 0.045
2.832IleIle: 2.832 ± 0.082
1.747IleLys: 1.747 ± 0.054
5.93IleLeu: 5.93 ± 0.119
1.227IleMet: 1.227 ± 0.047
1.651IleAsn: 1.651 ± 0.059
2.887IlePro: 2.887 ± 0.066
1.956IleGln: 1.956 ± 0.064
3.472IleArg: 3.472 ± 0.073
3.509IleSer: 3.509 ± 0.083
3.404IleThr: 3.404 ± 0.08
3.876IleVal: 3.876 ± 0.081
0.514IleTrp: 0.514 ± 0.03
1.679IleTyr: 1.679 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.204LysAla: 4.204 ± 0.102
0.501LysCys: 0.501 ± 0.029
2.246LysAsp: 2.246 ± 0.066
3.294LysGlu: 3.294 ± 0.082
1.192LysPhe: 1.192 ± 0.045
2.942LysGly: 2.942 ± 0.067
0.701LysHis: 0.701 ± 0.032
2.497LysIle: 2.497 ± 0.071
2.933LysLys: 2.933 ± 0.081
4.232LysLeu: 4.232 ± 0.089
1.312LysMet: 1.312 ± 0.047
1.794LysAsn: 1.794 ± 0.059
1.696LysPro: 1.696 ± 0.062
1.495LysGln: 1.495 ± 0.052
2.493LysArg: 2.493 ± 0.069
2.178LysSer: 2.178 ± 0.065
2.687LysThr: 2.687 ± 0.068
2.95LysVal: 2.95 ± 0.074
0.414LysTrp: 0.414 ± 0.027
1.479LysTyr: 1.479 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
9.851LeuAla: 9.851 ± 0.142
2.023LeuCys: 2.023 ± 0.059
5.775LeuAsp: 5.775 ± 0.112
6.653LeuGlu: 6.653 ± 0.109
3.847LeuPhe: 3.847 ± 0.096
7.622LeuGly: 7.622 ± 0.128
2.011LeuHis: 2.011 ± 0.065
4.648LeuIle: 4.648 ± 0.093
4.08LeuLys: 4.08 ± 0.092
11.177LeuLeu: 11.177 ± 0.189
2.596LeuMet: 2.596 ± 0.074
2.862LeuAsn: 2.862 ± 0.075
5.105LeuPro: 5.105 ± 0.104
3.283LeuGln: 3.283 ± 0.088
6.447LeuArg: 6.447 ± 0.135
6.698LeuSer: 6.698 ± 0.129
6.572LeuThr: 6.572 ± 0.129
6.852LeuVal: 6.852 ± 0.125
1.021LeuTrp: 1.021 ± 0.046
3.068LeuTyr: 3.068 ± 0.077
0.0LeuXaa: 0.0 ± 0.0
Met
2.786MetAla: 2.786 ± 0.072
0.347MetCys: 0.347 ± 0.026
1.78MetAsp: 1.78 ± 0.059
2.333MetGlu: 2.333 ± 0.066
0.72MetPhe: 0.72 ± 0.038
2.221MetGly: 2.221 ± 0.071
0.384MetHis: 0.384 ± 0.026
1.274MetIle: 1.274 ± 0.054
1.604MetLys: 1.604 ± 0.048
2.607MetLeu: 2.607 ± 0.077
0.805MetMet: 0.805 ± 0.043
1.054MetAsn: 1.054 ± 0.04
1.117MetPro: 1.117 ± 0.038
0.877MetGln: 0.877 ± 0.04
1.388MetArg: 1.388 ± 0.049
1.604MetSer: 1.604 ± 0.05
1.786MetThr: 1.786 ± 0.057
1.974MetVal: 1.974 ± 0.065
0.187MetTrp: 0.187 ± 0.019
0.562MetTyr: 0.562 ± 0.03
0.002MetXaa: 0.002 ± 0.002
Asn
2.854AsnAla: 2.854 ± 0.079
0.523AsnCys: 0.523 ± 0.027
1.444AsnAsp: 1.444 ± 0.045
1.596AsnGlu: 1.596 ± 0.044
1.07AsnPhe: 1.07 ± 0.047
2.736AsnGly: 2.736 ± 0.075
0.643AsnHis: 0.643 ± 0.033
1.879AsnIle: 1.879 ± 0.065
1.118AsnLys: 1.118 ± 0.046
3.127AsnLeu: 3.127 ± 0.067
0.887AsnMet: 0.887 ± 0.042
0.895AsnAsn: 0.895 ± 0.044
1.703AsnPro: 1.703 ± 0.054
1.047AsnGln: 1.047 ± 0.043
1.833AsnArg: 1.833 ± 0.06
1.403AsnSer: 1.403 ± 0.044
1.775AsnThr: 1.775 ± 0.057
2.12AsnVal: 2.12 ± 0.051
0.365AsnTrp: 0.365 ± 0.026
1.098AsnTyr: 1.098 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.529ProAla: 4.529 ± 0.086
0.602ProCys: 0.602 ± 0.031
2.873ProAsp: 2.873 ± 0.074
3.984ProGlu: 3.984 ± 0.095
1.602ProPhe: 1.602 ± 0.054
3.665ProGly: 3.665 ± 0.085
0.786ProHis: 0.786 ± 0.041
2.021ProIle: 2.021 ± 0.058
1.552ProLys: 1.552 ± 0.053
3.802ProLeu: 3.802 ± 0.077
1.06ProMet: 1.06 ± 0.045
1.221ProAsn: 1.221 ± 0.039
1.466ProPro: 1.466 ± 0.054
1.581ProGln: 1.581 ± 0.051
1.969ProArg: 1.969 ± 0.062
1.999ProSer: 1.999 ± 0.057
1.988ProThr: 1.988 ± 0.053
3.705ProVal: 3.705 ± 0.082
0.454ProTrp: 0.454 ± 0.027
1.441ProTyr: 1.441 ± 0.051
0.002ProXaa: 0.002 ± 0.002
Gln
3.736GlnAla: 3.736 ± 0.08
0.449GlnCys: 0.449 ± 0.026
1.77GlnAsp: 1.77 ± 0.055
2.673GlnGlu: 2.673 ± 0.075
1.148GlnPhe: 1.148 ± 0.04
2.568GlnGly: 2.568 ± 0.07
0.676GlnHis: 0.676 ± 0.033
2.073GlnIle: 2.073 ± 0.056
1.911GlnLys: 1.911 ± 0.057
3.536GlnLeu: 3.536 ± 0.092
1.265GlnMet: 1.265 ± 0.044
1.161GlnAsn: 1.161 ± 0.044
1.433GlnPro: 1.433 ± 0.053
1.622GlnGln: 1.622 ± 0.065
2.166GlnArg: 2.166 ± 0.068
1.87GlnSer: 1.87 ± 0.061
2.04GlnThr: 2.04 ± 0.06
2.738GlnVal: 2.738 ± 0.057
0.354GlnTrp: 0.354 ± 0.023
1.134GlnTyr: 1.134 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
4.522ArgAla: 4.522 ± 0.097
1.013ArgCys: 1.013 ± 0.042
3.131ArgAsp: 3.131 ± 0.072
4.573ArgGlu: 4.573 ± 0.091
2.142ArgPhe: 2.142 ± 0.065
3.697ArgGly: 3.697 ± 0.082
1.18ArgHis: 1.18 ± 0.043
3.264ArgIle: 3.264 ± 0.075
2.826ArgLys: 2.826 ± 0.068
5.672ArgLeu: 5.672 ± 0.1
1.742ArgMet: 1.742 ± 0.056
1.722ArgAsn: 1.722 ± 0.05
2.191ArgPro: 2.191 ± 0.067
2.799ArgGln: 2.799 ± 0.085
4.521ArgArg: 4.521 ± 0.099
2.938ArgSer: 2.938 ± 0.064
3.251ArgThr: 3.251 ± 0.078
3.571ArgVal: 3.571 ± 0.084
0.589ArgTrp: 0.589 ± 0.029
2.051ArgTyr: 2.051 ± 0.057
0.0ArgXaa: 0.0 ± 0.0
Ser
5.489SerAla: 5.489 ± 0.117
0.918SerCys: 0.918 ± 0.042
3.024SerAsp: 3.024 ± 0.07
2.95SerGlu: 2.95 ± 0.068
2.33SerPhe: 2.33 ± 0.064
5.512SerGly: 5.512 ± 0.108
1.084SerHis: 1.084 ± 0.045
2.868SerIle: 2.868 ± 0.067
2.0SerLys: 2.0 ± 0.057
5.313SerLeu: 5.313 ± 0.105
1.444SerMet: 1.444 ± 0.047
1.572SerAsn: 1.572 ± 0.048
2.301SerPro: 2.301 ± 0.068
1.948SerGln: 1.948 ± 0.058
3.215SerArg: 3.215 ± 0.076
3.059SerSer: 3.059 ± 0.074
2.772SerThr: 2.772 ± 0.082
4.221SerVal: 4.221 ± 0.084
0.548SerTrp: 0.548 ± 0.031
1.849SerTyr: 1.849 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
6.521ThrAla: 6.521 ± 0.096
0.904ThrCys: 0.904 ± 0.041
3.201ThrAsp: 3.201 ± 0.079
3.513ThrGlu: 3.513 ± 0.079
2.152ThrPhe: 2.152 ± 0.06
5.346ThrGly: 5.346 ± 0.103
1.01ThrHis: 1.01 ± 0.043
3.305ThrIle: 3.305 ± 0.08
1.901ThrLys: 1.901 ± 0.059
5.924ThrLeu: 5.924 ± 0.11
1.485ThrMet: 1.485 ± 0.056
1.517ThrAsn: 1.517 ± 0.065
2.999ThrPro: 2.999 ± 0.075
1.663ThrGln: 1.663 ± 0.048
2.566ThrArg: 2.566 ± 0.064
2.69ThrSer: 2.69 ± 0.071
2.961ThrThr: 2.961 ± 0.084
5.753ThrVal: 5.753 ± 0.106
0.622ThrTrp: 0.622 ± 0.029
1.985ThrTyr: 1.985 ± 0.062
0.003ThrXaa: 0.003 ± 0.002
Val
6.323ValAla: 6.323 ± 0.119
1.545ValCys: 1.545 ± 0.049
4.262ValAsp: 4.262 ± 0.089
5.055ValGlu: 5.055 ± 0.092
2.924ValPhe: 2.924 ± 0.071
5.455ValGly: 5.455 ± 0.111
1.312ValHis: 1.312 ± 0.045
4.165ValIle: 4.165 ± 0.104
3.054ValLys: 3.054 ± 0.078
8.363ValLeu: 8.363 ± 0.133
1.967ValMet: 1.967 ± 0.056
2.204ValAsn: 2.204 ± 0.068
3.41ValPro: 3.41 ± 0.084
2.341ValGln: 2.341 ± 0.063
4.116ValArg: 4.116 ± 0.078
4.877ValSer: 4.877 ± 0.095
4.798ValThr: 4.798 ± 0.087
5.937ValVal: 5.937 ± 0.113
0.745ValTrp: 0.745 ± 0.032
2.423ValTyr: 2.423 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.869TrpAla: 0.869 ± 0.04
0.189TrpCys: 0.189 ± 0.02
0.58TrpAsp: 0.58 ± 0.029
0.723TrpGlu: 0.723 ± 0.037
0.427TrpPhe: 0.427 ± 0.032
0.756TrpGly: 0.756 ± 0.036
0.224TrpHis: 0.224 ± 0.019
0.443TrpIle: 0.443 ± 0.027
0.531TrpLys: 0.531 ± 0.034
1.044TrpLeu: 1.044 ± 0.048
0.321TrpMet: 0.321 ± 0.022
0.439TrpAsn: 0.439 ± 0.029
0.356TrpPro: 0.356 ± 0.019
0.48TrpGln: 0.48 ± 0.029
0.548TrpArg: 0.548 ± 0.027
0.594TrpSer: 0.594 ± 0.033
0.506TrpThr: 0.506 ± 0.028
0.671TrpVal: 0.671 ± 0.035
0.139TrpTrp: 0.139 ± 0.018
0.389TrpTyr: 0.389 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.914TyrAla: 2.914 ± 0.08
0.539TyrCys: 0.539 ± 0.03
2.251TyrAsp: 2.251 ± 0.064
2.027TyrGlu: 2.027 ± 0.064
1.331TyrPhe: 1.331 ± 0.047
2.774TyrGly: 2.774 ± 0.074
0.715TyrHis: 0.715 ± 0.036
1.706TyrIle: 1.706 ± 0.055
1.011TyrLys: 1.011 ± 0.041
3.494TyrLeu: 3.494 ± 0.083
0.684TyrMet: 0.684 ± 0.039
1.073TyrAsn: 1.073 ± 0.043
1.364TyrPro: 1.364 ± 0.047
1.323TyrGln: 1.323 ± 0.044
1.963TyrArg: 1.963 ± 0.058
1.704TyrSer: 1.704 ± 0.054
2.008TyrThr: 2.008 ± 0.059
2.103TyrVal: 2.103 ± 0.062
0.381TyrTrp: 0.381 ± 0.026
1.3TyrTyr: 1.3 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.002XaaAla: 0.002 ± 0.002
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.003XaaGln: 0.003 ± 0.003
0.0XaaArg: 0.0 ± 0.0
0.002XaaSer: 0.002 ± 0.002
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.014XaaXaa: 0.014 ± 0.007
Statistics based on 2148 proteins (634855 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski